The Playground

  • Let's check it then again i 2..4 weeks how Omicron may bend the statistics. Noted. You should get out of here with your laughing smilies if you cannot come up with better argumentation, as others do...sad.

  • Another CDC narrative proved wrong!!!


    Natural Immunity More Potent Than Vaccines During Delta Wave In US: Study


    Natural Immunity More Potent Than Vaccines During Delta Wave In US: Study
    During America's last surge of the coronavirus driven by the Delta variant, people who were unvaccinated but survived Covid were better protected than those…
    www.ndtv.com


    During America's last surge of the coronavirus driven by the Delta variant, people who were unvaccinated but survived Covid were better protected than those who were vaccinated and not previously infected, a new study said Wednesday.

    The finding is the latest to weigh in on a debate on the relative strengths of natural versus vaccine-acquired immunity against SARS-CoV-2, but comes this time with the imprimatur of the US Centers for Disease Control and Prevention (CDC).


    The authors of the paper warned, however, against depending on infection as a strategy, given the higher risks to unvaccinated persons of hospitalization, long term impacts, and death, compared to vaccinated people.


    "Viruses are constantly changing, including the virus that causes Covid-19," the CDC said in a statement.


    "The level of protection offered by vaccination and surviving a previous infection changed during the study period. Vaccination remains the safest strategy for protecting against Covid-19," it added.


    The analysis was also carried out before the emergence of the Omicron variant, for which both vaccine and infection-derived immunity appear diminished, and before boosters were made widely available.


    The new study involved patients in New York and California between May 30 to November 30, 2021.


    Prior to Delta becoming dominant, vaccination conferred greater immunity than infection. But the relationship shifted when the variant became predominant in late June and July.


    By the week of October 3, case rates among vaccinated people without prior Covid were around six times lower in California and five times lower in New York compared to those who were unvaccinated and without prior Covid.

    But the rates were substantially lower among people with previous Covid, including around 29 times (California) and 15 times lower (New York) among unvaccinated persons with a previous diagnosis, compared to those who were unvaccinated and without prior Covid.


    Protection was highest among those who had both vaccination and prior Covid.


    Hospitalizations followed a similar pattern.


    Other research, including a notable paper from Israel in August, have similarly found that natural immunity was more potent than vaccines during the Delta surge.


    But the US CDC had previously taken the opposite position, based on pre-Delta data.


    "Further studies are needed to establish duration of protection from previous infection by variant type, severity, and symptomatology, including for the Omicron variant," the paper concluded

  • "The level of protection offered by vaccination and surviving a previous infection changed during the study period. Vaccination remains the safest strategy for protecting against Covid-19," it added.

    Once more a vaccine terrorist in full speed. Real - no crap treating of CoV-19 is the safest strategy also for the "vaccinated"....

  • Without a freedom of information act, would we be getting real data from authorities?


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  • One thing we seem to have missed: https://www.thedesertreview.co…ec-ae59-7718e6d063ed.html


    In a stunning 46-page legal filing to the International Criminal Court on December 6, an intrepid attorney and seven applicants accused Anthony Fauci, Peter Daszak, Melinda Gates, William Gates III, and twelve others of numerous violations of the Nuremberg Code. These included various crimes against humanity and war crimes as defined by the Rome Statutes, Articles 6, 7, 8, 15, 21, and 53.

  • An other not so nice outcome from experimental RNA gene therapy against CoV-19....


    Lipid Nanoparticles kill 80 percent of mice in PubMed Study
    In 1989, Dr. Robert Malone invented the platform technology that allowed mRNA to transfer into mammalian cells.
    www.thedesertreview.com


    The insurance company argued that the use of experimental medication or treatments, including the COVID vaccination, was excluded from the insurance contract. The court agreed and wrote this,

    “The side effects of the experimental vaccine are published, and the deceased could not claim to have known nothing about it when he voluntarily took the vaccine. There is no law or mandate in France that compelled him to be vaccinated. Hence his death is essentially suicide.”

    Suicide was also expressly excluded in the death benefit coverage, and the court agreed that taking the experimental vaccine was essentially the acceptance of a potentially fatal risk that was equivalent to suicide.

  • This intervention by the inventor of RNA vaccines has been banned from YOUTUBE. The text was published in extenso on the Official Journal of the Representatives' Debates by a deputy on Capitol Hill.





    Inventeur de la technologie ARNm, Robert Malone alerte les parents contre les vaccins anti-Covid
    L'article : https://www.francesoir.fr/politique-monde/robert-malone-plaidoyer-vaccination-enfants Toutes nos vidéos sont à retrouver sur videos.francesoir.fr/…
    odysee.com

  • "Vaccine" protection against Omicron for younger seems to be lower everywhere. https://www.covid19.admin.ch/d…?vaccStatusAgeRange=20-29

    I suspect these just do more tests and have more dangerous encounters (clubs, cinema, parties...)


    Also the kids do not have so much chance of getting the partial immunity gained from exposure to more common corona-virii circulating in the community that helps protect Millennials and older folk.

  • NL is the worst data cheating country since day one of pandemic. Thus just throw all NL studies in the bin.


    Facts we know from openly reporting countries like UK/IL. Boosters help nothing = 0 = Nada for Omicron.

