Covid-19 News

  • German pharma propaganda of today after a record of 50'000 cases..


    All patients are unvaxx young...Only 10% double vaxx... We know the figures from UK...But watching TV news is a waste of time today. The mafia has taken over all instances.


    India still does great : https://www.mygov.in/covid-19 no 4,5,6th wave...


    Except the two vaccine terror mafia states of Kerala/Mizoram that still account for >50% of all India cases with < 1/40 of India population.


    People have to learn that politics is not done for them. Politics always is to make the most out of your tax money for friends/Buddies. Your health has no value except the friends can sell drugs. Best case: Not working drugs like the RNA gene therapy.


    If the reality no longer matched the sales pitch. Then Potemkin is called.


    Only CoV-19 treatment works. RNA gene therapy just buys you a small time frame you can escape the virus. But you will pay for it. You damage your immune system and boosters will make things even worse.


    What does the German mafia propaganda say: Only vaccination can stop it.

    I start to hope that after 4 boosters all the idiots have killed themselves.

  • Effect of SARS-CoV-2 proteins on vascular permeability
    A specific SARS-CoV-2 proteins that affect the vascular permeability and impairs the functionality of other significant organs has been identified.
    elifesciences.org


    Here some good teaching about the basic mechanisms of the different virus proteins. Also in relation to heart problems.


    The SARS-CoV-2 genome encodes 29 proteins, whose contribution to the disease manifestations, and especially endothelial complications, is unknown. We cloned and expressed 26 of these proteins in human cells and characterized the endothelial response to overexpression of each, individually. Whereas most proteins induced significant changes in endothelial permeability, nsp2, nsp5_c145a (catalytic dead mutant of nsp5), and nsp7 also reduced CD31, and increased von Willebrand factor expression and IL-6, suggesting endothelial dysfunction. Using propagation-based analysis of a protein–protein interaction (PPI) network, we predicted the endothelial proteins affected by the viral proteins that potentially mediate these effects. We further applied our PPI model to identify the role of each SARS-CoV-2 protein in other tissues affected by coronavirus disease (COVID-19). While validating the PPI network model, we found that the tight junction (TJ) proteins cadherin-5, ZO-1, and β-catenin are affected by nsp2, nsp5_c145a, and nsp7 consistent with the model prediction.

  • Yahooist Teil der Yahoo Markenfamilie


    GlobeNewswire

    FLCCC Tells Children’s Health Defense: World’s Leading ICU Doctor Files Lawsuit Against Hospital System After Being Barred from Administering Proven COVID-19 Treatments

    Children's Health Defense

    November 10, 2021, 9:46 am

    A Virginia physician has been prohibited from using safe and time-honored medications inhospital while death rates from COVID-19 continue to mount


    Washington, DC, Nov. 10, 2021 (GLOBE NEWSWIRE) -- Paul Marik, MD, one of the most highly published critical care physicians in the world and the Director of the ICU at Sentara Norfolk General Hospital, was recently told by Sentara Healthcare that he could no longer administer a range of highly effective COVID-19 treatments to critically ill patients—the same treatments he has successfully used to reduce COVID deaths in the ICU by as much as 50%. The result of the prohibition has been a sharp increase in patient mortality. Because Dr. Marik can no longer stand by while patients needlessly die without proper treatment, he has filed a lawsuit to allow him and his colleagues to administer the combination of FDA-approved drugs and other therapies that has saved thousands of critically ill COVID-19 patients in the last 18 months.


    The Complaint filed today in the Circuit Court for the City of Norfolk, Virginia states that Sentara Healthcare is “preventing terminally ill COVID patients from exercising their right to choose and to receive safe, potentially life-saving treatment determined to be appropriate for them by their attending physician.” Under Virginia law, every patient has the right to receive treatment deemed appropriate for them by their attending physician, and terminally ill patients have the right to try investigational medicines that their treating physician recommends. Through its arbitrary prohibition of the COVID-19 treatment protocol developed by Dr. Marik and his colleagues, Sentara is violating the law and unjustly depriving critically ill patients of lifesaving treatment

  • COVID-19: A Mucosal Disease


    COVID-19: A Mucosal Disease
    Note that views expressed in this opinion article are the writer’s personal views and not necessarily those of TrialSite. Emeritus Professor Robert Clancy
    trialsitenews.com


    Note that views expressed in this opinion article are the writer’s personal views and not necessarily those of TrialSite.


