The Playground

    Quote from JedRothwell

    If a natural infection did not lead to the same response as the vaccine, the vaccine would not work. Both must result in an immune response, and antibodies. Granted, there are minor differences between them. For that matter, there are differences between patients, and between COVID variants.


    No, it is not.

    First you need to teach our immune system about the virus. The vaccine we used teach only one thing that we hoped should work but

    The whole virus teach many things and the body has a chance to match on more information, also the information used will differ from

    person to person. So Now the vaccinated will match the virus and the natural infection will match the virus and both is effective in a constant world,

    yes we can think of theoretical outcomes where the only thing that is important is the same for both, but this seam not to be true as we know that

    a natural infection lasts longer then the vaccine so they are _not_ the same. So to conclude the response is the same, but the dynamics

    most likely different, at least the data suggest so.

    Quote from JedRothwell

    No, it is not.

    Yes initially, and this is what you typically find in google, was that actually the response from the vaccine gave more anti bodies e.g. could detect the virus

    even better than many natural infections. This is why they recommended the vaccines even for people that had got covid. Now after time has passed

    the data suggest that a natural infection has a clear edge towards the vaccines we took so although the antibody response was not as good as the

    vaccine, (note antibodies may differ from person to person and from vaccination and natural infection but they all lead to a detection of the virus and then this is only one part of the immune story Tcells. ..), to me that either means that the natural response is either matching more information or is more up to date. Probably both are true.

    Merck and Ridgeback Report Full Phase 3 Analysis for Oral Antiviral COVID Pill; Efficacy Plunges from Interim Analysis


    Merck and Ridgeback Report Full Phase 3 Analysis for Oral Antiviral COVID Pill; Efficacy Plunges from Interim Analysis
    Merck and Ridgeback Biotherapeutics provided an update on the MOVe-OUT study of molnupiravir (MK-4482, EIDD-2801), an oral antiviral medicine for
    trialsitenews.com


    Merck and Ridgeback Biotherapeutics provided an update on the MOVe-OUT study of molnupiravir (MK-4482, EIDD-2801), an oral antiviral medicine for COVID-19. The full data show molnupiravir reduced the risk of hospitalization or death for patients with mild or moderate COVID-19 by about 30%, based on a study of more than 1,400 adults. Last month, an interim analysis showed about 50% efficacy, based on data from 775 patients.


    The final analysis is from all enrolled patients (n=1,433). In this study population, molnupiravir reduced the risk of hospitalization or death from 9.7% in the placebo group (68/699) to 6.8% (48/709) in the molnupiravir group, for an absolute risk reduction of 3.0% and a relative risk reduction of 30%. Nine deaths were reported in the placebo group, and one in the molnupiravir group. In October, the companies submitted an Emergency Use Authorization application to the FDA based on interim data from the MOVe-OUT study. At the planned interim analysis, molnupiravir significantly reduced the risk of hospitalization or death from 14.1% (53/377) in the placebo group to 7.3% (28/385) in the molnupiravir, for a relative risk reduction of 48%.


    The MOVe-OUT trial is a global Phase 3, randomized, placebo-controlled, double-blind, multi-site study of non-hospitalized adult patients with laboratory-confirmed mild-to-moderate COVID-19. Patients enrolled in the study were unvaccinated against SARS-CoV-2, had at least one risk factor associated with poor disease outcomes, and symptom onset within five days prior to randomization. The primary efficacy objective of MOVe-OUT was to evaluate the efficacy of molnupiravir compared to placebo as assessed by the percentage of participants who are hospitalized and/or die from the time of randomization through Day 29.


    About Molnupiravir

    Molnupiravir (MK-4482/EIDD-2801) is an orally administered form of a potent ribonucleoside analog that inhibits the replication of SARS-CoV-2, the causative agent of COVID-19. Molnupiravir has been shown to be active in several preclinical models of SARS-CoV-2, including for prophylaxis, treatment, and prevention of transmission. Additionally, pre-clinical and clinical data have shown molnupiravir to be active against the most common SARS-CoV-2 variants


    Merck and Ridgeback Biotherapeutics Provide Update on Results from MOVe-OUT Study of Molnupiravir, an Investigational Oral Antiviral Medicine, in At Risk Adults With Mild-to-Moderate COVID-19 - Merck.com
    Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Ridgeback Biotherapeutics today provided an update on the MOVe-OUT study of…
    www.merck.com

    Are the ‘Vulnerable’ and Aboriginals in Australia to be Rounded up in COVID-19 Quarantine Camps?


