Covid-19 News

    • Official Post
    Quote from RobertBryant

    Professor Didier Raoult filed an appeal with the Council of State. He challenges the decision of the Medicines Agency not to widely authorize the prescription of hydroxychloroquine against Covid-19.

    and says that he now has to ration his HCQ

    https://francais.rt.com/france…uine-faute-d-autorisation

    Western countries have used creative ways to effectively ban HCQ for COVID, without outright banning it. In the US they accomplish this through Pharmacy Boards, Medical Boards, warnings against use, threat of lawsuits, public shaming by the news media, political bullying, and social media censorship, In France, they have a few of their own ways it appears:


    "The prescription by a doctor of a drug outside the indications provided for by the marketing authorization (MA) must be done "on a case-by-case basis", by informing the patient of the risks incurred, of non-reimbursement, and of the "Non-Marketing Authorization" statement which must appear on the prescription."


    That said, it is good to hear from Dr. Raoult again. He had gone quiet after politics took over the issue,, and his taking action now shows he is still 100% behind his initial findings.


    If it were not for lives being on the line, this would be an entertaining story to follow. I have little doubt HCQ is effective to at least a statistically significant degree, and it will be fascinating to see how the politicians, media, and social media try and escape responsibility for their role in keeping it from being incorporated into the standard of care.


    Quote from Mark U

    unlike others they did not receive government funding for their R&D.

    The research has been done in Germany/Europe. Pfizer is just organizimg the trial and production. THis is teh normal way startup works in this field.

    Quote from Zephir_AWT

    Thus it may be also possible, that first mRNA from first shot gets depleted fast (which would give whole process at least some control) and second shot just replenished its load...

    Important is also to know the efficiency of one shot or three. Even more important whether the needed number of different T-Cell form out their memory. Further how severely sick vaccinated people do get? Sometimes it could be worse than without a vaccine! - Here too after 1,2,3 shots! But this data will be here only after some 100'000 got their shots.

    I don't think Pfizer really know what they are doing - they have found something that works in the short-term, but the long-term effects could be ghastly as Zephir_AWT has pointed out this type of manipulation of the immune system is entirely unpredictable......meanwhile Drugs.com have not responded to my last E-mail so I can't give you any update on ANTI-BAT (TM). But at least we know this works and would avoid the potential nightmare scenarios associated with mRNA-generated vaccination programs. And they don't directly kill the virus, whereas ANTI-BAT does, So there!:)

    Quote from Zephir_AWT

    The problem with Pfizer vaccine reportedly also it, it requires storage at -70°C or the mRNA will decompose or even worse: it will randomly mutate. The mRNA vaccine of Moderna is already better stabilized and it allows storage at zero temperature.

    Modification Of Endogenous RNA may be a dangerous strategy for human health. Wyttenbach have you researched this technology?

    not to pour cold water on a vaccine but vitamin d and zinc levels in individuals will play a very important part in how well this type of vaccine works.


    https://www.cambridge.org/core…2D0A5E4646839/core-reader


    Vitamin D

    Vitamin D is a fat-soluble steroid vitamin and pro-hormone that can be consumed in the diet as cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2), or synthesised by the skin in response to sunlight. In addition to its classical role in maintaining bone health and Ca homeostasis, epidemiological evidence has now identified a potential role for vitamin D deficiency in a range of conditions including diabetes( 82 ), CVD( 83 ), autoimmune disease( 84 ) and some cancers( 85 ). Vitamin D supplementation is now being investigated in the treatment and prevention of these diseases, with a particular focus on its potential as a cancer chemopreventative, due to the identified role of the vitamin D receptor (VDR) in cell-cycle regulation and differentiation( 86 ).


    The active vitamin D metabolite, calcitriol (1,25-dihydroxyvitamin D3), has long been known to directly regulate gene transcription via interaction with the VDR, which acts as a nuclear receptor transcription factor( 87 ). However, post-transcriptional regulatory mechanisms for vitamin D have also been proposed. Regulation of mRNA levels via miRNA signalling is now becoming recognised as a potential additional mechanism for action for vitamin D, and consequences of these interactions are now being investigated( 88 , 89 ).