    Particularly egregious Wyttenfact


    Effectiveness of COVID-19 vaccines against the Omicron (B.1.1.529) variant of concern
    Background A rapid increase in cases due to the SARS-CoV-2 Omicron (B.1.1.529) variant in highly vaccinated populations has raised concerns about the…
    www.medrxiv.org


    And that is protection against infection, which as we know is lower than protection against severe disease.

  • The results suggest that Omicron’s hyper-transmissibility does not stem from the release of large amounts of virus from infected people. Instead, the best explanation for its lightning-fast spread is its ability to evade SARS-CoV-2 immunity caused by either vaccination or past infection, says Emily Bruce, a virologist at the University of Vermont in Burlington.

    People seem to have a binary view of these things.


    Obviously past vaccine & survivor immunity is a very large part of the picture but omicron spreads much faster than original COVID. Faster than delta? Who knows. We most hope that specialising infectivity to nasal tract does make it spread betetr, if so that gives us pressure towards keeping COVID lower risk.

  • an intrepid attorney and seven applicants accused Anthony Fauci, Peter Daszak, Melinda Gates, William Gates III, and twelve others of numerous violations of the Nuremberg Code.

    Klaus Schwab, a wickedly intelligent, perhaps diabolical German


    Many consider Schwab the mastermind behind the current movement towards cryptocurrency, universal identification, and a one-world (fascist) government to be run jointly, in totalitarian fashion, with China.


    These attorneys sure are intrepid - and technologically challenged, if they think moving towards cryptocurrentcies - the untraceable - anarchic and beloved of teh dark web - independent of any government control - ideological currency - is connected to Chinese totalitarian aims.


    You can't make this stuff up. Thanks W for posting it. Oh, but I'd guess W and one or two others here actually takes it at face value... (Don't think W knows much about cryptocurrencies).

  • the inventor of RNA vaccines

    Malone was one of many involved with one of the technical advances that led to RNA vaccines. Then he went nuclear (see the pun) after a lack of academic ego stroking


    The real scientists on the frontlines of the anti-vaccine movement - Coda Story
    The Infodemic is a weekly newsletter, tracking how disinformation surrounding the coronavirus crisis is reshaping our world. Also in this edition: a boost for…
    www.codastory.com


    As we talk, I also hear notes of bitterness that may provide an insight into the ego issues within the scientific community. Something that can surely be manipulated by the anti-science movement.

    “I’ve been written out of history,” Dr. Malone tells me “It’s all about Kati.”

    By Kati he means Dr. Katalin Kariko who has been also described as a pioneer of mRNA vaccines and is now a senior vice president at BioNTech, the manufacturer of Pfizer Covid-19 vaccine. I got in touch with Dr. Kariko too. “Hundreds and thousands of scientists, experts contributed to the creation of the mRNA vaccine,” she tells me in an email.

    The Vaccine Scientist Spreading Vaccine Misinformation
    Robert Malone claims to have invented mRNA technology. Why is he trying so hard to undermine its use?
    www.theatlantic.com


    Whether Malone really came up with mRNA vaccines is a question probably best left to Swedish prize committees, but you could make a case for his involvement. When I called Malone at his 50-acre horse farm in Virginia, he directed me to a 6,000-word essay written by his wife, Jill, that lays out why he believes himself to be the primary discoverer. “This is a story about academic and commercial avarice,” it begins. The document’s tone is pointed, and at times lapses into all-caps fury. She frames her husband as a genius scientist who is “largely unknown by the scientific establishment because of abuses by individuals to secure their own place in the history books.”

  • Physician on a Mission: Sues Houston Hospital Seeking to Compel COVID-19 Financial Ties to Feds & Pharma


    Physician on a Mission: Sues Houston Hospital Seeking to Compel COVID-19 Financial Ties to Feds & Pharma
    Times have changed for physicians in this age of medicine, marked by large, often monopolistic desirous health systems leading to the practice of medicine
    trialsitenews.com


    Times have changed for physicians in this age of medicine, marked by large, often monopolistic desirous health systems leading to the practice of medicine by administration and bureaucracy, not to mention the drive for revenue capture over the sacrosanct physician and patient relationship. With ever less leverage in the domain called big medicine, physicians, once highly revered, now increasingly face a “system” that ultimately supersedes individuals, including both doctors and patients. This evolving dynamic is catalyzed by a rapidly federalized model—one where nearly 150 million Americans gain access to medicine via federal insurance (Medicare, Medicaid, VA, DOD, etc.). Meanwhile, the COVID-19 pandemic led to ongoing federal orchestration and direction of all treatment protocols. Federal dollars poured into hospitals and health systems and accepted strict protocols for how to treat patients infected with SARS-CoV-2 ensued. Thus, regardless of what the physician calls for at the point of care, even if potentially beneficial to the patient based on the doctor’s best judgment, a higher authority makes the call—one far away from the traditional local health care transaction. Doctors that don’t line up and align with this hierarchy find trouble—fast. Of the approximately one million physicians in the United States, emerges a small number of restless, energetic, angry, patient-centric, independently-minded firebrands. One such case covered by TrialSite is that of Doctor Mary Bowden, the Houston, Texas-based physician at the sprawling Houston Methodist Hospital who found herself in trouble with the administration that suspended her for public opposition to the COVID-19 vaccine mandate. In today’s climate, such public sentiment, along with the treating of patients with repurposed therapies such as ivermectin get doctors into trouble–quickly.


