While There’s Lots of Discussion about COVID-19 Vaccine-based Myocarditis in the West, What About ADEs’ in the East?

https://trialsitenews.com/whil…t-about-ades-in-the-east/

As you know, antibody disease enhancement (ADE) was a major concern during the development of the Covid-19 vaccines. These concerns were well-founded and even the regulators were on record of being concerned and watching closely for any signals during the randomized controlled trials (RCTs). Luckily, those signals never presented. Many anti-vax viewpoints still bring up the risk of ADE in the newly developed vaccines despite the fact that there are no signals of it after hundreds of millions of doses being administered at least for the vaccines under EUA in the USA. But that doesn’t imply that the risk of ADE in Covid-19 vaccines is no longer present. In fact, there are concerning signs of it potentially playing out already. Luckily, the signs are isolated to the Chinese developed vaccines. Specifically of concern is data from Sinopharm’s inactivated vaccine, BBIBP-CorV.

A recent entry in Medical News Today elicited response and discussion among a valued member from the TrialSite Community. Now, the efficacy of this vaccine is questionable and the data from the trials was not up to the standards of the better respected International Regulatory agencies. Yet, that didn’t stop the WHO from recommending its use.

Sinopharm Market—How are Vaccine Beneficiaries Faring?

It’s long been clear that countries that deployed the Sinopharm vaccine as a major component of their vaccine campaigns haven’t seen the dramatic reduction in cases per capita as expected from nations using more efficacious vaccines such as Israel, the USA, and the UK.

This is now being questioned in the media and the approach to address the reduced efficacy is being developed in many of these countries i.e. booster with an mRNA vaccine, 3rd shot of Sinopharm etc. The narrative that’s typically been used when PHAs and MSM have covered this topic is that the vaccines are still providing reduced disease severity. However, the data doesn’t back up those assertions. The island nation of Seychelles in the Indian Ocean provides a very illustrative example of the Sinopharm vaccine’s lack of efficacy. Based on entries in OurWorldinData.org, we find that Seychelles is among the most highly vaccinated countries in the world at 140 vaccination shots per 100 people. In comparison, the US is at 96 vaccinations per 100 people. However, Seychelles is still experiencing an alarmingly high new average daily case rate of 1442/1Million compared to the US at 36/Million.

Questionable Sinopharm Evidence?

Now if Sinopharm was resulting in cases with the dramatically less severe disease, one might argue that the vaccine is still providing benefits despite the staggering high new case count. However, even more concerning, is that Seychelles is suffering one of the highest new deaths per capita in the world at 11.6/million. This compares to the US at

only .9/million. What is causing this frighteningly high death rate in one of the most vaccinated populations in the world? Many would say this is a concerning signal of ADE caused by the Sinopharm vaccine that should be investigated immediately.

What’s the Priority?

Strange how a tiny fraction of mostly benign AEs of myocarditis in mRNA vaccines draw a firestorm of global media attention but a shocking death rate in a highly vaccinated population using Sinopharm goes unnoticed.

Signs of this Sinopharm issue are being seen in other countries such as Chile and Bahrain. However, those countries used larger percentages of other vaccines in addition to Sinopharm. This masks the negative effects from Sinopharm and makes analysis difficult to isolate without granular data by vaccine type. This granular data is not easily

obtained. Of course, this is to some extent speculation as the actual data is difficult to access in its entirety.

Sinopharm Background

Based in China, the Sinopharm vaccine BIBP was developed by Sinopharm/China National Pharmaceutical Group. Their parent company is Singopharm Industry Investment, according to an entry in Wikipedia a 51-49 joint venture of China state-owned enterprise China National Pharmaceutical Group and civilian-run enterprise Fosun Pharmaceutical. Its shares were listed on the Hong Kong Stock Exchange in 2009.

Quote from Fm1

In fact, there are concerning signs of it potentially playing out already. Luckily, the signs are isolated to the Chinese developed vaccines. Specifically of concern is data from Sinopharm’s inactivated vaccine, BBIBP-CorV.

There are clear signs or more clearly said facts from UK/Israel data: Pfizer/Astra do not protect from CoV-19 Delta. UK has > 18'000 cases and is now fully engaged in a 4th wave.