    Abnormal proliferation is a signature feature of cancer cells. Vitamin D has been demonstrated to suppress proliferation in multiple malignant cell lines( 90 – 93 ). In colon cancer cell lines (SW80-ADH and HCT116) the anti-proliferative effects of calcitriol treatment correlated with an induction of miR-22, -146a and -222 expression, and a reduction in miR-203 expression. miR-203 is a known suppressor of the proto-oncogene JUN ( 88 ). miR-222 and -22 are known epi-miRNA, targeting DNMT3 and HDAC4, respectively( 94 , 95 ). In particular, miR-22 expression was found to be induced in a dose-, time- and VDR-dependent manner. Moreover, miR-22 expression has also been shown to be lower in human colon cancer tissue, compared with surrounding normal tissue, correlating with changes in VDR expression levels( 92 ). This suggests that miR-22 may have an anti-cancer effect that is modulated by vitamin D and the VDR. However, in another colorectal cancer cell line (HT-29 cells), miR-627 was the only miRNA significantly up-regulated by calcitriol treatment. Blocking miR-627 inhibited the anti-proliferative effects of calcitriol treatment. miR-627 targets Jumonji domain containing 1A (JMJD1A), which encodes a histone demethylase( 96 ).


    Additional anti-cancer properties of vitamin D have been investigated in a range of cancer cell lines. Treatment of promyeloblastic leukaemia (HL60) and pro-monocytic leukaemia (U937) cells with low concentrations of calcitriol led to decreased expressions of miR-181a and -181b, in a dose- and time-dependent manner, and the arrest of cell-cycle progression in the G1 phase. Transfection of pre-miR-181a blunted these effects. Treatment of prostate cancer cell lines (RWPE-1, RWPE-2, PrEC and PrE) with calcitriol led to a significant up-regulation of the tumour-suppressor miRNA miR-100 and -125b( 89 ). In LNCaP prostate cancer cells, calcitriol treatment induced expression of miR-98, a tumour-suppressor miRNA, and suppressed proliferation. This occurred both via direct induction due to the enhanced binding of VDR to the vitamin D response element (VDRE) in the miR-98 promoter region, and indirectly via down-regulation of gene expression( 97 ). VDR–VDRE interaction has also been shown to up-regulate let-7a-2 expression in human lung cancer cells (A549 cells)( 98 ). Despite the diversity of the miRNA involved, these results suggest that aberrant expression of miRNA may contribute to the malignant phenotype and that this can be moderated by vitamin D treatment( 99 ).


    Vitamin D is also believed to play a role in protection from cellular stress. In a study using a breast epithelial cell line (MCF12F), calcitriol treatment protected cells against death in models of starvation, oxidative stress, hypoxia and apoptosis induction. Serum starvation led to significant increases in the expression of multiple miRNA (including miR-26b, -182, -200b/c, and the let-7 family). However, this was reversed in the presence of calcitriol, indicating that miRNA expression may be a mechanism that protects against cellular stress via a vitamin D-related process( 100 ). This may have implications in multiple disease states including diabetes, CVD and cancers( 101 ).


    Although the evidence generated in cell studies suggests a role for miRNA and vitamin D in modulating disease-related processes, these studies often used supra-physiological doses. Furthermore, limited studies involving correlation between serum levels of vitamin D and miRNA expression in human subjects have been conducted. In a study of forty subjects given oral vitamin D supplementation for 12 months compared with thirty-seven receiving placebo, serum miRNA and vitamin D levels were measured at baseline and post-supplementation. At baseline a positive correlation was detected between serum 25-hydroxyvitamin D levels and miR-532-3p expression. miR-532-3p has been shown to target the gene for glucose-6-phosphatase, an important enzyme in glucose homeostasis( 102 ). After 12 months of supplementation there was a significant difference in the expression of miR-221; however, this was due to a decrease in levels in the control, rather than the experimental, group( 103 ), possibly indicating that vitamin D deficiency in the placebo group led to the change in miR-221 expression.