    Resigning in protest due to suspended privileges for “spreading dangerous misinformation,” (20) Houston Methodist on Twitter: “Dr. Bowden, who has never admitted a patient at Houston Methodist Hospital, is spreading dangerous misinformation which is not based in science. (4/5)” / Twitter Dr. Bowden filed a lawsuit against Houston Methodist in the 5th circuit court for not complying with state non-profit corporation transparency laws. Specifically, the activist-plaintiff seeks to compel the large health system with a 2,500-bed hospital and over 300 clinics and satellite locations to share data about COVID-19 patients and associated payments from the federal government.


    The doctor went on the record Monday, January 17 disavowing her interest in any pecuniary gain declaring, “I want to make this clear, I’m not seeking any financial gains from this or personal gain, I’m simply seeking the truth, which we all deserve,” said Bowden.


    The Team

    Dr. Bowden has teamed up with a group of individuals with like-minded interests in what could likely be a David and Goliath-level legal battle. But nonetheless, the group brings fire, passion, and frankly, channeled anger that just might spell trouble for the hospital assuming sound legal arguments. The Houston-based physician has a team including the following:



    Attorney Steve Mitby

    Sylvia Anderson, one of Bowden’s patients who was successfully treated for COVID-19 using a combination regimen of steroids, Vitamin C, and high doses of ivermectin

    Jennifer Bridges, a former nurse at Houston Methodist who was terminated for failure to comply with the health system’s universal employee vaccine mandate. Bridges is part of a lawsuit against the vaccine mandates now pending appeal before the 5th Circuit Court

    Wayne Dolcefino, an investigative reporter

    The Plaintiff’s Target: ‘Secrecy’

    As reported recently in The Texan, the University of Texas and Stanford University-trained ear, nose, and throat (ENT) specialist now strikes back at what some doctors consider “The Empire,” a large health system, exemplifying for other doctors a toughness, resolve, and dedication to ideals perhaps higher than one’s own self-interests. At a recent Houston-based press conference, Bowden declared the target of “secrecy” was taken on because “Medical freedom has been hijacked by hospitals, big pharma, insurance companies, and the federal agencies.”


    The Issue

    Is Houston Methodist complying with the transparency provisions included in Texas state law applying to non-profit tax-exempt corporations? According to the physician-plaintiff, the health system has thus far failed to provide hospital financial data required since November and December to the plaintiff side, reports Holly Hansen, writing for The Texan.


    Specifically, the litigants’ claim filed Monday of this week in state district court states that the hospital needs to share financial data associated with COVID-19 reimbursements and other payments from the government, payers, and patients. Also, the plaintiff pursues to understand relevant ties between the health system and pharmaceutical companies for COVID-19 treatments. For example, this might include information associated with clinical trial deals. TrialSite has learned from multiple hospitals/health systems that entered contracts with Pfizer, for example, to conduct COVID-19 vaccine trials with contractual restrictions potentially inhibiting the hospital from seeking alternative, potentially competitive treatments.


    Data Transparency

    Among other things, the plaintiff seeks to understand if Houston Methodist benefitted financially from including remdesivir in its COVID-19 protocol. This antiviral was embraced early by the National Institutes of Health (NIH) in clinical trials, first granted Emergency Use Authorization (EUA) in May of 2020 then gained formal approval by October of that year. Mrs. Hansen reminds the reader that the drug failed to produce clinically relevant results in the World Health Organization’s Solidarity trial leading to that agency’s elimination of the product from its COVID-19 recommendations. While the drug is known to carry risks for kidney and liver damage not to mention renal failure, it continues to still be heavily relied upon in American hospitals.


    The plaintiff also seeks to understand just how many of the hospital’s patients and employees were involved with so-called breakthrough infections: those fully vaccinated persons that still became infected with SARS-COV-2 and how many of “the 2,879 patients who have died of COVID-19 at the system were denied early treatment protocols,” according to The Texan.


    Conclusion

    Have hospitals and health systems become more significantly entangled with federal payers and pharmaceutical companies during the pandemic? If so, is this trend to the detriment of physician flexibility and patient choice? For example, is remdesivir overprescribed in acute settings while federal COVID-19 guidelines unreasonably restrict physicians from considering other off-label approaches? How many of the infections and acute cases as well as deaths involved vaccinated patients at Houston Methodist? Are there patterns associated with the COVID-19 deaths (e.g., remdesivir associated with failure to improve)? What does the Medicare and Medicaid payment scheme look like for SARS-CoV-2 infected patients? Is the hospital receiving fixed payments for SARS-CoV-2 acute and then again ICU-housed patients? These are just some of the questions that may be addressed in this lawsuit.


