Covid-19 News

    Quote from THHuxleynew

    the only qualified medic is heavily involved with a pro-Ivermectin advocacy group FLCC.

    This is the reason why he is qualified. He understands how it works and how the mafia game is played.

    Quote from THHuxleynew

    (which is at much too high concentration)

    Only fools or dilettantes cite this sentence more than once. Also the virus concentration was much higher and usually lab (beaker) doses have no relation to human doses. Not so in animal trials.


    Quote from THHuxleynew

    Distrust in mainstream science and experts

    All leading doctors in Switzerland are FM/R/J/B members so guess how competent these are? Same for CDD/FDA/NHS. Even an idiot can climb up the ladder if he is a mafia member. But currently only idiots are in place. Unlucky people like you with missing undergrad math have no chance to see the problem.

    Quote from THHuxleynew

    The enormously lower death/infection ratio in the UK shows how well the Pfizer vaccine is working against delta

    Only fools repeat FM/R/J/B FUD. Israel says its 64% effective. This is the correct data. Pfizer is the worst vaccine ever given to mankind. It is responsible for more than 100'000 deaths. CH has silently switched to Moderna.

    Quote from THHuxleynew

    (1) Would another year window have fewer deaths - because the children with comorbidities have all died? No. That assumes that all children have been infected over that window. In fact it is not likely that even 30% of children have been infected.

    All kids so far certainly had classic corona. May be you could finance a private nanny and thus avoid the weekly cold...

    Currently 34% of all Swiss had corona. The chance that children had contact is much larger. But with low dose that gradually builds up immunity.


    Sorry I no longer read your links as you only reference mafia sponsored papers.


    Please comment first on Uttar Pradesh and try it a bit more hard and do not repeat again your last blunders.

    How could CoV-19 disappear in Uttar Pradesh after all inhabitants took Ivermectin?

    Tip look for a movie all did watch. Health from happines!?

    Only fools repeat FM/R/J/B FUD. Israel says its 64% effective. This is the correct data. Pfizer is the worst vaccine ever given to mankind. It is responsible for more than 100'000 deaths. CH has silently switched to moderna.


    W - Do you understand what efficacy is? it is %age NOT GETTING INFECTED compared with unvaccinated.


    The vaccines are maybe 65% efficacy against any infection (I do not have figures - from US protection against symptomatic disease is I think 88% - but maybe that is alpha)

    - but are 96% (Pfizer) able to reduce serious disease (e.g. hospital) and similar or more reduction in deaths.

    Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study
    Objective To estimate the real world effectiveness of the Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed covid-19…
    www.bmj.com


    The analysis suggests:

    • the Pfizer-BioNTech vaccine is 96% effective against hospitalisation after 2 doses
    • the Oxford-AstraZeneca vaccine is 92% effective against hospitalisation after 2 doses

    These are comparable with vaccine effectiveness against hospitalisation from the Alpha variant.

    Further work remains underway to establish the level of protection against mortality from the Delta variant. However, as with other variants, this is expected to be high.

    The analysis included 14,019 cases of the Delta variant – 166 of whom were hospitalised – between 12 April and 4 June, looking at emergency hospital admissions in England.


    This is UK real world data.


    I don't know about you, but I care more about not getting serious COVID, than I care about not getting asymptomatic or mild COVID.

    Please comment first on Uttar Pradesh and try it a bit more hard and do not repeat again your last blunders.

    How could CoV-19 disappear in Uttar Pradesh after all inhabitants took Ivermectin?

    Tip look for a movie all did watch. Health from happines!?


    So, you may not realise this but UP like the rest of India went into strong lockdown in response to the very large surge in infections. (Tip - lockdown reduces R < 1 and turns fast increase into fast decrease).


    The fact that inhabitants were taking ivermectin is a correlation not a causal link.


    From sciencebasedmedicine


    In May, ivermectin was being offered to every citizen of India as the pandemic was killing thousands of people a day in that country. This somehow lead to bizarre claims that ivermectin was “crushing” COVID-19 in India, claims based on highly dubious “analyses” supposedly correlating ivermectin use with decreased numbers of deaths in various regions of India. Ultimately, the Indian health ministry ditched ivermectin as a recommended treatment earlier this month because—surprise, surprise!—it could find no evidence that ivermectin was working. No wonder the FLCCC didn’t mention India.

    On only fools or dilettantes cite this sentence. Also the virus concentration was much higher and usually lab (beaker) doses have no relation to human doses. Not so in animal trials.


    Right, so you are saying this "negative at tolerated concentrations " in vitro result gives no useful information. I agree. But then why is it quoted? There is no positive lab evidence of anti-viral action at the concentrations used.


