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  • Prominent Journalist Calls Out Australian TGA for removing Ivermectin


    Prominent Journalist Calls Out Australian TGA for removing Ivermectin
    Rebecca Weisser, a well-respected journalist, recently criticized the Therapeutic Goods Administration for removing the so-called miracle drug ivermectin,
    trialsitenews.com



    Rebecca Weisser, a well-respected journalist, recently criticized the Therapeutic Goods Administration for removing the so-called miracle drug ivermectin, asserting that the ban was based on insufficient evaluations. On October 22, Weisser was a guest on the Asia Pacific Today Show expressing her disapproval of the ban TrialSite first covered. https://trialsitenews.com/aust…cination-as-clear-factor/ Weisser shared that there were no safety risks that could lead to life-threatening effects. The ban was apparently a rushed, improper decision.


    Rebecca Weisser was a career diplomat in the Department of Foreign Affairs Trade in 1990. She earned a First Class Honors degree in Arts at Australian National University. Weisser’s recent interview with Mike Ryan addressed the decision by the Therapeutic Goods Administration (TGA) to ban ivermectin –that is, as TrialSite explained in September, https://trialsitenews.com/aust…cination-as-clear-factor/ general practitioners (GPs) could not access the drug to treat COVID-19 patients, due to apparent “safety risk” concerns. This prompted Weisser’s outspoken disapproval of the decision, leading her to express concerns about what the TGA is doing.


    A Rushed Decision

    According to Rebecca, the monitoring of the response to not only ivermectin but also other COVID-19 interventions, such as the new mRNA vaccine technology, was inadequate. Rebecca explicitly stated that the TGA is not doing its job properly and effectively.


    Rebecca Weisser went on to say that the TGA had not done due diligence to thoroughly analyze ivermectin’s substantial studies, epidemiological evidence, in-vitro evidence, and in silico evidence.


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    Weisser asserted that the entire process of the ban was unacceptable, as a delegate of the Secretary from the Commonwealth’s Department of Health had allegedly changed the restrictions of ivermectin without proper consultation. The delegate’s reasoning behind the improper process was due to said emergency which Weisser declares was a statement without evidence.


    Poor Arguments Behind the Ban

    The TGA declared the ban was partly due to safety issues from the drug’s use. However, their reason contrasted with reports that show there are no life-threatening adverse effects related to ivermectin’s use in treating COVID-19. According to Dr. Carlos Chaccour, when it is used in the approved doses, ivermectin is a very safe drug.


    In light of this, Weisser concluded that the delegate’s reasoning behind the drug’s safety issues was simply not sufficient grounds on which to base their decision. Weisser also claimed that the decision was not grounded in a good understanding of the drug: “The delegate of the secretary … consulted, apparently, with the Therapeutic Goods Administration, and they consulted with the relevant committee … which was comprised of people who had no knowledge of ivermectin and its uses in relation to COVID-19,” she explained.


    Weisser also shared that when she spoke with the TGA, there appeared to be no means of reviewing the drug, which she described as ‘appalling’. She went on to say that ivermectin’s ban had gone through an absurd process, which was baseless and needed appealing.


    Weisser also expressed frustration that general practitioners can still legally prescribe ivermectin, but for only approved indications, while specialists can prescribe for off-label (but undoubtedly, they must go through enhanced bureaucratic scrutiny) and pharmacists refuse to fill the prescription if it is not for specified indications of river blindness, threadworm, or scabies. Doctors are said to be held back from thoroughly treating their patients. While ivermectin can be prescribed for certain conditions, the process required to get the prescription from a specialist makes accessing the drug very difficult. This of course sounds like a policy that helps the industry.


    Government Bureaucrat Involvement

    The Head of TGA, Professor John Skerrit, previously told TrialSite that there would be no issues lifting the ban as long as there is enough high-quality evidence to support the drug. He stated that they were willing to consider evidence coming from well-conducted trials that were unbiased.


    However, in the recent interview with Rebecca Weisser, she emphasized that the role of the TGA does not include intervention of patient-doctor relationships. That specific role is said to be within the scope of duties of the Australian Health Practitioner Regulation Agency (AHPRA). According to Weisser, the AHPRA has said that they are prohibited to go against the government’s decision. She asserted that behind the ban was a government bureaucrat with minimal knowledge of saving lives.


    Weisser stated that currently, healthcare workers who go against the government will face penalties. Two doctors have been suspended from practicing medicine for posting statements on social media about controversial issues such as mask efficacy, despite these posts being backed up by science. She went on to express that doctors should not be suspended for making science-based statements, calling the practice ‘appalling’ and something that should change.


