Covid-19 News

  • The situation in the U.S. is disastrous. Cases and deaths are spiraling out of control, and nothing is being done to stop it. Many people remain oblivious to the danger. New records are set every day. 132,540 infections were reported today. Massive deaths and long term economic destruction will surely follow.


    https://www.worldometers.info/coronavirus/country/us/

  • Cases and deaths are spiraling out of control,

    in El Paso Texas USA they have had to move in 4 mobile morgues to handle the bodies. One of the funeral homes with 6 chapels had to convert one chapel to a morgues. They have had to use the convention center and the center for preforming arts for hospital overflows. Some of the patients are actually crossing from Mexico (Juarez) to access the better health care.


    https://www.npr.org/sections/c…-as-coronavirus-deaths-mo


    https://kvia.com/health/2020/1…l-paso-convention-center/

  • As the virus continues to reach relatively untouched places there will continue to be short-lived mortality (word play intended) hotspots springing up from time to time.

    In the big picture, in 2020 deaths with coronavirus outpace deaths ascribed to the flu by just three to one.

    The US mortality per population is just 8/3 times that of Canada.

    The six states with the highest Covid-19 mortality per population happen to have Democrat governors, but it is probably a more a matter of demographics than policy.

  • In the big picture, in 2020 deaths with coronavirus outpace deaths ascribed to the flu by just three to one.

    Your numbers are off. First, because 2020 is not over yet. There are 55 more days. 900 people are dying per day from COVID. Unless the number of cases falls, the average will surely be above 1000. 242,000 people have died, so the total will be ~300,000. Between 22,000 and 61,000 people die of influenza, and the numbers are usually closer to the low end. See:


    https://www.cdc.gov/flu/about/burden/past-seasons.html


    So that's 5 to 14 times more than die of influenza. Furthermore, influenza seldom hurts your long-term health, whereas COVID will destroy the health of hundreds of thousands of people, with permanent damage to the lungs, brain, and other organs. It is a far more serious disease.



    The six states with the highest Covid-19 mortality per population happen to have Democrat governors, but it is probably a more a matter of demographics than policy.

    Not demographics or population density. Places such as Tokyo have much more dangerous demographics and density, but they have had few cases.


    It was mainly a coincidence. The disease happened to spread to New York, Massachusettes and other states before it reached Republican states. In the early weeks of the pandemic, the doctors did not know how treat it as well as they now do, and case mortality was higher. Also, wearing masks and case tracking was not implemented, so the numbers went out of control. New York and other east coast states now have far lower rates of infection and death than places such as Georgia, Florida and Texas. See:


    https://www.worldometers.info/coronavirus/country/us/


    (Also, by the way, you should write "Democratic governors." Not "Democrat.")

  • A new variant of Covid virus is spreading from mink farms - so what about all our other domesticated and wild mammals, stoats, squirrels, rats, cats, elephants and mice? When rabies rears its ugly head on the UK mainland, vast areas of farmland have to be quarantined and all the wildlife shot. There seems to be no limit to this SARS virus's ability to mutate and fox the mammalian immune system - which makes the vaccine approach much less likely to be successful. Broad spectrum anti-viral therapy may be the only way out of this mess.:)

  • A new variant of Covid virus is spreading from mink farms - so what about all our other domesticated and wild mammals, stoats, squirrels, rats, cats, elephants and mice?

    So far over 700 mutations are reported. The one circulating most today is claimed to spread a few percentage better than the former one with no obvious change in damage. The mink version will most certainly be no exception. But lets wait for the details.


    Your numbers are off. First, because 2020 is not over yet. There are 55 more days. 900 people are dying per day from COVID.

    CoV-19 is exponentially more deadly for older people much much worse than flu. But for younger its the other way round. But there we talk of a few deaths not of 200'000 old killed by a virus and not acting doctors.


    We here have almost 10x more cases than at the first wave peek. Deaths did decrease by more than 10x and we still have no lock-down despite 5x more cases than in Germany. What the US can learn: You will easily see 400'000 cases a day and some 2-3000 death/day because of the missing care/medicaments. Thus the medical establishment will kill thousands/day of Americans by not prescribing Ivermectin for seriously sick patients.

    Only the happy cows of Texas get it!

  • Coronavirus Mutation Concern Verified by Largest COVID-19 Viral Sequence Analysis in U.S.


    https://scitechdaily.com/coron…sequence-analysis-in-u-s/


    This is the largest viral sequence analysis in the U.S. right now and it’s one of the most comprehensive, continual snapshots of sequences that dates to the beginning of the outbreak,” said James Davis, a staff scientist in Argonne’s Data Science and Learning division. “It also provides a much clearer picture of how the strains are evolving.”

