Covid-19 News

Tokyo considers trials of parasite drug for COVID-19

Ivermectin tablets to be assessed for possible home use

https://asia.nikkei.com/Spotli…arasite-drug-for-COVID-19

TOKYO -- The Tokyo Metropolitan Government plans to conduct clinical trials of the anti-parasitic drug Ivermectin at metropolitan and public hospitals to assess its effectiveness against COVID-19, Nikkei has learned.

Clinical trials will be conducted on patients with mild symptoms. Patients who are hospitalized mostly have moderate or serious symptoms. The metropolitan government will finalize the details of the study, including the size and duration of clinical trials, after the infection situation settles down.

The Tokyo government hopes to support the trials using some beds at metropolitan and public hospitals. Ivermectin will be given to patients with mild symptoms, comparing their response with those receiving a placebo.

Experiments with cells have shown that Ivermectin is effective in inhibiting the growth of COVID-19.

If Iivermectin, which comes in tablet form and is easy to handle, is confirmed to be effective, it is expected to be used for home-care patients, whose numbers are rising as hospital beds fill up in Tokyo.

Kitasato University Hospital began clinical trials of Ivermectin last September. The hospital announced that it will administer the drug to 240 patients by the end of March to see if it shortens the time required for patients to test negative in polymerase chain reaction tests.

Clinical trials of Ivermectin have been carried out for treatment and prevention purposes in such countries as Japan, the U.S. and India.

Ivermectin was developed by Kitasato University professor emeritus Satoshi Omura, for which he won the 2015 Nobel Prize in physiology or medicine. The drug has proved effective in eradicating parasitic infections in Africa and other regions. It has been given to billions of people and no serious adverse effects have been reported.

Can someone explain to me why everyone is so scared of the UK variant? If this is mutation can spread so fast why are the number of cases falling dramatically in the UK? Or do we already have herd immunitie reached there? I have not heard of any new rules in the UK that might explain this rapid decline.

https://www.google.com/search?…AIHHfNOArEQ4dUDCAw&uact=5

Quote from Epimetheus

Can someone explain to me why everyone is so scared of the UK variant? If this is mutation can spread so fast why are the number of cases falling dramatically in the UK? Or do we already have herd immunitie reached there? I have not heard of any new rules in the UK that might explain this rapid decline.

https://www.google.com/search?…AIHHfNOArEQ4dUDCAw&uact=5

this will help explain the waves we have seen and when the next will come. It will start building around March 1st and peak around the 21st with deaths following over the next month.

The role of season in the epidemiology of influenza.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134066/

Sunspots and flu: a correlation

R. E. HOPE-SIMPSON

https://www.nature.com/articles/275086a0

Quote from Epimetheus

Can someone explain to me why everyone is so scared of the UK variant?

According to the most recent papers the UK,RSA/BAR versions contain a mutation that allows the virus to better attach a second receptor. The folding around ACE-2 is totally different from the old one, what is the reason why the Pfizer antibodies cannot block them.

Quote from zorud

To be fair - lets get back to this and check in a few months. Israel would be an ideal patient population under the current circumstances (ready with vaccinations by summer, contract with Pfizer and accurate follow up).

It's now all up to the induced T-Cell response. T-Cells always produce a set of antibody variations of a once seen template for an antibody. But recent serum studies do show that this T-Cell response is to weak to protect people from a re-infection with the RSA/BRA. Thus using Pfizer's vaccine should be banned now.

The real result (and possible side effects) of course we only will get/see after at least one year. The most dangerous thing that could happen is: If Pfizer now clandestine updates the RNA. The higher affinity with ACE-2 could end up as really sad story. This has already been discussed among people that produced anti body cocktails - what is the far low risk as the body will not reproduce them!

Epidemic influenza and vitamin D

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870528/

SUMMARY

In 1981, R. Edgar Hope-Simpson proposed that a ‘seasonal stimulus’ intimately associated with solar radiation explained the remarkable seasonality of epidemic influenza. Solar radiation triggers robust seasonal vitamin D production in the skin; vitamin D deficiency is common in the winter, and activated vitamin D, 1,25(OH)2D, a steroid hormone, has profound effects on human immunity. 1,25(OH)2D acts as an immune system modulator, preventing excessive expression of inflammatory cytokines and increasing the ‘oxidative burst’ potential of macrophages. Perhaps most importantly, it dramatically stimulates the expression of potent anti-microbial peptides, which exist in neutrophils, monocytes, natural killer cells, and in epithelial cells lining the respiratory tract where they play a major role in protecting the lung from infection. Volunteers inoculated with live attenuated influenza virus are more likely to develop fever and serological evidence of an immune response in the winter. Vitamin D deficiency predisposes children to respiratory infections. Ultraviolet radiation (either from artificial sources or from sunlight) reduces the incidence of viral respiratory infections, as does cod liver oil (which contains vitamin D). An interventional study showed that vitamin D reduces the incidence of respiratory infections in children. We conclude that vitamin D, or lack of it, may be Hope-Simpson's ‘seasonal stimulus

Quote from Wyttenbach

It's now all up to the induced T-Cell response. T-Cells always produce a set of antibody variations of a once seen template for an antibody. But recent serum studies do show that this T-Cell response is to weak to protect people from a re-infection with the RSA/BRA. Thus using Pfizer's vaccine should be banned now.