    According to her statements, Weisser believes there is an agenda behind the ivermectin ban which benefits the government and vaccine manufacturers more than the general public. With high levels of censorship of certain issues in mainstream media, and the absence of transparent evidence-based approaches, trust in the government begins to evaporate. Many viewers echoed Weisser’s sentiments in the comments below the video.


    TrialSite continues to follow the issue of ivermectin’s role in treating COVID around the globe, including the political implications related to its use.

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  • The EU vaccine terror nations are again in panic mode and the mafia "cricket brains" are in full action. Here in the Zürich location we had 73 peek cases in ICU during the last big wave (Januray..February). Since 3 months we see no significant change in serious (ventilation) ICU cases just fluctuations between 13..22. Now 17. So despite 3x PCR+ cases since August - 50% of last wave - we see no more ICU load!

    Vaccination is about 68% more or less the same as in most vaccine terror states.


    covid_19/COVID19_Fallzahlen_Kanton_ZH_total.csv at master · openZH/covid_19
    COVID19 case numbers of Cantons of Switzerland and Principality of Liechtenstein (FL). The data is updated at best once a day (times of collection and update…
    github.com



    So it looks like fear mongering campaigns just reemerge to get the max out of vaccine sales!

    German chief Dr. Mengele sees 100'000 more deaths or course without any treatment! These numbers were in the FAZ head lines and now are buried (deleted from www) already except on facebook Twitter...



    The reality is quite different also in Germany just emerging: The main problem are the vaccinated!!


    Zugleich ist der Anteil vollständig Geimpfter an den Corona-Fällen mit Symptomen in den letzten Wochen deutlich gestiegen, wie aus dem Wochenbericht des Robert Koch-Instituts (RKI) vom Donnerstag hervorgeht. Bei den Menschen ab 60 Jahren, also der Altersgruppe, die relativ früh mit dem Impfen dran war, lag der Anteil in den vergangenen Wochen (11.10.-7.11.) sogar bei über 60 Prozent.

    Coronavirus: Was ist dran an der „Pandemie der Ungeimpften“? - WELT
    Ein Großteil der Menschen, die auf Intensivstationen mit Covid-19 behandelt werden, ist ungeimpft. Der Begriff „Pandemie der Ungeimpften“ ist aber nur zum Teil…
    www.welt.de

  • Heureka!!



    Kerala finally managed to piece wise (daily 300..600) dump all 6000 hidden CoV-19 deaths. So now India shows a low 125 death/day for 1.35 billion people or about 0.1/million. Great!!

    > 50% of deaths still come from the small vaccine terror states Kerala/Mizoram (68/125...).


    All other states do see no more CoV-19 waves. Why are people blind despite the largest and best documented trial shows the full truth? Vaccines only do not work! In contrary. We see 35 mio. vaccine terror state victims produce more CoV-19 deaths than 1'320 Million treated people.

    Of course the early India Ivermectin states now show more or less zero daily deaths ....

  • For those who can read German (from Twitter commenting the increased value of double vaxx hospitalizations vs unvvaccinated in Germany). No wonder, why more and more double vaxx show up at hospitals an ICU's...if 100% of patients age 65+ were fully double vaaccinated, then we see of course 100% vaccinated patients, and none from the other group.


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    "Geimpfte werden also 1/0,081= ca 12mal seltener hospitalisiert als Ungeimpfte (Rechnung dazu: (45/55)/(91/9)=0,081). Die Darstellung erscheint zwar etwas sonderbar, aber genau so ist es im Moment zu erwarten." --> still the main problem is that the unvaccinated are at significant higher risk to end up at the ICU.


    Maybe this is all faked and paid by big pharma and the mafia...?

  • It seems we here in Germany will follow our neighbours in more strict ruling on 2G, 3G, 3G+...there is a huge discussion in the public on partial lock downs for the unvaxx group, very difficult. Since you can catch the virus even when double vaxxed, it is recommended to reduce your contacts anyway. The statistic and data luckily shows, that you (and recovered ones) will have a significant lower risk vs unvaccinated to end up in hospital or die....

  • I think that we did the right choice here to nuke the mandatory test for covid. Less freaked out people that way.

    I probably got Covid 2 weeks ago I just learnt and currently there is essentially almost no danger getting it except a few unlucky,

    pretty much like during a flue. I think that I and my family went through it with not much hazzle because of the

    vaccination , but this is not my point. Because the natural way to get an infection is more general e.g. not optimized for

    a good temporal antibody count, but for a robust functional response I feel quite great that we probably got it. I kind of like

    the idea to temporary vaccinate the population with a good enough protection and then let the natural infections

    move through the population and hardening the people. The authorities just need to have an eye on the number of