    In a study of pregnant women, plasma calcitriol was measured and patients were categorised as either low ( ≤ 25.5 ng/ml) or high ( ≥ 31.7 ng/ml)( 104 ). Respectively, these groups reflect deficiency and sufficiency( 105 ). A total of eleven miRNA were differentially regulated (ten down and one up) in the low group compared with the high group. However, this study was of limited power, as only thirteen subjects were assayed and no functional conclusions were drawn( 104 ).


    Zinc

    Zn is required for numerous structural, catalytic and regulatory functions. Deficiency has been linked to growth retardation, dermatitis, taste impairment, delayed puberty, haematological abnormalities and immune dysfunction( 151 ). In a study using varied dietary intakes of Zn (acclimatisation, depletion and repletion) in healthy adult males, nine miRNA were identified in plasma that were sensitive to plasma Zn concentrations. miR-10b, -155, -200b, -296-5p, -373, -92a, -145, -204 and -211 were all reduced in abundance during the depletion phase of the diet and increased during the repletion phase. Depletion corresponded to a compromised ability of blood cells to produce the inflammatory cytokine TNFα in response to inflammatory stimuli( 152 ). The consequences of the modulation of the miRNA profile may in fact be more extensive and require further investigation.

    Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: A new mechanism for the regulation of inflammation by vitamin D


    Ohttps://www.tandfonline.com/doi/full/10.1080/15592294.2016.1276681


    Inflammation of adipose tissue is believed to be a contributing factor to many chronic diseases associated with obesity. Vitamin D (VD) is now known to limit this metabolic inflammation by decreasing inflammatory marker expression and leukocyte infiltration in adipose tissue. In this study, we investigated the impact of VD on microRNA (miR) expression in inflammatory conditions in human and mouse adipocytes, using high-throughput methodology (miRNA PCR arrays). Firstly, we identified three miRs (miR-146a, miR-150, and miR-155) positively regulated by TNFα in human adipocytes. Interestingly, the expression of these miRs was strongly prevented by 1,25(OH)2D preincubation. These results were partly confirmed in 3T3-L1 adipocytes (for miR-146a and miR-150). The ability of VD to control the expression of these miRs was confirmed in diet-induced obese mice: the levels of the three miRs were increased following high fat (HF) diet in epididymal white adipose tissue and reduced in HF diet fed mice supplemented with VD. The involvement of NF-κB signaling in the induction of these miRs was confirmed in vitro and in vivo using aP2-p65 transgenic mice. Finally, the ability of VD to deactivate NF-κB signaling, via p65 and IκB phosphorylation inhibition in murine adipocyte, was observed and could constitute a driving molecular mechanism. This study demonstrated for the first time that VD modulates the expression of miRs in adipocytes in vitro and in adipose tissue in vivo through its impact on NF-κB signaling pathway, which could represent a new mechanism of regulation of inflammation by VD.

    Quote from Dr Richard

    I don't think Pfizer really know what they are doing - they have found something that works in the short-term, but the long-term effects could be ghastly as Zephir_AWT has pointed out this type of manipulation of the immune system is entirely unpredictable......meanwhile Drugs.com have not responded to my last E-mail so I can't give you any update on ANTI-BAT (TM). But at least we know this works and would avoid the potential nightmare scenarios associated with mRNA-generated vaccination programs. And they don't directly kill the virus, whereas ANTI-BAT does, So there!:)

    Agreed,

    The timing was so incredible and the data so sketchy that, (like all things Rossi), I am very skeptical.


    If we have a verifiable controlled test of 10,000 people and it is successful by this time next year I will be surprised.

    Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375825/


    Background: Immunosenescence contributes to reduced vaccine response in elderly persons, and is worsened by deficiencies in nutrients such as Vitamin (Vit-D). The immune system is a well-known target of Vit-D, which can both potentiate the innate immune response and inhibit the adaptive system, and so modulate vaccination response.


    Objective: This randomized placebo-controlled double-blind trial investigated whether Vit-D supplementation in deficient elderly persons could improve influenza seroprotection and immune response.