    Plaintiff’s counsel Steve Mitby remains upbeat, declaring he expects victory in the courts: “I expect we will get these records. It’s state law.” Meanwhile, Houston Methodist’s spokesperson wouldn’t provide any comment to the local Texas newspaper, rather instructing them to refer to past statements. ‘Personally offended’: Houston Methodist Hospital CEO on doctor who made controversial claims about COVID-19 treatments (click2houston.com)


    Note, Dr. Bowden joins fellow Texan Dr. Peter McCullough and other physicians and health care workers from around the USA and beyond at the forthcoming Medical Freedom march on Sunday, January 23 in Washington, DC


    Doctor Mary Bowden Sues Houston Methodist Hospital for COVID-19 Data, Financials
    After sparring with the healthcare giant over COVID-19 treatments, Bowden says Houston Methodist is not complying with transparency laws for non-profit…
    thetexan.news

  • How CDC handles VERS... https://goodsciencing.com/covi…-by-covid-vaccines-in-us/


    The US VAERS system records reports of vaccine injuries and deaths due to vaccines. It has been well documented that the database only contains 1% to 10% of the true numbers, for various reasons. In other words, the real numbers may be 10x to 100x the numbers in the database. Currently, it shows 46 children killed by Pfizer COVID vaccine shots in the USA.

    It has been documented that the people who maintain that database have carried out campaigns of removing records that people added. Several researchers discovered the deletions by taking multiple daily snapshots and discovering missing records days or weeks later.


    At lot of cleanup to do after the US freedom day... If no war happens until then...

  • https://www.unige.ch/medecine/demed/files/8416/4200/1852/MEDRXIV-2021-268491v2-Eckerle.pdf

    Omicron:: Also Swiss paper finds 86x reduction in neutralization for RNA gene therapy (vaccines..)

    Recovered protection depends on virus type but also is reduced by about 23x. Best is first infection then vaccine, with only 18x reduction....


    Double dose vaccination showed robust neutralization for Alpha, Beta, Gamma, Delta and Zeta, with fold-change reduction of only 2.8 (for Alpha) up to 6.9 (for Beta). Escape from neutralization for Zeta was largely restored in vaccinated individuals, while Omicron still showed a loss of neutralization of 85.7-fold compared to pre-VOC SARS-CoV-2.

  • Same findings in:: https://www.nature.com/article…022-04399-5_reference.pdf


    However, boosted individuals had, at least within the short time after the booster dose, significant protection against symptomatic disease in the range of 75%. Although it is unclear how long this protection lasts,we observe titers similar to those in boosted individuals in convalescent vaccinated individuals, suggesting that those individuals may experience significant protection.


    As we know from the Swiss paper the wording "significant protection" in the nature paper is totally misleading.. The real difference for a delta recovered with vaccine is just a tick better than that of a recovered (23x reduced) and still 18x reduced!!!

  • Preventive Ivermectin: international scientific review confirms 68% efficacy in SUS study


    Preventive Ivermectin: international scientific review confirms 68% efficacy in SUS study
    Note that views expressed in this opinion article are the writer’s personal views and not necessarily those of TrialSite by Filipe Rafaeli Dr Flávio
    trialsitenews.com


    by Filipe Rafaeli



    Dr Flávio Cadegiani, one of the authors of the study, presenting the pre-print at the World Congress – World Council for Health – Doctors for Life, held in Brasilia in December.

    Over the weekend, after reviewing the data by three independent groups of scientists, the 68% efficacy of the preventive ivermectin against deaths caused by COVID-19 was confirmed. The final results of the study were published in the prestigious scientific journal Cureus, based in San Francisco, USA, and with a chapter in Munich, Germany.


    Cureus has two esteemed editors-in-chief in the scientific community: Dr John Adler Jr, Professor of Neurosurgery and Radiation Oncology (Emeritus) at Stanford University in California, and Dr Alexander Muacevic, the medical director of the European Radiosurgery Center in Munich, Germany and a professor at the University of Munich Hospitals.



    The medical research took place in Itajaí, a port city in Santa Catarina, in the southern region of Brazil, between July and December 2020. The lead scientist of the study is the Brazilian medical doctor Lucy Kerr. Other important scientists collaborated with the scientific article and co-signed the research. Among them are Jennifer Hibberd, from the University of Toronto, Canada, Fernando Baldi, professor at the State University of São Paulo (UNESP), Dr Pierre Kory, North American medical professor and one of the world’s leading experts in intensive care, among several others.


    The largest ivermectin study in the world only occurred because of the excellence of SUS


    UBS – Basic Health Unit Promonar was one of several health points used to distribute ivermectin, record data on comorbidities, previous diseases, perform COVID tests, and serve the population of Itajaí during the study. Photo: Google Street View.

    The study was only possible due to the excellence of the Brazilian public health system. “The National Health System (SUS) functions as full healthcare support to the entire population allowed the city to establish a non-restricted population program,” the scientists explained in the study.


    Only people over the age of 18 participated. “Children were excluded. And also people who have had COVID before,” Lucy Kerr explained.


    Thus, of the 223,128 citizens of Itajaí considered for the study, a total of 159,561 individuals were included in the analysis: 113,845 (71.3%) ivermectin users and 45,716 (28.7%) non-users.


    The drug was offered by the municipal government to all citizens and only those residents who wanted it participated. “Patient preferences and medical autonomy were preserved,” the scientists explained.


    SUS professionals in Itajaí monitored and recorded the data of both patients who took ivermectin and those who did not take the drugs. “The whole city had digital registration at SUS and it was being updated with the new consultations as people went to get their medication,” Kerr said.