    ICU cases and use the break only if things starts to be too nasty like overflow at ICU's. I cannot overstate how glad I am

    that we are guided by Anders Tegnell and co. here. The thing with Sweden is that the one in charge is not optimizing on

    the number of dead by the virus, but actually tries to weigh in many different factors, like how much young people are hit

    by the measures, how resistant people will be, how to get trust from the public, how persistent people will be, and so on,

    it was and always was a marathon and trust is of utmost importance. They explained every choice they make to the public

    treating it like an adult. Not overreacting, listen to other voices, but are not weak and bend for every wind that blows

    and so on. Hmm maybe I shall get a Tattoo of Anders Tegnell or Anders Tengele as he also are named by the smartest

    people here in Sweden 8)

  • I cannot overstate how glad I am

    that we are guided by Anders Tegnell and co. here. The thing with Sweden is that the one in charge is not optimizing on

    the number of dead by the virus, but actually tries to weigh in many different factors, like how much young people are hit

    by the measures, how resistant people will be, how to get trust from the public, how persistent people will be, and so on,

    it was and always was a marathon and trust is of utmost importance.

    Sweden is where I plan to be reincarnated. Hopefully Tegnell is still running it when I get there.

  • Survey of COVID-19 Trends in 10 Most Vaccinated Nations & 10 Least Vaccinated Nations


    Survey of COVID-19 Trends in 10 Most Vaccinated Nations & 10 Least Vaccinated Nations
    TrialSite surveyed the world’s most vaccinated as well as least vaccinated places for COVID-19. One would expect to find that in the highly vaccinated
    trialsitenews.com


    TrialSite surveyed the world’s most vaccinated as well as least vaccinated places for COVID-19. One would expect to find that in the highly vaccinated countries—especially if they are isolated—to report a low SARS-CoV-2 caseload, and in the least vaccinated nations, a high number of new SARS-CoV-2 infections. That just doesn’t seem to be the case as the poorest, and least vaccinated places, in many cases, are more stabilized or under control than the wealthiest, most vaccinated places. Meanwhile, some of the wealthiest, most vaccinated places in the world continue to report trouble, as was declared yesterday regarding Europe.


    The World’s Most Vaccinated

    As described in the table below, the top ten (10) most vaccinated places aren’t necessarily safe to visit. Of the top ten most vaccinated nations, only two (2) are stabilized, two (2) experience an explosion of new cases (Cayman Islands and Singapore), and five (5) of the top ten report substantial increases in cases—meaning the SARS-CoV-2 infection rate is on the rise due to breakthrough infections. Study after study indicate that the current vaccines on the market do not stop viral transmission—at least not after a few months as durability of the vaccine wanes.


    Out of the list of most vaccinated only the United Arab Emirates (UAE) and Cambodia report stabilized conditions. We didn’t find numbers for Northern Cyprus.


    Most Vaccinated


    Nation % Fully Vaccinated Pandemic Direction Comments

    Gibraltar 99% Increase New cases on rise

    United Arab Emirates 89.1% Stabilized Pandemic in control

    Portugal 86.4% Increase News cases on rise

    Cayman Islands 83.2% Explosion Worst surge on record

    Singapore 82.7% Explosion Worst surge on record

    Chile 82.2% Increase New cases on rise

    Malta 81.9% Increase New cases on rise

    Northern Cyprus 81.4% N/A N/A

    Spain 79.1% Increase New cases on rise

    Cambodia 79% Stabilized Cases declining

    World’s Least Vaccinated

    TrialSite reviewed the least vaccinated places as well. Not surprisingly, the least vaccinated places are very poor, and in most cases are in Africa. Haiti, the poorest country in the Western Hemisphere, is an exception as is Yemen, the most impoverished country in the Arab-speaking world.


    But as TrialSite has reported before, these least vaccinated nations have fewer observable problems with the pandemic. Of course, these figures could be off based on adequacy of national public health reporting systems. The data herein was gleaned from Our World in Data as well as the COVID-19 Data Repository by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University.


    Out of the world’s ten least vaccinated places, six (60%) currently find themselves in a stabilized situation with the pandemic seemingly in control. This compares to only 22% of the most vaccinated nations that appear to have the pandemic in control.


    In four (4) of the nations some increases are occurring. But suffice to say there would be an expected high case rate in these nations which just isn’t the case—at least not as of this writing.


    Least Vaccinated


    Nation % Fully Vaccinated Pandemic Direction Comments

    Haiti .4% Increase New cases on rise

    Chad .4% Stabilized Pandemic in control

    South Sudan .6% Stabilized Pandemic in control

    Cameroon .6% Some Increases Near Control

    Madagascar .7% Stabilized Pandemic in control

    Yemen .7% Stabilized Pandemic in control

    Guinea-Bissau .9% Increase New cases on rise

    Uganda .9% Stabilized Pandemic in control

    Papua New Guinea 1.2% Increase New cases on rise

    Ethiopia 1.2% Stabilized Pandemic in control

    The Anglosphere


    Nation % Fully Vaccinated Pandemic Direction Comments

    United States 57% Increase New cases on rise

    Canada 75.4% Decreases Cases seem on way down

    United Kingdom 68.4% Increases Volatile period

    Australia 66.1% Decreases Cases on way down

    New Zealand 67.1% Explosion Record cases

    We include the “Anglosphere” category where generally rates are high, and most of the countries report increases including explosive growth of cases in New Zealand.