    Emeritus Professor Robert Clancy AM


    The Influenza Model: Pandemic Experience.

    Covid-19 is an RNA viral infection of airways’ mucosa with mechanisms and clinical characteristics similar to those of influenza and both can occur in pandemics. Currently it is Covid-19 that has our attention, with 250 million documented infections and in excess of 5 million deaths. In 1918-1919 Spanish influenza infected 500 million people (one third of the world), with 10% mortality (compared to Covid with 3% infected and 2% mortality). Spanish influenza swept the world in three waves over two years. The middle and most lethal wave was driven by a mutant, involving haemagglutinin and RNA polymerase, identified from naturally stored virus (1).


    How is this relevant to Covid-19?


    After 1919, H1N1 became the “driver” of influenza during the following century. Within 3 years H1N1 had mutated into “seasonal” flu with a mortality less than 0.1%. The question is “will this happen with SARS-CoV-2?” We do not know but antigen drift and herd immunity are probable connected variables likely to determine any switch from pandemic to endemic disease. Differences in population exposure and the impact of vaccination on mutant selection remain unknowns (2). Currently 51% of the world’s population have had at least one “jab”, but in low-income countries, this figure is only 4%. Mortality appears higher in those countries with high vaccination rates (3). Vaccine-induced immunity is less durable and more restricted than natural immunity, possibly leading to a greater chance of mutant selection (4). Epidemiologists in Sweden point to the near absence of a third wave (less than 1000 cases and 10 deaths per day for 5 months) and attribute this shift towards “seasonal flu status”, to less lockdowns and less restrictions, leading to higher natural immunity (5). Also, vaccination in Sweden was delayed, with less than one third vaccinated by mid 2021.


    In summary, populations least “protected” by lockdowns and vaccination, may most closely resemble the 1918-1919 influenza pandemic transition to “seasonal” infection with a low mortality.


    The Influenza Model: Infection of a mucosal compartment.

    “Textbook assurances that T-cell and B-cell memory priming give lasting protection—–were looking thin”: this conclusion from a recent review (6) on booster shots should not have surprised.It is exactly what is to be expected of a systemic vaccine, given for a viral infection of the respiratory tract and is amply illustrated by influenza vaccination. Attenuation of systemic and mucosal immunity follows the “rules” of mucosal immunology. Four eminent mucosal immunologists identified mucosal immunology as “Neglected but Critical” to the understanding of Covid-19 infection (7). They traced the sIgA2 antibody response from inductive sites within the nasopharynx-associated lymphoid tissue (NALT) of Waldeyer’s Ring, to the homing of B-lymphocytes to mucosal sites (IgA) and systemic lymphoid tissue (IgG) determined by receptors, specific for respective target tissues. Important additions to this “classic” review include:


    Similar circuitry for T cells – Th17 cells from aggregated lymphoid tissue recruit neutrophils, drive protective cytokines and control innate immunity (8).

    Complicated cell interactions at mucosal surfaces including antigen & functionally specific dendritic cell populations, activate both CD4+ CD25+ and CD8+ T-reg cells which powerfully supress both mucosal and systemic immune responses (9).

    A “common mucosal system” exists based on cell-homing characteristics: NARES is important within the nasopharynx, but Peyer’s patches in the gut populate the bronchus mucosa with T- and B-cells (10).

    Viral interaction with the microbiome influences infection outcome (11).

    Recent data from study of nasal secretions in Covid-19 (11) has confirmed:


    the compartmental distribution of antibody and cytokine responses.

    linkage of impaired innate immunity with clinical Covid.

    the importance of the microbiome.

    Differences between Covid-19 and seasonal influenza such as a twenty-fold greater mortality from Covid-19, are due, in part, to SARS-CoV-2 receptors extending to within the alveoli (favouring alveolitis) (12) and the toxic effect of the Spike protein on micro-vasculature (13).


    Understanding Covid-19 Vaccine limitations.