    The scientist praises the health professionals in Itajai. “They all collaborated very, very much,” said Dr. Lucy. “It wasn’t just data if they took it or didn’t take it. It was also knowledge of all people’s previous comorbidities and illnesses. Whether they had asthma, diabetes, cancer.”


    “I don’t know if this would be possible in other countries, since Brazil, through SUS, is one of the most digitalized countries, and with accurate data, in the health system,” said Dr Flavio Cadegiani, one of the scientists involved in the data analysis.


    Result: 44% reduction in chance of getting COVID-19, study concludes


    The study was published in the journal Cureus (link)

    Among all citizens over the age of 18 with no history of COVID, 113,845 volunteered to take Ivermectin every two weeks. Among those who did not volunteer, there were 45,716 people.


    Over the next six months, among those taking ivermectin, 3.7% became infected with the virus. Among non-users, 6.6%. There was a 44% reduction, therefore, in the chance of being infected with Sars-Cov-2, the virus that causes COVID-19.


    Once infected, 56% reduction in chance of being hospitalized

    Among the 113,845 who took ivermectin, 4,197 had Covid. Among the 45,716 who did not take it, 3,034 had Covid.


    In the study, from this point on, there was an advanced statistical technique called Propensity Score Matching, where two groups were balanced to be similar with regard to age and risk factors, such as previous diseases and sex. Thus 3,034 citizens using ivermectin were matched and compared with 3,034 non-users.


    The hospitalization rate among users of the preventive medicine was 1.6%. Among non-users, it was 3.3%. Therefore, ivermectin reduced the need for hospitalizations by 56%.


    A 68% reduction in mortality among ivermectin users

    Among the 3,034 with COVID not users of preventive ivermectin, 79 people (2.6%), died. Among the 3,034 in the comparison group, ivermectin users, 25 people (0.8%) died. So there was a 68% reduction in mortality.


    “There was no early treatment established by the municipality, so there was no interference in the study regarding hospitalization and death. It’s just the effect of prophylaxis. With treatment after infection, the numbers tend to improve,” says Dr Flavio Cadegiani.


    “The statistical technique used, the PSM, allows us to affirm that the study has the power close to a randomized clinical trial,” he added.


    How peer review happened

    Peer review, when other scientists review and attest to the scientific quality of articles, is an essential scientific process. In the case of this study, three independent groups had access to all the data and the manuscript. Subsequently, they contacted the authors anonymously via the Cureus journal communication system. Each group of reviewers was classified with a letter of the Greek alphabet: Alpha, Beta, and Gamma.


    “In addition to peer review, the study goes through three editorial stages. And all three need to accept the work. In our case, due to the relevance of the study, we didn’t even have the opportunity to appoint reviewers. All were completely independent”, says Dr. Flavio Cadegiani.


    Transparent and available data for the scientific community


    Aerial photo of Itajaí. Photo by Eduardo Marquetti, under Creative Commons license, published in Wikipedia.

    “Health status was assessed and data were entered prospectively throughout the period of the program, in a fully digitized system provided by the National Health System (SUS),” the scientists stated in the study.


    “Since the system existed prior to the pandemic, a significant number of the population were already registered with their health information, including past and current diseases, use of medications, and other characteristics.,” they added.


    Soon, in about two weeks, with the objective of total transparency with the national and international community, the raw data extracted from the SUS system of Itajaí, containing all the characteristics of the residents, preserving their identities, will be made available. The data will be publicly available on a platform. The electronic address will be announced on the blog of the journal Cureus.


    “Unlike studies with vaccines and patent medicines, this is a unique opportunity in the pandemic where scientists from around the world will be able to analyze the data. To our knowledge this is unprecedented for a study of this level and importance in Covid-19,” said Cadegiani.


    This was a decision of the team that produced the study. It comes at the same time as an editorial in the BMJ (British Medical Journal), one of the world’s most respected medical journals, published yesterday, calling for all raw data on vaccines and new treatments for COVID to be made public.


    Official data from the epidemiological bulletin confirm the drop in mortality throughout Itajaí

    Of the more than 220 thousand inhabitants of Itajaí, only a little more than 114 thousand volunteered to use ivermectin every two weeks. Even so, the impact on the entire city was quite significant, compared to the other cities in the state.



    One of the study’s results tables shows a dramatic drop in mortality before and during the study, even with much of it not using the drug. Deaths dropped from 3.5% of those infected to 1.4%.


    “The most basic confirmation that there can be of this whole result is to do an analysis on all the epidemiological bulletins of the state of Santa Catarina. The difference between hospitalizations and mortality, before and during the ivermectin program, was striking. Anyone can check this at any time with official numbers,” says Cadegiani.


    Doses used

    ivermectin was offered in biweekly doses of 0.2mg per kg per day for two days. In other words, a person weighing between 60 and 90 kg was given 3 ivermectin tablets a day every two weeks for two consecutive days. If the weight was greater than 90 kg, 4 tablets a day for two consecutive days were offered.


    “I believe the results could be even better if the use was weekly, in the same amount, while maintaining the same unquestionable level of safety,” Cadegiani explained.