    Conclusion

    This latest survey doesn’t surprise as previous ones also couldn’t correlate high national infection rates with levels of vaccination. Most countries with high vaccination rates are currently experiencing surges in COVID-19 cases, while a majority of the least vaccinated nations seemingly have the pandemic under control. Of course, the public health reporting systems may not be adequate—or undoubtedly other factors could be at play. TrialSite notes that generally the COVID-19 vaccines appear to slow down hospitalization while reducing death rates. As Bill Gates recently admitted, the novel treatments were helping more for “health” versus stopping viral transmission. Meanwhile, the WHO Director General called for a moratorium on booster programs in wealthy countries, yet the WHO doesn’t call out that generally the wealthy, more heavily vaccinated nations fare worse with SARS-CoV-2 than mostly poor heavily unvaccinated nations.


    TrialSite will continue to review these numbers for any changes and update accordingly

  • Doctors Targeted for Punishment? Be Careful with Discussing Ivermectin or Critiquing the COVID-19 Vaccines


    Doctors Targeted for Punishment? Be Careful with Discussing Ivermectin or Critiquing the COVID-19 Vaccines
    Doctors a heads up—if you express your own opinion and if that deviates from a federally established party line then you will lose your license and
    trialsitenews.com


    Doctors a heads up—if you express your own opinion and if that deviates from a federally established party line then you will lose your license and ability to practice medicine and earn an income. That is just what happened to Dr. Mary Bowden who was employed with the Houston Methodist Hospital. Because she repeatedly defended ivermectin on Twitter the Houston-based hospital has suspended the doctor’s privileges. She is just the latest physician to face punishment for deviating from an established script.


    Doctors should understand that if they do not follow what is established by groups such as the National Institutes of Health (NIH) or the Centers for Disease Control (CDC) and of course the U.S. Food and Drug Administration (FD) they may just lose their license, at least temporarily.


    As reported initially in Business Insider Dr. Bowden found herself under scrutiny when she was repeatedly posting tweets showcasing the positive data points with the anti-parasite drug. Bowden also went on the record criticizing COVID-19 mandates as “wrong.”


    Recently published on CNN, A Texas hospital suspends a doctor’s privileges for spreading ‘misinformation’ about Covid-19 – CNN Steven Mitby, Dr. Bowden’s attorney, shared that the doctor isn’t against vaccinations at all and that “People should have a choice.” Meanwhile Houston Methodist Hospital declared in a tweet (20) Twitter that the doctor used her account to “express her personal and political opinions about the COVID-19 vaccine and treatments.”



    Recently Sue McIntosh, a retired physician, voluntarily surrendered Doctor Who Gave Out Fake COVID Exemption Forms Surrendered Medical License (businessinsider.com) her medical license as she was giving patients “blank, signed COVID-19 exemption waivers.”


    Call to Action: Physicians should be careful with how they use social media. The Congress needs to look into this form of censorship and information suppression.


    A Texas doctor who defended ivermectin as a treatment for COVID-19 and criticized vaccine mandates has been suspended
    Mary Bowden is the latest doctor to face discipline after going against COVID-19 guidelines backed by leading health officials nationwide.
    www.businessinsider.com

  • No wonder, why more and more double vaxx show up at hospitals an ICU's...if 100% of patients age 65+ were fully double vaaccinated, then we see of course 100% vaccinated patients,

    Children never get it!


    Its a pandemic of the vaccinated now. Why does the state use terror methods for the few left over vulnerable?

    These few infections make no big difference!

    As you can see from UK: Deaths rates among vaxx/unvaxx age > 70 UK are only marginally different now, also for Sweden. If you properly count in natural protection it is 0 for age 80+ that's why now all use boosters...


    The best ever vaccines fully fail after 6 months....

  • Depressing news ...

    The swedish doctor


    Based on the paper,

    Lancet paper !!


    Beware, this is a preprint thingie, not weel peered yetr, would love some discussions about it. Jesus a booster every 4th month and only Moderna.


    But why is the swedish figures so bloody stable, doesn't seam to rocketing looking at the ICU data. If we consider 6000 dead / mi

    for 100% of population (peru) natural infections should be of the order 25% in Sweden by now. I don't get it. Maybe the climate

    have been good recent months, we are late in the cycle, or that that we manage to get the young ones to get a natural infection.

