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  • Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study

    DEFINE_ME


    Summary

    Background

    There are few data on the incidence of thrombosis among COVID-19 cases, with most research concentrated on hospitalised patients. We aimed to estimate the incidence of venous thromboembolism, arterial thromboembolism, and death among COVID-19 cases and to assess the impact of these events on the risks of hospitalisation and death.

    Methods

    We conducted a distributed network cohort study using primary care records from the Netherlands, Italy, Spain, and the UK, and outpatient specialist records from Germany. The Spanish database was linked to hospital admissions. Participants were followed up from the date of a diagnosis of COVID-19 or positive RT-PCR test for SARS-CoV-2 (index date) for 90 days. The primary study outcomes were venous thromboembolic events, arterial thromboembolic events, and death, all over the 90 days from the index date. We estimated cumulative incidences for the study outcomes. Multistate models were used to calculate adjusted hazard ratios (HRs) for the association between venous thromboembolism or arterial thromboembolism occurrence and risks of hospitalisation or COVID-19 fatality.

    Findings

    Overall, 909 473 COVID-19 cases and 32 329 patients hospitalised with COVID-19 on or after Sept 1, 2020, were studied. The latest index dates across the databases ranged from Jan 30, 2021, to July 31, 2021. Cumulative 90-day incidence of venous thromboembolism ranged from 0·2% to 0·8% among COVID-19 cases, and up to 4·5% for those hospitalised. For arterial thromboembolism, estimates ranged from 0·1% to 0·8% among COVID-19 cases, increasing to 3·1% among those hospitalised. Case fatality ranged from 1·1% to 2·0% among patients with COVID-19, rising to 14·6% for hospitalised patients. The occurrence of venous thromboembolism in patients with COVID-19 was associated with an increased risk of death (adjusted HRs 4·42 [3·07–6·36] for those not hospitalised and 1·63 [1·39–1·90] for those hospitalised), as was the occurrence of arterial thromboembolism (3·16 [2·65–3·75] and 1·93 [1·57–2·37]).

    Interpretation

    Risks of venous thromboembolism and arterial thromboembolism were up to 1% among COVID-19 cases, and increased with age, among males, and in those who were hospitalised. Their occurrence was associated with excess mortality, underlying the importance of developing effective treatment strategies that reduce their frequency.


    Low Vitamin D Levels Are Associated With the Development of Deep Venous Thromboembolic Events in Patients With Ischemic Stroke

    https://journals.sagepub.com/doi/full/10.1177/1076029618786574


    Vitamin D and Its Relationship with the Pathways Related to Thrombosis and Various Diseases

    Chapter: Vitamin D and Its Relationship with the Pathways Related to Thrombosis and Various Diseases
    Vitamin D known for its vital role in diverse biological function such as calcium and phosphorus homeostasis, also exert an anticoagulant effect emphasizing…
    www.intechopen.com

  • Overall, 909 473 COVID-19 cases and 32 329 patients hospitalised with COVID-19 on or after Sept 1, 2020, were studied. The latest index dates across the databases ranged from Jan 30, 2021, to July 31, 2021. Cumulative 90-day incidence of venous thromboembolism ranged from 0·2% to 0·8% among COVID-19 cases, and up to 4·5% for those hospitalised.

    How many bachelor rubbish studies will be publish to confirm that some old patients get a venous thrombosis?


    If you are a smoker and do undergo surgery, then your chance to get a thrombosis in hospital is 30% !!!!!!!!!!!


    So a tiny percentage of smokers going to hospital "with CoV-19" is needed to explain the rates...

  • How many bachelor rubbish studies will be publish to confirm that some old patients get a venous thrombosis?


    If you are a smoker and do undergo surgery, then your chance to get a thrombosis in hospital is 30% !!!!!!!!!!!


    So a tiny percentage of smokers going to hospital "with CoV-19" is needed to explain the rates...

