Routine observation periods following COVID-19 vaccination
Actually, I was looking up some regular school-age vax stuff, and the guidelines are the same.
Turns out one common any-vax-effect is syncope (fainting) : kids were getting their shot, rushing out on their bikes/skateboards ... fainting falling and suffering head injuries!
Vaccinations cause cracked skulls !!!!!
In the U.S., they ask you to hang around for 15 minutes after getting a vaccine. Any vaccine, COVID or other. That's what a nurse told me. I don't recall waiting around after other vaccines, but apparently that's the procedure nowadays. On very rare occasions people have allergic reactions, or they faint. Most severe reactions occur soon after inoculation, if ever.
Same here.
Display MoreEdit - already covered, but ..
Actually, it's true
https://www.ott.nih.gov/royalt…rmation-nih-cdc-inventors
First $2000 of any patent royalty, then a sliding scale of about 25% up to a maximum of $150,000 per year (per patent, I presume).
Thanks for the detail Alan. So I admit my error. But this is a modest employee incentive scheme, not a money-making scam - as it has been represented by some.
This wording implies that 150K is a total income cap, which makes sense:
Inventors receive the first $2,000 collected from a licensee. Next, they receive 15 percent of royalties above $2,000 and up to $50,000. Finally, they receive 25 percent of royalties in excess of the first $50,000 collected each year. Each inventor cannot receive more than $150,000 in royalty payments for a calendar year.
THH
Display MoreReport on blood clots from AZN vaccine.
This UK sourced study is being reported today in The Guardian (which is left wing) and The Daily Mail (which is right wing) as well as other sources on the Internet.
"Although extremely rare, a blood clot syndrome after the first dose of the Oxford/AstraZeneca vaccine carries a high risk of death and can occur in otherwise young and healthy people, UK researchers have found.
In those aged under 50, this blood clot syndrome occur in around one in 50,000 people who have received the vaccine, and that number falls to one in 100,000 in the over 50s, data suggests. But the risk of blood clots is much higher with Covid itself — research shows that more than a fifth of hospitalised patients with Covid have evidence of blood clots.
Researchers examined the symptoms, signs and outcomes in 220 confirmed and probable cases who presented in UK hospitals between 22 March and 6 June.
“It’s important to stress that this kind of reaction to the Oxford/AstraZeneca vaccine is very rare,” said Dr Sue Pavord, consultant haematologist at Oxford University Hospitals NHS Foundation Trust and lead author of the analysis published in the New England Journal of Medicine.
But for those who do develop blood clots, the results “can be devastating,” she added. “It often affects young, otherwise healthy vaccine recipients and has high mortality. It is particularly dangerous when the patient has a low platelet count and bleeding in the brain.”"
Of the COVID vaccines the Astrazeneca one is worst for side effects because of this blood clot thing.
Of course your chances of developing blood clots after COVID are much higher than this 1 : 50,000
Currently my list of vaccines would be be
Moderna > Pfizer > Astrazeneca
But they would all be (a lot) better than no vaccine!
If we reckon 50% of blood clots are equivalent to death and suppose other injuries balance out (they don't - COVID has a much higher risk of severe but not fatal injury due to long COVID)
1 : 100,000 corresponds to the overall death rate age 5
You might want to make an adjustment given that the blood clot risk doe snot seem to vary muhc with health, whereas COVID death risk will. An adjustment dividing COVID death risk by 4 (IMO far too much) puts the age at which COVID risk equals AZ blood clot risk at around 20. So the UK specification of 30 as the age below which you might want not to have AZ looks pretty safe.
Ideally AZ would be given only to over-60s, for whom the blood clot risk is 1000 X smaller than the COVID risk (blood clot risk halves, COVID risk is > 0.5%)
THH
mRNA-1273 was generally safe and well tolerated, with a safety profile consistent with that seen in prior Moderna infectious disease vaccine clinical studies.
Real data comparison of the RNA gen therapies. Pfizer is already crap 42% (Ivermectin still 100%) Moderna still at 3/4.
The paper: https://www.medrxiv.org/conten…08.06.21261707v1.full.pdf
But the risk of blood clots is much higher with Covid itself — research shows that more than a fifth of hospitalised patients with Covid have evidence of blood clots
This is silly to compare the few hospitalized cases with micro cloths with the several thousands of cases from vaccines with macro cloths.
1 : 100,000 corresponds to the overall death rate age 5
Yes.. for one whole year ... not 2..24 hours after the vaccination....
I didn't know that NASA (and maybe lots of other agencies) also pay royalties to inventors!