  • Cancer And Birth Defects: Potential Risks Of Molnupiravir?


    Cancer And Birth Defects: Potential Risks Of Molnupiravir?
    Scientists continue to share their concerns over the potential mutagenic side effects of the candidate COVID-19 drug molnupiravir, as Merck apply for
    trialsitenews.com


    Scientists continue to share their concerns over the potential mutagenic side effects of the candidate COVID-19 drug molnupiravir, as Merck apply for Emergency Use Authorization for the drug. As part of the efficacy and safety research on molnupiravir, Merck has set criteria for both male and female participants related to reproduction, fueling questions about the drug’s safety in patients of reproductive age. However, despite the potential risks, Merck has continued to ink deals worldwide.


    Concerns for Impact on New Life?

    Participants in Merck’s molnupiravir trials must agree to stringent criteria related to reproduction both during and up to 4 days after the end of the trial. Males must abstain from heterosexual intercourse or use contraception. Women of childbearing potential (WOCBP) must either use a highly effective contraceptive method or abstain from sexual intercourse, and should have a negative pregnancy test result within 24 hours before taking the first dose. Female participants should not be breastfeeding while taking the drug.


    The detailed criteria have resurrected queries over the safety of molnupiravir. As the U.S. Food and Drug Administration (FDA) prepare to consider the application for Emergency Use Authorization (EUA) for molnupiravir at the end of November, TrialSite takes a closer look at the science surrounding this pharmaceutical.


    Mutagenic By Design

    Molnupiravir disrupts the viral replication by introducing mutations during viral RNA replication. William A. Haseltine, an American scientist, Harvard Medical School professor, and businessman discussed how the drug halts SARS-COV-2 through lethal mutagenesis.


    The drug tricks the virus into replicating.

    When replicating, errors are inserted into the genetic code assuming the nucleotide uracil and cytosine

    Once re-replicated, mutations are developed (changing of nucleotides from U to C and C to U)

    Once more faulty codes are copied, the virus is killed, shortening replication and infection period, and transmission.

    However, there are two potential negative consequences of this method of action: one to the virus, and one to the patient.


    Firstly, it is imperative that the optimal dose is delivered. Use of a suboptimal dose would increase the mutations occurring during viral replication, without ensuring the virus is killed. The result would not only be ineffective treatment, but the potential to produce new variants of the virus itself. These new variants could potentially be more virulent than the original strain.


    The second issue of concern is the potential for host DNA to be subject to the same mutagenesis as the viral DNA.


    Abandoned Trials

    As reported previously on Trialsite, Dr. Raymond Schinazi, an organic medicinal chemist specializing in antiviral agents, pharmacology, and biotechnology, and his scientist colleagues states that NHC, the initial metabolite of molnupiravir, may result in ‘animal cell culture mutations’. Research into the drug was abandoned in 2003 when they found out about its mutagenic properties.


    A study published in August 2021 found that NHC is mutagenic to mammalian cells as well as to the COVID virus. Their research on SARS-CoV-2 showed antiviral and mutagenic effects at concentrations as low as 0.3 μM. Using a cell line that allows detection of mutation in a single gene, the scientists reported that doses of rNHC did not inhibit cell growth, but induced mutagenesis in a dose-dependent fashion.


    The paper clarified that the experiment involved exposing the cells to the drug for 32 days. The doses of NHC tested were between 0.3 μM up to 3 μM. While all tests involving NHC had greater levels of mutations than the negative control, the values were not statistically significant when NHC concentrations were below 3 μM. The authors specified that these changes would be limited to dividing cells where synthesis of DNA precursors is ongoing.


    Merck scientists responded to the publication stating that because the mutation observations were based on lab cell culture, they were “not relevant to how the drug would affect an entire animal.”


    However, the scientific community is not convinced. Dr. Rafael R. Castillo, a member of the Board of Medicine in the Philippines, discussed the ability of mutagenic drugs to cause cancer or congenital defects. He stated that although a five-day course should not cause lasting side effects, it should not be recommended for longer courses. He also suggested that the FDA issue precautions and warnings to patients, especially those of reproductive age.


    Scientists also raise concerns that the effects of mutations at the molecular level, including cancer and birth defects, may present later in life, meaning it may be hard to prove the causal link with molnupiravir.


    Profit Over Safety?

    Dr. Haseltine wrote in a Forbes article that two prices are going to be paid: when taking molnupiravir: the cost of the drug and its side effects.


    Merck secured funding to conduct research on molnupiravir as a potential drug against the COVID-19 virus. Of course the $356 million was thanks to the taxpayer. Rick Arthur Bright, an immunologist, vaccine researcher, and former director of the Biomedical Advanced Research and Development Authority (BARDA), raised his concerns about funding the research of the drug using taxpayers’ money given its mutagenic property. Mr. Bright states that an unauthorized $20 million fund for molnupiravir was given from BARDA’s money.