    Covid-19 and influenza vaccines reduce the incidence of severe disease for 6-9 months, with little effect on asymptomatic infection (due to control of alveolitis by IgG antibody but minimal impact on the mucosal compartment (14,15). Corona and influenza viruses in the community cause recurrent mucosal infections and downregulation of systemic immunity by T-reg cells (16). Unregulated synthesis of spike protein following genetic vaccines means unpredictable stimulus-response dynamics, including potential for high-dose tolerance in some subjects (17). Attenuation of antibody responses (18), and the blunted anamnestic antibody responses following “second jabs” (19) reflect down regulation. Injected vaccines have little impact on mucosal immunity, mucosal infection and viral transmission. (20).

    Increased Covid infections in UK and Sweden in older vaccinated subjects (21), may reflect enhancing antibody outlasting protective antibody as documented with infections such as Dengue (22).

    “Booster Shots”. Spacing may be critical as frequent vaccination with the same antigen may cause net immune suppression (23). Given that there is uncontrolled antigen dose with genetic vaccines, annual vaccination with antigen-based vaccines, as used in influenza, is a more logical way forward (and avoids unacceptable adverse event profiles, seen in current reports). Combining vaccines with drugs to prevent or treat early disease, offers an attractive option.

    Immune-mediated cell toxicity. The high incidence of reports ofpost-vaccination adverse events, including death (24), may involve antibody or T-cell induced toxicity directed against surface expressed spike protein (25). “Boosters” loom as a particular risk. Ongoing vaccine strategy must consider such issues.

    Mucosal Immune senescence. Generation of adaptive immune mechanisms and linked threshold innate immunity required to control virus-initiated mucosal damage, is less efficient in those aged over 65, especially in men (26). Delayed immunity in those over 65, causes an increase in viral load, more severe disease and delayed antibody response following vaccination (27).

    Conclusion. Covid-19 is a mucosal infection influenced by the rules of mucosal immunology. Influenza, its vaccine and natural history, is a useful model enabling an understanding and prediction of Covid-19 behaviour. The host-virus relationship within the airways drives the course of Covid: locally it restricts virus extension into the gas exchange apparatus. The balance between T- and B- cell immunity and T-reg cells, generated within the mucosa and their interaction with viral antigen within alveoli, influences disease outcome, vaccine efficacy and adverse events. While genetic vaccines have played a role in the pandemic, they are “experimental”, with unanswered questions including a potential impact on the transition to “seasonal” infections. Review within the frame of mucosal immunology is an opportunity to define a vaccine strategy best suited to control of Covid-19. The strategic rejection of safe, inexpensive and effective re-purposed drugs to help confine infection to within the mucosal compartment, to protect a vaccine of limited value and pharmaceutical company interests, will be noted in history as a monumental error of the pandemic (28).

  • Update



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  • I am back from vacation. I see that the Lunatic Death Cult Fanatics have just about taken over this discussion. I will not bother reading it any more, but I have a couple more interesting observations that occured to me while I was talking to an old friend about Russia.


    The Fanatics have uploaded a number of social media memes regarding COVID. All of these memes are lies. Not just lies, but outrageous lies that no sensible person would believe. For example:

    1. Anyone who bothers to fact check will know that White House staff is not exempt from vaccination requirements.
    2. Anyone who knows the difference between DNA and RNA will know that the biology claims are preposterous.
    3. The notion that every public health agency in the world is conspiring to lie about vaccinations is an extreme conspiracy theory.

    Many of these memes were planted in US social media by Russian agents. This has been widely reported. It is readily apparent to people who are familiar with Russian agitprop. These memes are either Russian agitprop or a good imitation of it. They bear the hallmarks of Russian propaganda.


    I find this interesting because I have some knowledge of the Soviet era, and Soviet propaganda. I have read books about it. I also heard many accounts of life in Russia because my parents were stationed by the U.S. in Russia during WWII, and I knew many people growing up who had been there, such as George Kennan’s secretary, and several Russian people who fled the regime.


    Anyway, here are some of the hallmarks of Russian propaganda that may surprise you. They may seem counterintuitive. They are readily apparent in the Facebook memes.