    Dr john Campbell talks vaccine


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    Unfortunately the pharmaceutical industry has a sad history of using under-tested drugs or therapies - remember thalidomide? To relieve a trivial complaint like morning sickness? I think they are playing with fire again with this mRNA-engineered vaccine. Do they really care whether it could be teratogenic or worse still carcinogenic in older feeble patients, the very sector of the population they are trying to protect? Such longer-term symptoms would not show up for a long time, long after the COVID dust had settled. Also if such symptoms did occur, they always have a get-out clause by blaming the COVID virus itself. Its an ethical and immunological minefield.:(

    500 000 cases and 1000 more deaths are projected in Sweden to 1 of January if nothing is changed. That's 15Million cases and 30000 deaths if we where US (multiply by 30). Again we have strict recommendations and the streets are empty, very few go to restaurants etc. The death rate is lower now as we are better at protecting the elderly at the nurseries and much improved hospital care. There is a risk of flooding the Hospitals though so we need to socially distance ourselves. Lot's of angry nurses in the media calls for better behavior. But with cold and winter the virus becomes much more potent and it is difficult to hold it back, we do see less R0 than in spring so there is an effect of people behaving, just that this virus is very contiguous and that's the nature of it and we need to live with that. Interestingly the spread is now more in wealthier areas that was spared in spring. I guess we will start vaccinating in February that will decrease the deaths but still we need to make sure not to flood the health care so most likely spring is lost next year as well as it is projected that vaccination for everybody in second or third quarter.

    Quote from Dr Richard

    Unfortunately the pharmaceutical industry has a sad history of using under-tested drugs or therapies - remember thalidomide?

    The thalidomide tragedy occured from 1958 to 1961. The pharmaceutical industry and the FDA instituted wide ranging reforms in response to it. Both changed radically to prevent anything like that from happening again. You might as well say: "ships are not safe, remember the Titanic?"


    Quote from stefan

    500 000 cases and 1000 more deaths are projected in Sweden to 1 of January if nothing is changed. That's 15Million cases and 30000 deaths if we where US (multiply by 30). Again we have strict recommendations and the streets are empty, very few go to restaurants etc.

    This is very similar to the per capita rates in the U.S. 15 million cases and 300,000 deaths is approximately how many there will be in the U.S. by January. Unfortunately, we can be sure that is how many there will be. Nothing will be done to reduce the carnage until Biden takes office. In most cities there are no restrictions about going to restaurants etc., but they have few customers because people are not stupid and will not risk their health or their lives. Movie theaters opened across the U.S., but they have mostly closed again, or gone bankrupt, because very few people will go to one. Not because of any government restrictions.


    A false dichotomy keeps coming up in the discussions of COVID-19, and in the exit polls in the recent election. The question is posed as:


    "Which is more important? Limiting COVID-19 or opening the economy?"


    You cannot open the economy unless you first control and limit COVID-19. As long as the present catastrophic rates of infection and death, and the exponential increase continues, the economy will only grow worse and worse.


    People in U.S. cities tend to take precautions and wear masks more than rural or small states such as North and South Dakota. That is why North and South Dakota are now the center of the U.S. epidemic, with the most number of cases, serious cases, and deaths per capita. In Atlanta, no store, library or any other facility will let you in the door without a mask. Individual stores decided to do this. The city also mandated it. The governor sued the city to try to stop it from making masks mandatory. The governor apparently wants to kill as many people in Atlanta as he can. The city ignored him and the lawsuit was dropped.

    Quote from Alan Smith

    Scientists welcome the first compelling evidence that a vaccine can prevent COVID-19. But questions remain about how much protection it offers, to whom and for how long.

    Quoting the article:


    Lasting immunity?

    One key unanswered question is how long the vaccine’s effectiveness will last. On the basis of when the trial started and previously published data on immune responses in early-stage trials, many trial participants are likely to still have high levels of protective antibodies in their blood, says Rafi Ahmed, an immunologist at Emory University in Atlanta, Georgia. “To me, the main question is what about six months later, or even three months later,” he says.



    It does not seem like such a critical issue to me. Naturally, the longer immunity lasts, the better. But even if it only lasts about a year, it can still be used to give the population herd immunity, which can drive the disease into extinction in the human population. It will still be out there in the bat population (or minks) but it will not be found in nature as widely as, say, tetanus.