  • COVID-19 Patient Zero: Data Analysis Identifies the “Mother” of All SARS-CoV-2 Genomes

    TOPICS:COVID-19GeneticsInfectious DiseasesPublic Health


    https://scitechdaily.com/covid…f-all-sars-cov-2-genomes/


    They found the “mother” of all SARS-CoV-2 genomes and its early offspring strains have subsequently mutated and spread to dominate the world pandemic. “We have now reconstructed the progenitor genome and mapped where and when the earliest mutations happened,” said Kumar, the corresponding author of a preprint study.

  • So, Kumar is this more useless information confirming how impossible it will be to develop a vaccine? The time would be better spent on purifying the s-enantiomer of HCQ or developing other ways to make known anti-viral compounds much more active therapeutically. But nobody listens to me! :(

  • Cytokine storm hypothesis called into question.


    Two papers in JAMA and one in the NEJM find no positive effect from drugs used to quell cytokine storms.


    https://www.nytimes.com/2020/1…covid-cytokine-storm.html

    Its a Bradykinin response attacking organs from over production of t and b-cells because of a Vitamn D deficenccy

    May IL-17 have a role in COVID-19 infection?


    https://www.ncbi.nlm.nih.gov/p…drome-related%20mortality.


    Immune regulation mechanism of vitamin D level and IL-17/IL-17R pathway in Crohn's disease

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447769/

  • Just adding to my previous post. Take vitamin D and zinc!!!


    The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609465/


    Abstract

    Objectives. To assess zinc (Zn) and vitamin D (Vit. D) status in chronic Hepatitis C virus- (HCV) infected patients and their relationship to interleukin- (IL-) 17 and disease severity and then investigate whether Zn and Vit. D3 modulate IL-17 expression in chronic HCV patients. Methods. Seventy patients and fifty healthy subjects were investigated. Serum levels of Zn, Vit. D, and IL-17 were assessed in the patients group and subgroups. Patients lymphocytes were activated in vitro in the presence or absence of Zn or Vit. D3 and then intracellular IL-17 production was assessed using flow cytometry. Results. Zn and Vit. D were significantly decreased in HCV patients. Increasing disease severity leads to more reduction in Zn level opposed by increasing IL-17 level. Zn potently reduced IL-17 production in a dose-related fashion; however it did not exert any toxic effects. Although Vit. D apparently increases IL17 expression, it is unclear whether it is due to its toxic effect on cell count or lack of definite association between Vit. D and both IL-17 and disease severity.

  • A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complication

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267506/


    Abstract

    As of April 20, 2020, over time, the COVID‐19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative that safe and effective pharmacotherapeutic strategies are rapidly explored to improve survival. In this paper, we use established and emerging evidence to propose a testable hypothesis that, a vicious positive feedback loop of des‐Arg(9)‐bradykinin‐ and bradykinin‐mediated inflammation → injury → inflammation, likely precipitates life threatening respiratory complications in COVID‐19. Through our hypothesis, we make the prediction that the FDA‐approved molecule, icatibant, might be able to interrupt this feedback loop and, thereby, improve the clinical outcomes. This hypothesis could lead to basic, translational, and clinical studies aimed at reducing COVID‐19 morbidity and mortality.

  • The Bradykinin Hypothesis: What It Is And What It Can Tell Us


    https://www.forbes.com/sites/j…-tell-us/?sh=1ba081d7204e


    A team of researchers led by Jacobson combined genetic analyses and supercomputing to come up with a hypothesis explaining the wide constellation of Covid-19 symptoms. Published in eLife in July, their findings reveal a potential mechanism that suggests bradykinin storms could be causing the coronavirus’s diverse effects.

  • Biontech is one of the 3 best new approaches for a working vaccine. But the crucial questions will only be answered after years. How long does the immunization last? How many shots will you need? How strong will it be compared with cross immunity. Can you become ill with a large high virus dose (almost ever very likely). Are all types of T-cells needed induced? Are there no long term cross immunity deficits with others vaccines, or vectors?


    This year a flu shot very likely killed more than 60 Koreans. One swine flu vaccine left behind 10'000ds of narcoleptic patients. You can say rare cases, but not the later. So safety first, except, may be for the persons at real risk!

    Only 16% (last Sunday inquiry) of the Swiss would take a vaccination now!