    Despite the questionable funding and questions raised concerning the side effects of the drug, Merck conducted a Phase 3 trial, finding positive results.


    Trialsite reported on Merck’s planned tiered-pricing approach for molnupiravir after closing a deal with the US government. Research on molnupiravir pricing showed a calculated cost of about $18-$20 per course of treatment, while it will be sold for 35 times more at about $700 per course. Merck also applied to the FDA on October 11, 2021 for molnupiravir’s emergency use based on their unfinished trial results.


    Up to old tricks?

    This is not the first time Merck have pushed a drug to the front lines despite evidence for its dangerous side effects. Vioxx (rofecoxib) was a pain relief drug targeting arthritic patients, which was approved by the FDA in May 1999 but had to be withdrawn in 2004 for fatal cardiac side effects.


    That may sound simply unfortunate, but the facts point to a more sinister unfolding of events. In November 1999, just six months after the FDA’s approval of the drug, interim results of Merck’s clinical trial drew attention to the fact that twice as many recipients of Vioxx had experienced serious heart problems or died, compared with the control group taking naproxen. The data and safety monitoring board voted to continue the study, named Vioxx Gastrointestinal Outcomes Research study (VIGOR), re-evaluated the data the following month and requested that Merck make a plan to analyze the cardiovascular effects of the drug.


    However, when the results of the VIGOR study were published in November 2000, no such analysis was included. Not only that, but several scientists involved in the study raised warnings about data related to cardiovascular adverse events that had been left out of the publication. Even when cardiologists published a re-analysis of the complete dataset in August 2001, raising “a cautionary flag about the risk of cardiovascular events”, Merck did not move to withdraw its drug.


    Only in September 2004, after another study highlighted an increased risk of heart attacks with long-term use, did Merck finally withdraw Vioxx from the market. By this time, it had been taken by an estimated 20 million Americans, of whom 88,000 were estimated to have had heart attacks because of the drug and 38,000 died.


    In the court cases that followed, it emerged that Merck had drawn up a list of doctors and scientists that it “wanted to neutralize and discredit” during its marketing of Vioxx.


    In light of this history of disinformation strategies, Merck’s apparent confidence in the safety profile of molnupiravir should be scrutinized. The fact that they are loudly discrediting the safety profile of their own ivermectin, has led to speculation that they are clearing the way for their profitable, patented alternative.


    On November 4, TrialSite reported on the UK’s decision to authorize molnupiravir. This follows its use in parts of Vietnam, and other deals being struck around the world. TrialSite will be watching the FDA’s evaluation of molnupiravir with interest, and will continue to report on these unfolding events.

  • 8 Dead, Dozens Infected With COVID-19 Due to Outbreak at Connecticut Nursing Home

    The Canaan senior community houses only 70 residents


    8 Dead, Dozens Infected With COVID-19 Due to Outbreak at Connecticut Nursing Home
    Eight people are dead and just shy of 100 more have become infected with COVID-19 after an outbreak at a Connecticut nursing home. The outbreak at the Geer…
    www.nbcconnecticut.com


    Eight people are dead and just shy of 100 more have become infected with COVID-19 after an outbreak at a Connecticut nursing home.


    The outbreak at the Geer Village Senior Community, a nursing home and rehabilitation center in Canaan, started around the beginning of October when the nursing home was reporting three positive COVID-19 cases.


    Now, eight residents have died, and 67 residents and 22 staff members caught COVID-19 sometime in the past month and a half. Nursing home officials said 48 residents and 21 staff members have recovered from the virus.


    The state Department of Public Health said they're monitoring and providing on-site consultation at this facility.

    Family members of residents in long-term care facilities should also encourage their loved ones being cared for in these facilities to get a booster vaccine," a spokesperson for the DPH said.


    The nursing and rehab center houses only 70 residents and all eight people who died has serious underlying health issues.


    Of the 89 total infections, 87 people were fully vaccinated, the nursing home said.


    "While we must continue with Covid-19 prevention protocols, we want to assure everyone we are doing our best to keep residents and staff safe," officials said.


    Get the latest news on COVID-19 delivered to you. Click here to sign up for our daily coronavirus newsletter.

    All visits will continue to remain on hold because of the outbreak; anyone who wishes to see their loved ones can do so virtually or through window visits.


    "Despite the highly infectious nature of this disease, our employees were able to protect their residents, themselves, and their families through the initial peak of this pandemic. They did this during a time when we least understood Covid-19 and struggled to find the supplies and funding to persevere as the virus spread. We are tremendously proud of our employees for their dedication to the people we care for," Geer Village Senior Community CEO Kevin O'Connell said in a statement.