    Edit - AFAIK - please give proper link to paper if you think you have such evidence.

    You can just block W again if it bothers you. But I noticed that if I actually reply to him he ends up making shorter, less understandable, more difficult to reply to posts than when I block him. I guess that is doing everyone a service?


    But you will find the moderators do not want to interfere.


    If you want pure thread groupthink you can block me. it is easy. Your loss, though.


    :)


    Edit. I have not analysed whether there is a color change in W's posts when I block him. I think we'd need an RCT to get any reliable data on that one. It would probably not get ethical committee approval.

    Ivermectin in Bangladesh..

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    low dose fluvoxamine for Severe Covid

    chymotrypsinogen for lung fibrin?

    Vaccines are on the way..few as yet

    a few adverse allergy reactions so far

    one patient given IVM

    Bangladesh hopeful of receiving 3.5 million vaccine doses from Covax in July
    2.5 million of them are likely to be AstraZeneca doses, says Foreign Minister Dr AK Abdul Momen
    www.dhakatribune.com

    Israel says its 64% effective. This is the correct data. Pfizer is the worst vaccine ever given to mankind.


    You are correct that Pfizer is 64% effective (against symptomatic delta-COVID disease) - 94% against hospitalisation.


    The annual flu vaccinations, which save many lives each year, are less effective (40% - 60% typically)


    Upcoming 2019-2020 Influenza Season
    What you need to know about the upcoming 2019-2020 influenza season in the United States.
    www.cdc.gov


    During years when the viruses in the flu vaccine and circulating flu viruses are well matched, it’s possible to measure substantial benefits from flu vaccination in terms of preventing flu illness. However, even during years when the vaccine match is good, the benefits of flu vaccination will vary across the population, depending on host factors like the health and age of the person being vaccinated and even potentially which flu vaccine was used.

    Recent studies by CDC researchers and other researchers suggest that flu vaccination usually reduces the risk of influenza illness by 40% to 60% among the overall population when the vaccine viruses are like the ones spreading in the community.

    For more information about vaccine effectiveness, click here.

    COVID-19 Case Data in Israel: A Troubling Trend?


    COVID-19 Case Data in Israel: A Troubling Trend?
    Data out of Israel reveals some troubling trends involving this heavily vaccinated population. The daily number of SARS-CoV-2 cases in Israel is
    trialsitenews.com


    Data out of Israel reveals some troubling trends involving this heavily vaccinated population. The daily number of SARS-CoV-2 cases in Israel is increasing, having recorded the highest number on Thursday since March. TrialSite delved into a recent data trove made available by the Israeli government and has found that a majority of those now vaccinated actually, according to the numbers, face as much risk testing positive for the Delta-driven SARS-CoV-2 infection as unvaccinated individuals. Meaning, at this point, the vaccine appears to have a negligible effect on an individual as to whether he/she catches the current strain. Moreover, the data indicates that the current vaccines used (Moderna, Pfizer-BioNTech, AstraZeneca) may have a decreasing effect on reduced hospitalizations and death if one does get infected with the Delta variant. With a majority of vaccinations using the mRNA-based BTN162b2, what are the implications for this trend? What does it mean for the transmission of SARS-CoV-2? Is this a significant trend or can it be explained away? As TrialSite reported recently, Pfizer has moved aggressively to introduce a third booster vaccine for at least the immunocompromised population. The primary regimen actually involved two doses, with one essentially serving as a booster dose. While the Delta variant seems to introduce a considerable challenge, TrialSite asks the question: Is it wise, practical, and scalable to introduce booster doses so soon after a considerably powerful two-dose regimen? Is it wise to consider boosters for a vaccine that is still considered experimental? Will the need for a booster occur each and every time new variants emerge? If so, how can such an approach be scaled around the world—especially in low-and middle-income countries (LIMIC)? Already, the World Health Organization (WHO) issued strong statements about their opposition to a third booster dose given vaccine equity issues—much of the LMIC world isn’t vaccinated. That represents a great majority of people on earth. TrialSite, a media and social network hub dedicated to transparent and accessible research, asks the question: Who among academia, government and industry is monitoring this initiative objectively and candidly with an eye for transparency directed to what should be the correct public health policy and action decisions? Pharmaceutical companies are critically important, but they are also driven by economic considerations—not by choice, but by the very logic of the market system.


