Covid-19 News


  • Yes, the IFR estimates defined as mortality / infections look pretty stable, but going down a bit due to better treatment. 80% fall in mortality looks too high but I expect it is a demographic issue. The infections at that time were skewing towards young people who went out and partied, or children who went to school. You expect over time that shielding arrangements for at risk older people will become better (and perhaps those badly shielded will catch COVID and be removed from the statistics). With this disease the IFR is critically depoendent on the age of those catching it - and that is not modelled by the UK data.


    From the UK on R4 today:


    Survival chances in hospital of increased significantly (with Dexamethasone and better management - not sure if that includes other drugs). Average 10 days in hospital (vs 21) and 80% now survive (vs it did not say but it must have been at least 50%).



    it is expected that over about 6 months we get better at treating the disease, and the figures for hospital stay time show this is not just keeping people alive, but also reducing the severity of the disease.


    All without wonder-drugs!



    eTurboNews talked to a medical professional in Germany involved in the treatment of Coronavirus.

    He or she did not want to be named but said there is a reason for it.

    Kept as an internal secret the treatment protocol in the Federal Republic of Germany looks very different from other regions.

    211,060 infections, 395 new cases today, 9226 dead, including two more today.


    9226/211,060 = 0.43% IFR - a little bit lower than other estimates but comparable? Look at the details of antibody test sampling for the infection figure since this can skew things.


    They might have slightly better treatment, but why on earth would it be a secret - and how could it be a secret, with doctors everywhere knowing it? Does not make sense.

  • Re East vs West Germany:


    https://www.nature.com/articles/s41375-020-0871-4


    Speculation that BCG vaccine will reduce COVID death rates, just as it (article suggests) it reduces Leukemia rates, and perhaps other infections, with (again speculation) that it trains the immune system beneficially. Can't rule this out. But...


    I trust this (definitely pro-vax) association no more than I trust the corresponding anti-vax associational arguments. Too many confounding variables, and correlation is not causation. Trust the vaccine Phase 3 trials and detailed mass population data, not these correlations.

  • Vitamin D and zinc could be the safe and cheap anti bat virus.: Here's a look at zinc and zinc deficenccy


    Zinc is involved in numerous aspects of cellular metabolism. It is required for the catalytic activity of approximately 100 enzymes [1,2] and it plays a role in immune function [3,4], protein synthesis [4], wound healing [5], DNA synthesis [2,4], and cell division [4]. Zinc also supports normal growth and development during pregnancy, childhood, and adolescence [6-8] and is required for proper sense of taste and smell [9]. A daily intake of zinc is required to maintain a steady state because the body has no specialized zinc storage system [10].


    https://ods.od.nih.gov/factshe…0Zinc-HealthProfessional/


    Now vitamin D


    Vitamin D has other roles in the body, including reduction of inflammation as well as modulation of such processes as cell growth, neuromuscular and immune function, and glucose metabolism [1-3]. Many genes encoding proteins that regulate cell proliferation, differentiation, and apoptosis are modulated in part by vitamin D. Many tissues have vitamin D receptors, and some convert 25(OH)D to 1,25(OH)2D.


    https://ods.od.nih.gov/factshe…aminD-HealthProfessional/



    Something so easy yet no alerts. Lots of people out there are using both supplements using common sense because there is nothing coming from our experts

  • Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor



    https://www.sciencedirect.com/…cle/pii/S0960076016301029


    Abstract

    Vitamin D3 regulates genes critical for human health and its deficiency is associated with an increased risk for osteoporosis, cancer, diabetes, multiple sclerosis, hypertension, inflammatory and immunological diseases. To study the impact of vitamin D3 on genes relevant for the transport and metabolism of nutrients and drugs, we employed next-generation sequencing (NGS) and analyzed global gene expression of the human-derived Caco-2 cell line treated with 500 nM vitamin D3. Genes involved in neuropeptide signaling, inflammation, cell adhesion and morphogenesis were differentially expressed. Notably, genes implicated in zinc, manganese and iron homeostasis were largely increased by vitamin D3 treatment. An ∼10-fold increase in ceruloplasmin and ∼4-fold increase in haptoglobin gene expression suggested a possible association between vitamin D and iron homeostasis. SLC30A10, the gene encoding the zinc and manganese transporter ZnT10, was the chiefly affected transporter, with ∼15-fold increase in expression. SLC30A10 is critical for zinc and manganese homeostasis and mutations in this gene, resulting in impaired ZnT10 function or expression, cause manganese intoxication, with Parkinson-like symptoms. Our NGS results were validated by real-time PCR in Caco-2 cells, as well as in duodenal biopsies taken from healthy human subjects treated with 0.5 μg vitamin D3 daily for 10 days. In addition to increasing gene expression of SLC30A10 and the positive control TRPV6, vitamin D3 also increased ZnT10 protein expression, as indicated by Western blot and cytofluorescence. In silico identification of potential vitamin D responsive elements (VDREs) in the 5′-flanking region of the SLC30A10 promoter and dual-luciferase reporter assay showed enhanced promoter activity in the presence of vitamin D receptor (VDR) and retinoid X receptor (RXR) constructs, as well as vitamin D3, but not when one of these factors was absent. Electrophoretic mobility shift assay (EMSA) and competition EMSA revealed binding of select sequences, namely, nt −1623/-1588 and nt −1758/-1723 relative to the transcription start site, to VDR-containing nuclear extracts. In conclusion, we have shown that vitamin D3 transactivates the SLC30A10 gene in a VDR-dependent manner, resulting in increased ZnT10 protein expression. Because SLC30A10 is highly expressed in the small intestine, it is possible that the control of zinc and manganese systemic levels is regulated by vitamin D3 in the intestine. Zinc, manganese and vitamin D are important for bone metabolism and brain health. Future examination of a possible role for supplementation or chelation of zinc and manganese, alongside vitamin D3 administration, will further our understanding of its potential benefit in the treatment of specific illnesses, such as osteoporosis and Parkinson’s disease


    .

  • Fm1 good find, this article demonstrates that taking D3 supplements over a period of time would up-regulate the density of Zn transporters expressed by cells! Which is good justification for taking such supplements to fend off COVID. A similar effect I believe can be by taking a low dose of quinine found similarly in tonic water, which over a period of time gradually elevates quinine levels in cells to be therapeutic. I never recommended using HCQ continuously, only in acute situations when severe symptoms begin to arise, along with the other anti-bat components.:)

  • Possibly another way to impede Covid --

    Exportin 1 inhibition as antiviral therapy

    "... Clinical studies using the XPO1 inhibitor selinexor as a therapy for COVID-19 infection are in progress."

    https://pdf.sciencedirectasset…f257a81cgxrqa&type=client


    Several small molecules, including curcumin and piperlongumine, inhibit this pathway,

    Small Molecule Inhibitors of CRM1

    https://www.frontiersin.org/ar…389/fphar.2020.00625/full

  • This from Harvard TH Chan school of public health


    Zinc is a component of many enzymes and transcription factors in cells all over the body, and inadequate zinc levels limit the individual’s ability to mount an adequate immune response to infections. [2] Multiple meta-analyses and pooled analyses of randomized controlled trials (RCTs) have shown that oral zinc supplementation reduces the incidence rate of acute respiratory infections by 35%, shortens the duration of flu-like symptoms by approximately 2 days, and improves the rate of recovery. [3,4] The studies were conducted in the US as well as in multiple low- and middle-income countries such as India, South Africa, and Peru. The dose of zinc in these studies ranged from 20 mg/week to 92 mg/day. Dose does not appear to be the main driver of the effectiveness of zinc supplementation.