    Other possible uses of ivermectin

    In addition to having identified no relevant side effects from the use of ivermectin citywide, the scientists wrote about promising data found: “Prophylactic use of ivermectin can be particularly impactful in older subjects. In addition, ivermectin seemed to reduce the exceeding risk of hypertension, T2D, and other diseases.,” they wrote in the study.


    Dr Flavio Cadegiani, one of the authors, is excited about the possibility of other uses of the drug besides COVID-19. “Preliminary data surprised us. It helped for liver, kidney and inflammatory issues. In other words, ivermectin may help reduce fat in the liver, kidney problems, prevent inflammatory disease, and other potential metabolic benefits. It may work to control cholesterol and diabetes,” he says. “It would be a crime not to study it for those diseases,” he exclaimed.


    Press attacked the action, but there was good reception among the citizens

    The prophylactic action of ivermectin against COVID was proposed by Dr Volnei Morastoni, a medical doctor and mayor of the city of Itajaí. Soon after, he came under attack.


    Among the various aggressions at the time, Dr Volnei was called a “witch doctor” by a local newspaper, the NCS total. In the newspaper O Estado de S. Paulo, one of the most important in the country, biologist Natália Pasternak wrote an article with the following title: “Analysis: the case of Itajaí shows how the fight against the pandemic is marked by science denialism”.


    “The mayor of Itajaí seems to build public health policies based on social network fads and conspiracy theories,” she stated in the article. In her twitter, she classified the action concluded now as effective as “Itajaí madness.”


    However, even at that time, the population was already suspicious of the excessive aggressiveness of the press. The positive result was felt by the population during the action, and they gave their answer in the ballot box. In October 2020, Marastoni was re-elected mayor of the city for another four-year term.


    So far, four days after the international review confirming that lives were saved, there has been no apology to the mayor for the offenses. “The denialism came exactly at the person who colored himself as a defender of science. This is a great example of the catastrophe that occurs when science and political passions mix,” says Cadegiani.


    “How many lives would be here today if it weren’t for the attacks devoid of logic and valid arguments?” he questions. “Vanity will never allow people to turn back. It would be to confess that they killed in the name of a false science.”


    “It is important to make it clear that I did not believe in the effectiveness of ivermectin as a preventative. That doesn’t mean to say that I was against using it, because, after all, any scientist with the least humanity, knowing that there were no theurapeutic alternatives and the drug is safer than any medicine we use for headache, I would never smear or contraindicate it in a pandemic of intubated people,” Cadegiani said. “I was wrong in my bet of ineffectiveness and I assume it. That’s science.”


    Journalists and science communicators got everything wrong, even the speculation that ivermectin would relax other measures

    At the time, journalists and science communicators bet that the use of the drug would lead to the loosening of other measures to contain the pandemic. “The narrative that using preventive and early treatment therapies will have people relax their caution of remaining socially and physically distanced to allow more COVID-19-related infections is not supported here,” the scientists concluded in the study.


    “These study data demonstrate that the use of preventive ivermectin significantly lowers the infection rate and that benefits outweigh the speculated increased risk of changes in social behaviors. Hence, we can speculate that the prophylactic use of ivermectin could play an important role in the reduction of the pandemic burden.,” they added.


    Other studies on the same data from Itajaí will be coming out soon

    This study aimed to evaluate the impact of the whole preventive program in the city during five months. However, many residents who started with ivermectin, discontinued after some time of use and did not complete the five months.


    Now, in a phase two analysis of the data collected by the SUS, efficacy calculations are being done only on those residents who kept using the drug for the full five months. “At first, looking at the data, those who used more than 75% of the doses had zero deaths. That’s surprising. Too bad it was a minority. We are calculating the data to hand over to reviewers,” Cadegiani said.


    “In the third month, of the more than 100,000 who volunteered to take ivermectin, only a little more than 8,000 continued, and even then we had this 68% reduction in deaths. Even the most optimistic were shocked.”


    Daughter of a fish, a little fish is (a Brazilian saying, when sons follow their fathers)


    Dr Lucy Kerr, during the World Council for Health

    The father of Lucy Kerr, the main scientist of the Itajaí study, was Warwick Stevam Kerr, a Brazilian scientist who died in 2018, at age 96, in the city of Ribeirão Preto, where he developed most of his brilliant career.


    Warnick, with a worldwide career, besides several Brazilian universities, lectured in North American universities (Louisiana, California, Wisconsin and Columbia University in New York.). In Brazil he held important positions, such as Scientific Director of FAPESP. He was also president of the prestigious Brazilian Society for the Advancement of Science.


    With relevant scientific productions, he was a member of the “National Academy of Sciences”, in the USA, besides being admitted by President Itamar Franco in the National Order of Scientific Merit in the “Grã-Cruz” class in 1994.


    Lucy confesses to be inspired by her father: “I used to accompany him whenever I could. He didn’t bother to help”, she says.


    There are 15 other studies on ivermectin prophylaxis. All are unanimously positive.

    The Itajaí study is the largest in the world with ivermectin. Besides it, there are 15 other studies on prophylaxis, all finding positive effects of the drug against COVID-19. However, because it was with a large number of patients and uses the statistical technique PSM – Propensity Score Matching, due to the data having great precision, there is a greater weight in this study as scientific evidence. That is, Itajai only confirmed other studies.



    Check out the complete list here.