    Are the ‘Vulnerable’ and Aboriginals in Australia to be Rounded up in COVID-19 Quarantine Camps?
    With the advent of the new Omicron variant of the coronavirus, additional travel restrictions are being imposed. Travel has been banned
    trialsitenews.com



    With the advent of the new Omicron variant of the coronavirus, additional travel restrictions are being imposed. Travel has been banned from some African countries to Europe and the United States. Some countries may begin to overreact to not only the new variant but the current state of the pandemic. One of those countries may be Australia, which has seemingly imposed Chinese-style authoritarian measures across select states. Reports of Aboriginals rounded up and placed in military guarded quarantine camps raised considerable alarms based on past injustices to this vulnerable population.


    Are Reports of COVID-19-Positive Camps Authentic?

    Several news outlets, including Zerohedge.com, are reporting the Australian Defense Force is now physically transferring non vaccinated indigenous people in Northern Australia to a quarantine center located in Howard Springs. Could this be the case? If so, the rounding up of anyone, let alone indigenous Aboriginal Australians seems like a completely unethical if not illegal action for this modern age.


    Themanews.com is reporting the move to force residents to quarantine camps comes after “hard lockdowns” in the towns of Binjari and Rockhole didn’t stop the spread of the virus. The residents being forced into quarantine camps are already infected with covid; however, according to the article, more residents may be transferred who are not infected but have been identified as “close contacts”.


    But Australian Broadcasting Corporation (ABC News) doesn’t appear to be as alarmed as other news outlets. ABC is reporting Australian troops are being brought into the territories simply to help boost covid testing numbers because of a growing outbreak. The article repeats the fact that the outbreak is among aboriginal people. But ABC News says the troops are there in a “supporting role” to Northern Territory police.



    According to a InDaily report, South Australia state health officials are on the record defending the rapid set up of COVID quarantine camps to “house hundreds in Renmark, Port Augusta, Port Lincoln and M. Gambier,” yet are silent on details from location and cost to staffing.


    The Australian media discovered that this particular Australian state had issued a tender—a request for interest to manage 100-resident quarantine facilities in four regions to concerns of vulnerable and Indigenous people who will be “unable to quarantine at home during a COVID-19 outbreak.”


    Apparently, the document indicates a rush job—”mandatory criteria for the successful tenderer would be an “ability to mobilize on or before December 10, 2021.” It would appear that this particular state government is planning for what could be a forced quarantine from November 30 to June 30.


    A FactCheck organization, however, denies these claims. The Poynter Institute’s PolitiFact did acknowledge that the State of Queensland is building a quarantine facility for arriving travelers, whether vaccinated or not, that state authorities plan to use for fully vaccinated students upon their arrival in the country, as well as possible use for unvaccinated travelers.


    Moreover, leaving the door open, the fact-checker declared, “in the future, the Australian government might impose different quarantine requirements on vaccinated and unvaccinated travelers, but unvaccinated people living in the country would not be put in camps.” This contradicts to an extent the aforementioned claims. However, TrialSite suggests that if these fact-checkers are admitting to the camps, they are most certainly representative of an ominous movement in what has been one of the world’s most open, democratic of nations—that is, until COVID-19.


    Just as concerning, at one point, America was contemplating militarized camps. TrialSite sought out the point of view of the USA Today Fact Check operation to elicit their point of view. According to that account, the Department of Defense was considering military facilities for quarantine use, but several people on social media took great liberty to apply all sorts of conspiracy theories.