2.2.1 Distribution of royalties or other payments shall be calculated on a fiscal year basis and shall be distributed following the fiscal year quarter that the royalties or other payments are received. Monies remaining after distribution under this subparagraph shall be distributed in accordance with subparagraph 2.3.
2.2.2 Distribution shall be calculated on a per license or a per assignment basis and shall be based on the total royalties received for a particular license or assignment in the fiscal year for which the distribution is being calculated. If one inventor is named, that inventor shall receive the first $5,000, plus 25 percent of the remainder. For two to four inventors, each inventor shall receive an equal share up to $5,000 each, plus 25 percent of the remainder up to the first $25,000 received, and an equal share of 30 percent of the remainder after the first $25,000 received by NASA. For five or more inventors, each inventor shall receive an equal share of the first $25,000 received plus an equal share of 30 percent of the remainder after the first $25,000 received by NASA.
2.2.3 Distribution of royalties or other payments to any one recipient shall not exceed $150,000 per calendar year, unless the President approves a larger amount (with the excess over $150,000 being treated as a Presidential Award under Section 4504 of Title 5, U.S.C.).
Vaccination Crisis or False Alarm in Israel? 90% of COVID-19 Patients Fully Vaccinated
Israel led the pandemic as an organized, prepared, and aligned population that accepted an aggressive, methodical, and overall successful effort leading to one of the most vaccinated populations against SARS-CoV-2, the virus behind COVID-19. But with the delta variant came breakthrough infections. That is, individuals who were fully vaccinated became infected anyway. This raised serious questions concerning some major assumptions around COVID-19 vaccination. Then just last month, the Jerusalem Post reported on 143 COVID-19 patients admitted to the hospital. The popular wisdom to date is that vaccinated people will largely avoid any hospitalization or worse. The idea was that, at least with the delta variant, herd immunity wouldn’t be possible due to transmissibility. At least those who were vaccinated could rest a little easier. Then came this hospitalization report by the Jerusalem Post that revealed 58% of those patients were fully vaccinated, while only 39% were unvaccinated.
This wasn’t supposed to happen. Maayan Jaffe-Hoffman reported that even though there were more vaccinated than unvaccinated in the hospital with breakthrough infections, the actual percentage of those who required invasive treatment was low. Only three fully vaccinated people needed ventilation.
Worsening Crisis
However, now this situation gets a closer look by TrialSite. Recently a top health official here, Dr. Koby Haviv, Director of Jerusalem’s Herzog Hospital, declared the following in a television interview on Channel 13:
“95% of the severe patients are vaccinated. 85%-90% of the hospitalizations are in Fully vaccinated people. We are opening more and more COVID wards. The effectiveness of the vaccine is waning/fading out.”
Moreover, Dr. Haviv continued that “90% of severe COVID-19 hospitalizations are fully vaccinated.” From worsening breakthrough infections to “outbreaks in hospitals” where a single patient can infect a large group, the doctor expressed real concern that won’t be shared in American or British media.
The Interview
For those interested in watching this interview on Israeli television, a Regulatory Affairs Specialist and Computational Biologist, Ran Israeli, posted it via Twitter.
TrialSite had a few reviewers look at the video, and it appears to be real. TrialSite did a review of other media and the right-leaning Epoch Times picked up the story. No major media of any kind appeared to show interest.
Full Throttle Third Vaccine at Herzog Hospital
TrialSite reviewed the Herzog Hospital Facebook page, which listed Dr. Haviv declaring that all patients and staff are getting the third dose of the vaccine. He clarified that this was still the preferred path in Israel, despite the recent interview revealing what appears to be a very different situation than we read about in the United States.
Perhaps this third dose will gain effectiveness. In the meantime, TrialSite will seek to better understand some of these unfolding anomalies.
Vaccinated and unvaccinated individuals have similar viral loads in communities with a high prevalence of the SARS-CoV-2 delta variant
Abstract
SARS-CoV-2 variant B.1.617.2 (delta) is associated with higher viral loads [1] and increased transmissibility relative to other variants, as well as partial escape from polyclonal and monoclonal antibodies [2]. The emergence of the delta variant has been associated with increasing case counts and test-positivity rates, indicative of rapid community spread. Since early July 2021, SARS-CoV-2 cases in the United States have increased coincident with delta SARS-CoV-2 becoming the predominant lineage nationwide [3]. Understanding how and why the virus is spreading in settings where there is high vaccine coverage has important public health implications. It is particularly important to assess whether vaccinated individuals who become infected can transmit SARS-CoV-2 to others. In Wisconsin, a large local contract laboratory provides SARS-CoV-2 testing for multiple local health departments, providing a single standard source of data using the same assay to measure virus burdens in test-positive cases. This includes providing high-volume testing in Dane County, a county with extremely high vaccine coverage. These PCR-based tests provide semi-quantitative information about the viral load, or amount of SARS-CoV-2 RNA, in respiratory specimens. Here we use this viral load data to compare the amount of SARS-CoV-2 present in test-positive specimens from people who self-report their vaccine status and date of final immunization, during a period in which the delta variant became the predominant circulating variant in Wisconsin. We find no difference in viral loads when comparing unvaccinated individuals to those who have vaccine “breakthrough” infections. Furthermore, individuals with vaccine breakthrough infections frequently test positive with viral loads consistent with the ability to shed infectious viruses. Our results, while preliminary, suggest that if vaccinated individuals become infected with the delta variant, they may be sources of SARS-CoV-2 transmission to others.