    Final note: Nostradamus against anxious fact-checkers

    Hello, fact-checker. You are now going after some expert to refute the study, right? I know. Your goal is to say that the study proves nothing. There is one thing left for your expert to say: that the study is not randomized and double blind. He is in the mood to shout: “observational studies do not prove effectiveness”.


    If he says that, throw in his lap the Anglemeyer study, published in Cochrane in 2014, and watch him have a sudden malady. This study says that there are no significant differences between observational studies with “gold standard” RCT study, especially when the difference is greater than 8% efficacy, as is the case. In other words. It says that observational studies do prove efficacy.


    Was that not enough? Show Kjell Benson’s study, published in 2000 in the New England Journal of Medicine, where the author reached the same conclusions. He will run out of answers. He will have a stroke.


    Don’t even make up an answer, think that you are refuting the study with two or three sentences, without mentioning Anglemeyer and Benson. Are we agreed?


    Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching


    Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching
    Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both coronavirus disease 2019 (COVID-19) infection and…
    www.cureus.com


    The Cureus Blog
    Medical publishing powered by community
    blog.cureus.com


    Covid-19 vaccines and treatments: we must have raw data, now
    Data should be fully and immediately available for public scrutiny In the pages of The BMJ a decade ago, in the middle of a different pandemic, it came to…
    www.bmj.com


    COVID-19 / CORONAVIRUS


    Ivermectin for COVID-19: real-time meta analysis of 63 studies
    Ivermectin for COVID-19. Early treatment - 72% improvement, p < 0.0001. All studies - 68% improvement, p < 0.0001. 1 in 1 trillion probability results of the…
    ivmmeta.com


    https://www.nejm.org/doi/full/10.1056/NEJM200006223422506

  • Perfect Storm: Vaccine Booster ‘Fatigue’ + Antiviral & mAb Shortages = Push to Introduce State Laws Ensuring Ivermectin Access


    Perfect Storm: Vaccine Booster ‘Fatigue’ + Antiviral & mAb Shortages = Push to Introduce State Laws Ensuring Ivermectin Access
    While TrialSite reported that a Brazilian rural state recently passed a law allowing the use of ivermectin and hydroxychloroquine for COVID-19, now in the
    trialsitenews.com


    While TrialSite reported that a Brazilian rural state recently passed a law allowing the use of ivermectin and hydroxychloroquine for COVID-19, now in the United States, Republican lawmakers from New Hampshire, Kansas, and Indiana push to ensure access to such repurposed drugs in those states, despite a stance by the U.S. Food and Drug Administration (FDA) that such drugs should only be used for COVID-19 in clinical trials. In Concord, New Hampshire, some politicians seek to make it easier for patients to access ivermectin as an early-onset treatment for COVID-19. In the ‘Live Free or Die’ state, House Bill 1022 would enable pharmacists to dispense ivermectin via what’s known as a standing order, reports local media WMUR 9, despite the FDA’s declaration on the drug for off-label use against COVID-19. In Kansas, a growing Republican-led movement calls for a similar bill for early treatment to include ivermectin and hydroxychloroquine, while similar calls are heard in Indiana. Will 2022 be the year of the push for repurposed therapies at the state level? Prominent U.S. government-backed clinical trials that include ivermectin may help or hinder the momentum for state-level initiatives. Meanwhile, with record COVID-19 infection counts, health authorities become more intent on educating people about the benefits of vaccination versus the risks of COVID-19. A lack of early treatments combined with the concern that monoclonal antibodies may not work as well against Omicron leaves the sick fewer choices, as it appears only Sotrovimab works well against the latest variant of concern, according to some critical care doctors.


    What to do?

    With an explosion of Omicron COVID-19 cases across America, concerns grow that vaccination does not stop viral transmission, as observed with mounting breakthrough infections. TrialSite covered the recent study from Denmark’s Statens Serum Institut which reported in an uploaded preprint study that the second doses of Pfizer and Moderna mRNA-based vaccines may actually increase the likelihood of SARS-CoV-2 infection after 90 to 150 days.


    It would be misleading to declare that the vaccines are not effective against Omicron. Rather, the investigators from Denmark found them to be effective, but the durability of the vaccines raised concerns. The study authors declared, “In light of the exponential rise in Omicron cases, the findings highlight the need for a massive rollout of vaccinations and booster vaccinations.” The latter was emphasized with the Pfizer vaccine, due to waning effectiveness but an identified rebound in positive efficacy with a booster.


    Regardless, “booster fatigue” becomes a growing topic, as a confluence of forces increasingly indicate countries such as the USA, the UK, and perhaps soon Israel’s health authorities will signify a transition to an endemic stage of COVID-19.


    Authorized Treatments in Short Supply

    While both Pfizer and Merck have antiviral-like medications now coming to market there are still limited supplies amidst the historic rises in new infections due to the highly transmissible nature of Omicron.


    Concerns with Merck’s Molnupiravir are mounting in some parts of the world—so much so that in the world’s second most populated nation, India, the apex research organization ICRM has cautioned against the use of the drug.


    The antivirals, key for many as a tool to end the pandemic, are hard to come by in many locations. With Omicron raging, the timing of the shortages couldn’t be worse.