    But around the world, it would appear authoritarian and even totalitarian-like impulses manifest based on visceral, fear-based responses to the pandemic. TrialSite has reported on violence in Europe because of COVID-19 lockdowns. Now there are reports of possible forced internment in Australia. Even though this is among “indigenous people,” what will happen if forced quarantine spreads to the general population? Considering past injustices to Australia’s first peoples, we here at TrialSite cannot help but raise concern. COVID-19-based protests, some leading to violence, have spread even to small islands in the French Caribbean. Will the violence in Europe spread to other continents


    Australian army transfers contact cases to quarantine camp - RT en français
    38 residents of an indigenous community in contact with nine people who tested positive for Covid-19 were taken on November 21 to the Howard Springs
    newsnetdaily.com

    Quote from JedRothwell

    If a natural infection did not lead to the same response as the vaccine, the vaccine would not work.

    You never will get!


    It's the other way round. A vaccine mimics, or at least tries to mimic the natural response to an infection. Good vaccines produce even a stronger immune response than a natural infection e.g. the one for TB.


    First: Gene therapies = Pfizer,Moderna, J&J just mimic vaccines. Pfizer and J&J just induce monoclonal antibodies and a very weak narrow single point immune memory. The body would would do the same for any random substance he has contact with for a longer time.

    The body response to CoV-19 produces a broad range of antibodies and a zoo of memory B-Cell or Ig-G. Pfizer just produces one type. Even worse the RNA induced immune memory does no longer fit --> ADE. Thus we we now see an overreaction to CoV-19 in UK with up to 5x more cases in the vaccinated.


    These are the facts and all blogs that try to calm people down are just cheating you. Protection from death looks like its still here for a few percentage. But nobody knows how many (50%,60%, 70%) people are protected from an infection. In India it was 70% in May without any vaccines. Here also above 50% in the Geneva hot spot.


    If you had Pfizer or J&J an no infection, then I would buy medication ASAP. The criminals will try to deprive you and once end up in a "criminals" hospital you will potentially die or come out as a cripple.

    If you are age <50 then your risk from CoV-19 is close to 0.


    It's like in traffic a few will die, but we use cars despite this fact. But here some people like Fox news like car accident stories...


    Germany plays down natural infection. In fact they discourage people from doing an antibody test. A friend just told me that his wive went to the doctor for a booster after an antibody test. There was a big surprise! She had a record level showing a recent - silent infection.

    So no booster needed!

    But Germany is one of the most corrupt countries in Europe. But the rest just catches up.

    I talked with my best friend today which is a doctor of medicine and practicing doctor. We talk a lot about corona and I get a lot of inspiration

    from her. Turns out that we have an epidemic of the RS virus atm because last years had very little of that in the society. I mention this because

    people here talk about how good it was that we nuked almost all sicknesses but corona last year. So it looks like we will probably end up with some extra

    dead children now which is horrible. Say 1 child is equal 200 or more very old very frail soon to die people (lost years and an awfulness factor

    of around 2) so with these numbers, then 5 extra dead children are like 1000 old frail ones. Yeah one cannot count like this but at least it shows that public

    health are a difficult subject.


    If you like to know more use google translate on the link below,

    RS Virus

    What's behind the rapid disappearance of the delta variant in Japan? It could be self-extinction.
    Many scholars point to a variety of explanations for the sudden end of the fifth wave, but one research group says the coronavirus variant may have actually…
    www.japantimes.co.jp


    Why did Japan’s fifth and biggest wave of the coronavirus pandemic, driven by the supercontagious delta variant, suddenly come to an abrupt end following a seemingly relentless rise in new infections? And what made Japan different from other developed countries that are now seeing a fresh surge in new cases?

    According to one group of researchers, the surprising answer may be that the delta variant took care of itself in an act of “self-extinction.”

    Three months after the delta variant spurred record daily nationwide caseloads of nearly 26,000, new COVID-19 infections in Japan have plummeted, dropping below 200 in recent weeks. Highlighting that drop was the fact that no deaths were reported on Nov. 7 — the first time that had happened in about 15 months.

    Many scholars point to a variety of possibilities, which include one of the highest vaccination rates among advanced countries with 75.7% of residents fully vaccinated as of Wednesday. Other potential factors are the social distancing and mask-wearing measures that are now deeply embedded in Japanese society.

