Covid-19 News

    TM 2.47 the pharmacist picked up the dog version IVM +pyrantel..

    the horse version comes in two forms.. IVM only and IVM+pyrantel..


    although pyrantel is not so toxic..

    the IVM only form is preferable,

    "Pyrantel is a safe, effective, and inexpensive treatment for intestinal worms, and usually cures the condition after a single dose. It has very few side effects and is not known to cause toxicity in humans."

    Here is a private company seeking to make money by selling people Ivermectin as a COVID prophylatic.


    I've nothing against companies making money, and, frankly, people spend money on all sorts of things: not my business to decide for others what is wise or not.


    But it should concern all of us how evidence is reported. The idea here is that IVM can act as a prophylatic - essentially the same type of protection as a vaccination. That is valuable if it works, but also has a high bar to get over before the cost/reward equation looks good, because _only a few_ of the people who take the IVM in this form will actually be exposed to COVID, and therefore be in any position to gain benefit. Whereas all of them will risk any side effects.


    Vaccines therefore have phase I, II, III trials involving increasingly more people to check for side effects. And even after phase III, as we have seen, side effects at incredibly low levels - 1 in 1,000,000 are monitored and can put pauses on vaccine rollout.


    The safety study here is 3 X 8 volunteers. A phase 1 type study. A long way to go before the safety profile of this form of prophylaxis can be established. And prophylactic drugs are a worse bet for safety than vaccines - unless they are taken selectively only by those people who know they have been exposed, because the drug is delivered over a long period.


    More important, I know of no clear evidence that links IVM at the serum levels produced in this study to protection from COVID. There are neither theoretical (quantitative) estimates, not in vitro evidence (the much quoted in vitro evidence is at very high IVM levels) nor good study data.


    i know there is some study data - enough to keep IVM on people's radars just as HCQ was. And just as HCQ, there are many trials in process:


    https://pharmaceutical-journal…therapy-trials#Ivermectin


    Worth noting that the only randomized clinical trial that has results so far was negative.


    So - let us hope - but I think other anti-virals have better prospects.


    The big good news story for COVID is that vaccines work really well. And the mRNA vaccines, never before tried, seem very safe and effective, and are also very quickly tweaked to make boosters that squash variants with escape mutations.


    The next big respiratory disease pandemic will be met by and even faster vaccine response - so far that is the only way we know to deal with these threats that works.


    https://www.bbc.co.uk/news/health-56844220


    https://www.mirror.co.uk/news/…-pandemic-thanks-23966406


    You would think that this extraordinary success of vaccines in improving public health would knock the anti-vax arguments on the head. But no, it seems that the endemic anti-vax memes circulate widely on social media and only get more virulent (pandemic?) when we are in a position as now for vaccines to save the world, and where vaccine hesitancy costs lives and maybe livelihoods.


    It would interest me to know whether there is anyone on this forum who would not take any one of the COVID vaccines if offered, now the evidence is so compelling?

    Early evidence that vindicates the UK pragmatic "2 doses separated by 12 weeks" vaccine policy.


    First dose protection 65%

    second dose (separated by 12 weeks) protection: 90%

    Antibody response stays high up to 12 weeks.


    Based on these figures the saving in deaths is very large using a 2 dose wisely separated regimen. No clear evidence that it encourages vaccine-evading variants. We know those get encouraged anyway as soon as most of teh population has immunity.


    We now have COVID rates reducing, even as we open up, with 65% of people vaccinated one dose.

    Watch the FLCCC update video, if ivermectin can work as a vaccine big pharma will lose emergency use for vaccine. It's all about $$$ not about saving lives and stop with the anti vax crap! Many people who believe in ivermectin have been vaccinated. I am one and would rather take a drug that has years of study behind it rather than a great world study vaccine. But that's just common sense!!!!

    Scientists uncover a molecule that can help coronavirus escape antibodies


    https://medicalxpress.com/news…oronavirus-antibodies.amp


    Researchers have found that a natural molecule can effectively block the binding of a subset of human antibodies to SARS-CoV-2. The discovery may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.

    In their research, published in Science Advances today (April 22, 2021), teams from the Francis Crick Institute, in collaboration with researchers at Imperial College London, Kings College London and UCL (University College London), found that biliverdin and bilirubin, natural molecules present in the body, can suppress the binding of antibodies to the coronavirus spike.