The two vaccines do also not protect from death from Delta at least not better than taking no vaccine. The only good news. Delta seem to be the harmless variant we all wait for, that gives us a free of cost/risk immunization!

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

https://www.nature.com/articles/s41467-021-24007-w#Sec9

Abstract

Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces autophagy. Accordingly, compound-driven induction of autophagy limits SARS-CoV-2 propagation. In detail, SARS-CoV-2-infected cells show accumulation of key metabolites, activation of autophagy inhibitors (AKT1, SKP2) and reduction of proteins responsible for autophagy initiation (AMPK, TSC2, ULK1), membrane nucleation, and phagophore formation (BECN1, VPS34, ATG14), as well as autophagosome-lysosome fusion (BECN1, ATG14 oligomers). Consequently, phagophore-incorporated autophagy markers LC3B-II and P62 accumulate, which we confirm in a hamster model and lung samples of COVID-19 patients. Single-nucleus and single-cell sequencing of patient-derived lung and mucosal samples show differential transcriptional regulation of autophagy and immune genes depending on cell type, disease duration, and SARS-CoV-2 replication levels. Targeting of autophagic pathways by exogenous administration of the polyamines spermidine and spermine, the selective AKT1 inhibitor MK-2206, and the BECN1-stabilizing anthelmintic drug niclosamide inhibit SARS-CoV-2 propagation in vitro with IC50 values of 136.7, 7.67, 0.11, and 0.13 μM, respectively. Autophagy-inducing compounds reduce SARS-CoV-2 propagation in primary human lung cells and intestinal organoids emphasizing their potential as treatment options against COVID-19.

.

Discussion

Our data show that highly pathogenic SARS-CoV-2 reprograms the metabolism of cells, induces ubiquitination, and limits autophagy (graphical abstract and working model, Supplementary Fig. 15a, b). SARS-CoV-2 inhibits autophagy as part of its manipulation of the host cellular machinery, whereas the induction of autophagy initiation limits SARS-CoV-2 propagation. Our mechanistic approach, including metabolomics, autophagy signaling, and targeted SARS-CoV-2 inhibition assays, identified two main autophagy-related putative drug targets: the polyamine pathway, and the control of BECN1 abundance through AKT1/SKP2 signaling.

Regarding the polyamine pathway, we found in vitro and in vivo evidence for transcriptional activation of SAT1, which is responsible for acetylation of spermidine and spermine and their conversion to putrescine. Indeed, the putrescine levels were increased in SARS-CoV-2-infected VeroFM and Calu-3 cells suggesting enhanced SAT1 activity. As an ISG, SAT1 showed an overall expression pattern comparable to other ISGs in our in vitro and in vivo data except for ciliated lung cells from mucosal brushes of COVID-19 patients (Fig. 3d). Patients with low SARS-CoV-2 RNA levels expressed significantly more SAT1 that would reduce spermidine levels and autophagy similar to what we observed in our in vitro experiments. The expression pattern inverted to increased ISG levels but reduced SAT1 in patients with high SARS-CoV-2 RNA concentrations. The virus concentration-dependent transcriptional dynamics suggest direct intervention of SARS-CoV-2 into immune and autophagy gene regulations. High SARS-CoV-2 RNA level-dependent SAT1 downregulation might be explained by a SARS-CoV-2 papain-like protease-driven degradation of P5358, which is key to SAT1 activation59. Interestingly, it has previously been shown that spermidine-dependent eIF5A hypusination, which inversely correlates with aging, is also a key factor in efficient B cell activation15. Our findings suggest that SAT1 manipulation is a possible mechanism by which SARS-CoV-2 evades a durable antibody response, as preliminary reports have indicated60. Additionally, the proposed SARS-CoV and SARS-CoV-2 NSP2 interactions with mitochondrial-residing proteins such as prohibitin (PHB)1 and 2, STOML2, and VDAC2 might limit mitophagy61,62,63 and P53-dependent SAT1 activation64. Damaged mitochondria might accumulate in the host cell, with consequences for ATP production and release of reactive oxygen species.