    In the meantime, although monoclonal antibodies have helped infected Americans fight off COVID-19, a crisis emerged with this class of treatment as well. A confluence of factors, including product shortages in part due to federal meddling of the supply chain combined with the fact that only one of the mAb products appears to work well with the new mutant version of SARS-CoV-2 (GSK and Vir’s Sotrovimab), makes access to these products exceedingly elusive.


    Meanwhile, with vaccinated persons becoming infected all over America due to the highly transmissible mutant, concern and fear associated with breakthrough hospitalizations become a daily fear. Yes, it appears that the vaccines still protect people from more severe Omicron-based disease, but again, the effectiveness wanes and booster fatigue become a growing reality. What about other treatments?


    Moves to Ivermectin?

    Despite the incredible controversy surrounding ivermectin, TrialSite reports that elected officials are proposing bills to ensure access to this FDA-approved repurposed drug. Even though the FDA recommends only in clinical trials, a medical freedom movement thrusts forward with what is supposed to culminate in a large march in the nation’s capital Sunday, January 23. TrialSite follows proposed legislation involving ivermectin, and the even more controversial hydroxychloroquine.


    New Hampshire’s Move

    The medical freedom movement takes on steam in anticipation of a forthcoming march in Washington, DC (January 23), as several groups testified against the proposed New Hampshire Bill while others “say there should be more research.”


    Recently tracked on local media, New Hampshire Republicans seek to guarantee access to the repurposed drug. Recently showcased on WMUR 9, a Hearst Media-owned station, Dr. Nick Perencevich, a retired surgeon was filmed on television declaring, “I would like to think that the standard of care in New Hampshire is that a patient can certainly have ivermectin prescribed off-label if that patient, ideally, gets put into some clinical trial, whether it’s a drug company, or whether it’s an academic institution like Dartmouth.”


    Now before the House Health and Human Services Committee, the WMUR 9 report shared [the Bill] is expected to make it to the House floor for a vote in the weeks ahead. The broadcast ended with a segment on ivermectin indicated for horses. TrialSite notes that the media didn’t bother to interview the proponents of the bill nor hear their argument, indicating the possibility of bias.


    Kansas Callings

    Meanwhile, In Kansas, Sen Mark Steffan recently announced forthcoming bills to promote off-label use of approved FDA prescription drugs including hydroxychloroquine and ivermectin for COVID-19 patients.


    The bill was introduced in a special session, however, has not yet been acted upon in a recent Kansas Senate committee resolution, reports the Kansas Reflector, an independent non-profit-based media.


    In the recent report, reporter Noah Taborda referred to the proponents of the forthcoming bill as driven to appease “anti-vaxxers,” and that would “undermine local health officials and promote off-label use of prescription drugs.”


    An anesthesiologist, Sen. Steffen has been critical of the medical establishment’s efforts to block use of off-label early care treatments such as ivermectin and hydroxychloroquine. Taborda writes that “the Hutchinson Republican advocated for more avenues to use these treatments,” even though the FDA is on the record that ivermectin, for example, should only be used for COVID-19 in clinical trials. TrialSite reports a couple of sizable clinical trials including ivermectin have been underway in the United States.


    Meanwhile, COVID-19 continues to rage in Kansas, breaking new daily case counts. The issue of off-label drug use continues to be positioned as an “anti-vaxxer” issue, yet this clearly isn’t the case for all proponents. In the case of Steffen, he is on the record that the risk-benefit analysis associated with the COVID-19 vaccine products favors avoidance for children who rarely end up hospitalized. Yet, according to the Kansas Reflector, while the movement for medical freedom gains momentum in parts of this plains state, there has been an explosion of cases, many of which are either Delta or Omicron-based, with a total of 7,162 deaths in a state with a population of 2.93 million residents.


    Tragically, Tim Carpenter writing for the local media reported child deaths—three children under ten years old and three additional adolescents between the age of 10 and 17. Hence, medical establishment proponents argue the risks of hospitalization and death are too high, justifying universal vaccination.


    Hoosier Hope?

    In the meantime, in the midwestern state of Indiana, Rep. Curt Nisly, R-Goshen, authored a bill that would allow for use of ivermectin to treat COVID-19. Like Kansas, this agricultural state has more access to the animal variety of the drug. Nisly went on the record for the Indy Star in an email declaring, “Why wouldn’t we make this available, especially if we want Hoosiers to stop using horse paste. Hoosiers should be able to care for their health safely and effectively.”


    The proposed House Bill 1372 allows for a physician or advanced practice registered nurse to write a standing order for ivermectin ensuring the pharmacist would dispense the drug while stipulating that the pharmacist couldn’t try to dissuade the patent from accessing the drug.


    Conclusion

    The surge in Omicron cases, in a way, is the perfect bad storm, as a combination of vaccine booster fatigue and antiviral and monoclonal antibody shortages along with the rising medical freedom movement lead to state legislatures pushing for new bills to make economical repurposed drugs like ivermectin available on demand.


    An imminent march on Washington this Sunday, January 23 possibly intensifies the medical freedom movement which very well may influence midterm elections. TrialSite predicts within a couple of weeks more proposed off-label bills will contribute to a growing clash of interests. Luckily, thus far, omicron infections appear milder but exponential numbers of cases, hospitalization rates, and deaths move higher, regardless