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  • 100% Vaccinated and Christmas Cancelling Surge: The Gibraltar Situation


    100% Vaccinated and Christmas Canceling Surge: The Gibraltar Situation
    Gibraltar, the British territory situated on the southern tip of the Iberian Peninsula is a tiny, compact place at just 2.6 square miles. Bordered to the
    trialsitenews.com


    Gibraltar, the British territory situated on the southern tip of the Iberian Peninsula is a tiny, compact place at just 2.6 square miles. Bordered to the north by Spain Gibraltar is the most protected place on the planet as 100% of its population have been immunized against COVID-19—predominantly with the Pfizer-BioNTech vaccine known as BNT162b2. But in a situation that seems to play out over and over despite full vaccination a serious surge of SARS-CoV-2 infections has Gibraltarians cancelled Christmas events as residents are “strongly” discouraged from having guests over during this traditionally celebrated time despite universal vaccination status. This is due to a government edict that what started as a few breakthrough cases has quickly “become even more exponential in the last few days” leading to re-activated public health rules to stop transmission. A confluence of factors are likely involved but a fundamental culprit appears to be the waning effectiveness of the Pfizer-BioNTech vaccine or its “durability.”


    As the government announced recently with 359 active COVID-19 cases including 5 hospitalizations which mirrors a general surge of cases throughout Europe. Since the onset of the pandemic this British territory of 34,000 people reports 6,634 COVID-19 cases with 98 deaths.


    Ranked as the most vaccinated spot on the planet, back in April the Wall Street Journal celebrated that life was getting back to normal thanks to the universal vaccines. A majority of the vaccination has been with the mRNA-based BNT162b2 from Pfizer-BioNTech. However, as TrialSite has learned from several studies, the Pfizer-BioNTech vaccine wanes in effectiveness over time. By month 6 the durability of the vaccine is in question and after month seven one study revealed there was negligible benefit. Hence why the intense focus on boosters in many wealthy nations.


    Christmas Cheer Gives Way to Pandemic Protection

    So many people here were looking forward to a normal holiday season. Unfortunately one would have hoped that with a 100% vaccinated population Christmas 2021 would be not only merry, but sociable. But unfortunately COVID-19 breakthrough cases lead the government here to cancel a number of functions including official Christmas parties, official receptions and similar gatherings, reports the government.


    The Government strongly advises against any large informal social events, parties or receptions being held over at least the next four weeks while the vaccine booster program is rolled out. It will also become necessary at this point to make sure that the use of official premises is carefully scrutinized and where necessary events are postponed to a later date.


    Pfizer Booster Campaign

    The COVID-19 booster vaccination campaign is currently underway for the over 40s, health and care workers and other vulnerable groups. Members of the public are strongly encouraged to register their interest online to receive a booster vaccine as they are rolled out.


    Health Minister POV

    Minister for Health, the Hon Samantha Sacramento, said: ‘The drastic increase in the numbers of people testing positive for COVID-19 in recent days is a stark reminder that the virus is still very prevalent in our community and that it is the responsibility of us all to take every reasonable precaution to protect ourselves and our loved ones. The vaccination program for 12-15 year old youth and the booster vaccination program are now underway—apparently Gibraltar received 4680 more doses this week. Everyone who is eligible for a vaccine or a booster is strongly encouraged to take up the offer when they are called.”


    New Public Health Guidance Given Surge


    Meet in open outdoor spaces where possible and to pay attention to ventilation where it is not. When people are meeting indoors, a window should be open for at least 10 minutes every hour.

    Wear a mask where it is required. This remains a great way to protect yourself, customers, clients, friends and family members.

    Maintain some physical distance when greeting. Shaking hands, kissing, hugging and close forms of endearment increase your exposure to viruses.

    Take responsibility when hosting an event or occasion to ensure all guests are safe. We are all responsible for our own health and wellbeing, but as a host, you are also taking on the obligation and responsibility to protect others.

