Dr. Mizuno's protocol, nonetheless, seems ironclad,
I assure you, it is not ironclad. That much is already clear. The preliminary attempts at replications by people skilled in the art have failed. So obviously it is not ironclad. Those people are asking questions, making comments and sending us SEM photos and other analyses. Progress is being made. I will eventually update the Supplement or the paper to reflect improvements, clarifications and additional data. Whether it will pan out or not, and whether the experiment can be replicated is unknowable. It is the nature of ground breaking research that no person can know that. That's why science is based on experiments and not knowledge, or the human imagination. As spelled out by Francis Bacon in Novum Organum, 1620. No one ever said it better!
"For the end of our science is not to discover arguments, but arts, nor what is agreeable to certain principles, but the principles themselves, nor probable reasons, but designations and indications of effects.
[T]he empire of man over things is founded on the arts and sciences alone, for nature is only to be commanded by obeying her."