    All of the claims are blatant nonsense. Any person with education, common sense, or knowledge of the subject will instantly see that these claims are nonsense. You will also see crude “mistakes” in English which “give away” the fact that these memes were placed in the U.S. by Russian agents. This is deliberate. The Russians want you to know that they are putting this information into our social media. They have three reasons for doing this:


    1. They want to exclude anyone with common sense. They want to attract fanatics, delusional people, and people who already believe the lies they are selling. They call such people “useful idiots.”


    The technique of putting out information that is obviously wrong is crafted to attract only stupid and gullible people, and to exclude sensible people. Microsoft published a paper about this technique titled “Why Do Nigerian Scammers Say They Are from Nigeria?” The idea is to attract “marks” (fools who fall for the scam) while eliminating false positives (people who know better). See:


    https://www.microsoft.com/en-us/research/wp-content/uploads/2016/02/WhyFromNigeria.pdf


    If the people posting these memes are not actually Russians, they want you to think they are Russians. For the same reason some guy in Peoria who wants to scam you will pretend he is in Nigeria. He only wants to attract marks who are so stupid and so ill-informed they have not heard of Nigerian Scammers.


    2. The people posting the agitprop want to stop sensible, sane people from looking at the propaganda in the first place. An ordinary educated person who glances at these memes will think, “No one would believe that. We do not need to take that seriously.” No doctor or biologist would argue with the ridiculous claims about DNA, because they violate high school level biology. It would be like arguing with creationists about evolution. Also, it is such a torrent of obvious bullshit there is no way you can counter all of it.


    3. The propaganda reflects the nature of Stalinism in a way that seems incomprehensible to people who did not live through it. Here is an example of what happened. A person would be dragged into a kangaroo court and charged with a crime. The prosecutor would accuse the person of “destroying the stone bridge on the Neva River.” That bridge would be readily visible outside the courtroom window, and it would be standing intact, as it has been for a century. No one had destroyed it. Yet the defendant would be convicted of destroying it and summarily sentenced to be shot or sent to Siberia. The purpose was not to make the judge and the court look ridiculous, but to assert the regime’s right to say anything without regard to visible reality, logic, or common sense. Anyone who objected by saying: “But Your Honor, the bridge is still standing; it is right there!” would also be sent to Siberia. The regime asserted its right to say or do absolutely anything and tell people that two and two is five, or night is day. This was described by Orwell in the book "1984."


    Extreme conformists are happy to pretend they believe that a bridge they see standing was destroyed. They like being ordered to believe nonsense. Anti-vaxxers are extreme conformists who jump to accept and swear allegiance to any nonsense on Facebook or TrialSiteNews. They are ideal Stalinist citizens.



    . . . If the spirit moves me, I may post one more comment about the melancholy resemblance of the antivaxxers and the anti-cold fusion brigades. So similar, in so many ways!

  • I live in Russia ... Jed Rothwell wrote a lot of letters, but did not write anything concrete ... We in Russia do not like when the interlocutor carries a "gag" and writes "blah, blah, blah ..." What should you do? Give a specific quote and indicate the source of information in the form of a link ... So I can check you and make sure that you are telling the truth ... Otherwise, it's all "verbal diarrhea" ... By the way, Russia is full of idiots who are also are engaged in "blah, blah, blah ..." and do not give the source of information, but at the same time they blame the United States for all the sins ... You should apologize to me - you are not writing the truth - and my conclusion is the following - you are doing it maliciously. .. Where is the evidence for your statements? This is obscurantism and you go back to the days of "McCarthyism" ... This is wrong! And this does not help mutual understanding and mutual assistance in the face of the same threat ... Personally, I do not like much of what the authorities in Russia are doing, but when I don’t like something and I criticize the Power of Russia, then I will definitely quote that, what I do not like and give a link - that is, indicate the source ... Thank you for your understanding.

  • Here’s a good example… The Swiss Policy Research website, regularly linked to by the plonker du jour, offers up various “facts” about covid vaccines that begin with the usual un-nuanced nonsense about VAERS numbers, and follows with a library of the guff normally repeated here by the “useful idiots”.


    Oddly enough, the same website also seems to want to discredit Sergei Magnitsky, an accountant who died in a Russian prison, that no-one cares about, except for a group of Kremlin kleptocrats, whose massive embezzlements were exposed by him.

