Covid-19 News

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

Human naïve antibodies contain anti-SARS-CoV-2 RBD antibodies

The virus elicits neutralizing antibodies that prevent viral entry into the host cells. Most of these antibodies are directed against the viral spike glycoprotein, specifically its receptor-binding domain (RBD), a small immunodominant region. Antibodies to the RBD are of several types, each type targeting a different epitope, though there is a degree of overlap. This indicates that neutralization can occur via multiple mechanisms occurring via inhibition of viral entry at more than one site on the RBD.

The majority of RBD antibodies described so far are surprisingly similar to their germline precursors, a state called low somatic hypermutation. This means that not only is it easy to produce anti-SARS-CoV-2 RBD antibodies, it makes it convenient for researchers to use naïve antibody libraries to pick out novel therapeutic antibodies and to compare antibody clones selected by their ability to bind the viral antigens in vitro with those that arise during natural infection or vaccination.

The researchers used yeast display techniques to isolate three novel neutralizing antibodies from one such library. Of these antibodies, ABP18 blocks RBD-ACE2 binding, while two (NBP10 and NBP11) do not. Thus, the technique proved to be capable of differentiating antibodies that blocked ACE2 and those that did not.

Treat early, treat often, and treat all!

interesting, but my main reason for posting is that it's the perfect example. Medicine is still in its infancy concerning the imune system.

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

https://www.news-medical.net/n…S-CoV-2-binding-site.aspx

A shadow over the promising inhaled interferon beta COVID-19 therapy has been cleared with the discovery that although it appears to increase levels of ACE2 protein - coronavirus' key entry point into nose and lung cells - it predominantly increases levels of a short version of that protein, which the virus cannot bind to.

Naturally occurring antiviral proteins called interferons have shown promise in treating COVID-19. However, previous studies have shown that interferons increase levels of ACE2 - casting doubts over the potential for such treatments, with the possibility that increased ACE2 could see these drugs actually worsen COVID-19 impacts.

But this latest research shows that it is predominantly the short ACE2, which lacks the viral binding site, that is increased in response to interferons. Since levels of the longer form of ACE2 remain unchanged, interferons do not appear to boost entry points for the virus, supporting their use in treating COVID-19 patients.

Treat early, treat often, and treat all!

The New U.K. Variant May Cause False Negatives on Some COVID-19 Tests, FDA WWarns

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

The genetic mutations in new strains of the coronavirus could affect the results of some COVID-19 tests, according to a warning from the Food and Drug Administration (FDA). Because the mutations affect the part of the virus's genetic material that these tests look for, the tests could end up giving a false negative result, meaning the results are negative but an infection is present.

The FDA recently discovered that three particular COVID-19 tests could give a false negative result if the sample contains the B.1.1.7 variant of the virus, which triggered the London lockdown in December. It has since spread to other countries, including the U.S. The risk for a false negative in this situation is low, according to the letter. But the FDA is flagging the issue to health care workers and lab staff.

N439k pathway?

Treat early, treat often and treat all!

this supports Wyttenbach theory on covid cold imunity

Parental Guidance: Research suggests kids may have COVID-19 immunity predating pandemic

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

While researching new studies around the globe, I came across this interesting piece of information on Nature.com that was published in November. Nature carries a compilation of research from around the world and this one research said scientists at the Francis Crick Institute in London analysed blood samples—from adults and children—who had not been infected with the new virus and found they contained antibodies. Nature says: “Scientists have found antibodies that recognize SARS-CoV-2 in the blood of people who have never caught the virus. Children are particularly likely to harbour such antibodies, which might explain why most infected children have either mild illness or none at all.” The blood samples in question were collected before Covid began to wreak havoc worldwide or just when it started to, which means that immunity to it already existed in some people.

The "common mechanism" is based on some posters opinion already well-known (= "human engineering" of this SARS-CoV2 in Wuhan)...

Quote from Fm1

Study identifies genetic changes likely to have enabled SARS-CoV-2 to jump from bats to humans

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

A new study, involving the University of Cambridge and led by the Pirbright Institute, has identified key genetic changes in SARS-CoV-2—the virus that causes COVID-19—that may be responsible for the jump from bats to humans, and established which animals have cellular receptors that allow the virus to enter their cells most effectively.

The genetic adaptions identified were similar to those made by SARS-CoV—which caused the 2002-2003 SARS epidemic—when it adapted from bats to infect humans. This suggests that there may be a common mechanism by which this family of viruses mutates in order to jump from animals to humans. This understanding can be used in future research to identify viruses circulating in animals that could adapt to infect humans (known as zoonoses) and which potentially pose a pandemic threat.

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Quote from zorud

The "common mechanism" is based on some posters opinion already well-known

Not exactly: It's (How CoV-19 virus has been created inside the Wuhan lab) based on the opinion of some of the most famous experts in the field of genetics. A random mutation path form all known paths, Pangolin etc. virus to SARS-CoV-19 would take at least 20 years. Not even to talk that this (the best fitting ) virus had to walk some 1000 miles and must exactly land in a human with the right condition. May be a Pangolin on drugs can do this..walking 1000 miles ( if It manages to escape 100'000'000 Chines hunters..)