    Vaccination Nation

    First, we start with an introduction to Israel, a nation with just over 9 million people and one of the most vaccinated places on the planet. According to data from Reuters, Israel has administered 10.9 million doses, and given a majority of the population received the two-dose mRNA-based regiment, the estimated total vaccination rate against COVID-19 stands at 60.5% of the country’s total population. According to Fortune, that rate is 65%. These rates would imply that overall infections would wane, particularly in an advanced society driven by stringent public health policy.


    Is the Pfizer Vaccine Losing Potency?

    Recently in the Jerusalem Post, it was reported that the mRNA-based vaccine was less effective against the SARS-CoV-2 Delta variant than “health officials hoped,” reported Prime Minister Naftali Bennett last Friday. This online media reported that “855 people tested positive for coronavirus and more countries were listed as places of high infection.” The Prime Minister declared, “We do not know exactly to what degree the vaccine helps, but it is significantly less.”


    More Concerning Data

    TrialSite was able to secure the data sources from the Israeli government. Links include the data set as well as a public health data dashboard as well as a broader data resource link.


    An initial review of the data surprised the analysts. A summary follows a review of some examples. The first one reveals the week of June 27th to July 3rd in the age cohort 20-29 years old. According to the data in this cohort, those new COVID-19 cases involving individuals fully vaccinated totaled 79%. How about the percentage of this population that’s fully vaccinated? It turns out to be 78%, indicating that at least for this cohort, the vaccination rate doesn’t seem to impact the infection rate.


    In another cohort, aged 30-39 from the week of June 27th to July 3rd, the new COVID-19 cases percentage involving people fully vaccinated came out at 80% while the percentage of the population in that age group fully vaccinated came in at 83%.


    In yet another example from the week of July 27th to July 3rd in the 40-49 years old age group, new COVID-19 cases involving fully vaccinated people totaled 84%, and the percentage of the population in this age group that were fully vaccinated stood at 86%.


    TrialSite notes that a number of questions needed to be asked involving sample size and whether this data is statistically significant.


    But what about hospitalization numbers and deaths? One would expect the hospitalized rate to be significantly higher for the unvaccinated than the vaccinated. According to the data set herein, the total number of hospitalizations is slightly higher in the vaccinated. Is this due to the potency of the Delta variant or waning immunity from the vaccine? Could this be linked to vaccine-induced Antibody-Dependent Enhancement? This is something many vaccine experts wary of fast-tracked mRNA-based vaccines predicted could be a factor. Could this be a small difference now (with smaller numbers) yet lead to worsening numbers in forthcoming seasons?


    See the chart based on the links to the data:



    Breakthrough Infection Problem?

    In a recent study published in the Journal of Clinical Microbiology and Infection, Israel-based scientists and researchers link a growing number of bad SARS-CoV-2 cases, including death, to a minority of fully vaccinated individuals in this eastern Mediterranean nation.


    This study was led by corresponding authors Tal Brosh-Nissimov, Head of Infectious Diseases Unit, Samson Assuta Ashdod University, Israel; and Efrat Orenbuch-Harroch affiliated with Hadassah Hebrew University Medical Center, Jerusalem, Israel; and a team of other investigators. Of course, during Phase 3 clinical trials, the mRNA-based products exhibited compelling efficacy rates in protecting subjects from more severe forms of the pathogen. This efficacy was generally noted across all age groups, including the elderly and those with compromised immune systems and the like.


    Israel earned the status as one of the highest vaccinated nations worldwide. It was able to marshal its government and private sector resources across a population of just over 9 million. A great amount of collaboration across societal sectors helped, which hasn’t necessarily been the case in some other advanced nations.


    But now, approximately just 6 months out from the start of an aggressive vaccination campaign, a disturbing set of data points emerge with breakthrough infections across the majority of vaccinated populations. There still isn’t sufficient data to determine the true nature of these observations. The tendency on one side is to declare that these products may not be working optimally while, on the other side, the data points are minimized with an emphasis on overall trends. But there isn’t sufficient data to declare that these vaccines are an overwhelming success. This takes time and observation, and that leads to a discussion below on third booster shots.


    The Recent Israeli Study

    The multi-site-based study team organized the research endeavor to better understand the nature and trends associated with those who are vaccinated and hospitalized due to breakthrough SARS-CoV-2 infection while seeking to isolate actual risk factors that could inform care and public health policy moving forward.


    Thus, analyzing 17 Israeli hospitals in various segments, the investigators targeted subjects who not only received two doses of BNT162b2—the Pfizer-BioNTech vaccine but also were infected with SARS-CoV-2, but also hospitalized in one of the hospitals’ units set up for the novel coronavirus.