    Anyone whose loved one tests positive for coronavirus or becomes symptomatic will be notified.


    "Our priority is always the health and safety of the staff and residents at Geer. We are saddened to see some in the Geer family become ill. We pray for their speedy recovery and continue to do everything in our power to minimize the risk across all our operations,” O’Connell said.


    Residents and staff will become eligible for the booster shot when the community has gone two full weeks without any new COVID-19 cases, they said. For more information on the outbreak, click here.


    Nursing Covid-19 Update 11-12-2021 - Geer Village Senior Living Located in the Northwest Hills of CT
    To Our Staff, Residents and Family Members: We want to provide you with an update on the current Covid outbreak within the nursing home. As stated in our…
    www.geercares.org

  • For those interested in science - and now this thread is demoted i will leave the non-science stuff alone.


    Pfizer’s new COVID-19 protease inhibitor drug is not just “repackaged ivermectin”
    Last week, Steve Novella discussed announcements of drugs that, unlike the "miracle cures" (primarily hydroxychloroquine in 2020 and ivermectin this year) that…
    sciencebasedmedicine.org


    a lot of interesting detail on the new Pfizer protease inhibitor that shows such good prelim results.


    It looks like it has been some 10 years in the making... and it shows why it works, when ivermectin does not, it is easily absorbed and not active against mammalian proteases.

    PF-07321332 is a class of protease inhibitor that targets the 3C-like protease, which is the main protease found in coronaviruses. (Other names for this protease include coronavirus 3C-like protease, Mpro, SARS 3C-like protease, SARS coronavirus 3CL protease, SARS coronavirus main peptidase, SARS coronavirus main protease, SARS-CoV 3CLpro enzyme, SARS-CoV main protease, SARS-CoV Mpro and severe acute respiratory syndrome coronavirus main protease.) This particular protease has long been recognized as a potential drug target for the treatment of coronavirus-induced diseases because it plays a key role in processing the polyproteins translated from the viral RNA into functional viral proteins.


    Quote
    In effort to identify inhibitors of the SARS-CoV-1 Mpro in response to the 2002 SARS outbreak led to the identification of PF-00835231 (1, Fig. 1) as a potent inhibitor of recombinant SARS-CoV-1 Mpro in a fluorescence resonance energy transfer (FRET)-based substrate cleavage assay (17). PF-00835231 also demonstrated potent inhibition (inhibition constant (Ki) = 0.271 nM) of recombinant SARS-CoV-2 Mpro, which is expected given that the SARS-CoV-1 and -CoV-2 Mpro share 100% sequence homology across their respective substrate binding sites (18).
    Quote

    Unfortunately, potent in vitro activity against a drug’s target does not necessarily translate to a good drug, and PF-00835231 had poor bioavailability. Specifically, it was poorly absorbed when given orally to experimental animals. So, as pharmacologists do when they have a potent drug candidate that isn’t well absorbed, Pfizer scientists started chemically modifying it to improve its oral bioavailability and testing those analogues in vitro for activity against the 3CL, and:

    Quote
    PF-07321332 demonstrated potent inhibition in FRET Mpro assays representing Mpro from all coronavirus types known to infect humans (6, 7, 30), including beta-coronaviruses (SARS-CoV-2, SARS-CoV-1, HKU1, OC43, MERS) as well as alpha-coronaviruses (229E, NL63) (Fig. 3B and table S2). No inhibitory effects were noted against several mammalian cysteine (caspase 2, cathepsin B, cathepsin L), serine (chymotrypsin, elastase, thrombin) and aspartyl (cathepsin D) proteases at the highest concentration tested (100 μM) of PF-07321332 (table S3). This was also the case for HIV-1 protease, a viral aspartyl protease (table S3).
    Quote

    That last part is important, because specificity is important. PF-07321332 would not have been very useful if, in addition to the SARS-CoV-2 protease, it also inhibited human proteases important in a number of processes, such as protein digestion. Such inhibition could have caused a number of undesirable and potentially harmful gastrointestinal side effects. PF-07321332 did not and was therefore deemed a good candidate with good oral bioavailability. It also exhibited potent antiviral activity against SARS-CoV-2 in vitro.


    and ivermectin?


    As is the case with many COVID-19 conspiracy theories, there is a tiny grain of truth in the comparison of the drugs, but only a very tiny grain that conspiracy theorists seem to view as a whole field of wheat. In this post, I’ll discuss how one has to ignore some very basic pharmacological principles that differentiate the drugs in order to make the leap to the claim that ivermectin is just like Paxlovid, but being “suppressed” because it’s cheap and generic, as opposed to Paxlovid, which will be on patent and, of course, not cheap. In fact, ignoring one principle will do, the same pharmacological principle whose willful misunderstanding led to people claiming that ivermectin is a miracle cure for COVID-19, namely that concentration matters.


