Covid-19 News

    Here is a fascinating look at the Pfizer production lines. Amazing! It looks a lot like a top-quality experiment. Which it is. See:


    https://www.nytimes.com/intera…-coronavirus-vaccine.html


    This has both text and short, high resolution video portions. It shows close-ups of the equipment. It briefly explains many of the steps in the processing. For example, it shows how the RNA is encased in lipids. For much more detail about that step, see:


    https://www.mdpi.com/2076-393X/9/1/65/htm


    This will sound familiar to an experimentalist:


    "A rack of 16 pumps precisely controls the flow of the mRNA and lipid solutions, then mixes them together to create lipid nanoparticles. . . .

    Synchronizing eight pairs of pumps is not an ideal solution, but Pfizer engineers chose to scale up existing technology instead of trying to build a larger, unproven type of precision mixing device. . . ."


    New York Times articles about the pandemic are not behind their paywall, so anyone can see this, I think.

    Quote from Shane D.

    I understand what you are saying, but speaking for myself, I am vaccinated and have no problem with being in the company of those who are not. One of the reasons for getting vaccinated is so we can get out and do what we want, without worry about how others choose to live their life.

    Many will feel this way and agree with Shane D.

    But many will agree with Jed.


    How many would want to move a beloved parent into a care home if many of the staff were not vaccinated?


    How many would not want to get on a plane knowing that the person talking to you from the next seat is not vaccinated?


    Seems to me that a lot of the debate is about politicians forcing people to have vaccinatation.

    As I said before I am not aware of any country doing such. You are free not to have the vaccine.


    I think the real debate is about business.

    Care homes, airlines and many other businesses need to weigh up who they are going to pander to.

    Do they lose more business by having no restrictions, or do they lose more business by having more restrictions?

    Quantas has already made a decision.

    Just as individuals are free to decide what is best for them, so the free market means that businesses will do what they feel is best for their business.


    As an addendum; It would be interesting if anybody knows how the insurance business reacts to this, travel insurance, business insurance etc. Does anybody have any updates on this topic?

    Why don't you mature your thinking - if we don't want a govt and want a free market - let's go there.

    In a free market, people could decide to take IVM, or the V or nothing.

    We have a private group of individuals who have co-opted the free market and are in control of the govts by policy (WHO).

    The v agenda was clear as day, in retrospect began years ago by private collusion in cooperation with CDC/NIAD/etc

    Let's raise the level of conversation from the simple minded - "everyone can do what they want" - if we were in a Liberterian world - we would never have even had a pandemic - not private gof research - no pandemic.

    Quote from Navid

    Why don't you mature your thinking - if we don't want a govt and want a free market - let's go there.

    In a free market, people could decide to take IVM, or the V or nothing.

    That is what we have! You have nothing to complain about. Everyone is free to take or not take the vaccine. Also, companies are free to ban people who do not take the vaccine, just as they are free to ban people who do not wear shoes.

    Quote from JedRothwell

    That could be bad news, because the mRNA vaccines produce only the spike protein.

    You mix it up once more. The mRNA vaccine only contains - a portion of - the spike protein. So if this portion has the wrong shape it could effectively do some harm what we did see. But the vaccine disappears after some hours and there is no long time interaction.


    So the RNA vaccine finally induces anti bodies to the spike protein what could be a problem as this blocks an important signaling path.

    Quote from ZenoOfElea

    How many would not want to get on a plane knowing that the person talking to you from the next seat is not vaccinated?

    Vaccinated people express about 50% less virus than a person without does - after an infection. But you sit close to this guy for hours! Do you really want to sit near a vaccinated person that spreads virus without a mask???


    You better take some ivermectin before boarding. This would cost less than a candy and fully protects you!

    Quote from Wyttenbach

    Vaccinated people express about 50% less virus than a person without does - after an infection. But you sit close to this guy for hours! Do you really want to sit near a vaccinated person that spreads virus without a mask???