Further the same work has already been done at the Wuhan-Lab once before with an influenza virus... For details of the experiment please ask Fauci! He paid for it = did authorize the payment!

Strong claims.... what about that one? (just as an example...)

https://www.businessinsider.co…han-lab-2020-10?r=DE&IR=T

Coronavirus in cat flea: findings and questions regarding COVID-19

https://parasitesandvectors.bi…0.1186/s13071-020-04292-y

Abstract

The coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide. Recent evidence raised the question about the possibility that cats may be a domestic host for SARS-CoV-2 with unknown implications in disease dissemination. Based on the fact that the domestic cat flea, Ctenocephalides felis, are abundant ectoparasites infesting humans, companion animals and wildlife and that coronavirus-like agents have been identified in the ectoparasite tick vector, Ixodes uriae of seabirds, herein we considered the presence of coronaviruses in general and SARS-CoV-2 in particular in C. felis. We identified coronavirus-derived and cell receptor angiotensin-converting enzyme RNA/proteins in C. felis. Although current evidence suggests that pets are probably dead-end-hosts with small risk of transmission to humans, our results suggested that cat flea may act as biological and/or mechanical vectors of SARS-CoV. Although preliminary, these results indicate a possibility of ectoparasites acting as reservoirs and vectors of SARS-CoV and related beta-coronavirus although with little disease risk due to systemic transmission route, low viremia, virus attenuation or other unknown factors. These results support the need to further study the role of animal SARS-CoV-2 hosts and their ectoparasite vectors in COVID-19 disease spread.

Hmmmmmm parasitic infection, ivermectin, covid 19. Connecting the dots

Treat early, treat often and treat all!

Quote from zorud

Strong claims.... what about that one? (just as an example...)

https://www.businessinsider.co…han-lab-2020-10?r=DE&IR=T

You just did unmask you as a conspiracy theorist spreading mafia information. This links contains 0 explanations just bla bla about experts without names. We here debunked all these "undergrad experts" papers long time ago.

But you can go one with your top down conspiracy spreading! Suggestion one: You can e.g. deny that Fauci off signed the Wuhan project.

Quote from Fm1

Coronavirus in cat flea: findings and questions regarding COVID-19

Disparate try to find a better explanation as all others failed so far. What about the pink unicorns?

Some weeks ago the international FM/R/J press started a concentrated effort to blame Sweden for the bad tactics not to follow the international force an fear behavior.

"Sweden has to put in place more strong measures" was the key spell spread.

But for people following the Sweden data it was clear that only the case numbers did increase but the number of deaths all the way did go down. Today these are 3x lower that in Switzerland and 5x lower than in Germany despite higher case numbers...

So what went wrong - outside Sweden??

So Mr. Jürg Allwissend - why the hell did I forgot that you of course know better than all other experts the truth? ... It is hard to take you serious with your mafia mania, your rude language and disrespect of all others out there which are not in line with your opinion...

I am pretty sure that next to SARS-Cov2, Covid-19, „mafia“ is probably the 3rd most used term in this forum...

Quote from zorud

So Mr. Jürg Allwissend

Dear Zorud: Most half grown have this perception problem that they start to believe others know everything better. Once you are grown up you may be you will understand better, if you in the mean time have learned how a science discussion is run.

So far, I recommend that you between a change of diapers at least write one sentence about what you want to tell us about CoV-19? May be your supporter can help you a bit with this task?!

Quote from zorud

next to SARS-Cov2, Covid-19, „mafia“ is probably the 3rd most used term in this forum...

let's coin a neologos... La Covida Nostra..

Interesting read about the UK delays in the 2nd vaccine dose..

https://www.bmj.com/content/372/bmj.n18

"Could the gap lead to vaccine resistant strains of SARS-CoV-2?

Paul Bieniasz, a retrovirologist from Rockefeller University who is studying how the virus can acquire mutations, has warned that the UK was taking a gamble that risked fostering vaccine resistant forms of the virus. He told the news site STAT, “My concern, as a virologist, is that if you wanted to make a vaccine-resistant strain, what you would do is to build a cohort of partially immunized individuals in the teeth of a highly prevalent viral infection.”14

When asked about this concern, a Department of Health and Social Care spokesperson did not directly answer the question, saying rather that it was “vital we do everything we can to quickly and safely protect as many vulnerable people as possible from this virus” and that data from manufacturers showed considerable protection for patients after the first dose.