    Clean your hands regularly to protect you and others from germs. Do so as often as you can. Use soap and water or 70% alcohol gel. Encourage guests to do the same.

    Take note of those who remain in close proximity to you. Be ready to provide this information if asked by the Contact Tracing Bureau.

    Risk assess all and any events. The main issue of concern will be the mix of those people attending. If there are significant numbers of people present, or expected to attend, who come from outside Gibraltar, it is important to consider that they may not be vaccinated or that they might be incubating/ carrying the virus. The size of the group and the density of the setting must be considered alongside other precautions.

    Masks continue to be one of the most effective methods of reducing transmission


    Rise in active COVID-19 cases – Public urged to be cautious and reduce mixing - 845/2021

  • I would LOVE to see days to be cleared of virus and other metrics from the two! But there is not a chance in hell that will happen! Not that two cases would prove anything, but it sure as heck would be interesting to see. (Although, if Rogers would have died or became incapacitated, Jed would have been jumping on the case as "see what happens when you do not get vaccinated!"

    Why would it be interesting?


    COVID is variable. Vaccination protects, imperfectly, but better than anything else (the new Pfizer antiviral looks to be a s good, but is still very new).


    There is no way you could get meaningful info from an ad hoc comparison.


    If you want to know how ivermectin does wait for results from one of the several big ivermectin-at-home studies. I can tell you now, because no-one is stopping them early like they did the Pfizer antiviral trial - the results will not be great.


    There have been decent studies looking at all combos of vax/unvax prior infection/no prior infection, and dealing with the confounding factors. They show a clear picture.

  • If 80% or 90% of the population had been vaccinated, the virus would be extinct in the human population, and the pandemic would be over.

    Yippee yahooo!!! That would be great, a few "lucky" countries are over 80% I guess we'll be seeing cases drop to 0 soon. ^^ :D


    Bordered to the north by Spain Gibraltar is the most protected place on the planet as 100% of its population have been immunized against COVID-19—predominantly with the Pfizer-BioNTech vaccine known as BNT162b2. But in a situation that seems to play out over and over despite full vaccination a serious surge of SARS-CoV-2 infections has Gibraltarians cancelled Christmas events as residents are “strongly” discouraged from having guests over during this traditionally celebrated time despite universal vaccination status.

    Oh darn - i guess reality is a little different ;(

  • Vitamin D deniers, listen up!


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  • Yippee yahooo!!! That would be great, a few "lucky" countries are over 80% I guess we'll be seeing cases drop to 0 soon. ^^ :D

    That has already been seen. Look at Japan, Israel or Argentina, for example:





    All are dropping asymptotically to zero. They have 72% to 88% vaccinated. They would have more, if children were vaccinated.

  • Natural Plant Product Eugenol Blocks SARS2 Spike Protein in the Lab


    Natural Plant Product Eugenol Blocks SARS2 Spike Protein in the Lab
    More commonly known as Clove Oil, Eugenol, derived from the Tulsi plant, appears to “inhibit” the action of the infamous spike protein of the SARS2 virus.
    trialsitenews.com



    More commonly known as Clove Oil, Eugenol, derived from the Tulsi plant, appears to “inhibit” the action of the infamous spike protein of the SARS2 virus. The effect has been verified both in silico, in vitro, and in mice, by a research group at Rush University in Chicago.


    In India, Tulsi is revered by traditional Ayurvedic medicine. Some studies suggest that certain natural products can be useful in treating COVID. For example, Rosner et al found CBD can block viral replication and stimulate immune factors. Likewise, Curcumin has been looked at by Celes for its binding affinity with both the spike protein and the ACE2 receptor, showing promise.


    Dr. Kalipada Pahan, lead author of the Eugenol study, is the Floyd A. Davis, M.D., Professor of Neurology at Rush University Medical Center in Chicago, also affiliated with the Chicago VA’s R&D Division. Pahan’s Lab studies neuropathology, T-cells, and is also exploring cinnamon and aspirin’s possible value for neurodegenerative and auto-immune conditions. The study was published in late October in the Journal of Neuro-Immune Pharmacology.