    Vitamin C is a cofactor for many enzymes. It enhances the function of many enzymes all over the body by keeping their metal ions in the reduced form. It also acts as an antioxidant, limiting inflammation and tissue damage associated with immune responses. [5] RCTs evaluating the effectiveness of vitamin C have been conducted among soldiers, young boys, and older people in the US, the Soviet Union, the UK, and Japan. In these studies, vitamin C supplementation was shown to significantly reduce the incidence of respiratory tract infections. [6] The effectiveness of vitamin C has also been studied among hospitalized patients in the US, Egypt, and Iran, admitted for a wide variety of conditions including severe sepsis, postoperative complications, burns, lung contusions, and cardiac conditions. [7] Vitamin C was shown to reduce the duration of stay in the intensive care unit and need for mechanical ventilation among these patients. [8] The dose of vitamin C varied from 1-3 g/day, and dose does not appear to be the main driver of effectiveness. Doses of vitamin C above 2 g/day should be avoided outside of medical care.

    Evidence from several clinical trials and pooled studies show that vitamin D supplementation lowers the odds of developing acute respiratory tract infections (most of which are assumed to be due to viruses) by 12% to 75%. [9-12] These studies included both the seasonal and pandemic flu caused by H1N1 virus in 2009. The beneficial effect of supplementation was seen in patients across all ages, and individuals with pre-existing chronic illnesses. [13] Among those who were infected, flu symptoms were fewer and recovery was earlier if they had received doses of vitamin D greater than 1000 IU. [14] The benefits were relatively greater in individuals with vitamin D deficiency than in those who had adequate levels of vitamin D.

    Older adults are most often deficient in these helpful micronutrients, and thus can derive the greatest benefit from supplementation. [15,16

  • recomended daily supplementation of vitamin D from the staff at mayo clinic


    Overview

    Vitamin D is necessary for building and maintaining healthy bones. That's because calcium, the primary component of bone, can only be absorbed by your body when vitamin D is present. Your body makes vitamin D when direct sunlight converts a chemical in your skin into an active form of the vitamin (calciferol).


    Vitamin D isn't found in many foods, but you can get it from fortified milk, fortified cereal, and fatty fish such as salmon, mackerel and sardines.


    The amount of vitamin D your skin makes depends on many factors, including the time of day, season, latitude and your skin pigmentation. Depending on where you live and your lifestyle, vitamin D production might decrease or be completely absent during the winter months. Sunscreen, while important, also can decrease vitamin D production.


    Many older adults don't get regular exposure to sunlight and have trouble absorbing vitamin D, so taking a multivitamin with vitamin D will likely help improve bone health. The recommended daily amount of vitamin D is 400 international units (IU) for children up to age 12 months, 600 IU for ages 1 to 70 years, and 800 IU for people over 70 years.


    And this study from 5 years ago.


    https://www.ncbi.nlm.nih.gov/p…PMC4210929/?report=reader


    Just a ball of confusion .......... And the band plays on!

  • The governments of Georgia and Florida are doing all they can to reopen restaurants. In Florida they now allow 100% occupancy. This is despite the fact that the CDC found a high percent of COVID-19 patients were infected in restaurants. The governments are doing the opposite of a lockdown. They are pleading with people to back to restaurants, and trying to reassure the public that all is well. But people are not going back, because they are not idiots who will not risk their lives when they can eat at home. Quoting a restaurant owner, "I think people are scared to be inside." Yes, that is the problem. The lockdown is imposed by the public, not by governments, and unless the government begins to implement effective steps to step the pandemic, the lockdowns will continue until a vaccine is deployed. People do not trust the government of Georgia because it has been lying to the public hiding the data. People have no confidence that restaurants are safe even though the government says they are.


    In other words, there are two ways to impose a lockdown and strangle the economy:


    1. Government ordering a lockdown.

    2. Government NOT ordering a lockdown, but instead lying and hiding the facts and destroying confidence.


    There is only one way to lift a lockdown and restore the economy:


    1. Fix the problem, with testing, case tracing and quarantine. The government in Georgia has not done these things, so it makes no difference how fervently it pleads with people to go back to restaurants.