New items from 'The Defender', Robert F. Kennedy, Jr's website

regarding the rise of Corporatist power and the decline of freedom --

COVID Ushers in Brave New World of Vaccines

In his video report, "The Future of Vaccines," investigative journalist James Corbett reviews how the novel COVID-19 vaccine is paving the way for non-consensual medical experimentation on the general public.

https://childrenshealthdefense…ve-new-world-of-vaccines/

‘If Wall Street Really Believed in Defending Our Democracy,’ It Would End Political Donations … Forever

In the wake of last week’s attack on the Capitol, some Wall Street firms paused political donations. But critics point out they can still give to 'dark money' groups that don't disclose their donors and often raise far more money than corporate PACs.

https://childrenshealthdefense…-end-political-donations/

And, from a libertarian website --

No Vaccine Trials Made on the Elderly Vaccinate Them Even if it Kills Them?

https://www.lewrockwell.com/20…em-even-if-it-kills-them/

Quote from Lou Pagnucco

In his video report, "The Future of Vaccines," investigative journalist James Corbett reviews how the novel COVID-19 vaccine is paving the way for non-consensual medical experimentation on the general public.

https://childrenshealthdefense…ve-new-world-of-vaccines/

Quote from Lou Pagnucco

And, from a libertarian website --

No Vaccine Trials Made on the Elderly Vaccinate Them Even if it Kills Them?

https://www.lewrockwell.com/20…em-even-if-it-kills-them/

Story-at-a-glance:

• By pushing for mandatory COVID-19 vaccination, or imposing social restrictions on those who refuse, the COVID-19 vaccine is paving the way for non-consensual medical experimentation on the general public.
• Since the beginning of the pandemic, world leaders have warned that social distancing, mask wearing, travel restrictions and other measures will become part of our “new normal.” And, while the vaccine is sold as a way to end the pandemic and return us to normal, it cannot, since it has only been evaluated for its ability to lessen COVID-19 symptoms, not reduce the risk of infection, hospitalization or death.
• While some COVID-19 vaccines have been granted emergency use authorization, they still haven’t even completed Stage 3 clinical trials. Data for some endpoints won’t even be collected until 24 months after injection. As such, they are still entirely experimental.
• COVID-19 vaccines’ adverse side effects are still relatively unknown. It’s also unknown whether they might affect fertility — a real concern since the vaccine triggers your body to produce antibodies against the SARS-CoV-2 spike protein, and spike proteins in turn contain syncytin-homologous proteins that are essential for the formation of placenta. If a woman’s immune system starts reacting against syncytin-1, then there is a possibility she could become infertile.
• Pfizer’s mRNA vaccine contains polyethylene glycol (PEG), and studies have shown 70% of people develop antibodies against this substance. This suggests PEG may trigger fatal allergic reactions in many who receive the vaccine.

Quote from Lou Pagnucco

And, from a libertarian website --

No Vaccine Trials Made on the Elderly Vaccinate Them Even if it Kills Them?

https://www.lewrockwell.com/20…em-even-if-it-kills-them/

Bad coincidence. But not giving them Ivermectin did definitely kill them. So you should start to find all names that act behind the scene and block Ivermectin. This will give us the next Nürnberg trial and may be in US once a good reason to use federal executions...

didnt china say it was 90% effective

Sinovac: Brazil results show Chinese vaccine 50.4% effective

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

A coronavirus vaccine developed by China's Sinovac has been found to be 50.4% effective in Brazilian clinical trials, according to the latest results released by researchers.

It shows the vaccine is significantly less effective than previous data suggested - barely over the 50% needed for regulatory approval.

The Chinese vaccine is one of two that the Brazilian government has lined up.

Brazil has been one of the countries worst affected by Covid-19.

Sinovac, a Beijing-based biopharmaceutical company, is behind CoronaVac, an inactivated vaccine. It works by using killed viral particles to expose the body's immune system to the virus without risking a serious disease response.

Several countries, including Indonesia, Turkey and Singapore, have placed orders for the vaccine.

Covid strain found in South Africa 'could evade' Eli Lilly's antibody drug, CEO warns

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

The South African variant ... is the one of concern. It has more dramatic mutations to that spike protein, which is the target" of these antibody drugs, Ricks said on "Squawk Box." "Theoretically, it could evade our medicines."

Eli Lilly's antibody drug received emergency use authorization from the U.S. Food and Drug Administration in November. The drug is targeted toward people who are recently diagnosed with Covid-19, with the hopes of preventing the need for hospitalization. Regeneron's Covid-19 antibody treatment, which President Donald Trump received after contracting the disease, also has received limited clearance from the FDA.

WHO Scientists Will Arrive in China This Week to Begin Probe of Corovanirus Origins

https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

China says a team of scientists from the World Health Organization will arrive this week in Wuhan to begin its investigation of the origins of the coronavirus pandemic.

Foreign Ministry spokesperson Zhao Lijian said Tuesday that the 10-member team will leave from Singapore this Thursday and fly directly to Wuhan, the central city where the coronavirus was first detected in late 2019. The virus eventually spread to nearly every corner of the globe, leading to more than 1.9 million fatalities out of nearly 91 million infections.

China has sought to change the narrative over the virus’s origins, with officials eagerly pushing theories that it first emerged in other nations

Australian experts raise doubts over AstraZeneca vaccine efficacy

https://asia.nikkei.com/Spotli…raZeneca-vaccine-efficacy

Australian scientists have raised questions over the efficacy of the AstraZeneca COVID-19 vaccine in establishing herd immunity, calling for a pause on its widespread rollout as the country recorded one new coronavirus case on Wednesday.

The opposition to the vaccine casts a cloud over Australia's immunisation plans with 53 million doses of the AstraZeneca jab already on hand.