    Pahan set out with the aim of seeing if Eugenol had any broad interaction with the virus, then drilling down to find the actual binding site.


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    As a first step Pahan’s group used a SARS2 assay screening kit. They also ran in silicostudies. They further sought to differentiate whether the Eugenol was interacting more with the receptor site versus the spike protein. “It is interesting to see that eugenol binds to viral spike S1, not ACE2,” said Dr. Pahan.


    In addition, they tested other compounds from Tulsi, concluding that “ursolic acid, oleanolic acid and β-caryophylline remained unable to inhibit the association between SARS-CoV-2 spike S1 and ACE2,” thus “the specificity of the effect.”


    Subsequently, Pahan’s team used ACE2-expressing human stem cells to test whether SARS2 and a control virus could gain access to the cell. (Not all human cells have ACE2 receptors – they are especially present on lung cells, thus the initial respiratory impact of COVID.)


    Lastly, the team orally administered Eugenol to mice, finding it “reduced lung inflammation, reduced fever, inhibited arrhythmias, and enhanced locomotor activities.” Note that this was a pre-clinical, early-stage study.


    Rush University Medical Center has licensed this technology to a biotech company for clinical development. “If eugenol results can be replicated in patients, it would be a remarkable advance in the treatment of COVID-19,” Dr. Pahan said.v


    Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses - Journal of Neuroimmune Pharmacology
    Spike S1 of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) on host cells to enter the cell and…
    link.springer.com

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  • Interesting viewpoints claiming everybody is wrong :)

    Stefan:: You obviously linked a dilettante big pharma agent.

    Citation::

    Any issues? We don’t know how patients were allocated, but they discuss patient characteristics and they don’t look different enough to produce this big an effect size. The experimental group got a lot of things other than ivermectin, but I would be equally surprised if vitamin D or azithromycin cured COVID this effectively. It deviated from its preregistration in basically every way possible, but you shouldn’t be able to get “every experimental patient tested negative when zero control patients did” by garden-of-forking-paths alone!


    So we can safely conclude this guy knows nothing about CoV-19. Everybody involved knows how vitamin D or azithromycin works the mechanism have been research in all detail.


    So its just a waste in time to read into big pharma fairy tales...

  • Yes, again on something "bad" that is related to and induced by vaccines....one can get the overall impresssion that all reports, cited sources, theories, hypothesis and claims (like in the old closed thread) deal mostly with one side of the curtain

    May be also children should once notice that there only is one side. If you do proper treatment after first symptoms then COV-19 for most is just a cold. So only vaccines do damage here and of course the fascist FM/R/B mafia that does not allow treatment just for making money with vaccine, masks, tests etc...


    May some also like watching dying people...

  • The most recent peer-reviewed study was conducted as the delta variant raged across Israel. Given the recent booster push, conditions appear to be stabilizing in Israel. Cases of SARS-Cov-2 infections have come substantially down. A big test for the Pfizer-BioNTech vaccine will be if infections surge yet again in this heavily vaccinated nation.

    This is already reality. The down turn that time was to about 400/Day for a week now its back to 500 already...

    No, the surge is because people refuse to be vaccinated, and because the vaccines have not been manufactured and distributed in the third world.

    The third world like In India is doing 10'000x better than claimed brilliant ( idiots) from first world....

  • WHO urges Regeneron to lower prices for monoclonal antibody COVID-19 drug


    WHO urges Regeneron to lower prices for monoclonal antibody COVID-19 drug
    Regeneron’s monoclonal antibody cocktail REGEN-COV is the current most promising antibody treatment for COVID-19 known to healthcare practitioners and
    trialsitenews.com



    Regeneron’s monoclonal antibody cocktail REGEN-COV is the current most promising antibody treatment for COVID-19 known to healthcare practitioners and ordinary citizens alike. The famous monoclonal antibody cocktail is made up of two potent virus-neutralizing antibodies called casirivimab and imdevimab. As the monoclonal COVID-19 drug continues to provide positive clinical results for patients who are at high risk of progressing into severe illness, Regeneron earns an endorsement from the World Health Organization (WHO).