  • The Swiss Policy Research website, regularly linked to by the plonker du jour, offers up various “facts” about covid vaccines that begin with the usual un-nuanced nonsense about VAERS numbers,

    I know that children don't like facts as this leaves no room for cheating. But I can confirm you that the spot (SWPRS) is a free masons honey pot.


    I just repeat the facts we can gain from actual data.

    - Most patients (80% age > 60 = the vulnerable) in hospitals in Pfizer&Astra countries are double vaxx.

    - UK/Sweden data shows that "vaccines" promote CoV-19 infections and only give marginal protection after 6 months.

    - Swiss data shows Moderna is way better.

    - We should no longer discuss about fake institutions like FDA/CDC that are currently run by US big pharma.

    - So VAERS is just a fig leave to hide the black hole of unknown facts.

    - Really concerning will be the long time damage from ASTRA/Pfizer monoclonal gene therapy that induces an immune suppression.


    > 90% of India is free of CoV-19- without vaccination. No new wave since > 5 months. So I hope the Dr. Mengele fans here will stop posting nonsense and will support treatment of all CoV-19 sick. (Except you expect a nice heritage.)

  • An Austrian husband and wife in their mid 50s are talking


    Husband : Dear, I've decided you're right about the Covid vaccine.

    I should get it.


    Wife : Talk about the Sound of Music! Finally, you've come to your senses!


    Husband : I've realized now that the benefits outweigh the potential risks.


    Wife : So you've finally freed yourself of that anti-vax Russian propaganda that's causing ruin in the USA. Good!


    Wife : Hmmm, but don't think just because you're getting vaccinated you're out of the dog house. Repairing the roof and getting the vaccine are only half of it. You still have to paint the living room and re-tile the bathroom before you're done sleeping on the couch.


    Husband : Yes, dear.


    COVID-19: Vienna brothel offers customers 30 minutes with 'lady of their choice' in exchange for coronavirus jab
    Vaccination uptake levels in Austria are among the worst in western Europe. Roughly 64% of Austria's population is fully vaccinated and those who are unjabbed…
    news.sky.com

  • Why HCQ and Ivermectin were removed from India’s Covid-19 treatment protocol

    Ivermectin and HCQ were dropped from the clinical guidance after studies found that these drugs have little to no effect on Covid-related mortality or clinical recovery of the patient.


    Why HCQ and Ivermectin were removed from India’s Covid-19 treatment protocol
    Ivermectin and HCQ were dropped from the clinical guidance after studies found that these drugs have little to no effect on Covid-related mortality or clinical…
    www.indiatoday.in

  • We in Russia do not like when the interlocutor carries a "gag" and writes "blah, blah, blah ..." What should you do? Give a specific quote and indicate the source of information in the form of a link ..

    Here is an example:

    Facebook bans Russian disinformation network that claimed coronavirus vaccines turn people into chimpanzees


    August 11, 2021 at 3:58 a.m. EDT


    Facebook has removed hundreds of accounts it said were part of a disinformation campaign largely run out of Russia that also used social media influencers to peddle fake claims about coronavirus vaccines, including that some shots could turn people into chimpanzees. . . .

    https://www.washingtonpost.com/world/2021/08/11/facebook-russia-disformation-covid-vaccine/


    There are hundreds more like this. Ask Mr. Google. As I said, Russian disinformation techniques work well, but they are not subtle. Everyone knows about them, including you, I expect.


    This disinformation campaign has turned around and bit Putin on the butt. Many people in Russia do not believe the government's claims, as Putin said the other day. Some of the disinformation they cite came back from U.S. social media. (I expect you know that as well.)

  • I know that children don't like facts as this leaves no room for cheating. But I can confirm you that the spot (SWPRS) is a free masons honey pot.


    If you search this thread for “swprs”, it returns 40 hits, with you making up the vast majority of those. (Second place was Toffoli, who apparently was banned for being into stuff that was too weird for for even this thread).


    Here the link to the Swiss anti mafia site: https://swprs.org/on-the-treatment-of-covid-19/


    I found no errors in their fact list. Of course all right wing people including the FRJM mafia hate them as e.g. some of their exponents present the truth for the WTC building 7 blow off by placed explosives.