Other explanations for limited autophagy in SARS-CoV-2-infected cells include recently described ORF3a, ORF7a, NSP15 involvement65, and particularly NSP1-dependent host protein translational shutoff26,27 that might prevent the synthesis of autophagy-regulating proteins, maintain a high ATP/AMP ratio, and increase amino acid availability. The reduction of multiple autophagy-regulating proteins, including key regulator BECN1, led to reduced ATG14 oligomerization and limited fusion of AP with lysosomes in agreement with previously described mechanisms22 and similar to MERS-CoV21. Noteworthy, despite the relatively global reduction of several autophagy-regulating proteins the most pronounced effect seems to be on the inhibition of AL fusion resulting in P62 and LC3B accumulation in vitro and in vivo that might be explained by a recently discovered ORF3a-mediated mechanism affecting VPS39 and HOPS-RAB7-interaction66. The recently described SARS-CoV-2-induced deacidification of lysosomes, necessary for viral egress52, would further contribute to reduced AL formation, disruption of autophagic flux, accumulation of P62 and LC3B, and subsequently reduced protein degradation. As virus production relies on available amino acids provided either by anabolic synthesis or catabolic recycling processes, the observed global K48-dependent ubiquitination and subsequent proteasomal degradation of cellular proteins might additionally compensate for the limited autophagy-dependent untargeted protein degradation. As global K48-ubiquitination modulates cellular pathways including antiviral IFN and proinflammatory responses67, deubiquitinating and deISGylating functions of the CoV nsp3-encoded papain-like protease68 might balance UPS-linked amino acid supply and cellular antiviral countermeasures. In summary, SARS-CoV-2 limits autophagy-dependent protein degradation, possibly to prevent virus particle destruction, drive deacidified lysosome-dependent virus egress52 and exploit autophagy-related lipid resources for omegasome-dependent DMV formation and virus particle production69.

The IC50 values of the tested compounds indicated efficient virus inhibition in vitro and in ex vivo lung and intestinal models, encouraging clinical trials. Spermidine/spermine plasma levels in humans range between 12–29 ng/ml or 70-280 nM70,71 being up to 1,000-fold below the detected IC50. Such a high IC50 might be expected, as spermidine is an endogenous metabolite with intracellular concentrations of 500 μM or more72. As long-term spermidine supplementation increased intracellular levels of polyamines in polyamine-deprived cells in old-aged individuals73, further well-designed in vitro and in vivo studies should clarify putative benefits of polyamine supplementation before or during SARS-CoV-2 infection. Regarding MK-2206, a clinical phase II study found peak plasma concentrations of 0.176 μg/ml (430 nM)74, which was well above the IC50 value of 0.11 μM determined here. A phase I clinical study of niclosamide has reported peak plasma concentrations ranging from 35.7–182 ng/ml (109–556 nM)75, which encompasses the IC50 value of 0.13 μM reported here. Niclosamide is known to have limited resorption efficacy, which might be enhanced by improving the niclosamide formulation or by developing an inhalable derivate for local application76. Both MK-2206 and niclosamide might be promising candidates for clinical trials. This work paves the way for the identification and rational design of effective autophagy-modulating antiviral compounds.

KT McFarland: Second COVID cover-up – China, we know about but was there another one in the US?

Scientists insisted that anyone promoting the lab leak theory was an anti-science conspiracy theorist

https://www.foxnews.com/opinio…rup-china-us-kt-mcfarland

The world rightfully wants to find out what really happened in Wuhan and how what should have been a run-of-the-mill virus set off a global pandemic. We probably never will, however, because of the Great Chinese Cover-up.

But is there another cover-up, hiding right here in plain sight in Washington?

Did America bungle our initial handling of the pandemic because a handful of government scientists and bureaucrats, and their unwitting media enablers, deliberately sent us off in the wrong direction in order to cover up their own complicity in creating COVID-19?

These scientists insisted that anyone promoting the lab leak theory, including our leading governors and well-respected scientists, was a hysterical, xenophobic, anti-science conspiracy theorist.

Did they react with such velocity and venom because they were covering up for their own misguided actions? What did they not want the world to know? That they were funding risky gain-of-function research and genetically engineering fairly harmless viruses to make them more contagious, virulent and lethal in order to study them? That they were awarding grants to an adversarial nation’s research lab, where the Chinese military was also involved?