    A few days ago in Brampton (bordering Toronto) a 13 year old girl died of pneumonia brought on by Covid. Her father and brothers had been tending to her at home, but she was found unexpectedly deceased in the morning in her bedroom. The mother had been (and still is) in the hospital, fighting Covid. The entire family had been isolating at home for weeks (per government lockdown instruction!) , and the father, who was an 'essential' worker in a warehouse, was the only person who was out and about. So the wife and his daughter in all likelihood caught Covid from the husband. The husband had been vaccinated two weeks earlier, and had tested negative.


    (False negatives occur relatively frequently ; false negative rates reach their lowest about 3 days after symptoms start, at about 20 percent, and rise steeply before that time and not as steeply after that time.)


    So to the natural, unvaccinated souls out there, who are concerned about Covid : be aware of vaccinated people, especially those recently vaccinated! They are more likely to be asymptomatic while shedding the virus.

    Quote from Mark U

    The entire family had been isolating at home for weeks (per government lockdown instruction!) , and the father, who was an 'essential' worker in a warehouse, was the only person who was out and about.

    Lockdowns done the Western style increase death by about a factor of 3.


    The main problem is that you stay at home in a closed room and restlessly breath in virus brought home by the only person that is allowed to go out without any protection.

    Surgical masks are no protection at all. Only FP98 are more or less are safe for 8 hour work. Also FP95 is to weak no even talking about FP2...

    So the best thing you can do is leave your home as long as you can stay outdoors, of course without any mask. A curfew is meant to intentionally kill people by increasing the exposure time indoors.


    If a droplet with virus falls on your silly surgical masks, then it will sooner or later dry out and you will breath in all the virus on yr mask. So it is mandatory to remove the mask when you leave a shop!!!


    Other orders (mandatory mask outdoors) as in France, USA etc.. are made by ruthless idiots that want to kill as many people as possible.

    Quote from Wyttenbach

    Other orders (mandatory mask outdoors) as in France, USA etc.. are made by ruthless idiots that want to kill as many people as possible.

    It's so crazy, it's tempting to think that. I would say the leadership in such countries wants to give the impression that they are soooo concerned for the safety of their electorate that they would go to such extreme measures as mandating masks outdoors, despite the science. Also, much of the citizenry like the idea that they can do *something*, anything, against the virus. It doesn't hurt that they can then feel good about their virtuous act of self sacrifice and compliance to Mommy state.

    But Mommy is turning into a tyrant.

    Just look at Canada. Late on Friday the following happened, thanks in large part to the atmosphere of panic surrounding Covid.


    https://nationalpost.com/news/…ed-assault-on-free-speech


    The Liberal-dominated House of Commons Heritage committee has cleared the way for the federal government to regulate video content on internet social media, such as YouTube, the same way it regulates national broadcasting, under a new amendment made to a bill updating the Broadcasting Act.

    Critics denounced the move to give the country’s broadcast regulator the ability to oversee user-generated content, and said it amounted to an attack on the free expression of Canadians, particularly in light of Heritage Minister Steven Guilbeault’s recent plans to give Ottawa power to order take-downs of online content it deems objectionable.

    • Official Post
    Quote from ZenoOfElea

    Seems to me that a lot of the debate is about politicians forcing people to have vaccinatation.

    As I said before I am not aware of any country doing such. You are free not to have the vaccine.

    My impression is that in the UK people are (mostly) jumping at the chance to get vaccinated, the clinics are always busy. As a nation of masterless eccentrics with a highly diverse population there are of course dissenters- both silent and noisy, but they mostly seem to be among the under-40's (the Facebook kids) who are less at risk personally.

    Control-theoretic immune tradeoffs explain SARS-CoV-2 virulence and transmission variation


    https://www.biorxiv.org/content/10.1101/2021.04.25.441372v1


    Abstract

    Dramatic variation in SARS-CoV-2 virulence and transmission between hosts has driven the COVID-19 pandemic. The complexity and dynamics of the immune response present a challenge to understanding variation in SARS-CoV-2 infections. To address this challenge, we apply control theory, a framework used to study complex feedback systems, to establish rigorous mathematical bounds on immune responses. Two mechanisms of SARS-CoV-2 biology are sufficient to create extreme variation between hosts: (1) a sparsely expressed host receptor and (2) potent, but not unique, suppression of interferon. The resulting model unifies disparate and unexplained features of the SARS-CoV-2 pandemic, predicts features of future viruses that threaten to cause pandemics, and identifies potential interventions.