    If they are rated as a conspiracy site then the presented site information must be precise and dangerous for many folks. So highly recommended!

    Here an overview of science about masks : https://swprs.org/face-masks-evidence/

    But this is science based not fascist mafia order based.


    In fact, looking at the history it would seem that most of your idees fixes over the past 12 months had their genesis in posts from their website.


    Looks like they sucked you in good! Probably by appealing to your paranoid tendencies, and refusal to trust anything other than “truther” type information sources.


    I guess all good things can’t last though, and now even they too have fallen under the spell of this nefarious mafia - scourge of psychiatric wards across the land.

  • Let's pretend that those athletes are collapsing because of a strangely undiagnosed Covid infection - induced myocarditis. I wonder what, specifically, could be causing it? Now, we know for a fact that the vaccine also induces myocarditis. What are the two things the vaccine and SARS COV-2 have in common? Hmmm, could it be the spike protein that is causing the immune system to attack heart muscle?

    Myocarditis is quite common in athletes. You are the one claiming it has increased. Without quatitative evidence, so we do not know how much, or even that it has.


    You have no info about this to decode things, I'm just pointing out:

    • We KNOW that COVID causes myocarditis in athletes. Paper I linked above, or google it.
    • We KNOW that unlike vaccine-induced myocarditis, COVID myocarditis is serious. there are long-term effects (paper I linked above).
    • We KNOW that myocarditis is a common side-effect of COVID (1 ; 100). Paper I linked above.
    • We KNOW that a good proportion of the world's population has by now had COVID. (No link needed).
    • We KNOW that vaccine-induced myocarditis is very rare (approx 2 : 100,000, max males 9 - 29 1:10,000) and usually mild. https://www.nejm.org/doi/full/10.1056/NEJMoa2110737


    If you tell me that some of athletes collapsing like flies are known not to have COVID I would point out that COVID is often undiagnosed.


    Now, I have substantiated my statements about COVID myocarditis.


    You are merely making typical:

    I am an antivaxxer - I know more than anyone else, and anyway they are all incompetent / corrupt / part of a conspiracy so I don't need evidence

    unsubstantiated comments.


    THH

  • Taiwan Temporarily Stops Administration of Second Dose Pfizer-BioNTech Vaccine in 12 to 17-year-old Cohort to Evaluate Safety Situation


    Taiwan Temporarily Stops Administration of Second Dose Pfizer-BioNTech Vaccine in 12 to 17-year-old Cohort to Evaluate Safety Situation
    Known as the Republic of China or, more commonly, Taiwan, this island nation formed after the communist revolution on the Chinese mainland has, for the
    trialsitenews.com


    Known as the Republic of China or, more commonly, Taiwan, this island nation formed after the communist revolution on the Chinese mainland has, for the most part, avoided much of the pandemic except for a huge Delta variant-driven surge during the spring of 2021. With approximately 23.5 million people, the island has recorded approximately 16,400 cases of SARS-CoV-2 with 848 deaths. Recently Chen Shih-chung, the leader of their Central Epidemic Command Center (CECC), reported that a panel of experts opted to suspend the administration of the second dose of the Pfizer-BioNTech COVID-19 vaccine known as BN2162b2 to young people aged 12 to 17-years-old due to growing concerns of the heightened risk of myocarditis.


    As reported recently in Taiwan News, health regulators here are increasingly concerned about the safety associated with the mRNA-based vaccine. The Taiwanese report authored by George Liao referred to mounting U.S. safety statistics indicating growing heart muscle inflammation risk to youth post the second Pfizer-BioNTech jab—in some cases as much as 10X higher the risk when compared to the first dose.


    TrialSite has reported much of Scandinavia has changed policy around the use of Moderna, the other mRNA-based COVID-19 vaccine. Denmark, Sweden, Norway, and Iceland have all either temporarily or permanently halted the inoculation of young people with the Moderna vaccine known as mRNA-1273. Finland also joined the Scandinavian nations out of safety concerns.


    In Asia, public health and regulatory officials also adjust to account for the mounting safety data. For example, in Hong Kong, people aged 12 to 17 only receive a single dose of the BNT162b. The UK recommends only one shot for children between the ages of 12 to 18, reports Liao, referencing articles in Channel News Asia (CNA).