Did they do these things without the approval, or perhaps even knowledge of their bosses and therefore need to cover their tracks, lest the world demand answers for their role for inadvertently contributing to a global pandemic?

I was President Trump’s first deputy national security adviser and knew nothing about these potentially dangerous gain-of-function research projects, nor that the U.S. government was funding Chinese labs.

If President Trump had been briefed, he NEVER would have agreed to it. First, he would have railed against U.S. tax dollars being used to pay for research in China. He was elected to change China policy, not subsidize it. Trump, a notorious germaphobe, would have railed even more loudly against paying mad scientists to create Frankenstein monster viruses.

So, who did give the go-ahead to resume risky gain-of-function research? Government bureaucrats? The so-called "expert class" who have been proven wrong again and again over the course of the pandemic? Even if they were not specifically funding gain-of-function research at the Wuhan lab, what were we funding there?

If we weren’t funding gain-of-function research in China, were we doing so at other labs in other lands? Surely the decision to create killer viruses capable of creating global pandemics if mishandled should have been made at the highest levels of government. But it wasn’t.

We now learn that National Institutes of Health scientists, whose gain-of-function research was shut down by the Obama administration, suddenly restarted it in January 2017, just as Donald Trump was taking office.

When discussing the possibility of a lab leak in gain-of-function research, Dr. Anthony Fauci wrote "that the benefits of such experiments and the resulting knowledge outweigh the risks." Tell that to a world still in the throes of a pandemic that has caused almost 4 million deaths.

When President Trump entertained the lab leak theory, they blamed him for the death of hundreds of thousands of Americans. These same government experts urged their allies in the media, social media and Silicon Valley to censor and silence anyone who questioned their pronouncements. Evidence is mounting that it likely was a lab leak, and these same scientists thought so all along, but refused to say so.

It is not fearmongering or conspiracy theorizing to ask legitimate questions of our own officials. It is only prudent. We are just emerging from a global pandemic that has caused more damage to our society and economy than a world war. Surely, we need to examine every aspect of the origin and spread of COVID, even if holding up a mirror to our own actions unveils a cover-up in Washington.

Once a clear FOX TV summary:

When discussing the possibility of a lab leak in gain-of-function research, Dr. Anthony Fauci wrote "that the benefits of such experiments and the resulting knowledge outweigh the risks." Tell that to a world still in the throes of a pandemic that has caused almost 4 million deaths.

Of course Fauci meant the benefits of his Big pharma FM/R/J buddies....

Quote from Fm1

Our data show that highly pathogenic SARS-CoV-2 reprograms the metabolism of cells, induces ubiquitination, and limits autophagy (graphical abstract and working model, Supplementary Fig. 15a, b).

Such research is not very fruitful if you do not focus on a wide range of virus genomes. The cellular engine can completely change after one virus mutation and even worse each human cell reacts differently as nobody has the same genes not even twins.

Clear (reproducible) results can only be seen for basic mechanism needed by the virus. So far best results are seen with ivermectin that also blocks influenza, Zikka, Westnil, Hanta and many other virus. Others Zink/Quercetin, HCQ/Zink, Sutherlandia, Nigella Sativa,...

Other clear signals we get from antibodies like: Hesperidin (Orange juice), DOXY, Heparin, Ivermectin, ...

Or immune suppressives: DEXA, Budenosid, famtoid

Quote from Fm1

KT McFarland: Second COVID cover-up – China, we know about but was there another one in the US?

Scientists insisted that anyone promoting the lab leak theory was an anti-science conspiracy theorist

https://www.foxnews.com/opinio…rup-china-us-kt-mcfarland

The world rightfully wants to find out what really happened in Wuhan and how what should have been a run-of-the-mill virus set off a global pandemic. We probably never will, however, because of the Great Chinese Cover-up.

But is there another cover-up, hiding right here in plain sight in Washington?

Did America bungle our initial handling of the pandemic because a handful of government scientists and bureaucrats, and their unwitting media enablers, deliberately sent us off in the wrong direction in order to cover up their own complicity in creating COVID-19?

These scientists insisted that anyone promoting the lab leak theory, including our leading governors and well-respected scientists, was a hysterical, xenophobic, anti-science conspiracy theorist.