    As vaccines are rolled out globally, understanding immunity to SARS-CoV-2 and also how the virus evades antibodies is critically important. However, there are still many unknowns. The ability of the immune system to control the infection and the quality of the antibody response are highly variable, and not well correlated, between individuals.


    The Crick researchers were involved in the development of tests that see if a person has been exposed to the virus. The scientists discovered that the SARS-CoV-2 spike protein strongly binds to biliverdin, a molecule which was giving these proteins an unusual green colouration.


    Working with teams at Imperial College London, UCL and Kings College London, they found that this natural molecule reduced antibody binding to the spike. They used blood sera and antibodies from people who were previously infected with SARS-CoV-2 and found that biliverdin could suppress the binding of human antibodies to the spike by as much as 30-50%, with some antibodies becoming ineffective at neutralizing the virus.


    Such a significant impact was completely unexpected, as biliverdin only binds to a very small patch on the virus' surface. To find out the mechanism at work, the team at the Crick used cryo-electron microscopy and X-ray crystallography to look in detail at the interactions between the spike, the antibodies and biliverdin. They found that biliverdin attaches to the spike N-terminal domain and stabilizes it so that the spike is not able to open up and expose parts of its structure. This means that some antibodies are not able to access their target sites and so cannot bind to and neutralize the virus.


    Annachiara Rosa, first author and postdoctoral training fellow in the Chromatin structure and mobile DNA Laboratory at the Crick, says: "When SARS-CoV-2 infects a patient's lungs it damages blood vessels and causes a rise in the number immune cells. Both of these effects may contribute to increasing the levels of biliverdin and bilirubin in the surrounding tissues. And with more of these molecules available, the virus has more opportunity to hide from certain antibodies. This is a really striking process, as the virus may be benefiting from a side effect of the damage it has already caused."


    Peter Cherepanov, author and a group leader of the Chromatin structure and mobile DNA Laboratory at the Crick, says: "In the first months of the pandemic, we were extremely busy churning out viral antigens for SARS-CoV-2 tests. It was a race, as these tests were urgently needed. When we finally found the time to study our green proteins, we expected a mundane answer. Instead, we were astonished to discover a new trick the virus uses to avoid antibody recognition. This is a result of a collaborative effort of several amazing teams working at the Crick and three partner universities, led purely by scientific curiosity."


    The researchers will continue this work from various angles, including measuring the levels of biliverdin and other haem metabolites in patients with COVID-19 and also exploring if it is possible to hijack the binding site used by biliverdin to potentially find new ways to target the virus.

    Quote from THHuxleynew

    But it should concern all of us how evidence is reported. The idea here is that IVM can act as a prophylatic - essentially the same type of protection as a vaccination. That is valuable if it works, but also has a high bar to get over before the cost/reward equation looks good, because _only a few_ of the people who take the IVM in this form will actually be exposed to COVID, and therefore be in any position to gain benefit. Whereas all of them will risk any side effects.

    Welcome back to our FM/R/J mafia trumpet THH! In the Argentina trial 600 healthcare people did take Ivermectin. None did contain CoV-19 but 256 in the control. So Ivermectin works much better than any vaccines. In Africa several millions of people take this prevention dose for river blindness every week.

    So we have evidence of no harm from a > 10 mio people trial....

    Quote from THHuxleynew

    The big good news story for COVID is that vaccines work really well. And the mRNA vaccines, never before tried, seem very safe and effective, and are also very quickly tweaked to make boosters that squash variants with escape mutations.

    We still have no evidence for no harm for RNA vaccines that in my opinion should have been stopped since week two. If ever you need a vaccine then take J&J. It is by far the safest- that why the mafia did black mail it.


    I guess our trumpet did never read any details in the VERS/Wonder database where about 1/10 of the US adverse cases are registered or even less. We know this as we now have the European database, that shows far more than 10X severe adverse reactions for the RNA vaccines than VERS/Wonder. This only shows how our US mafia friends act behind the scene.


    Further there is absolute no need for a vaccine for healthy people younger than 65 except these have risks. If you have ivermectin ready then CoV-19 is just a medium cold.


    It seems once more our trumpet just sounds for the pharma money laundering people.