    Spoiler alert: Ivermectin does inhibit the same protease that PF-07321332 does, but, as is the case for viral replication, it requires a concentration that is not achievable by oral dosing.


    As noted, the activity of ivermectin in cell culture has not reproduced in mouse infection models against many of the viruses and has not been clinically proven either, in spite of ivermectin being available globally. This is likely related to the pharmacokinetics and therapeutic safety window for ivermectin. The blood levels of ivermectin at safe therapeutic doses are in the 20–80 ng/ml range [44], while the activity against SARS-CoV2 in cell culture is in the microgram range. Ivermectin is administered orally or topically. If safe formulations or analogs can be derived that can be administered to achieve therapeutic concentrations, ivermectin could be useful as a broad-spectrum antiviral agent





  • stefan , yes you can be proud of your politics personal. There have been times, where Sweden has been used as "a bad example", "corona mismanagement", etc...

    I think swedes have more patients and trust in their political leaders.


    Unfortunatley our new (since April) health secretary is a heavy smoker! and a GP himself, telling a famous, young and healthy soccer player via media that he better gets the jab!

    Believe me, we have a few r..... tomatoes who call themselves political elite.

  • Of the 89 total infections, 87 people were fully vaccinated, the nursing home said.

    Vaccine terror kills people. Only Treatment saves live. Vaccines only postpone the point of death...

    Spoiler alert: Ivermectin does inhibit the same protease that PF-07321332 does, but, as is the case for viral replication, it requires a concentration that is not achievable by oral dosing.

    One more clown FUD alert! The clown still does not understand the paper he claims is relevant for doses. This always happens when FM produced FUD papers.


    Ivermectin works perfectly well in the standard doses. 100% success in prevention of CoV-19. Pfizer-mectin only 87%. Ivermectin costs 6 cents/dose but some obese UK/US people possibly need >= 3 dose...What of course is not done in UK Trials and all other FM fake trials....

  • stefan , yes you can be proud of your politics personal. There have been times, where Sweden has been used as "a bad example", "corona mismanagement", etc...

    I think swedes have more patients and trust in their political leaders.


    Unfortunatley our new (since April) health secretary is a heavy smoker! and a GP himself, telling a famous, young and healthy soccer player via media that he better gets the jab!

    Believe me, we have a few r..... tomatoes who call themselves political elite.

    Actually the politicians mostly stay out of the way from the experts who are not affiliated with any political party. The leaders of the strategy got there because of a vast experience handling epidemics.

  • Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study


    Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study
    SARS-CoV-2 replication in cell cultures has been shown to be inhibited by ivermectin. However, ivermectin's low aqueous solubility and bioavailability hinders…
    www.ncbi.nlm.nih.gov


    Introduction

    SARS-CoV-2 replication in cell cultures has been shown to be inhibited by ivermectin. However, ivermectin's low aqueous solubility and bioavailability hinders its application in COVID-19 treatment. Also, it has been suggested that best outcomes for this medication can be achieved via direct administration to the lung.


    Objectives

    This study aimed at evaluating the safety of a novel ivermectin inhalable formulation in rats as a pre-clinical step.


    Methods

    Hydroxy propyl-β-cyclodextrin (HP-β-CD) was used to formulate readily soluble ivermectin lyophilized powder. Adult male rats were used to test lung toxicity for ivermectin-HP-β-CD formulations in doses of 0.05, 0.1, 0.2, 0.4 and 0.8 mg/kg for 3 successive days.


    Results

    The X-ray diffraction for lyophilized ivermectin-HP-β-CD revealed its amorphous structure that increased drug aqueous solubility 127-fold and was rapidly dissolved within 5 s in saline. Pulmonary administration of ivermectin-HP-β-CD in doses of 0.2, 0.4 and 0.8 mg/kg showed dose-dependent increase in levels of TNF-α, IL-6, IL-13 and ICAM-1 as well as gene expression of MCP-1, protein expression of PIII-NP and serum levels of SP-D paralleled by reduction in IL-10. Moreover, lungs treated with ivermectin (0.2 mg/kg) revealed mild histopathological alterations, while severe pulmonary damage was seen in rats treated with ivermectin at doses of 0.4 and 0.8 mg/kg. However, ivermectin-HP-β-CD formulation administered in doses of 0.05 and 0.1 mg/kg revealed safety profiles.


    Conclusion

    The safety of inhaled ivermectin-HP-β-CD formulation is dose-dependent. Nevertheless, use of low doses (0.05 and 0.1 mg/kg) could be considered as a possible therapeutic regimen in COVID-19 cases.

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