Did they react with such velocity and venom because they were covering up for their own misguided actions? What did they not want the world to know? That they were funding risky gain-of-function research and genetically engineering fairly harmless viruses to make them more contagious, virulent and lethal in order to study them? That they were awarding grants to an adversarial nation’s research lab, where the Chinese military was also involved?

Did they do these things without the approval, or perhaps even knowledge of their bosses and therefore need to cover their tracks, lest the world demand answers for their role for inadvertently contributing to a global pandemic?

I was President Trump’s first deputy national security adviser and knew nothing about these potentially dangerous gain-of-function research projects, nor that the U.S. government was funding Chinese labs.

If President Trump had been briefed, he NEVER would have agreed to it. First, he would have railed against U.S. tax dollars being used to pay for research in China. He was elected to change China policy, not subsidize it. Trump, a notorious germaphobe, would have railed even more loudly against paying mad scientists to create Frankenstein monster viruses.

So, who did give the go-ahead to resume risky gain-of-function research? Government bureaucrats? The so-called "expert class" who have been proven wrong again and again over the course of the pandemic? Even if they were not specifically funding gain-of-function research at the Wuhan lab, what were we funding there?

If we weren’t funding gain-of-function research in China, were we doing so at other labs in other lands? Surely the decision to create killer viruses capable of creating global pandemics if mishandled should have been made at the highest levels of government. But it wasn’t.

We now learn that National Institutes of Health scientists, whose gain-of-function research was shut down by the Obama administration, suddenly restarted it in January 2017, just as Donald Trump was taking office.

When discussing the possibility of a lab leak in gain-of-function research, Dr. Anthony Fauci wrote "that the benefits of such experiments and the resulting knowledge outweigh the risks." Tell that to a world still in the throes of a pandemic that has caused almost 4 million deaths.

When President Trump entertained the lab leak theory, they blamed him for the death of hundreds of thousands of Americans. These same government experts urged their allies in the media, social media and Silicon Valley to censor and silence anyone who questioned their pronouncements. Evidence is mounting that it likely was a lab leak, and these same scientists thought so all along, but refused to say so.

It is not fearmongering or conspiracy theorizing to ask legitimate questions of our own officials. It is only prudent. We are just emerging from a global pandemic that has caused more damage to our society and economy than a world war. Surely, we need to examine every aspect of the origin and spread of COVID, even if holding up a mirror to our own actions unveils a cover-up in Washington.

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The purpose of the media is to throttle thought, and give you content to make you skeptical. If "these guys aren't so sure and they were in the driving seat, maybe I should be skeptical." Oh it's sooo complicated...who knows what happened....they use Fox to create legitimacy by telling a little truth. There is no independent media, there is no independent media. Capiche?

The deep state runs all of this. Pfizer is C-I-A.

Time to grow up children (not speaking to FM1 but all). Seriously enough is enough. A year ago it was ok if you thought that the good guys were coming to rescue you from military (Operation Warp Speed). It is all run centrally.

You are on a LENR board and you don't understand why LENR isn't screaming obvious as the place to invest. Why doesn't Gates "see it". Hmm...I wonder!

Quote from Navid

You are on a LENR board and you don't understand why LENR isn't screaming obvious as the place to invest. Why doesn't Gates "see it". Hmm...I wonder!

Or why google is cheating the field with nonsensical experiments run by untalented people.

Or industrial heat (Deep military guys) tries to block all independent researchers with bread & peanuts give away's...

Google/Facebook/Instagram/Youtube now are the best Orwell 1984 tools. People are so foolish that they even don't notice the subtle mind control.

How they (Google/Facebook/Instagram/Youtube) manipulate your kids: I just got teh vaccine 999 likes ... Go! get a CoV-19 vaccine and protect your parents. Do something good for society and its free. We are going to draw a playstation among the first who vaccinate today!!

But nobody will pay your hospital bill, in case you have to stay for 3 weeks. Best case: They will suck out your Mum & Dad.

Quote from Navid

The purpose of the media is to throttle thought, and give you content to make you skeptical. If "these guys aren't so sure and they were in the driving seat, maybe I should be skeptical." Oh it's sooo complicated...who knows what happened....they use Fox to create legitimacy by telling a little truth. There is no independent media, there is no independent media. Capiche?