    Two Week Pause

    Taiwan News reports that Mr. Chen shared with the media that the Ministry of Health and Welfare’s Advisory Committee for Immunization Practices (ACIP) opted to stop the administration of the second dose of the mRNA-based vaccine produced by BioNTech so experts at the Centers for Disease Control (CDC) there can review 16 specific cases of myocarditis among younger people. This prerequisite stage-gate appears rational given the risk-benefit analysis associated with young people and the COVID-19 vaccines.


    Chen shared that Taiwan won’t take up the vaccination of even younger people in the 5 to 11 age cohort until they resolve the current safety issues.


    Reports of More Vaccine Death in Taiwan

    The internet is abuzz with stories that more people in Taiwan have died from the COVID-19 vaccines than from COVID-19 itself. In one study produced in the Journal of Chinese Medicine, the Taiwanese authors from the National Yang Ming Chiao Tung University and Taipei Veterans General Hospital did acknowledge that while COVID-19 deaths were declining, vaccination-based deaths were increasing. The paper also noted that most of these deaths were the elderly with comorbidities.


    Some news sites suggest that the total number of deaths is higher, but it is difficult to prove that the vaccine causes these deaths. For example, last month, China In Focus reported that “Taiwan’s health authorities say that as of Monday, # Deaths after #Vaccination reached 865, while deaths from the virus are at 845.”


    Countering Point of View

    Yet other purported fact-checking sites question these claims. Polygraph reported that the numbers associated with Taiwan’s Centers for Disease Control (CDC) aren’t reliable, and the Taiwan Vaccine Adverse Event Notification System (VAERS) doesn’t provide information on deaths—which seems strange to the TrialSite team.


    In a rationale often heard in America, the Chinese CDC notes, “The reported events occur after vaccination, but that does not indicate that they are caused by vaccination. … The number of adverse event notifications alone cannot explain or be used to draw conclusions on the existence, severity, frequency or incidence rate of vaccine-related problems, and they should be explained in the context of other scientific information.”


    Conclusion

    It is not clear if more people have died in Taiwan due to the COVID-19 vaccines as opposed to the disease itself. However, a respectable medical journal suggests there is a growth in deaths, and clearly, Taiwanese authorities are concerned enough to pause and review the data. TrialSite will continue to monitor and update the situation.


    Taiwan halts 2nd-dose BioNTech vaccinations for ages 12-17 amid concerns of myocarditis

    CECC says approval of COVID vaccines for children under 12 will not be considered until 2nd dose issue settled

    Taiwan halts 2nd-dose BioNTech vaccinations for ages 12-17 amid concerns of myocarditis | Taiwan News | 2021-11-10 15:42:00
    CECC says approval of COVID vaccines for children under 12 will not be considered until 2nd dose issue settled | 2021-11-10 15:42:00
    www.taiwannews.com.tw

  • Bill Gates Acknowledges COVID-19 Vaccines Not Stopping Viral Transmission: Fundamental Premises Questioned?


    Bill Gates Acknowledges COVID-19 Vaccines Not Stopping Viral Transmission: Fundamental Premises Questioned?
    Recently, a nonprofit group called Policy Exchange facilitated a filmed interaction with Jeremy Hunt and Bill Gates. A British politician, Hunt has served
    trialsitenews.com



    Recently, a nonprofit group called Policy Exchange facilitated a filmed interaction with Jeremy Hunt and Bill Gates. A British politician, Hunt has served the UK’s government as chair of the Health and Social Care Select Committee since 2020. Of course, Gates, one of the world’s wealthiest people, has become a high-profile figure in the world of philanthropy and vaccine development. During the recent exchange, the Microsoft founder made some eyebrow-raising statements about the current COVID-19 vaccines on the market. Specifically, in addition to several views on topics from the pandemic to climate change, Gates declared, “We didn’t have vaccines that block transmission” which seemingly refutes previous comments by the billionaire. Gates got even more frank declaring, “We got vaccines that help you with your health, but they only slightly reduce transmission.”