    Confusion continues to rule! Pfizer-BioNTech said boosters would be needed by as early as September but John hopkins says not so fast

    Question... Why would pfizer announce the need for boosters? I'll answer for you....$$$$$$$$$$$$$$$$$


    Study shows vaccines may protect against new COVID-19 strains—and maybe the common cold


    https://medicalxpress.com/news…trainsand-common-cold.amp


    A new study by Johns Hopkins Medicine researchers provides evidence that CD4+ T lymphocytes—immune system cells also known as helper T cells—produced by people who have received either of the two messenger RNA (mRNA) vaccines for COVID-19 caused by the original SARS-CoV-2 strain also will recognize the mutant variants of the coronavirus that are rapidly becoming the dominant types worldwide.

    The researchers say this suggests that T cell responses elicited or enhanced by the vaccines should be able to control the current SARS-CoV-2 variants without needing to be updated or modified. They also found that the same T cells may provide some protection from another member of the coronavirus family that is responsible for one type of the common cold.


    The findings were reported April 6, 2021, in the Journal of Clinical Investigation.


    CD4+ T cells get their "helper" nickname because they assist another type of immune cell, the B lymphocyte (B cell), in responding to surface proteins—antigens—on cells infected by invaders that include viruses such as SARS-CoV-2. Activated by the CD4+ T cells, immature B cells become either plasma cells that produce antibodies to mark infected cells for disposal from the body or memory cells that "remember" the antigen's biochemistry for a faster response to future infections.


    In the case of SARS-CoV-2, the antigen is the protein making up the spikes that protrude from the surface of the virus. The mRNA vaccines—known by their manufacturer's names, Pfizer-BioNTech and Moderna—provide genetic instructions to a vaccinated person's immune system to recognize the spike protein and start production of antibodies against SARS-CoV-2.


    CD4+ T cells also send out chemical messengers that attract another type of T cell—known as the CD8+ T cell (or "killer T cell")—so that the virus-infected cells can be removed.


    To conduct their helper T cell study, the researchers evaluated blood samples from 30 healthy health care workers and laboratory donors who had not previously tested positive for SARS-CoV-2—both before and after two doses of a COVID-19 mRNA vaccine. The participants, 12 women and 18 men, ranged in age from 20 to 59.


    CD4+ T cells extracted from the blood samples were analyzed for their responses to various components (protein fragments known as peptides) from the original strain SARS-CoV-2 spike protein and three common cold coronaviruses.


    The researchers discovered that vaccine recipients—as expected—had broad T cell responses to the original strain SARS-CoV-2 spike peptides.


    "We identified 23 distinct T cell-targeted peptides, of which only four appear affected by the mutations that created the variant coronaviruses first seen in the United Kingdom and South Africa," says study senior author Joel Blankson, M.D., Ph.D., professor of medicine at the Johns Hopkins University School of Medicine. "That means the other 19 peptides are the same in the original SARS-CoV-2 and the newer strains, so the mRNA vaccines should induce T cells that respond well to the variants."


    Blankson says this is important because previous studies showed that antibodies don't recognize the SARS-CoV-2 variants as well as the CD4+ T cells.


    "So the T cells may help prevent the variant viruses from causing severe COVID-19 disease even if antibodies don't stop them from infecting a person," he explains.


    When the researchers looked at the vaccine-induced T cell response to the spike proteins of three common cold coronaviruses, they saw a three-fold increase for one, HCoV-NL63, but not the other two.


    "Further studies are needed to determine why this occurred," says Blankson. "We suspect that HCoV-NL63 may have more epitopes [peptides that elicit an immune response] in common with SARS-CoV-2 than the other common cold coronaviruses."


    In a recent and related study, Blankson and Johns Hopkins Medicine colleagues looked at blood from convalescent patients who had recovered from a SARS-CoV-2 infection and identified the unique receptors on memory CD4+ T cell that recognize the spike proteins of both the original strain of SARS-CoV-2 and four common cold coronaviruses.


    Blankson says that characterizing these T cell receptors may be helpful in guiding development of future vaccines for a variety of coronaviruses.

    Beijing Urges WHO Leader Not to Pursue 'Lab Leak' Theory


    https://www.voanews.com/covid-…ursue-lab-leak-theory?amp


    China is lashing out at the chief of the World Health Organization for suggesting that more study is needed into the possibility that the coronavirus responsible for the COVID-19 pandemic initially escaped from a laboratory in Wuhan, China.


    Global Times, an influential news outlet controlled by China's ruling Communist Party, pointed this week to comments by Tedros Adhanom Ghebreyesus, the Ethiopian-born director-general of the WHO, to the effect "that further investigation is needed on the hypothesis of a 'lab leak' being the origin of COVID-19."