    COVID-19 alters human genes, explaining mystery behind coronavirus ‘long haulers’


    https://www.studyfinds.org/cov…s-genes-long-haulers/?amp


    For some COVID-19 patients, getting over their infection is just the beginning of the recovery. Over the last year, COVID “long haulers” have continued experiencing a variety of symptoms months after the virus clears. These include anything from skin problems, to shortness of breath, to losing the sense of taste or smell. Now, researchers say they may know why this is happening. A new study finds coronavirus actually causes long-term changes to an infected patient’s genes

    Specifically, scientists reveal the spike protein of SARS-CoV-2, the virus causing COVID-19, creates long-lasting changes to human gene expression. These tiny spikes cover the surface of coronavirus cells. They allow the virus to bind to certain receptors on human cells and hijack their functions — leading to COVID infection. Once the spike cuts into a patient’s cells, the virus releases its own genetic material into the cell so it can replicate.

    Spikes make long-term changes to human lung cells

    Researchers examined how exposure to spike protein impacts cultured human airway cells in lab experiments. They also compared the results to studies using cell samples from actual COVID-19 patients.

    The team notes culturing human airway cells requires time and specific conditions which help the cells mature. This allows the lab cells to develop into the different cells living in a real human airway. To do this, study authors refined a culturing technique called air-liquid interface so they could more closely simulate the conditions in an actual patient’s lungs.


    After culturing, scientists exposed the cells to low and high concentrations of purified spike protein. The results reveal differences in gene expression which remained in the cells even after the infection passed. The most affected genes include ones controlling the body’s inflammatory response.

    The team notes culturing human airway cells requires time and specific conditions which help the cells mature. This allows the lab cells to develop into the different cells living in a real human airway. To do this, study authors refined a culturing technique called air-liquid interface so they could more closely simulate the conditions in an actual patient’s lungs.


    After culturing, scientists exposed the cells to low and high concentrations of purified spike protein. The results reveal differences in gene expression which remained in the cells even after the infection passed. The most affected genes include ones controlling the body’s inflammatory response.

    The team is presenting their findings at Experimental Biology (EB) 2021, a virtual meeting of the American Society for Biochemistry and Molecular Biology.

    New insights into how South African SARS-CoV-2 variant sacrifices tight binding for antibody evasion


    https://www.news-medical.net/a…for-antibody-evasion.aspx


    The highly infectious SARS-CoV-2 variant that recently emerged in South Africa, known as B.1.351, has scientists wondering how existing COVID-19 vaccines and therapies can be improved to ensure strong protection.


    Now, researchers reporting in ACS' Journal of Medicinal Chemistry have used computer modeling to reveal that one of the three mutations that make variant B.1.351 different from the original SARS-CoV-2 reduces the virus' binding to human cells -- but potentially allows it to escape some antibodies.


    Since the original SARS-CoV-2 was first detected in late 2019, several new variants have emerged, including ones from the U.K., South Africa and Brazil. Because the new variants appear to be more highly transmissible, and thus spread rapidly, many people are worried that they could undermine current vaccines, antibody therapies or natural immunity.

    Variant B.1.351 bears two mutations (N501Y and E484K) that can enhance binding between the receptor binding domain (RBD) of the coronavirus spike protein and the human ACE2 receptor.

    However, the third mutation (K417N; a lysine to asparagine mutation at position 417) is puzzling because it eradicates a favorable interaction between the RBD and ACE2. Therefore, Binquan Luan and Tien Huynh from IBM Research wanted to investigate potential benefits of the K417N mutation that could have caused the coronavirus to evolve along this path.


