Covid-19 News

Study: Respiratory failure in COVID-19 usually not driven by cytokine storm

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

A new study from Washington University School of Medicine in St. Louis and St. Jude Children's Research Hospital in Memphis, Tenn., however, suggests that an out-of-control immune response is not the main problem for the vast majority of hospitalized COVID-19 patients. Only 4% of patients in the study had the sky-high levels of immune molecules that signify a so-called "cytokine storm." The rest had inflammation, but not a remarkably high amount for people fighting infection. If anything, the COVID-19 patients had less inflammation than a comparable group of influenza patients.

This might be the coronavirus breakthrough the world has been waiting for

https://bgr.com/posts/5884954/…rld-has-been-waiting-for/

started in late September when a couple of studies described a key interferon-related phenomenon that can increase the risk of death in COVID-19 patients, including younger men. Genetic issues impacting interferon that go undetected until a COVID-19 diagnosis could worsen the prognosis. Those studies indicated that looking for hidden interferon imbalances would allow doctors to determine which COVID-19 patients are at risk of developing severe complications.

Coronavirus Reinfections: The Mystery Continues

https://www.newsmax.com/headli…ion/2020/11/13/id/996991/

A case study published in The Lancet revealed a 25-year-old man in Washoe County, Nevada, suffered two episodes of COVID-19, one in April and the second at the beginning of June. Genetic testing showed the viruses that caused his two bouts with COVID-19 were different, so it was not a case of one prolonged illness. In fact, the second time around he had a worse outcome from the disease.

The United States May Have Set Itself Up for the Spread of a Pandemic Without Even Knowing It

https://scitechdaily.com/the-u…-without-even-knowing-it/

According to new research from the McKelvey School of Engineering at Washington University in St. Louis, pollution may bear part of the blame for the rapid proliferation in the United States of SARS-CoV-2, the virus responsible for the spread of COVID-19.

Pandemic puzzle solved as scientists decode why Covid-19 largely spares children

Researchers at Vanderbilt University Medical Center figured out that children have lower levels of a receptor protein that SARS-CoV-2 – the virus that causes Covid-19 – needs to invade the lungs.

Researchers at Vanderbilt University Medical Center figured out that children have lower levels of a receptor protein that SARS-CoV-2 – the virus that causes Covid-19 – needs to invade the lungs.

Study: New Mutation Sped Up Spread of Coronavirus

https://www.webmd.com/lung/new…tation-accelerates-spread

Researchers at the University of Wisconsin in Madison infected 16 hamsters with the SARS-CoV-2 virus. Eight hamsters were infected with the new 614G strain. Eight others were infected with the original strain that was first identified in China. Each infected hamster was paired with a healthy hamster that was separated by a partition in a cage, so that the animals couldn’t touch but did breathe the same air. By the second day of the experiment, five of the eight healthy hamsters sharing air with animals infected with the 614G strain had fallen ill and were shedding the virus themselves, but none of the healthy hamsters paired with those infected with the original strain had gotten sick. The original strain did eventually sicken the healthy animals, but it took 2 more days for that to happen, proving that the changes helped to speed the spread of the virus

Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)

https://www.docwirenews.com/ab…rolled-study-shade-study/

CONCLUSION: Greater proportion of vitamin D-deficient individuals with SARS-CoV-2 infection turned SARS-CoV-2 RNA negative with a significant decrease in fibrinogen on high-dose cholecalciferol supplementation.

Vitamin D and Covid-19, the good, the bad and the ugly. Its all here, decide for yourselves

https://vitamin-d-covid.shotwell.ca/

The argument for supplementation

Vitamin D reduces the risk of other acute respiratory infections. One interesting finding of this meta-analysis is that people who were very deficient (less than 25 nmol/L) saw the largest protective effect with an adjusted odd ratio of 0.58 and a 95% CI of 0.40 to 0.82. These are the same populations which seem to be at risk for severe Covid-19

Calcitriol, the active form of Vitamin D is active against the SARS-COV2 virus

Patients treated with calcifediol are less likely to be admitted to the ICU than controls

Several studies have now observed lower vitamin D levels among severe Covid-19 patients

Vitamin D is very low risk an adverse events of vitamin D supplementation can be easily managed by clinicians

Evidence Regarding Vitamin D and Risk of

COVID-19 and Its Severity

https://www.google.com/url?sa=…19a4T&cshid=1605445517178

Until the 21st century, vitamin D was primarily recognized for its role in regulating calcium and

bone health and preventing rickets [1]. In the last 20 years, however, research has shown that vitamin

D also profoundly influences immune cells and generally lowers inflammation [2,3]. Vitamin D is

a powerful epigenetic regulator, influencing more than 2500 genes [4] and impacting dozens of our

most serious health challenges, including cancer [5,6], diabetes mellitus [7], acute respiratory tract

infections [8], and autoimmune diseases such as multiple sclerosis [9].