    But the chief reason may be related to the genetic changes that the coronavirus undergoes during reproduction, at a pace of around two mutations per month. According to a potentially revolutionary theory proposed by Ituro Inoue, a professor at the National Institute of Genetics, the delta variant in Japan accumulated too many mutations to the virus’s error-correcting, non-structural protein called nsp14. As a result, the virus struggled to repair the errors in time, ultimately leading to “self-destruction.”

    FM1 wrote....

    Quote

    Australia, which has seemingly imposed Chinese-style authoritarian measures across select states

    and

    Quote

    But Australian Broadcasting Corporation (ABC News) doesn’t appear to be as alarmed as other news outlets. ABC is reporting Australian troops are being brought into the territories simply to help boost covid testing numbers because of a growing outbreak

    The press in Australia, including the ABC, is alert for any new news story. Any would-be forced internment would be headline news. Your so called 'FactCheck organization' is a front for mis-information and built out of male cow manure.


    The Australian Aboriginal community is vulnerable to most Western vices including alcohol, drugs, disease and mis-information. FactCheck styled mis-information is placing these vulnerable ethnic groups at increased risk, particularly as the new African strain advances.


    Immunisation generates anti-bodies that afford a level of protection and a less severe dose of Covid should you contract it; Covid for the un-vaccinated provides post-infection anti-bodies if your body (your kidneys, spleen, liver etc.) survives; and if you survive a severe dose without dying, the health problems can continue for quite some time afterwards. Its a no brainer. Vaccine is your best bet.

    Quote from Innerspace

    Immunisation generates anti-bodies that afford a level of protection and a less severe dose of Covid should you contract it; Covid for the un-vaccinated provides post-infection anti-bodies if your body (your kidneys, spleen, liver etc.) survives; and if you survive a severe dose without dying, the health problems can continue for quite some time afterwards. Its a no brainer. Vaccine is your best bet.

    Innerspace


    Forum software tip:- If you click and drag to highlight any text in a previous post a dialogue box will pop up saying 'save quote, insert quote'. You choose - and it automatically attributes the quote to the member that made it, as in the example above, and also alerts the original poster that you have done so. It works best - for me- if you highlight backwards, from the last word you want including to the first, but that might be a foible of my old desktop.

    Nine cases of Covid-19 have been detected in an indigenous community in northern Australia, prompting authorities to move 38 contact cases to a quarantine camp. The latter was supposed to accommodate only travelers.


    38 residents of an indigenous community in contact with nine people who tested positive for Covid-19 were taken on November 21 to the Howard Springs quarantine center, near Darwin, in the Northern Territory in Australia.


    Australian army transfers contact cases to quarantine camp - RT en français
    38 residents of an indigenous community in contact with nine people who tested positive for Covid-19 were taken on November 21 to the Howard Springs
    newsnetdaily.com

    New C19 mutation announced in Africa: Defies science, but good for lockdown


    New C19 mutation announced in Africa: Defies science, but good for lockdown
    Shabnam Palesa Mohamed TrialSite News Africa 26 November 2021 African timing plot twist The timing of announcements by the South African and Botswana
    trialsitenews.com



    African timing plot twist

    The timing of announcements by the South African and Botswana governments, regarding a new ‘Omicron’ variant with 32 spike protein mutations, sent waves of fear but also disbelief around the world. Hong Kong announced two fully vaccinated cases, while Belgium and Israel also reported cases. There is no proof that this variant of concern is more contagious or lethal. Just last week, news headlines were focused on how Africa has managed to escape the worst of the C19 virus impact.



    Government statements

    The Botswana government released a media statement regarding the B.1.1.529 variant in four fully vaccinated residents, while the South African government will meet with its scientists on Saturday to evaluate 77 reported cases. This follows political rallies and elections in the resource-rich country.


    Africans locked out

    Despite WHO cautioning against travel bans, travel to Dubai from Botswana, eSwatini, Lesotho, Mozambique, South Africa and Zimbabwe is suspended from Monday 29 November, while travel from Dubai is permitted. The US, UK and Germany have similar measures. Meanwhile, a video from Twitter shows passengers from South Africa not being allowed to disembark in the Netherlands.