    The researchers used molecular dynamics simulations to analyze the consequences of the K417N mutation in variant B.1.351. First, they modeled binding between the original SARS-CoV-2 RBD and ACE2, and between the RBD and CB6, which is a SARS-CoV-2-neutralizing antibody isolated from a recovered COVID-19 patient.


    They found that the original amino acid, a lysine, at position 417 in the RBD interacted more strongly with CB6 than with ACE2, consistent with the antibody's therapeutic efficacy in animal models. Then, the team modeled binding with the K417N variant, which changes that lysine to an asparagine. Although this mutation reduced the strength of binding between the RBD and ACE2, it decreased the RBD's binding to CB6 and several other human antibodies to a much greater extent.


    Thus, variant B.1.351 appears to have sacrificed tight binding to ACE2 at this site for the ability to evade the immune system. This information could prove useful to scientists as they work to enhance the protection of current vaccines and therapies, the researchers say.

    If this is confirmed and antibodies remain robust, WOW!!!


    Antibody responses to SARS-CoV-2 mRNA vaccines are detectable in saliva


    https://www.biorxiv.org/conten…/2021.03.11.434841v1.full


    Abstract

    Vaccines are critical for curtailing the COVID-19 pandemic (1, 2). In the USA, two highly protective mRNA vaccines are available: BNT162b2 from Pfizer/BioNTech and mRNA-1273 from Moderna (3, 4). These vaccines induce antibodies to the SARS-CoV-2 S-protein, including neutralizing antibodies (NAbs) predominantly directed against the Receptor Binding Domain (RBD) (1-4). Serum NAbs are induced at modest levels within ∼1 week of the first dose, but their titers are strongly boosted by a second dose at 3 (BNT162b2) or 4 weeks (mRNA-1273) (3, 4). SARS-CoV-2 is most commonly transmitted nasally or orally and infects cells in the mucosae of the respiratory and to some extent also the gastrointestinal tract (5). Although serum NAbs may be a correlate of protection against COVID-19, mucosal antibodies might directly prevent or limit virus acquisition by the nasal, oral and conjunctival routes (5). Whether the mRNA vaccines induce mucosal immunity has not been studied. Here, we report that antibodies to the S-protein and its RBD are present in saliva samples from mRNA-vaccinated healthcare workers (HCW). Within 1-2 weeks after their second dose, 37/37 and 8/8 recipients of the Pfizer and Moderna vaccines, respectively, had S-protein IgG antibodies in their saliva, while IgA was detected in a substantial proportion. These observations may be relevant to vaccine-mediated protection from SARS-CoV-2 infection and disease.


    Vaccines are critical for curtailing the COVID-19 pandemic (1, 2). In the USA, two highly protective mRNA vaccines are available: BNT162b2 from Pfizer/BioNTech and mRNA-1273 from Moderna (3, 4). These vaccines induce antibodies to the SARS-CoV-2 S-protein, including neutralizing antibodies (NAbs) predominantly directed against the Receptor Binding Domain (RBD) (1-4). Serum NAbs are induced at modest levels within ∼1 week of the first dose, but their titers are strongly boosted by a second dose at 3 (BNT162b2) or 4 weeks (mRNA-1273) (3, 4). SARS-CoV-2 is most commonly transmitted nasally or orally and infects cells in the mucosae of the respiratory and to some extent also the gastrointestinal tract (5). Although serum NAbs may be a correlate of protection against COVID-19, mucosal antibodies might directly prevent or limit virus acquisition by the nasal, oral and conjunctival routes (5). Whether the mRNA vaccines induce mucosal immunity has not been studied. Here, we report that antibodies to the S-protein and its RBD are present in saliva samples from mRNA-vaccinated healthcare workers (HCW). Within 1-2 weeks after their second dose, 37/37 and 8/8 recipients of the Pfizer and Moderna vaccines, respectively, had S-protein IgG antibodies in their saliva, while IgA was detected in a substantial proportion. These observations may be relevant to vaccine-mediated protection from SARS-CoV-2 infection and disease.