    TrialSite provides a link to the interview. A number of websites such as Rebel News also featured the interview Bill Gates admits COVID-19 vaccines don’t stop viral transmission – Rebel News suggesting that one of the world’s preeminent public health investors and prominent supporters of the current COVID-19 vaccine strategy admits to the failure of the vaccine industry.


    No vaccine is full proof, and the COVID-19 vaccines are no exception. Still early-stage life science-based products, the vaccines will become better over time. A historical milestone during the COVID-19 pandemic, powerful new vaccines were produced in less than a year—simply unprecedented. Moreover, significant evidence supports part of the government narrative—that the vaccines have prevented millions of more severe COVID-19 cases while preventing death so TrialSite doesn’t agree that Gates’ comments are an admission of outright failure.


    However, where Gates’ comments become controversial is when considering the underlying premise behind mass vaccination, including mandates for adults in businesses with over 100 employees or aggressive pushes by the federal government in the United States to get all children vaccinated.


    From this point of view, children are “reservoirs” for the pathogen, and vaccination could stop the spread of the disease via this reservoir. But numerous studies now indicate durability challenges, including waning effectiveness and considerable viral transmission—from vaccinated persons.


    The vaccine products represent historically notable progress in vaccination development with the first product releases comparable to the version 1.0 analogy. While on the one hand, they represent an amazing set of accomplishments, on the other hand, it might be too early to declare they are designed to end the pandemic.


    TrialSite, an apolitical place, shares the video interview so the community members can determine for themselves the comments made by Gates and associated implications. TrialSite has discussed that vaccines can help save lives, particularly the elderly and people with higher risk profiles. As Bill Gates declared in the interaction with Hunt the vaccines are on the one hand providing protection against more serious forms of COVID-19. However, on the other hand, accumulating data points indicate higher risks for some serious adverse events than are disclosed. Importantly, due to durability challenges, viral transmission increases in the vaccinated just months after the administration of the second dose.


    Gates Departs from Pack?

    A fundamental premise for the mass vaccination programs has been that the vaccines would stop viral transmission. However, that isn’t the case as study after study reveals durability challenges with the vaccines. These are new products that will improve over time but it could very well be that no vaccine can simply stop COVID-19.


    Is the recent admission by Gates as to limitations of the vaccines indicative of changes to come in his approach to funding novel vaccines?


    What is the Policy Exchange?

    The London-based Policy Exchange is according to Wikipedia a British center-right-wing think tank that can inform government policy in the UK. The group was formed in 2002 as an independent, non-partisan educational charity with a mission to promote new policy ideas for improved outcomes—e.g. better public services while bolstering society


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  • De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report


    De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report
    SARS-CoV-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. We…
    www.medrxiv.org


    Abstract

    SARS-CoV-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. We present a case of an immunocompromised patient with acquired B-cell deficiency who developed an indolent, protracted course of SARS-CoV-2 infection. Remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. Whole genome sequencing identified a mutation, E802D, in the nsp12 RNA-dependent RNA polymerase which was not present in pre-treatment specimens. In vitro experiments demonstrated that the mutation conferred a ∼6-fold increase in remdesivir IC50 but resulted in a fitness cost in the absence of remdesivir. Sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. Although the fitness cost observed in vitro may limit the risk posed by E802D, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with SARS-CoV-2 infection


    In summary, we identified the de novo emergence of a RDV-resistance mutation, E802D, following initiation of RDV in an immunocompromised patient with persistent SARS-CoV-2 infection. While the finding is limited to a single case and requires confirmation of its generalizability in larger patient populations, it suggests that RDV can impart selective pressure in vivo to drive evolution of the virus. E802D is associated with a fitness cost in vitro which may limit the broader impact of this mutation on the development of secondary resistance during treatment and the risk for primary resistance through transmission of resistant variants. Yet, our findings underscore the importance of immunocompromised hosts with uncontrolled viral replication as a source of genetic diversification4,17 and selection of mutations that may potentially impart adverse consequences for antiviral therapy. Enhanced genomic surveillance of immunocompromised patients may thus be warranted. As observed in this case, initiation of anti-SARS-CoV-2 mAb may serve as a therapeutic option to achieve rapid and sustained virologic responses and improved clinical outcomes in immunocompromised patients

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