Covid-19 News

Maybe hydroxychloroquine isn't the the problem but it's interaction with azithromycin

Using hydroxychloroquine together with azithromycin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Maybe using doxycycline instead as there are no adverse interactions with hydroxychloroquine and zinc

Quote from Zeus46

So it seems yet another Robert Bryant discussion has degenerated into disingenuity

I was wrong .. Google is not Zeus's friend

Zeus appears to be not able to connect dots together.. but twists them to say it supports his point

....that the patient did not die from QT elongation..???

Prolongation of the QT interval can predispose to a potentially fatal polymorphic ventricular tachycardia called torsades de pointes (TdP). Although usually self-limited, TdP may degenerate into ventricular fibrillation and cause sudden death.

Some medications that cause QT prolongation and possible TdP are commonly used in general practice. This paper presents a case of sudden death that is likely from drug-induced TdP.

The patient died from Torsades de Pointes... drug induced via QT elongation..

This is why QT elongation is the subject of multiple warnings in pharmacological tomes and largely why quinine has been banned from most hospital formularies...in the last two decades.. it was dropped around 2000 in Australia

the old gin and tonic is frowned upon.

"Quinine has dose-dependent QT-interval-prolonging effects and should be used with caution in patients with risk factors for QT prolongation or in those with atrioventricular block.

https://www.gov.uk/drug-safety-update/quinine-reminder-of-dose-dependent-qt-prolonging-effects-updated-medicine-interactions#:~:text=Quinine%20has%20dose%2Ddependent%20QT,in%20those%20with%20atrioventricular%20block.

QT morbitdity is rare in the normal young healthy patient but it is unknown what the effect of 1 billion little Covid stickies is on the aged cardiovascular system which is a very good reason not to give 2400 mg/d of HCQ..

which is why I would not have signed off on the RECOVERY dosage...too many unknowns.. why go so unprecedentedly high? 1561 patients?

Goodness gracious me..

Zeus has little idea of the complexity of modern clincal pharmacology ..

Vaccine problem in South Korea as deaths reach 59

https://www.reuters.com/articl…rea-singapo-idUSKBN27B02N

Quote from Fm1

Vaccine problem in South Korea as deaths reach 59

https://www.reuters.com/articl…rea-singapo-idUSKBN27B02N

To clarify, these are influenza vaccines, not COVID-19 tests.

Gosh, they've allowed me back in, after hacking for several hours. Well what more can I say - I have to avoid any sensitive issues with the 'forces that be' breathing down my neck. Their latest venture is trying to freeze my bank accounts but fortunately that great money-laundry business HSBC will have no truck with them. Come on! Are you going to throw every state pensioner off your pay list?????? I can only appeal to Team Google to act in a moral, empathic, fair, honest way on the side of justice etc etc. Anyway, so what's up doc? What's new on the COVID scene???? Nothing much it seems THHuxleynew is still grinding on that antivirals will never work whilst others with more common sense but are perhaps more intelligent (eg Wyttenbach who is also unconstrained in his analysis living in the somewhat privileged German free state of Switzerland). My money would be on the latter being correct anytime with his purely objective analysis of the facts as they stand. No bias there!!! And, after all he is a genius inventing a totally novel view of theoretical physics.

Hydroxychloroquine, nitazoxanide and ivermectin have similar effects in early COVID-19

- a head-to-head comparison of the Pre-AndroCoV Trial.

Conclusion: Hydroxychloroquine, nitazoxanide and ivermectin seem to be similarly

effective for overall clinical outcomes in COVID-19 when used before seven days of

symptoms, and overwhelmingly superior compared to untreated COVID-19 population,

even for those outcomes not influenced by placebo effect, at least when combined with

azithromycin, and vitamin C, D and zinc in the majority of the cases. Between these

drugs, nitazoxanide demonstrated the strongest broad spectrum antiviral activity,

plausibility to act as an anti-COVID agent, and safety profile, at least at the time

of the choice of the drug for the AndroCoV Trial.

https://www.researchgate.net/p…of_the_Pre-AndroCoV_Trial

Quote from Lou Pagnucco

Conclusion: Hydroxychloroquine, nitazoxanide and ivermectin seem to be similarly

effective for overall clinical outcomes in COVID-19 when used before seven days of

symptoms, and overwhelmingly superior compared to untreated COVID-19 population,

even for those outcomes not influenced by placebo effect, at least when combined with

azithromycin, and vitamin C, D and zinc in the majority of the cases.