    Here is an article for the layman explaining exponential decay in epidemics. I wish more people understood this.


    https://www.nytimes.com/2021/0…id-exponential-decay.html


    The author describes how decay curves tend to be smoother than the exponential increase phase. Quote: "Fortunately, the exponential dynamics that lead to wild swings in case numbers when cases are high lead to far less dramatic swings when cases are low. And as more and more people are vaccinated, the swings will also shrink, since fewer people are susceptible to infection." She mentions Israel. The curves in Israel are a close match to her description:


    https://www.worldometers.info/coronavirus/country/israel/


    Another version:


    https://ourworldindata.org/coronavirus/country/israel


    QUOTE:


    "It is possible to bring Covid-19 case numbers down quickly via exponential decay even before vaccination rates reach herd immunity. We just need to keep transmission rates below the tipping point between exponential growth and exponential decay: where every person with Covid-19 infects fewer than one other person. Every single thing people can do to slow transmission helps — including wearing masks, getting tested and avoiding crowded indoor spaces — especially given concerns about current and future variants, since it could be what gets us past the threshold into exponential decay. . . ."


    This is what you see in Japan. Vaccination rates are still low. The 4 peaks were caused by people slacking off on social distancing, masks, and voluntary partial lockdowns. The previous 3 peaks were brought down by the voluntary lockdowns, and the 4th one is starting to respond to the latest lockdown. Of course it is far better to use vaccination, but unfortunately the Japanese government has not been able to purchase large numbers of vaccines yet.


    People who claim that masks, social distancing and (at last resort) lockdowns do not work should look closely at events in Japan. They are the most clear proof that these things work. The vaccines work far better, and they are a permanent solution, as you see in the data from the UK and Israel.

    FLCCC weekly update, ivermectin in india and around the world.


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    This person says "We still believe that IVERMECTIN is SAVING INDIA." Nothing is saving India. The pandemic is out control, with exponential growth. The only thing that can possibly reduce the carnage in the short term would be universal masks and a strict lockdown. It is not possible to deploy the vaccines quickly enough to avoid hundreds of thousands more deaths. That is dreadful, but that's how things are. It should be a warning to all other countries, including the U.S. It should also tell anti-vaccine Death Cult lunatics how wrong they are, but nothing will disabuse them of their delusions.


    It could be that ivermectin is effective, and the situation would be even worse without it. I do not know enough to judge. But to say that anything is "saving" India now is grotesque. If 379,000 new cases per day and 3,600 deaths is "saving" India, what would a catastrophe be like? Obviously, however good ivermectin may be, it is not good enough to stop mass deaths. Whereas it is 100% certain that vaccines would stop the pandemic, as you see in the UK and Israel. If 90% of the people in the world were vaccinated, the virus would go extinct in the human population. (It might infect people from some animal again in the future.)


    Prophylaxis is never as good as a vaccine. The best treatment is never as good as prevention. And public health saves more lives than all the hospitals combined.

    Quote from JedRothwell

    It could be that ivermectin is effective, and the situation would be even worse without it. I do not know enough to judge. But to say that anything is "saving" India now is grotesque. If 379,000 new cases per day and 3,600 deaths is "saving" India, what would a catastrophe be like?

    Did you listen to the above video?? All answers about India are in there.


    You are a guy that just makes noise with no foundation!

    Overview of Israel data until end of February: https://www.nature.com/articles/s41591-021-01337-2.pdf


    Clearly shows that the older are well protected after 2 jabs. Also clearly shows that the Pfizer jab's effect are delayed at least by 2-4 weeks.

    Today Israel has less than 150 cases. Why they discuss about a Covid pass is nuts. 150 cases is less than any flu or other illness....Further Israel did not totally block ivermectin so far.

    Peru did block Ivermectin after a successful campaign and now is in a total mess. We will soon know which big pharma did help do spoil the last Peru elections...in favor of a vaccinator - vampire...

    Bulgaria is on track with ivermectin and Mexico too, Slovakia just got the first large batch.

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