    Seeking more data in a quest to better understand risk factors, the investigators also included in the study record not only a review of electronic medical records but also viral genomic sequencing to assess which particular SARS-CoV-2 variants were involved with the breakthrough infections. Ultimately seeking to understand if these breakthrough infections were leading to poor outcomes, such as hospitalization with a need for mechanical ventilation or death or, hopefully, positive outcomes associated with no need for assisted ventilation and, of course, hospital discharge.


    Findings

    As TrialSite reported recently, Israel was seeking a third booster shot for those vaccinated individuals who have comorbidities, such as individuals who are immunocompromised. Undoubtedly, this study influenced that movement, as in this study involving 152 subjects, the number of poor outcomes equated to 22% of the study population, or 38 patients. A majority of these subjects fell into the elderly category while also facing a number of other health challenges categorized as comorbidities.


    The team discovered that those study subjects with comorbidities (e.g. immunocompromised, etc.) faced a higher risk of breakthrough infection than those who were not. This analysis was based on an assessment associated with a large group of unvaccinated patients who were also hospitalized a range of conditions from central nervous system-based conditions to cardiovascular challenges to cancer, etc.


    Conclusion

    The Israeli study conclusion was tempered and careful, denoting that only “a small minority of fully-vaccinated BNT162b2 recipients might still develop severe SARS-CoV-2 infection despite the vaccine’s high effectiveness, with need for in-patient care.” Of course, the authors noted the risk cohort associated with these findings: those with a “high rate of comorbidities predisposing for progression to severe COVID-19, and a high rate of immunosuppression.”


    That is, in this class of patients receiving the Pfizer BNT162b2 two-dose regimen (that already includes a booster), the outcomes are similar in that it makes no difference whether the subject was vaccinated or not. This Israeli study team recommended that “additional prospective longitudinal studies are urgently needed to identify predictors for vaccine breakthrough infection and simple correlates of vaccine protection” in a bid to find more granular ways to identify those with higher risk. The authors suggest that these individuals be included in a more protected regimen, from “strict precautions” to “repeated active vaccination or other prophylactic measures such as passive vaccination.” They argue for a “mass vaccination” approach to lead to “herd immunity.”


    Considerations

    TrialSite finds the data a bit concerning and suggests it justifies a close watch. No severe conclusions can be drawn at this point. Some items that should be considered with the data is the relatively small sample size since Israel still has a low case count, an even lower hospitalization count, with an almost non-existent death rate. The cases are growing though, so this could change in the forthcoming weeks.


    The other element here is that Israel experienced a high infection rate before their mass vaccine rollout. Here, it is possible that a sizable percentage of the unvaccinated cohort is protected by natural immunity. Thus, many of the recovered COVID-19 patients may not feel a need to take a vaccine since they already have natural protection. If that is indeed occurring, the comparable numbers of vaccinated and unvaccinated cases could perhaps just confirm that natural immunity and vaccine-derived immunity provide similar levels of protection. The key is to remain open-minded to the myriad scenarios. But regardless, the data points coming out of Israel should prompt concern with more intensified monitoring of what unfolds over the next weeks.


    Call to Action: TrialSite asks the community to review the Israel data shared herein. Do you agree with the findings? Disagree? Let us know in the comments, or submit a response in our OpEd feature. TrialSite is a place for dynamic scientific discussion, debate, and even dissension. Only with that do you have true advancement of science and health

    Quote from THHuxleynew

    but are 96% (Pfizer) able to reduce serious disease

    95% of all un-vaccinated do not develop a serous disease.

    Now that's all inclusive. If you go to age below <65 then 99% do not develop a serous disease so what does Pfizer add? nothing.

    Quote from THHuxleynew

    You are correct that Pfizer is 64% effective (against symptomatic delta-COVID disease) - 94% against hospitalisation.

    Compare this with what is originally claimed:: Emergency Use Authorization (EUA) for an Unapproved ProductReview Memorandum.pdf


    Here you will also find that Pfizer did exclude 250 more people from the Vaccine group than the placebo. The ratio is 311: 60 = 5x This is criminal as said because we today know that between 1-2 % develop CoV-19 during the first 7 days after the vaccination due to total immune suppression by the added spike protein that blocks up-regulation of interferon. So we must clearly say that in a pandemic the Pfizer vaccine has 0 efficiency or in contrary it initially will cause much more cases than a placebo.

    You also can see that the median age is 55 and only 20% are older than 65 years. So 80% of the phase III people are from the no risk group. Only 4.3% from the high risk group age >75.

    You can learn many other things form the initial data what you certainly not will do, like your fake info that the older will have much more CoV-19 infections after a vaccination. Obviously the vaccine flattens the sensitivity....