    The front-page report quoted a Chinese foreign ministry spokesperson urging "the WHO to play a leading role in respecting science."


    The criticism is ironic, given that Tedros has been widely accused of being too close to China, including by former U.S. President Donald Trump, who described the WHO leader as "China-centric" in cutting off U.S. funding to the health agency last year.


    Beijing's latest broadside appears aimed at remarks by Tedros on March 30, when the WHO released the findings of an investigative team that had spent four weeks in China.

    Speaking in Geneva, Tedros listed various scenarios to account for the origin of the virus, including that it originated in bats and then infected another animal, leading to widespread contamination in the Huanan Seafood Market in Wuhan.


    The WHO director also addressed a theory that the virus could have escaped from a virology laboratory just kilometers from the Huanan market, where similar viruses are being studied.


    "Although the team has concluded that a laboratory leak is the least likely hypothesis, this requires further investigation, potentially with additional missions involving specialist experts, which I am ready to deploy," Tedros said.


    "The team also visited several laboratories in Wuhan and considered the possibility that the virus entered the human population as a result of a laboratory incident," he said. "However, I do not believe that this assessment was extensive enough. … Further data and studies will be needed to reach more robust conclusions."


    Chinese media this week quoted an unnamed Chinese expert who took part in the investigation as saying that Tedros' remarks have "already been used by those with ulterior motives to question the authority and scientific quality" of the report issued by WHO.


    The expert warned that "WHO will have to be held accountable if worldwide effort at [virus] origin tracing enters a deadlock."

    Wyttenbach , you being the ivermectin man, I found this study on ivermectin and glucose, it seems to me to be the smoking gun for ivermectin as an emergency use drug for Covid. I'd like your thoughts.


    The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism


    https://www.nature.com/article…%20as%20an%20FXR%20ligand.


    Abstract

    Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the FXR with distinctive properties in modulating coregulator recruitment. The crystal structure of ivermectin complexed with the ligand-binding domain of FXR reveals a unique binding mode of ivermectin in the FXR ligand-binding pocket, including the highly dynamic AF-2 helix and an expanded ligand-binding pocket. Treatment of wild-type mice, but not of FXR-null mice, with ivermectin decreases serum glucose and cholesterol levels, suggesting that ivermectin regulates metabolism through FXR. Our results establish FXR as the first mammalian protein targeted by ivermectin with high selectivity. Considering that ivermectin is a widely used clinical drug, our findings reveal a safe template for the design of novel FXR ligands.


    Metabolic effects of ivermectin in mice on a high-fat diet

    To investigate whether ivermectin has effects on glucose and cholesterol metabolism in vivo as a FXR ligand, wild-type and FXR–/– mice were fed with high-fat diet and intraperitoneally (i.p.) injected daily with vehicle or ivermectin for 14 days. Of note, no liver injury of ivermectin treatment was observed when evaluated by aspartate aminotransferase, alanine aminotransferase and liver histology (Supplementary Fig. S7), in consistency with published results30,31. Interestingly, serum glucose and cholesterol, including high-density lipoprotein and low-density lipoprotein (LDL)/very LDL levels, were significantly decreased in wild-type mice after treatment with ivermectin (Fig. 5 and Supplementary Fig. S8), whereas ivermectin treatment had no effect on food intake and body weight (Fig. 5a). In contrast, no significant differences of serum glucose and cholesterol levels were observed by ivermectin treatment in FXR–/– mice. Notably, the serum insulin level was significantly decreased in ivermectin-treated wild-type mice (Fig. 5d), suggesting that ivermectin might have lowered the serum glucose levels through improving insulin sensitivity. Indeed, ivermectin-injected mice showed improved insulin sensitivity as well as glucose tolerance compared with vehicle-treated controls (Supplementary Fig. S9). We conclude that ivermectin is capable of regulating serum glucose and cholesterol levels by directly targeting FXR.

    Quote from Fm1

    Watch the FLCCC update video, if ivermectin can work as a vaccine big pharma will lose emergency use for vaccine. It's all about $$$ not about saving lives and stop with the anti vax crap! Many people who believe in ivermectin have been vaccinated. I am one and would rather take a drug that has years of study behind it rather than a great world study vaccine. But that's just common sense!!!!

    I think it’s common sense to get

    Vaccinated and have Ivermectin

    handy.

    Quote from THHuxleynew

    It would interest me to know whether there is anyone on this forum who would not take any one of the COVID vaccines if offered, now the evidence is so compelling?