    According to WHO, the REGEN-COV drug combination had excellent effects on at-risk individuals, as well as those diagnosed with a severe case of COVID-19 who have not yet formed antibodies to fight the virus. The drug gained its emergency use authorization (EUA) after President Trump used it as a treatment for his recovery from the virus. Being the third COVID-19 drug to be endorsed by WHO, the organization called for affordable prices and better access.


    TrialSite followed the development of this investigational product from near the onset of the pandemic. Generally, Regeneron has been responsive to critical questions including those inquiring early on about the unorthodox initial Phase 1 study via FDA Sentinel Initiative.


    Calling costs into question

    As of September 2021, Regeneron’s COVID-19 antibody-drug retails at between $820 and $2,100 per dose, in India and the US, respectively. WHO advised Regeneron to lower its price as well as to distribute the drug equitably worldwide. They also suggested releasing patents for other drug manufacturers to create biosimilar versions. Health professionals also agree with WHO’s recommendations, urging that lives should take priority over monetary gain.


    Doctor Elin Hoffmann Dahl, the Infectious Disease Advisor, strongly expressed his approval for WHO’s suggestions, stating, “It is simply not fair that people living in low and middle-income countries cannot access new COVID-19 treatments that can decrease the risk of death because of pharmaceutical companies’ monopolies and wishes for high returns.”


    As Regeneron partners up with the Swiss pharma company, Roche, they have released a statement claiming that they are trying their best to handle the drug’s affordability in low- and middle-income countries. “We have utilized international differential pricing to address affordability challenges in low- and middle-income countries,” Roche said in their statement.


    According to Roche, they have coordinated with the Access to COVID-19 Tools (ACT) and are currently discussing plans to donate the drug in low-income countries.


    It was also mentioned that an alternative pricing program is currently being planned for these countries. WHO announced that an international health agency called UNITAID has coordinated with Roche and negotiated deals for lowering rates and distributing the drug across the globe.


    Other monoclonal antibody treatments for COVID

    Regeneron decisions on market prices may also be affected by its direct competitors in the global market. There are several other anti-COVID monoclonal antibody products in development, some of which have already received provisional approval in a number of countries.


    The big pharmaceutical company Eli Lilly produced their own version of a monoclonal antibody treatment called “Lilly.” The initial product, based on bamlanivimab (LY-CoV555), received an EUA in November 2020 for high risk patients with mild to moderate COVID symptoms. However, on its third trial, the drug failed to provide positive clinical results to hospitalized COVID patients in January 2021. This led to the halt of the phase 3 trial in compliance to the recommendation of the Data Safety and Monitoring Board.

    Eli Lilly went on to partner with Chinese company Junshi Biosciences, who had developed another monoclonal antibody, etesevimab (known both as JS016 and LY-CoV016). In February 2021, the FDA granted an EUA for a combination of neutralizing antibodies containing both bamlanivimab and etesevimab, to be used in patients with mild to moderate COVID symptoms. Together, the monoclonal antibodies were shown to have significant results in reducing hospitalization and deaths in this group.


    Bamlanivimab, used alone, was found to be no longer effective because of resistance in the emerging gamma and beta variants. Eli Lilly requested that the EUA of the drug be revoked in April 2021. Distribution of the combined antibody treatment was also restricted due to concerns regarding resistance.


    In September 2021, the FDA elected to limit use of the antibody cocktail to states and territories where resistance was known to be below 5%. In the same month, the combination therapy was granted a revised EUA, extending its emergency use for post-exposure prophylaxis for COVID-19, despite the combination never having been tested for post-exposure prophylaxis in any clinical trials.