The deep state runs all of this. Pfizer is C-I-A.

Time to grow up children (not speaking to FM1 but all). Seriously enough is enough. A year ago it was ok if you thought that the good guys were coming to rescue you from military (Operation Warp Speed). It is all run centrally.

You are on a LENR board and you don't understand why LENR isn't screaming obvious as the place to invest. Why doesn't Gates "see it". Hmm...I w

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You don't read very much, I've been posting over the last month of the people making money off of covid and their relationship to big pharma. Read about the 9newest billionaires thanks to Covid. Keep up navid

Quote from Fm1

You don't read very much, I've been posting over the last month of the people making money off of covid and their relationship to big pharma. Read about the 9newest billionaires thanks to Covid. Keep up navid

Comment was not directed at you, but at those who consider softball mainstream stories. Already addressed inline.

navid, I think this is part of what you were saying, follow the money!

Man Discovers His Four Months in Hospital With COVID Cost $2.8M

https://www.newsweek.com/four-…n-discovers-1604649?amp=1

Aman has revealed the financial cost of his four-month stay in hospital with COVID-19, after receiving an itemized breakdown amounting to $2.8 million.

The man, going by the name Al online, shared the eye-opening list on his TikTok page. Without revealing which hospital he stayed at, he shared a clip captioned: "4 months in a USA hospital with COVID-19. Total cost... wow."

The total cost came to $2,850,776.10 according to the rundown, of which Al said: "So this is crazy."

The list, described as a "summary of charges and payment activity," shows the patient received occupational as well as speech therapy.Some of the most expensive charges include the intensive care stay, which cost $324,349, while the laboratory use amounted to $350,203.50.

Other charges included a CAT scan for $9,410, radiology costing $15,535, pharmacy which came to $155,218.60 while pulmonary function was $110,375.

The two-sided letter was not a bill for Al to pay, rather it appears to be the breakdown which is being sent to his insurance. Al confirmed: "I'll update everyone on the cost after insurance in my next post."

Newsweek reached out to Al for a comment.

The video, shared on Wednesday, has blown up on the site, amassing more than 10 million views. And although Al confirmed he won't be expected to pay the full amount due to his insurance, people were outraged by the cost.

"USA is not a country, it's a business," Mytiktok wrote.

Ben Furer said: "Why do people think that one of the richest countries in the world can't afford universal healthcare??"

Jrast52 thought: "The rest of the modern world laughs at the U.S. healthcare scam."

Eaathan Applewhite wrote: "You could sell all your non essential organs and still not even make a dent in that."

Ruben Diaz wrote: "I love American but stuff like this really needs to be changed."

While PinkPreahneang added: "It's sad how I'd rather be in pain at home then go to the hospital for anything."A LendingTree survey, which was conducted in March and released earlier this month, indicated as many as 12.5 million Americans could be saddled with medical debt relating to COVID-19.

"A lot of people are getting bills they can't pay," David Himmelstein, a professor at City University of New York School of Public Health at Hunter College, said shortly after the survey's releas

"We're heading towards a mounting debt crisis for many people who have been sick during this COVID period that will ripple through the economy unless something is done about it."e.

The U.S. passed 500,000 deaths from COVID earlier this year, and reports indicate currently there are fewer than 300 deaths a day from the illness across the country.

Quote from Fm1

"USA is not a country, it's a business," Mytiktok wrote.

It's run by the blood sucker FM/R/J/B mafia...

And the propaganda goes on: LA/NY times: vaccines protect you from delta please have it! Despite contradicting UK/Israel data.

Oh sorry - only a study said vaccines protect you from delta... may be financed by the FM/R/J/B mafia .. The independent study (Cell) already found a 7x decrease in protection for the basic delta strain not for the later now dominant delta+ or delta+++ variants. Vaccines don't protect you at all against 1.3.5.1 (RSA) but this variant is not very contagious. Delta is the fast train.

So please if you had the Pfizer/Astra vaccine then have Ivermectin ready!

But experts said this does not undermine what we know about the efficacy of the vaccines. ???

Vaccinated people are dying from the Delta variant, but in small numbers and almost all are over 50, UK data shows

https://www.businessinsider.co…tively-few-uk-data-2021-6

Of those who were fully vaccinated who caught the Delta variant, 50 died, data from Public Health England that was published on Friday indicated.