The real result (and possible side effects) of course we only will get/see after at least one year. The most dangerous thing that could happen is: If Pfizer now clandestine updates the RNA. The higher affinity with ACE-2 could end up as really sad story. This has already been discussed among people that produced anti body cocktails - what is the far low risk as the body will not reproduce them!

So authorities should then bet on other horses ..Next to Ivermectin see promising early Leronlimab results from the linked TED presentation above...that may seem to help to live with a "degraded" SARS-CoV2 like wiht any other "cold"...? Without getting seriously sick (the vast majority of infected), simply take a pill....

Quote from Roseland67

What blithering idiots,

Why were there no arrests?

White privilege. The same reason the mob was politely escorted out of the capital building on Jan. 6.

This is a serious matter. The people in line were delayed for an hour. Those are mostly elderly people. It takes another 30 minutes to an hour to process them, so they were stuck in their cars probably with only porta-potties a half-mile a way, for 2 hours.

Quote from Bob#2

I must be missing something. .....Fewer than 66% of the people contracting Covid WITHOUT the vaccine do not have serious cases. This does not make much sense...this would imply the vaccine is basically useless.

You are missing something. It is a little complicated and confusing. When they say the vaccine reduces cases by 66%, they mean a large group of vaccinated people has 66% fewer infections than a control group of unvaccinated people. Neither group has many infections, even when there are, say, 20,000 members in both. So the numbers are approximate at best. But they are significant.

Here are the numbers from the Pfizer tests:

Among 36,523 participants who had no evidence of existing or prior SARS-CoV-2 infection by the time of the immunizations, there were 170 cases of COVID-19 observed with onset at least 7 days after the second dose; 8 cases occurred in vaccine recipients, and 162 in placebo recipients, corresponding to 95.0% vaccine efficacy (95% credible interval [CI, 90.3, 97.6]). Among participants with and without evidence of prior SARS CoV-2 infection, there were 9 cases of COVID-19 among vaccine recipients and 169 among placebo recipients, corresponding to 94.6% vaccine efficacy (95% CI [89.9, 97.3]).

https://www.businesswire.com/news/home/20201210005703/en/

Yesterday, NHK reported on a meta-analysis of COVID-19 papers done with a AI supercomputer. Apparently there are thousands of papers. Anyway, the conclusion of this meta-analysis is that many doctors and nurses became somewhat immune to the disease even before they were vaccinated. Apparently, they were breathing in tiny amounts of the virus, through N95 masks. Not enough for the virus to multiply and trigger a full scale infection, but enough to cause the body to produce antibodies. It is a sort of dangerous, accidental vaccination. The Russian Roulette school of medicine. Not recommended of course, but interesting.

Cases in Japan seem to be declining rapidly even though they have not begun vaccinations. That's good! But they need vaccinations to eliminate the disease completely. See:

https://covid19japan.com/

They plan to begin vaccinations at the end of February in Japan and S. Korea. See:

https://www.nytimes.com/2021/0…h-korea-vaccinations.html

In Japan, the government is mailing notices to every person telling them when and where to go for a vaccination. Of course it is no obligatory. If 80% of people get the vaccination, that should eliminate it with herd immunity.

Quote from JedRothwell

Apparently, they were breathing in tiny amounts of the virus, through N95 masks.

That's what we tell since masks were mandatory. Masks help other people to get "soft infections". A lock down has the opposite effect. If you get a soft infection and go/stay home the person at your side will get a strong/high dose infection. That's why Germany has a very high death rate with using the wrong masks.

Quote from JedRothwell

Here are the numbers from the Pfizer tests:

Among 36,523 participants who had no evidence......

Pfizer did heavily cheat. They excluded > 300 person from the vaccine group and only some 100 from the placebo. You simply cannot trust this figures as they in reality can be anything between 50...94%. But Pfizer is anyway out of business.

Quote from JedRothwell

Cases in Japan seem to be declining rapidly even though they have not begun vaccinations.

Tokyo just starts a broader use of Ivermectin for the less severe cases! I hope they will learn fast and stop the epidemic soon. Of course in Japan there is enough sunlight now!

Quote from JedRothwell

White privilege. The same reason the mob was politely escorted out of the capital building on Jan. 6.

This is a serious matter. The people in line were delayed for an hour. Those are mostly elderly people. It takes another 30 minutes to an hour to process them, so they were stuck in their cars probably with only porta-potties a half-mile a way, for 2 hours.

It wasn't the protestors who stopped the cars. They were at the side of the road with their signs and voices. It was the the LAPD or LAFD who decided to close the gate and pause the vaccinations. The protest was peaceful and civil. Perhaps you have these concerned citizens confused with some crazed leftists who were allowed to set fire to certain neighbourhoods shortly before the election last November.

About two days previous to this, the Baltimore Sun reports:

Jimmie Guzman, 42, who works at a homeless shelter, joined the stadium line at 1:10 p.m. He waited, crawled forward, waited, crawled forward. He got his shot more than four hours later, at about 5:30 p.m.