    See:


    https://www.ajc.com/things-to-…MBQJXSJVHRDNKYINIKUTH3VU/


    Still crippled by pandemic, Atlanta restaurants struggle to hang on


    Germane quote:


    . . . . Even though counter-order concepts like Suzy Siu’s are ripe for takeout, traffic at the food hall is far from normal. “It’s still eerily empty,” said Yu. “Jeni’s Ice Cream used to have a line after lunch. Now, you see like one person. I think people are scared to be inside. It’s eerily creepy and different.”



    CDC and restaurants:


    https://www.cdc.gov/mmwr/volumes/69/wr/mm6936a5.htm


    https://www.restaurantbusiness…ut-significant-covid-risk


    NEW CDC REPORT CITES DINING OUT AS A SIGNIFICANT COVID RISK


    Adults who contract COVID-19 are twice as likely as the general population to have eaten at a restaurant in the two weeks beforehand, the Centers for Disease Control and Prevention (CDC) said in a report on Friday.


    Both indoor and outdoor dining pose a risk of infection because patrons can’t eat or drink with a mask on, the CDC noted. It advised that alternative defenses against coronavirus be considered “to protect customers, employees, and communities.”

  • it is expected that over about 6 months we get better at treating the disease, and the figures for hospital stay time show this is not just keeping people alive, but also reducing the severity of the disease.


    All without wonder-drugs!


    As I recall, the number of cases and deaths from tuberculosis was reduced by more than half in many countries by 1920, long before drugs were developed that cured it specifically. It was reduced by public health measures alone, mainly improved sanitation and nutrition. Clean water, fresh air and getting enough food prevented it. Public health measures can reduce COVID-19 infections and deaths by a huge factor. Testing, tracing and quarantine -- proven to work!

  • In other words, there are two ways to impose a lockdown and strangle the economy:


    1. Government ordering a lockdown.

    2. Government NOT ordering a lockdown, but instead lying and hiding the facts and destroying confidence.


    The government not ordering a lockdown is ... not a lockdown. Citizens voluntarily minimizing things like eating out is not a lockdown.

    Conflating the two seems like an attempt to blunt the stark reality of what a real lockdown is : an enforced, blatant overreach of government control.


    About Georgia holding back their data ; this should come as no surprise as they probably caught that habit from the CDC, headquartered in Atlanta.

  • The First Clinical Trial to Support Vitamin D Therapy For Covid-19


    https://medium.com/microbial-i…for-covid-19-906a9d907468


    Astudy from Spain finally presents the first clinical evidence for the use of vitamin D to treat Covid-19. The study, “Effect of Calcifediol Treatment and best Available Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study,” was published in The Journal of Steroid Biochemistry and Molecular Biology on 29 August. It is called a pilot because the sample size is small, but its randomization and prospective design still make it a robust research.

  • Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19?


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415215/


    Abstract

    The world is currently in the grips of the coronavirus disease (COVID-19) pandemic, caused by the SARS-CoV-2 virus, which has mutated to allow human-to-human spread. Infection can cause fever, dry cough, fatigue, severe pneumonia, respiratory distress syndrome and in some instances death. COVID-19 affects the immune system by producing a systemic inflammatory response, or cytokine release syndrome. Patients with COVID-19 have shown a high level of pro-inflammatory cytokines and chemokines. There are currently no effective anti-SARS-CoV-2 viral drugs or vaccines. COVID-19 disproportionately affects the elderly, both directly, and through a number of significant age-related comorbidities. Undoubtedly, nutrition is a key determinant of maintaining good health. Key dietary components such as vitamins C, D, E, zinc, selenium and the omega 3 fatty acids have well-established immunomodulatory effects, with benefits in infectious disease. Some of these nutrients have also been shown to have a potential role in the management of COVID-19. In this paper, evidence surrounding the role of these dietary components in immunity as well as their specific effect in COVID-19 patients are discussed. In addition, how supplementation of these nutrients may be used as therapeutic modalities potentially to decrease the morbidity and mortality rates of patients with COVID-19 is discussed.