There is only a small critic. The overall usage of 3 x Ivermectin standard dose is low and OK for most. But for > day 5 others recommend increased dosage up of to 12x normal normal = 20mg or 0.mg/kg body weight) in total.

The problem is that with a higher viral load a lot of Ivermectin is used for function 1= blocking the virus before entry of a cell and less is available for function 2: blocking the viral replication in the cell!

This might be the main reason because all three drugs work about the same as the other two only have function 1: (So far I did read..)

Nsp7 and Spike Glycoprotein of SARS-CoV-2 Are Envisaged as Potential Targets of Vitamin D and Ivermectin

https://www.preprints.org/manuscript/202005.0084/v1

Abstract

COVID-19 has emerged as deadly pandemic worldwide with no vaccine or suitable antiviral drugs to prevent or cure the disease. Because of the time-consuming process to develop new vaccines or antiviral agents, there has been a growing interest in repurposing some existing drugs to combat SARS-CoV-2. Vitamin D is known to be protective against acute respiratory distress syndrome (ARDS), pneumonia and cytokine storm. Recently it has been used as a repurposed drug for the treatment of H5N1 virus-induced lung injury. Circumstantial evidences indicate that people with low level of vitamin D are more susceptible to SARS-CoV-2. Although, vitamin D was suggested to interfere with viral replication, its interaction with any SARS-CoV-2 protein is unexplored yet. Beside this, ivermectin, a well-known anti-parasitic agent, exhibits potent anti-viral activities in vitro against viruses such as HIV-1 and dengue. Very recently, ivermectin has been found to reduce viral load of SARS-CoV-2 in vitro. We have analyzed available structures of SARS-CoV-2 proteins to identify probable binding partner(s) of vitamin D and ivermectin through knowledge-based docking studies and figured out possible implication of their binding in SARS-CoV-2 infection. Our observations suggest that the non-structural protein nsp7 possesses a potential site to house 25-hydroxyvitamin D3 (VDY) or the active form of Vitamin D, calcitrol. Binding of vitamin D with nsp7 likely to hamper the formation of nsp7-nsp8 complex which is required to bind with RNA dependent RNA polymerase (RdRP), nsp12 for optimal function. On the other hand, potential binding site of ivermectin has been identified in the S2 subunit of trimeric spike(S) glycoprotein of SARS-CoV-2. We propose that deeply inserted mode of ivermectin binding at three inter-subunit junctions may restrict large scale conformational changes of S2 helices which is necessary for efficient fusion of viral and host membrane. Our study, therefore, opens up avenues for further investigations to consider vitamin D and ivermectin as potential drugs against SARS-CoV-2.

Quote from Alan Smith

Q-T disturbances explained.

Goodness gracious me, Pixie Lott does energy innovation as well!

Could ASPIRIN be the first over the counter treatment for coronavirus? Hospitalized

patients already taking the drug daily were 47% less likely to die of COVID-19

https://www.dailymail.co.uk/health/article-8881285

Whiteboard Doctor - Oct-26

Ivermectin, Azithromycin, Vitamin D Combination Therapy For Early, Outpatient COVID-19: New Study!

- Small sample size of early symptomatic patients, very positive results

Trial Site News - Oct-26

Clinical Trials and Research News Weekly Roundup | USAMRDC Develops COVID-19 Vaccine Candidate SpFN

- U.S. Army vaccine, RLF-100 provides 9X increase in survival rate in late stage COVID

- MATH+ protocol includes ivermectin for prophylaxis and early treatment

Drbeen Medical Lectures - Oct-27

Ranitidine Bismuth Citrate (RBC) For COVID-19

- RBC (aka Zantac) appears to be potently anti-COVID-19

Referenced paper - SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase

Activities That Can Be Inhibited by Bismuth Salts

https://www.ncbi.nlm.nih.gov/p…2250_2020_Article_242.pdf

“Remdesivir for COVID-19” Study accidentally proved effectiveness of Hydroxychloroquine

https://wattsupwiththat.com/20…ss-of-hydroxychloroquine/

This from Web MD

COVID Syndrome Seen in Kids Also Strikes Adults

https://www.webmd.com/lung/new…-kids-also-strikes-adults

When the new coronavirus pandemic first began, respiratory distress immediately became the hallmark of severe COVID-19 illness. News reports focused on the inability to breathe, low oxygen saturation levels and the alarming need for ventilators.