    Appeal for more IMF debt

    On Friday 26 November, Brazilian-born bioinformatician Prof Tulio de Oliveira tweeted a series of messages just after announcing the new mutant. In it, Oliviera, who spoke on an Illumina SPARK panel with former FDA commissioner and now Pfizer director Scott Gottlieb, appealed for billionaires like Bill Gates and others, as well as the IMF and World Bank, to rescue South Africa and Africa’s “oppressed”. It is unclear whether the appeal is approved by the South African government, whose debt to GDP rate is 83%. Meanwhile, the variant – detectable with a qPCR test according to Oliviera – seems to have an S-gene dropout, and can allegedly be spotted without full genetic sequencing.


    Experts weigh in

    Francois Balloux, professor of computational systems biology at University College London, said, “For the time being, it should be closely monitored and analysed, but there is no reason to get overly concerned, unless it starts going up in frequency in the near future.” By contrast, biochemist, molecular biologist and physicist Dr Doug Corrigan did not mince his views on Twitter.


    Science, experiments, and theft

    In well-established virus science, viruses weaken over time and eventually disappear. The WHO announced earlier this year that South Africa was experimenting with the virus. In July 2020, vehicles with C19 samples were hijacked in South Africa. There have been no public updates on investigation.


    Africa’s natural immunity

    While the push is towards more “leaky” vaccines as the only response, and despite pharmaceutical companies admitting vaccines will not stop infection nor transmission; virologist and vaccine expert Dr. Geert van den Bossche told TrialSite News Africa “I feel very concerned about Africa. We need to preserve people’s innate immunity and protect them from mass vaccination. Africa can still build herd immunity whereas the western world has now completely destroyed that option because of massive vaccination of their population.” In a consistent message, he writes about why mass vaccination during a pandemic enhances immune escape and creates an “irrepressible monster.”


    Economic health

    In South Africa, the economy for the masses is tanking, with over 30% unemployment, over 70% youth unemployment, and calls for mass protests and economic boycotts. Botswana is Africa’s largest diamond-producing country, with the largest destination being the US. In August 2021, the US government donated 81 000 Pfizer vaccines to Botswana. Over 57% of Botswana’s population is vaccinated. On the announcement of the Omicron variation, economics trading markets showed intriguing chaos, with US and global markets down, and with Pfizer up 6%, and Moderna up 20%.


    The bottom line

    With 41% of the population vaccinated, the South African government budgeted over 19 billion ZAR on vaccines for 3 years. These experiment products often reach expiry dates. By contrast, budget for repurposed medicines is negligible. The push for vaccines above all else is not sustainable, while cancer, for example, is neglected. On this issue, advocacy groups are raising the public health alarm.


    Practical protocols

    C19 early treatment protocols developed by the World Council for Health are available here.

    I posted an article yesterday on this, you'll notice that nsp 14 mutation is also associated with B.1.1.529

    Quote from Wyttenbach

    Hammer in more fake news ?? Just check the list of helpers like Twitter that usually flags e.g. Ivermectin as fake news.. So could be a more perfide version to introduce fake fake news ?

    Opinion: Anti-vaxxers are using the same tactics as cults do to attract followers on social media
    Looking back, I see that the fear tactics that Moon used to recruit and keep me in the cult are the same ones that leaders of the anti-vaccination ideology are…
    edition.cnn.com


    While there are many mind control techniques that destructive cults use, emotional control is one of their most powerful weapons for keeping people dependent and obedient. Known as phobia indoctrination, it exposes a person to a series of persistent, irrational fears that initiate a closed cycle of fearful images, thoughts and feelings. The goal is to cause people to fear things that are actually harmless in reality.


    NPR Cookie Consent and Choices


    Queen listens quietly as Benscoter explains how extremist groups need to control what people think in order to convince them to dedicate themselves to a cause, and so these groups paint everything else as a lie or evil. And she tells Queen how those indoctrination tactics worked on her.