    This is the first serious attempt I've seen to quantify difference in lethality of original / alpha / delta variants. It is very new (July 12 preprint)


    https://www.medrxiv.org/content/10.1101/2021.07.05.21260050v2.full.pdf


    It has alpha +61% and delta +137%, both measured from original COVID CFR.


    I have low confidence in this data. There are large confounding variables:

    age

    vaccination status


    These are compensated - but small errors in that compensation, because the patient cohorts for the different variants have markedly different ages and different vaccination fraction, as well as non-uniform vaccine age distribution - could contaminate these results.


    So - well done for trying - but we need a lot more data before we can come to any definite conclusion. At least we need vaccination status recorded for each patient, which would remove one potentially large source of confounding.

    95% of all un-vaccinated do not develop a serous disease.

    Now that's all inclusive. If you go to age below <65 then 99% do not develop a serous disease so what does Pfizer add? nothing.



    As I'd expect you to know, but if not I'm very glad to enlighten you, all these efficacy figures are ratios between vaccinated and unvaccinated probabilities of events

    95% efficacy (against hospitalisation) means any individual is very much less likely to be hospitalised as result of vaccination. Taking your figure of 1% for unvaccinated chance of hospitalisation, then the vaccinated chance of hospitalisation would be 0.05%.

    This is criminal as said because we today know that between 1-2 % develop CoV-19 during the first 7 days after the vaccination due to total immune suppression by the added spike protein that blocks up-regulation of interferon


    We do not know that. Please give a link. A number of people do catch COVID in the first 7 days after the 1st vaccination, because it takes time for the protective immune response to develop, also those being vaccinated may have caught COVID recently and not know it. How large a number this is depends on local infection rates.


    You do NOT see the same effect after the 2nd vaccination - because the 1st vaccination provides quite a lot of protection.


    Also, you need to modify these statements with delta which provides only partial protection against symptomatic (mild) infection.



    here is real-world data from the UK showing chance of catching COVID in the 1st 14 days after vacination is 0.2%. But of course as it says, this will vary with local infection rate and therefore chances of catching COVID. It does disprove the 1-2% claim.


    What’s my risk of COVID-19 after vaccination?
    Our latest analysis of data from the ZOE COVID Study app reveals who is most at risk from being reinfected with COVID-19 after vaccination.
    covid.joinzoe.com


    According to data from Reuters, Israel has administered 10.9 million doses, and given a majority of the population received the two-dose mRNA-based regiment, the estimated total vaccination rate against COVID-19 stands at 60.5% of the country’s total population. According to Fortune, that rate is 65%. These rates would imply that overall infections would wane, particularly in an advanced society driven by stringent public health policy.


    Well no it would not. R (without vaccination) of delta strain - now dominant in many places (it is about to take over the US which is why they are suddenly seeing an uptick in infections) - is anything between 4 - 9.


    At 4, you would need 75% vaccination to control an exponential increase. At 9 you would need 89% vaccination to control an exponential increase.


    You also need to check whether these figures are whole population or just adult population - since children can spread COVID.


    But, in any case, 65% is way too low for Delta - which is why it is spreading so fast even in the well vaccinated UK.


    There are some subtle effects making it worse than this due to population heterogeneity.


    Young people are least vaccinated - and tend to contact other young people - so in that age group the effective vaccination rate in the UK is still quite low, and therefore delta can spread very fast.

    Scientists protest against the great "Unlock"


    "“In New Zealand we have always looked to the UK for leadership when it comes to scientific expertise, which is why it’s so remarkable that it is not following even basic public health principles,” said Michael Baker at the University of Otago, a member of the New Zealand health ministry’s covid-19 technical advisory group"

    Read more: https://www.newscientist.com/a…scientists/#ixzz70pjuhmfA

    I stopped looking to the UK for leadership in 1977..

    • Official Post

    About lab leak hypothesis, it seems less credible than I believed before.

    Note that I don't hear much of the Mink farm hypothesis, that have good reason to be covered, and is not so crazy...

    The rapidly shrinking lab leak hypothesis - TheMoneyIllusion
    The late spring boomlet in the Covid-19 lab leak hypothesis is rapidly deflating. The hypothesis was mostly based on 5 pieces of evidence, 4 of which have now…
    www.themoneyillusion.com

    The supporther of the "unnatural origin of sars-cov-2" step back after new data (scientific behavior, cool)

    When a Good Scientist Is the Wrong Source - Issue 102: Hidden Truths - Nautilus
    Six weeks ago, a reporter, Nicholas Wade, published what seemed to be a blockbuster story, one that, if true, would expose the greatest&#8230;
    nautil.us

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