The figure represents almost half of the total 117 deaths associated with the variant in the UK, where Delta now represents most cases.

But experts said this does not undermine what we know about the efficacy of the vaccines, given that the deaths come from age groups at higher risk and represent a tiny proportion of the 92,029 Delta cases analyzed.

Eight people under the age of 50 died after getting the Delta variant, the data showed. None was fully vaccinated, while two had received one dose of the vaccine.

As of June 21, 92,029 cases of Delta have been confirmed by Public Health England, of which 117 ended in death.

Of those cases, 109 were in those over the age of 50. UK officials did not give a more detailed age breakdown, but coronavirus deaths disproportionately affect the very elderly.

One hundred and seventeen deaths from 92,029 cases is a death rate of about 0.13%.

"Does this mean the vaccines are ineffective? Far from it," the statisticians David Spiegelhalter and Anthony Masters said in an opinion piece published in The Observer newspaper on Sunday. "It's what we would expect from an effective but imperfect vaccine."

The bulk of the UK's vaccination program has been made up of the AstraZeneca and Pfizer vaccines.

The UK has recorded a total of 117 deaths in people with the Delta coronavirus variant.

Fifty were among people who'd taken two doses of vaccines — a reminder that the shots are imperfect.

No fully vaccinated people under 50 died, and the overall death rate was 0.13%.

See more stories on Insider's business page.

Of those who were fully vaccinated who caught the Delta variant, 50 died, data from Public Health England that was published on Friday indicated.

The figure represents almost half of the total 117 deaths associated with the variant in the UK, where Delta now represents most cases.

But experts said this does not undermine what we know about the efficacy of the vaccines, given that the deaths come from age groups at higher risk and represent a tiny proportion of the 92,029 Delta cases analyzed.

A table whos the number of deaths among people who caught the Delta variant of COVID-19 as of June 21, according to Public Health England, broken down by age and vaccination status.

Deaths among people who got the Delta variant as of June 21, as reported by Public Health England. Public Health England

Eight people under the age of 50 died after getting the Delta variant, the data showed. None was fully vaccinated, while two had received one dose of the vaccine.

As of June 21, 92,029 cases of Delta have been confirmed by Public Health England, of which 117 ended in death.

Of those cases, 109 were in those over the age of 50. UK officials did not give a more detailed age breakdown, but coronavirus deaths disproportionately affect the very elderly.

One hundred and seventeen deaths from 92,029 cases is a death rate of about 0.13%.

"Does this mean the vaccines are ineffective? Far from it," the statisticians David Spiegelhalter and Anthony Masters said in an opinion piece published in The Observer newspaper on Sunday. "It's what we would expect from an effective but imperfect vaccine."

The bulk of the UK's vaccination program has been made up of the AstraZeneca and Pfizer vaccines.

Two doses of these vaccines are highly protective against developing symptoms after catching the Delta variant: 88% for the Pfizer vaccine, and 60% for the AstraZeneca vaccine, earlier UK data showed.

But the risk of dying from COVID-19 after being fully vaccinated depends on people's age, Spiegelhalter and Masters said. The older a person is, the more likely they are to die from infection if it breaks through the protection given by the vaccines.

"Someone aged 80 who is fully vaccinated essentially takes on the risk of an unvaccinated person of around 50 — much lower, but still not nothing, and so we can expect some deaths," the statisticians said.

By contrast, the vaccine's efficacy on hospitalization among all age groups is clear.

Data showed that 1,320 were sick enough to spend a night in the hospital after catching the Delta variant. Of those, 190 were fully vaccinated — that is about 14%. And 831, or a much higher 63%, were unvaccinated.

The World Health Organization said on Friday that those who are fully vaccinated should continue to follow public-health measures to curb the spread of the virus, such as mask-wearing, physical distancing, and respecting correct hand hygiene.

"People cannot feel safe just because they had the two doses. They still need to protect themselves," said Dr. Mariangela Simao, the assistant director general for access to medicines and health products at the WHO.

An analysis from the Associated Press indicated that only 0.8% of COVID-19 related deaths in the US in May, where the Delta variant made up about 20% of cases, were among vaccinated people.