    If immunity only lasts a year, then in order to drive it into extinction, we need a coordinated, world-wide inoculation program. It has to happen quickly. The anti-vaccination lunatics will refuse to be vaccinated, but we can hope there are not enough of them to prevent herd immunity. If they die or they are maimed for life, it will be their fault, but that is no comfort for me, since they will keep the virus alive and keep giving to others. It would not bother me as much if they only endangered themselves, or only killed themselves, but unfortunately they will also kill and maim their own children, elderly people, and others.


    I just chatted with the lady at the CVS pharmacy who administers vaccinations for flu, shingles and other diseases. She said they are already gearing up for COVID-19 vaccinations. They assume the vaccine will need to be kept at dry-ice temperatures, so they are going to get new refrigerators. She said the older version of the shingles vaccine also needed to be kept very cold, so they are used to dealing with that. The cryogenic shingles and COVID-19 vaccines come as powder. You mix that with a liquid, and then you have to administer the vaccine within thirty minutes. She is expecting they will be extremely busy once the vaccine becomes available.


    UPS and FedEx are installing new refrigeration equipment at their transfer facilities worldwide, in preparation for the distribution. They also developed a new insulated box that will keep the vaccine cold for several days as long as it the box is not opened.


    There are some COVID-19 vaccines under development that do not require cryogenic storage. If one of these emerges then the new refrigeration equipment will not be needed. It will cost much less to distribute and administer the vaccines. It will also be cheaper if they develop one that does not require a booster shot.


    Biden had pledged to provide the vaccine for free to all US citizens. This is good news. There might be some resistance if they charge money for it. I mean in addition to the resistance from the homicidal anti-vaccination lunatics.

    Quote from JedRothwell

    People in U.S. cities tend to take precautions and wear masks more than rural or small states such as North and South Dakota. That is why North and South Dakota are now the center of the U.S. epidemic, with the most number of cases, serious cases, and deaths per capita. In Atlanta, no store, library or any other facility will let you in the door without a mask. Individual stores decided to do this. The city also mandated it. The governor sued the city to try to stop it from making masks mandatory. The governor apparently wants to kill as many people in Atlanta as he can. The city ignored him and the lawsuit was dropped.

    the governor isn't trying to kill people. Stop with the Phineas T Bluster bs.. history shows that's mask mandates will bring out protests and riots, super spreaders!!! In the early winter of 1918 local, county and state wide mandates went into effect and the protestors took to the streets, 9 weeks later, 195,000 americans died. Do you really wish to repeat this? Common sense will rule the day not unlawful mandates!

    Quote from Fm1

    the governor isn't trying to kill people. Stop with the Phineas T Bluster bs

    I was kidding. Governor Kemp is not trying to kill people. He is trying to avoid paying unemployment insurance to workers who are at risk of getting COVID-19. He wants to force them back to work in dangerous, unnessary jobs such as tattoo parlors. When he removed restrictions from these places, the owners were free to open. That meant that any worker who did not return was voluntarily unemployed, and would not longer be paid unemployment benefits. If a job is available to you, but you do not take it, you are denied benefits. In this case, the jobs meant you ran a very significant risk of getting severely ill, permanently maimed, or killed. The governor values money more than human life. So, in that sense, he was trying to kill people. Or at least, trade off lives for a small amount of money.


    When Kemp fought to stop people from wearing masks, he was also not trying to kill people. He was pandering to the anti-science Trump supporters. Obviously, the effect of his fight is to kill and maim people, and to destroy lives, but that is not the direct goal. The goal was to appease the ignorant fools who have killed 240,000 people for no reason.


    Quote from Fm1

    In the early winter of 1918 local, county and state wide mandates went into effect and the protestors took to the streets, 9 weeks later, 195,000 americans died. Do you really wish to repeat this? Common sense will rule the day not unlawful mandates!

    Every history book and every modern case study of the 1918 pandemic shows that cities that enforced masks and closed movie theaters suffered far lower infections and deaths than the ones that did not do this. The mandates are 100% lawful. Such public health mandates have been part of U.S. law since colonial times. The enforcement used to be a lot stricter than it is now. In 1918, you could go to jail for not wearing a mask, as shown in this photo:


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