According to the Worldometer website [10], the world had recorded 40,628,492 cases and

1,122,733 deaths from COVID-19 by 19 October 2020.

There are a number of findings regarding COVID-19 that may be related to vitamin D status.

THE RATIONALE FOR A MULTI-STEP THERAPEUTIC APPROACH BASED ON

ANTIVIRALS, DRUGS, AND NUTRIENTS WITH IMMUNOMODULATORY ACTIVITY

IN PATIENTS WITH CORONAVIRUS-SARS2-INDUCED DISEASE OF DIFFERENT

SEVERITY

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431858/

ABSTRACT

In December 2019, a novel human-infecting coronavirus, named SARS-CoV-2, has been

recognized to cause a pneumonia epidemic outbreak with different degree of severity in Wuhan,

Hubei Province in China. Since then this epidemic spread worldwide in Europe, and Italy also have

been involved. Effective preventive and therapeutic strategies are absolutely required to block this

serious public health concern. Unfortunately, few studies about SARS-CoV-2 concerning its

immunopathogenesis and treatment are available.

On the basis of the assumption that the SARS-CoV-2 is genetically related to SARS-CoV (about

82% of genome homology) and that its characteristics, like the modality of transmission or the type

of the immune response it may stimulate, are still poor-known, a literature search was performed to

identify the reports assessing these elements in patients with SARS-CoV-induced infection.

Therefore, we have analyzed:

1) the structure of SARS-CoV-2 and SARS-CoV;

2) the clinical signs and symptoms and pathogenic mechanisms observed during the development of

acute respiratory syndrome and the Cytokine Release Syndrome;

3) the modification of the cell microRNome and of the immune response in patients with SARS

infection;

4) the possible role of some liposoluble compounds (such as vitamin A, D and E) in modulating

directly or indirectly the replication ability of SARS-CoV-2 and host immune response.

Once more sad news Jed wont like to hear:

Japan:

Japan suicides rise as economic impact of coronavirus hits home

Of October's cases, 851 were women, a rise of 82.6% over the same month in 2019. The number of suicides by men rose 21.3%

So far more woman died by suicide than CoV-19....

FAZ:Beaking news! https://www.faz.net/aktuell/po…tember-2019-17053663.html

Das Coronavirus hat Italien schon viel früher erreicht als bisher angenommen. Gemäß einer Studie des Instituts für Tumorerkrankungen in Mailand und der Universität Siena, deren Ergebnis am Sonntag in der Fachzeitschrift „Tumori Journal“ veröffentlicht wurde, kursierte Sars-CoV-2 schon im September 2019 vor allem im Norden des Landes. Der erste positive Test auf eine Covid-19-Erkrankung war erst Mitte Februar 2020 bei einem Kranken mit atypischer beidseitiger Lungenentzündung in Codogno in der Lombardei festgestellt worden.

Virus entered Italy already before October 2019. This will reverse some Chinese claims and may be people will start to ask what CDC already did know early 2019 when it lifted corona to supervisory level!

Robert F. Kennedy exposes the extreme corruption of the regulators --

https://childrenshealthdefense…e3-4471-825b-98bebd2bea7f

Our immune systems can cope with Covid-19 – it's our politicians who can't

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

In reality, it is our inadequate policies and lack of evidence-based public health strategy that has gotten us to where we are today in the US, the UK and most of the rest of Europe. Our immune systems are mostly responding to this virus the way we’d expect; it is our leadership whose responses have failed.

Arthritis drug cuts COVID-19 deaths in hospitalized patients by two-thirds: study

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

An arthritis drug may cut deaths in hospitalized COVID-19 patients by about two thirds among those suffering from moderate or severe cases of the virus, according to a new study.

Called baricitinib, and marketed under the brand name Olumiant, the medication has been touted by its British company as a possible game changer in the fight against COVID-19, the Daily Mail reported.

Promising New Drug Compounds Identified to Potentially Treat Viruses Like COVID-19, Flu & Ebola

https://scitechdaily.com/promi…-like-covid-19-flu-ebola/

The protein complex, called SKI complex, is a group of human proteins that regulates various aspects of the normal functioning of a cell. In the new study, the researchers discovered that this complex also plays a crucial role in helping a virus replicate its genetic material, called RNA, within the cells it infects.

Injecting engineered viral RNA into human cells with liposomes.

What could goes wrong?

Quote

Injecting engineered viral RNA into human cells with liposomes. What could goes wrong?

I already discussed it here...

Coronavirus invades men’s reproductive organs, can affect their fertility

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

More men get sick and die from COVID-19 than women do and researchers at the University of Miami may have found part of the reason why.

According to a newly released study, COVID-19 invades some men’s testicles.

Researchers at the university tested the testicles of men who died from COVID-19 and found the virus inside the reproductive organs.