    Quote from Wyttenbach

    The cases in RSA have doubled within 1 day. The positive rate did explode to > 30%.

    New name (WHO) for the variant of concern Omicron. Have the socks ready. Pfizer did a very poor job on teh base variant already so what will happen ADE??


    Watch the news the next few days not just stock exchanges...

    One of the PR disasters in the medical response to COVID has been caused by the speed at which things change.


    Even well-read commentators like W here confuse vaccine efficicacy against original COVID (outstanding) with vaccine efficacy against delta (much less good). I'll bet mots people, including be, do not remember always whether as particular set of data is related to delta, original, alpha, or some combo.

    Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin


    https://www.tandfonline.com/doi/full/10.1080/21505594.2021.2006960


    Abstract

    The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta (B) and Delta (D) SARS-CoV-2 variants were assessed for their infection performance in single variant- and co-infections. The effectiveness of thapsigargin (TG), a recently discovered broad-spectrum antiviral, against these variants was also examined. Of the 3 viruses, the D variant exhibited the highest replication rate and was most able to spread to in-contact cells; its replication rate at 24 h post-infection (hpi) based on progeny viral RNA production was over 4 times that of variant A and 9 times more than the B variant. In co-infections, the D variant boosted the replication of its co-infected partners at the expense of its own initial performance. Furthermore, co-infection with AD or AB combination conferred replication synergy where total progeny (RNA) output was greater than the sum of corresponding single-variant infections. All variants were highly sensitive to TG inhibition. A single pre-infection priming dose of TG effectively blocked all single-variant infections and every combination (AB, AD, BD variants) of co-infection at greater than 95% (relative to controls) at 72 hpi. Likewise, TG was effective in inhibiting each variant in active pre-existing infection. In conclusion, against the current backdrop of the dominant D variant that could be further complicated by co-infection synergy with new variants, the growing list of viruses susceptible to TG, a promising host-centric antiviral, now includes a spectrum of contemporary SARS-CoV-2 viruses.


    Discussion

    A key finding from single-variant comparisons of SARS-CoV-2 infection is that the D variant is superior to the A and B variants in replication rate and in cell-to-cell transmission. Technically, the use of FFA in virus quantification, but not the use of median tissue culture infectious dose (TCID50) assay (Al-Beltagi et al., 2021; Coleman and Frieman, 2015), has an added advantage of visualising and quantifying infected cell clusters from direct collateral spread of SARS-CoV-2. Our in vitro finding of high replication rate of the D variant is consistent with a recent finding that in nasopharyngeal samples, virus load of the Delta variant was 2.5-fold higher (p < 0.05) than that of the Beta variant (Teyssou et al., 2021); and with a pre-print report based on clinical cases that found the D variant to proliferate more rapidly and accumulate to much higher levels (~100 times higher) in the respiratory tract than the first wave of 2020 variants (Li et al., 2021).


    This work has also highlighted that co-infection in certain SARS-CoV-2 variant combinations, such as the AD or AB pairing, can result in replication synergy. AD co-infection was particularly striking in that the A variant was quantitatively dominant over and at the expense of the D variant in progeny RNA production. Although there was no significant change in total infectious progeny, as detected by 18 h FFAs, between A variant single-infection and AD co-infection, we should closely monitor events of co-infection, in particular of new variants, for disease severity and population spread as the dynamics of virus replication in co-infection are unpredictable and can differ sharply from corresponding single-virus infections. In a case study, co-infection by two SARS-CoV-2 lineages, 20A and 20B, was thought to contribute to the extended duration and severity of disease in a 17-year-old patient (Pedro et al., 2021).