    GlaxoSmithKline and Vir Biotechnology’s monoclonal antibody Sotrovimab also has an EUA from the FDA. The treatment is in use for mild COVID cases in the UAE, and has provisional approval in Australia.

    Cerecor’s TNFSF14 monoclonal antibody also caught the attention of health experts due to its reduction in respiratory failure and deaths on COVID patients. The phase 2 trial of the drug provided efficient data on the decrease of hospitalizations in patients specifically with respiratory distress syndrome (ARDS). The results showed that it gives the highest efficacy to adults aging from 60 years old and above. The company plans to discuss with the FDA regarding a potential EUA for the drug.

    TrialSite is also following other monoclonal antibody treatments that may soon obtain EUA, including AstraZeneca’s AZD7442. This cocktail, discovered at Vanderbilt then licensed by AstraZeneca, contains two monoclonal antibodies – tixagevimab and cilgavimab – and stays in the body for a longer period of time, offering up to 12 months of protection against severe illness.

    Bottom Line

    Monoclonal antibody treatments for specific COVID-19 variants show promise for preventing COVID-19 from escalating into severe disease. While these treatments, including REGEN-COV, are undoubtedly useful weapons in the war against COVID-19, there is uncertainty around whether they can be accessed equitably. It remains to be seen how international public health organizations regulate authorizations for affordable treatments. With the introduction of pharmaceutical antivirals (e.g., Merck, Pfizer, et al.) and possible future acceptance of safe off-label repurposed drugs (e.g. Fluvoxamine, Ivermectin, etc.) combined with ever improving vaccines and awareness about the disease itself (including data-driven, risk-based early proactive care) as well as more easily accessible monoclonal antibodies, COVID-19 will become manageable in a possible next endemic stage.

  • This is trailsitenews bullshit. Gibraltar is very different from Japan or Argentina because it is exposed to the European population, which has much lower vaccination rates, so there are more breakthrough cases.

    JedRothwell did you read in my mind interesting post I found this interesting W did not like it, you might enjoy it, the writer is skilled. He drives the thesis that ivermectin do have good properties for covid, but not by directly attacking covid, but in stead suggest that people with both covid and worms is better off without the worms as ivermectin is a known worm killer, which is a theory I kind of like for it's logical soundness and explain why many intelligent persons have though that there was evidences for ivermectin. He also illustrates some of the mechanism of vacc/anti vacc hysteria in a entertaining and creative way.

  • Japan will see a surge by the end of December and into January, just like last year. Israel has already had 10'000 Breakthrough in boosted citizens and is on the verge of another small surge and Argentina is in the southern hemisphere and the virus is seasonal, check back on them around the fist of march.

  • Did you read it?, This would mean that it is probably good to supply ivermectin to at least parts of India just as you have been saying. He acknowledge that there are issues with the medication industry just as you say! He acknowledge that just spitting out "that's a cattle worm killler - don't bother" is so wrong they are even right. I really do not think this guy is bought by the big pharma, he bloody draw the pants down on them to show why people are skeptical and becomes anti everything they do.

  • Japan will see a surge by the end of December and into January, just like last year. Israel has already had 10'000 Breakthrough in boosted citizens and is on the verge of another small surge and Argentina is in the southern hemisphere and the virus is seasonal, check back on them around the fist of march.

    Yes very seasonal, we expect to get a sharp rise now here with a peak in december, and some measures are taken. I find the number of infection not especially interesting, ICU cases is what one should look at, and deaths if that is not available.

  • Vitamin D deniers, listen up!


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    Stats 101: correlation <> causation

  • Japan will see a surge by the end of December and into January, just like last year.

    Last year there were no vaccines! What you are saying is ridiculous. What will you say when this does not happen? I predict you will pretend you never said it.


    Unless another new variant comes along, the pandemic is over in Japan, and Argentina, Israel, and every other country with a functional public health system and sane citizens. It will continue to kill hundreds of thousands of lunatics who refuse to be vaccinated.

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