“I don’t mind at all,” Guzman said. “It’s a blessing to get it. I would have waited a lot longer than that.”

So people should have been expecting to be waiting in line for several hours anyway. Two layers of Depends for Grandma, and crank up the Nat King Cole.

Quote from Mark U

It wasn't the protestors who stopped the cars. They were at the side of the road with their signs and voices. It was the the LAPD or LAFD who decided to close the gate and pause the vaccinations. The protest was peaceful and civil.

It does seem that way from this video:

Quote from Mark U

So people should have been expecting to be waiting in line for several hours anyway.

Not in the DeKalb county site. It takes about 15 to 20 minutes in the middle of the day. About an hour if you show up for the first round at 8:30, because they have people line up before they open. It takes 10 minutes at a pharmacy, because they are better at filling in the forms over the internet before you come.

You have to stick around for 10 to 15 minutes after the vaccine, in case you have an allergic reaction.

Quote from Alan Smith

Knowing the way Japanese society is, I'm sure they will get 95% uptake.

You would think so, but the New York Times article points out that anti-vaccination propaganda has become widespread in Japan lately. I saw a couple of anti-vax bestselling paperback books when I was in a bookstore in Japan a few years ago. The Times says:

Another major potential complication for the Japanese government is a public that has demonstrated among the highest levels of skepticism about vaccines in the world. Misinformation, fueled by the media, has thwarted earlier campaigns.

Some of my crackpot elderly Japanese friends have been spewing QAnon and anti-vax conspiracy theories lately. It remains to be seen whether they will actually refuse to be vaccinated. Generally speaking, I think anti-vaccination people who actually mean it and follow through by not taking the vaccine are doing the rest of us a favor. They are giving us their place in line, and as a bonus, they may even remove themselves from the gene pool.

The notion that everyone should hurriedly take a medical product because some company and its cronies in govt said so, is rather comical. Chacon son gout! I once had fish head soup in France and definitely not for me!

Quote from Navid

The notion that everyone should hurriedly take a medical product because some company and its cronies in govt said so, is rather comical.

That is not the notion. Here is what people are saying. 3,000 people a day are dying in the U.S. 0.1% of the population has died. 6% of the people who go into the hospital with COVID-19 die. Among people age 65 who get the disease, ~4% die. Many people who survived said the pain was excruciating for weeks and they were afraid they might die at any moment. Hundreds of thousands of others are suffering from debilitating "long haul" symptoms that may last for years, or they may last the rest of their lives, the way the effects of the 1918 flu did.

The vaccine eliminates that threat close to 100% of the time. That's why people are hurrying to get it. Because they do not want to spend weeks in agony, or to die.

That is not a bit comical. It is the worst medical disaster since 1918. It has killed 2.2 million people, and it is likely to kill at least a million more before it can be contained. For you to describe this as "comical" is a lot like saying the bombing of Hiroshima was comical. You should shut the hell up.

Here is the case mortality graph. Navid apparently thinks this is hilarious, but I don't:

https://ourworldindata.org/mor…y-rate-of-covid-19-by-age

Quote from JedRothwell

You would think so, but the New York Times article points out that anti-vaccination propaganda has become widespread in Japan lately.

The New York Times only wants to protect the shareholder value.

Vaccine info:

Pfizer Biontech vaccine failed: Should no longer be used

Moderna : Still some use but only about 50%

J&J: So far a clear leader in effect/protection & safety & costs.

I would no longer tolerate the use of experimental RNA vaccines as we now have more than 2 classic ones with really known low safety issues.

Quote from JedRothwell

6% of the people who go into the hospital with COVID-19 die.

Obviously ^{these people are killed by the hospital/doctors} because they don't get the cheap & best working medication = ivermectin.

Pierre Kory,(the brawn), spelling out I V E R M E C T I N S A V E S L I V E S for the wilfully slow readers at NIH/FDA

Quote from Mark U

It wasn't the protestors who stopped the cars. They were at the side of the road with their signs and voices. It was the the LAPD or LAFD who decided to close the gate and pause the vaccinations. The protest was peaceful and civil. Perhaps you have these concerned citizens confused with some crazed leftists who were allowed to set fire to certain neighbourhoods shortly before the election last November.

About two days previous to this, the Baltimore Sun reports:

Jimmie Guzman, 42, who works at a homeless shelter, joined the stadium line at 1:10 p.m. He waited, crawled forward, waited, crawled forward. He got his shot more than four hours later, at about 5:30 p.m.

“I don’t mind at all,” Guzman said. “It’s a blessing to get it. I would have waited a lot longer than that.”

So people should have been expecting to be waiting in line for several hours anyway. Two layers of Depends for Grandma, and crank up the Nat King Cole.

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“Perhaps you have these concerned citizens confused with some crazed leftists who were allowed to set fire to certain neighbourhoods shortly before the election last November.”

Blasphemer, there is no way, none, that anyone from the political left would ever do that.

CNN would have told us if that was true, and they didn’t, so it must be a lie. 😂