Quote from AlainCo

In case you missed it, about the Covid Profiteers

https://252f2edd-1c8b-49f5-9bb…24d82b271a75e441cd06c.pdf

12 people manipulate masses

$36million industry, for 22 organizations. 266 employees

$1.5million of federal loans through PPP (USA)

total social media value is about $1.1 billion

Using affiliate marketing , paying for example $14Mn to partners.

Note that I expect the same guy oppose LENR, as it oppose their business.

(not fun in fact)

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The CCDH - Center for Countering Digital Hate is a front organization by deep state to censor the internet. Deep state uses racism as a ploy to do censor free speech discussion on their ploys. Two decades ago, they would call you a hater if you were opposed to WMDs and the need for Iraq and rooting out terrorism.

This is garbage you don't want to get involved with.

pros and cons the debate over ivermectin

Had to share this 30 second clip of the noble Covid police getting mocked in Britain by some unruly peasants.

Meanwhile, here in Ontario Canada, we are going to be entering "Stage 2" of the government's reopening plan on Wednesday. Two days ahead of schedule!

This means that we can actually go to a barber and get our hair cut. First time since November of 2020, when a little window of opportunity opened up.

It also means we can now eat at restaurants, indoors! Five whole people allowed inside.

Canada's Most High head doctor Theresa Tam has further blessed us and said that friends can get together inside houses in small groups without social distancing and masks, provided they are double vaccinated. If one person is not vaccinated, well, if they get the OK of their vaccinated peers, they can partake!

Our beneficent overlords are just too kind. Can it get any better?

I guess I must be a criminal paid mafia agent ... first time EVER on ANY forum (since 1997 or so)

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1. Wyttenbach Verified User

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Quote from Curbina

AFor three deaths prevented by vaccination we have to accept two inflicted by vaccination. Conclusions: This lack of clear benefit should cause governments to rethink their vaccination policy.

https://www.mdpi.com/2076-393X/9/7/693/htm

This article has now been flagged by the "Vaccine" editors as an "Expression of Concern"

https://www.mdpi.com/2076-393X/9/7/705

Vaccines 2021, 9, 705. https://doi.org/10.3390/vaccines9070705

http://www.mdpi.com/journal/vaccines

Expression of Concern Expression of Concern: Walach et al. The

Safety of COVID-19 Vaccinations—We Should Rethink the Policy.

Vaccines 2021, 9, 693 Vaccines Editorial Office MDPI, St.

Alban-Anlage 66, 4052 Basel, Switzerland; [email protected]

The journal is issuing this expression of concern to alert readers

to significant con-cerns regarding the paper cited above [1].

Serious concerns have been raised about misinterpretation of the

data and the con-clusions. The major concern is the

misrepresentation of the COVID-19 vaccination efforts and

misrepresentation of the data, e.g., Abstract: “For three deaths

prevented by vaccination we have to accept two > inflicted by

vaccination”. Stating that these deaths linked to vac-cination

efforts is incorrect and distorted. We will provide an update

following theconclusion of our investigation.

The authors have been notified about this Expression of Concern.

Reference 1.Walach, H.; Klement, R.J.; Aukema, W. The Safety of

COVID-19 Vaccinations—We Should Re-think the Policy. Vaccines2021,

9, 693, doi:10.3390/vaccines9070693.

/s/ Criminal Mafia Agent. Where's my dang payment !!??

Quote from Fm1

Does this mean the vaccines are ineffective? Far from it," the statisticians David Spiegelhalter and Anthony Masters said in an opinion piece published in The Observer newspaper on Sunday. "It's what we would expect from an effective but imperfect vaccine."

Yes! it means vaccines do not protect better than no vaccines. But for this this you must remember you undergrad math course. We know 50% had vaccines 50% not both groups have same number of deaths... I guess you must be around 4 years old to get this.

May be think think the vaccinated have much less cases. But this was never an issue. It was always about death!

Quote from Alan Fletcher

This article has now been flagged by the "Vaccine" editors as an "Expression of Concern"

https://www.mdpi.com/2076-393X/9/7/705

Here uploaded in case it will disappear:: The Safety of COVID-19 Vaccination We Should Rethinkthe Policy.pdf