    Everyone should be a vaccine sceptic.

    I am a vaccine sceptic to the extent that I am cautious and I want to hear the evidence.

    Is the vaccine safe, no medical treatment is perfectly safe, ok what are the risks then?

    Why do I need to take the vaccine? What are the risks if I don't take the vaccine?

    I certainly would not want to be one of the first million to take the vaccine.

    Being as i am in my 60's it seemed most prudent to have the vaccine.

    I have to admit I was secretly glad to get the Pfizer one rather then the Astra/Zeneca but I would have accepted either.


    I get that, for many, the risk of actually getting the vaccine is like being given a pill, or a sweet, and before you put it in your mouth you are told there is a 2 in 1 million risk of it killing you.

    On its own terms a lot of people would refuse the pill because is its a concrete risk. Whereas Covid is a more abstract risk, you might not even catch it, and if you do it most likely will not be severe.

    People are not good at risk assessment. Is taking a vaccine taking a risk or is it taking protection?


    I also get the selfish pragmatist who says, let everyone else go for herd immunity and I will then not need to take the vaccine.


    I even get that some people are by nature contrary to authority and so will refuse. Fine, I am not aware of any government that is forcing its citizens to have the vaccine.


    What I don't get are those people that don't wish to take the vaccine and then spread disinformation to discourage as many others from taking the vaccine as possible. Who does this help?

    This course of action disrupts the fight against the pandemic. As such it costs lives and damages the economy. Ironically many such protests carry the talismans of nationalism and yet they are actively damaging the recovery of their own country. So, as I say, it makes no sense to me.

    Quote from Fm1

    The expert warned that "WHO will have to be held accountable if worldwide effort at [virus] origin tracing enters a deadlock."

    The WHO is the servant of many masters.

    The Chinese want the WHO to run to their agenda.

    Others wants the WHO to act like a policeman and go into China and find something.

    Does the WHO have the power and authority to go wherever they want in any country?

    Quote from Fm1

    Blankson says this is important because previous studies showed that antibodies don't recognize the SARS-CoV-2 variants as well as the CD4+ T cells.

    This is why an infection protects you much better than a vaccine! The news about vanishing antibodies is just Pfizer marketing with no real medical background.

    Quote from Fm1

    The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

    2013 paper. They think it could help obese people - but not at the cost of 10 cents. Simply to cheap....

    Quote from ZenoOfElea

    Everyone should be a vaccine sceptic.

    Every one should be a big pharma sceptic. Glad to hear that you bought a car with no warranty. This must be something special for a layer...

    Quote from ZenoOfElea

    Everyone should be a vaccine sceptic.

    I am a vaccine sceptic to the extent that I am cautious and I want to hear the evidence.

    Is the vaccine safe, no medical treatment is perfectly safe, ok what are the risks then?

    Why do I need to take the vaccine? What are the risks if I don't take the vaccine?

    I doubt you want to hear the evidence. I say that because all the questions you raise here have been answered in detail. Enormous detail. More detail than any other vaccine or medical treatment in history. So, if you wanted to know, you would have read all of this by now, and you wouldn't be raising these questions here. I think you are raising them only to spread doubts and confusion. Either that, or you have not been paying attention, you do not realize what has been published, and you are not serious about finding out.

    Quote from Fm1

    someone posted that there is no coercion in the United States on getting vaccine......... FAKE NEWS!!!!!!


    Houston Methodist says it will fire hospital workers who refuse to take COVID vaccine

    You misunderstand. Houston Methodist is not part of the government. No U.S. Federal or local government is going to coerce anyone to get the vaccine. Private organizations are free to coerce anyone they like. That's between them and their employees. By the same token, no one can force you to wear a mask, or put on a shirt and shoes, but a grocery store can ban you from entering without a mask, shirt and shoes. A grocery store is private property and they can make any rules they want, as long as they do not demand you do something illegal, and their rules are not discriminatory (such as banning minorities).

    Quote from JedRothwell

    ou misunderstand. Houston Methodist is not part of the government.

    ..HM is in the US. Yes or No?

    Coercion is in HM..

    Therefore coercion is in the United States..

    Land of the free.. freedom is relative ask an Uighur..


    Here in Oz the 3000$ compulsory quarantine has been lifted for visitors from NZ

    and vice versa... pending infections.. we now live in a South Sea bubble

    https://www.bbc.com/news/business-56796943

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