    You miss the point. All adverse effects of Covid is caused by a vitamin d Deficiency, every single symptom, yet the NIH and CDC continue to say not enough evidence to promote vitamin D. Vitamin d deficency also affects the efficacy of vaccines!

  • I wonder what happened to those easily tweaked mRNA vaccines. Oh yes, they lied!!!!

    No evidence for that! No government has asked for (and volunteered to pay for) for the tweaked versions yet - because they think the original works well enough. It costs.


    Personally I don't agree - but governments look at the big picture not a few people dying of covid or flu. - so current vaccines are good enough. One reason for sticking with current is that the whole sfaety thing needs to be done over again then. Maybe it can be a bit quicker.


    I'm expecting we will have wide release of better vaccines within 12 months. Hope i'm right!

  • He is 100% right. For all vaxx - gene therapy patients - CoV-19 will become a never ending story. with an unknown terminal death...

    Thankfully, a smaller and smaller portion of society will get jabbed, so almost surely funding will dry up. This is already occurring - vaccine demand is dwindling. That fact is very conspicuous by its absence in the article. It would hinder the Messaging I suppose. Here is Ontario data on the number of people getting vaccinated over time :






    If memory serves, Canada has secured enough vaccine to jab every eligible Canadian nine times, which I believe is more than any other other country. I suppose that is a big reason behind the perpetual government funded media vaccine push in Canada. Wouldn't want all that money, all those vials filled with the elixir of life going to waste!

  • It was bound to happen eventually - mainstream media doing a significant report on vaccine injury, although this article makes a point to remind us over and over that the injuries are oh-so-rare. Newsweek also couldn't help itself but to try to diss the very elected government official who has done the most to bring vaccine injury to light, Republican Senator Ron Johnson.


    Doctors shrug off patients with rare vaccine disorders, delaying treatment
    COVID-19 vaccines are safe for the vast majority of people. That's small consolation for the few who fall between the cracks.
    www.newsweek.com

  • Thankfully, a smaller and smaller portion of society will get jabbed, so almost surely funding will dry up. This is already occurring - vaccine demand is dwindling. That fact is very conspicuous by its absence in the article. It would hinder the Messaging I suppose. Here is Ontario data on the number of people getting vaccinated over time

    That is surely because everyone (apart from a few cranks) is now vaccinated?


    The original COVID vaccines do not have regulatory agreement for an indefinite number of jabs - and each extra one will get more difficult given that COVID is so far now from what they were designed for, and data on reactogenicity shows it increasing with each jab.


    Still we will get better vaccines in a year or two - which I'd hope you will welcome.

  • A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19


    A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19
    The gut microbiota contributes to maintaining human health and regulating immune responses. Severe COVID-19 illness is associated with a dysregulated…
    www.frontiersin.org


    The gut microbiota contributes to maintaining human health and regulating immune responses. Severe COVID-19 illness is associated with a dysregulated pro-inflammatory immune response. The effect of SARS-CoV-2 on altering the gut microbiome and the relevance of the gut microbiome on COVID-19 severity needs to be clarified. In this prospective study, we analyzed the gut microbiome of 212 patients of a tertiary care hospital (117 patients infected with SARS-CoV-2 and 95 SARS-CoV-2 negative patients) using 16S rRNA gene sequencing of the V3-V4 region. Inflammatory markers and immune cells were quantified from blood. The gut microbiome in SARS-CoV-2 infected patients was characterized by a lower bacterial richness and distinct differences in the gut microbiome composition, including an enrichment of the phyla Proteobacteria and Bacteroidetes and a decrease of Actinobacteria compared to SARS-CoV-2 negative patients. The relative abundance of several genera including Bifidobacterium, Streptococcus and Collinsella was lower in SARS-CoV-2 positive patients while the abundance of Bacteroides and Enterobacteriaceae was increased. Higher pro-inflammatory blood markers and a lower CD8+ T cell number characterized patients with severe COVID-19 illness. The gut microbiome of patients with severe/critical COVID-19 exhibited a lower abundance of butyrate-producing genera Faecalibacterium and Roseburia and a reduction in the connectivity of a distinct network of anti-inflammatory genera that was observed in patients with mild COVID-19 illness and in SARS-CoV-2 negative patients. Dysbiosis of the gut microbiome associated with a pro-inflammatory signature may contribute to the hyperinflammatory immune response characterizing severe COVID-19 illness.