But six months later, experts are becoming increasingly concerned about a very different COVID-19 phenomenon, one that spares the lungs only to take direct aim at the patient's heart, digestive tract and nervous system.

Over 80 percent of 200 COVID-19 patients in a hospital in Spain have vitamin D deficiency, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

https://scitechdaily.com/over-…d-deficiency-study-finds/

https://www.cnn.com/world/live…50da829c313d5861590c8bb08

British study shows evidence of waning immunity to Covid-19

From CNN's Jen Christensen

A study of hundreds of thousands of people across England suggests immunity to the coronavirus is gradually wearing off -- at least according to one measure.

Researchers who sent out home finger-prick tests to more than 365,000 randomly selected people in England found a more than 26% decline in Covid-19 antibodies over just three months. . . .

See, I told you so. The emerging clinical trials are showing synergistic actions between the different anti-bat components, ivermectin potentiating HCQ action and even better with Zn, D3 etc. Er so what's up doc? I am still being severely hacked by I presume TG looking for our secret cold fusion reagents we are working out with Ecalox. So, Mum's the word until we have secured at least UK patent protection. But its expensive!!!!! Lend us some of your MILLIONS TG????? Maybe we could cut a deal?????

And now like hydroxychloroquine, the so called experts take aim at vitamin D

Vitamin D has its advocates, but some scientists say it's a waste of time to study it as a treatment for the virus.

https://www.healthing.ca/disea…nt-and-covid-19-treatment

Quote from Fm1

Vitamin D has its advocates, but some scientists say it's a waste of time to study it as a treatment for the virus.

V-D3 is not a treatment! It in general helps your body to fight off viral infections and prevents the cytokine storm. Thus usually patients with high V-D levels only see mild symptoms!

Do not believe the WHO dose of 500 ICU/daily. This is of no help. To fill up your depot you need a few days with at least 3000IU's of V-D3. And please take it with a soup spoon of oil!

Well, guys maybe its time to patent our ANTI-BAT (trade mark) I can simply formulate a prescription which could be given as a single pill containing all the essential components, at the correct dosages. The reason for doing this is not to make money for myself, but to encourage Big Pharma to take notice and thus mass produce it for Whole-World consumption. We are powerless to do this on our own. For example riots are beginning to break out in European Cities (eg Rome) after dark as the situation has more or less returned to the first peak level, Italy being the 'Crossroads of Europe', particularly with trade with China along the old Silk Trade Routes of the past. Covid has spread exponentially, like wildfire, across the whole World., as I predicted if any lockdown measures were relaxed. So, accordingly I will devote a few days to arriving at a final formulation, dosage etc since all the vaccine trials so far have totally flunked suggesting this is yet another blind alley Astra Zeneca. Pfizer and others are following. Hopefully it is not too late to try and convince these CEO's that Anti-Bat is the answer to our woes to end this frightful, devil-sent, pandemic. And look, NO POLITICS!!!!!!

Quote from Fm1

But six months later, experts are becoming increasingly concerned about a very different COVID-19 phenomenon, one that spares the lungs only to take direct aim at the patient's heart, digestive tract and nervous system.

I wonder what fraction of covid infections have this class of symptoms. The article says there are more than 1,000 of these cases found so far in the US. Let's make it 2,000. In the US about 8.5 million people have tested positive. To be very conservative, at least 20 million people in the US have been infected. So less than 1 in 10,000 infections of Covid result in what they are calling "Multisytem Inflammatory Syndrome." But, it may take months to show up after infection, so there's a chance is could be more than 1 in 10,000. The condition seems to arise after the virus is gone from the body, so it appears to be some kind of autoimmune disorder triggered by the virus. The article goes on to say, ""the vast majority of patients with MIS-A belonged to racial or ethnic minority groups" and that it can strike seemingly healthy people, particularly young people.