    The worrying breakthrough rate of D variant infection amongst fully vaccinated individuals suggests that current vaccines are less able to block virus proliferation to prevent transmission. The rapid replication rate and cell-to-cell spread of the D variant are likely viral traits responsible for infection breakthrough in fully vaccinated individuals. The ability of the D variant to rapidly spread through cells by direct contact without the prior need of extracellular progeny release could partly shield the virus from an existing humoral response. To tackle disease fallout from increased virus pathogenicity, infectivity and replication synergy, future management of COVID-19 may well require the use of contemporary multivalent vaccines, combined with effective broad-spectrum antivirals that can preferably be administered orally. We previously showed that the antiviral use of TG was highly effective against influenza viruses of different subtypes (Goulding et al., 2020), respiratory syncytial virus, coronavirus OC43 and an original isolate of SARS-CoV-2 (2019-nCoV/Italy-INMI1, clade V) (Al-Beltagi et al., 2021). Other groups have reported effective TG inhibition of paramyxoviruses (Kumar et al., 2019), and 229E, Middle-East respiratory syndrome and SARS-CoV-2 coronaviruses (Shaban et al., 2021). All available data (generated by us and others) as exemplified in influenza virus, RSV and coronaviruses, including SARS-CoV-2, indicate that TG does not prevent viral entry but rather triggers intracellular pathways to inhibit virus replication (Al-Beltagi et al., 2021; Goulding et al., 2020; Shaban et al., 2021). As a host-centric antiviral, TG hits several central host mechanisms connected to endoplasmic reticulum stress-unfolded protein response to inhibit several stages of virus replication. The antiviral potency of TG has now been extended to contemporary SARS-CoV-2 variants, including the D variant, in all combinations of single- and co-infections. We therefore submit that TG is potentially a truly broad-spectrum antiviral that targets a growing list of viruses.

    Quote from Innerspace

    Immunisation generates anti-bodies that afford a level of protection and a less severe dose of Covid should you contract it; Covid for the un-vaccinated provides post-infection anti-bodies if your body (your kidneys, spleen, liver etc.) survives; and if you survive a severe dose without dying, the health problems can continue for quite some time afterwards. Its a no brainer. Vaccine is your best bet.

    The vaccines induce

    1. neutralising antibodies preventing infection which alas decays quite quickly.

    2. memory so that new neutralising antibodies can be regenerated in response to a new infection more quickly than in an unprotected individual

    3. memory T-cell response.


    Only 1. prevents infection. 2. & 3. help prevent severe disease.


    In addition 1. and 2. are very specific to the spike proteins (1st gen vaccines use only those, and anyway they are better conserved than anything else). 3. is broader in response, and also it seems lasts longer.


    So the idea is that for delta, 1. & 2. response is lower, but probably still there. 3. response remains almots as good as for original covid.

    For omicron it seems likely based on number of mutations (3 X as many as delta) that 1. & 2 will be much lower. 3. however may stay high.


    Hence the current guess:

    Infection and transmission are likely not prevented by vaccines much for omicron

    Severe disease will probably still be significantly reduced by vaccines. Big question is how much.

    No, the big question is how long will it last if it works at all. With all the mutations this is very similar to a spillover event. I hope that's not the case but more and more animals are being found with Covid. Cross your fingers!

    Quote from stefan

    Turns out that we have an epidemic of the RS virus atm because last years had very little of that in the society. I mention this because

    Stefan we report about this since more than one month. In almost all western countries children hospital ICU's are full with RSV victims due to corona over (crazzy mask order, stay home alone..) . Far more children will die from RSV than from corona...

    Quote from Innerspace

    Vaccine is your best bet.

    Never heard about Ivermectin and the "India Ziverdo kit". Its a 99.99% insurance much better than vaccines and fights all version of virus.

    Quote from Fm1

    The effectiveness of thapsigargin (TG), a recently discovered broad-spectrum antiviral,

    It (thapsigargin) is highly toxic and carcinogenic. Its used in lab test as a C2 inhibitor. (See Wiki)


    Quote from THHuxleynew

    The vaccines induce

    1. neutralising antibodies preventing infection which alas decays quite quickly.

    2. memory so that new neutralising antibodies can be regenerated in response to a new infection more quickly than in an unprotected individual

    3. memory T-cell response.

    Correctly said:: Vaccines do this. But not Pfizer, Oxford-Astra/J&J CoV-19 gene therapies that produce monoclonal antibodies only...And no usable immune memory cells... Moderna is a bit broader.

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