  • That is surely because everyone (apart from a few cranks) is now vaccinated?

    One would think so, but that begs the question of why the public health officials and media in Canada are continually pushing for more vaccinations! They know that those remaining nutcase crazy crank nimcompoops who haven't yet received even one injection aren't going to start now. What about those sluggards who have received only two doses? They need to be topped up for the sake of their health and society's well being. Those who think they're something special getting three shots should see the ambition and prowess of those who have gotten their fourth and get themselves to a nearby clinic!

  • Bob Greenyer Live.

    Game Over.


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  • Total Lunar Eclipse in 1:32:00

    and counting.


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  • An important question.


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  • Magnetocatalytic Adiabatic Spin Torque Orbital Transformations for Novel Chemical and ... - arXiv

    by RB Little · 2006


    In this manuscript the theory and phenomena associated with the Little Effect are introduced as the spin induced orbital dynamics of confined fermions under strong magnetic and thermal environments. This Little Effect is considered in details for the electron transfer reactions associated with redox processes of Cu-Ag alloy within deionized water and for the orbital dynamics during the iron catalyzed covalent bond rearrangements associated with amorphous carbon conversion to diamond. Furthermore, prolong extreme conditions of 74,000 amps, 403 V, strong Lorentz compression, and thermal stresses upon this Cu-Ag- H2O system on the basis of the Little Effect of high spin, thermally induced orbital dynamics are predicted and demonstrated to cause the magnetically organized reverse beta, electron capture, proton capture and neutron capture processes for various infrequent pycnonuclear transmutations within the Cu-Ag coil. The general experimental verification and the broad implications of this Little Effect on chemistry are demonstrated within these two ideal systems: an ionic case and a molecular case. The Little Effect is contrasted with the Hedvall Effect as a dynamical phenomenon causing the kinematics of the Hedvall Effect. The compatibility of the Little Effect with the Woodward-Hoffmann Rule is demonstrated. The Little Effect provides greater understanding of order in systems far from equilibrium. The implications of the Little Effect for other interesting phenomena such as ferromagnetism, unconventional magnetism, superparamagnetism, superconductivity, and pycnonuclear effects



  • One would think so, but that begs the question of why the public health officials and media in Canada are continually pushing for more vaccinations! They know that those remaining nutcase crazy crank nimcompoops who haven't yet received even one injection aren't going to start now.

    Because, unlike governments (who are not worried as long as numbers are low enough) doctors don't like to see people die.


    Fact: vaccination reduces death from omicron (a lot) for first-time COVID infections.


    Fact: there are still a significant number of people who have never had COVID


    Fact: some proportion of those will be unvaccinated. And they are not all ideological mark U's. Some of them have been half-convinced by antivaxxer social media and because of that are slow to come forward. People are people.


    I agree you could try to caveat things, identify specific demographic groups mots at risk, target messages more at people who have not had COVID. But public health message that are nuanced and complex don't work.


    THH

  • No surprise, I have provided studies, you disagree with conclusions.

    No, I disagree with your interpretation of the conclusions.


    There is plenty evidence that Vit D correlates with many good things. Then, from RCTs, when specific things are tested to determine whether the correlation is related to taking or not taking Vit D supplements, it vanished. Which makes it clear (in these cases) this is either reverse correlation (less well people have lower Vit D) or indirect correlation (other thing e.g. being young that boost health also boost Vit D levels).


    I'm not ruling out some good effects from Vit D. It is quite reasonable there should be, and mots people are deficient so good reason to take supplements. It is juts that 100% of the claims - when tested for real, have so far proven wrong. Not sure therefore it is good to assume the ones not yet tested are correct.


    THH

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