From TrialSite
Vaccinated vs. Unvaccinated—Study Shows Viral Load the Same in COVID-19 Delta Variant Infections
Recently, a study collaboration involving investigators from the University of Wisconsin-Madison and Public Health Madison and Dane County showcases a disturbing but unsurprising trend associated with the delta variant of SARS-CoV-2. Led by Thomas C. Friedrich, a professor with the University of Wisconsin—Madison, Department of Pathobiological Sciences, the team revealed that the delta variant indeed foretells trouble ahead. That’s because this mutant strain, originating in India and an offshoot of the original Wuhan-based SARS-CoV-2 virus, evidences higher viral loads and increased transmissibility relative to other variants and partial escape from polyclonal and monoclonal antibodies. The delta variant is likely attributable as the cause to the growing case counts in many parts of the world—the U.S. is now in its fourth dangerous surge of the pandemic. But how and why this virus is spreading where vaccination coverage is high is of utmost concern from a public health and policy perspective. TrialSite has reported that among the most vaccinated countries now, a majority experience delta variant-driven troubles. Despite evidence of breakthrough infections on the rise, the current Biden Administration has declared the current surge a “pandemic of the unvaccinated.” But is this a true statement or just another form of government misinformation? According to this Wisconsin-based study, the investigators could find little difference between the viral loads associated with unvaccinated individuals versus those with vaccine “breakthrough” infections. While preliminary in nature—this study hasn’t been peer-reviewed—the results suggest that vaccinated individuals are not only susceptible to the delta variant, but more than likely are significant sources of transmission of the virus to others. While this study is too preliminary to declare any truths, there is mounting evidence that delta is triggering breakthrough infections and that these infected vaccinated persons have some viral shedding.
A Cautionary Note
TrialSite emphasizes that this study hasn’t been peer-reviewed as of yet, hence not scrutinized by the scientific and medical community. That means that these findings are preliminary and cannot be judged as fact as of yet. The introduction of social media and a plethora of online media sources introduces both opportunities and risks. TrialSite’s obviously committed to disseminating preliminary research results published in preprint servers, such as medRxiv; however, such studies cannot be considered complete until appropriate reviews have occurred.
Some of the comments associated with this paper clearly indicate concern for making these studies available early on. TrialSite agrees that the information can be misused and emphasizes the power and importance of more transparency and accessibility to preliminary research. We know of cases where companies have mined the preprint servers successfully to develop whole new profitable healthcare products, such as diagnostic testers: meaning the sharing of research results at this stage can lead to tremendous value.
Vaccination Definitions
In the paper, the authors remind the reader that the term “vaccine protection” offers several meanings and isn’t always operationalized for the masses, or for that matter, even the research community. They suggest that: “Ideally, vaccination would provide ‘sterilizing immunity,’ completely preventing virus replication in vaccinated individuals. Intramuscularly delivered vaccines against respiratory viruses are not necessarily expected to provide this level of protection, however.”
Do the present COVID-19 vaccine products under emergency use inhibit virus replication, protecting vaccinated people against symptomatic disease, severe disease, and/or death with a range of overall effectiveness? When the mass vaccination programs were first announced, spokespersons for companies, research institutes, and various public health authorities suggested that this was a path to herd immunity as the vaccines would essentially stop the transmission of the SARS-CoV-2 virus.
Well, that hasn’t turned out to be the truth as the delta variant wrecks havoc around the world, causing breakthrough infections. Real-world evidence indicates that those that are vaccinated are susceptible to infection, albeit less symptomatic ones. The public health authorities and government agencies have pivoted now, dropping the message that the vaccines stop transmission and focus on preventing hospitalization and death. Now there is most certainly evidence that, particularly in certain risky cohorts, vaccination can keep someone out of the hospital or worse.
But back to the original point the world assumed with these vaccines: they would “limit the magnitude of virus shedding in vaccinated individuals who become infected.” Put another way—vaccines stop breakthrough infections by lowering the overall viral load in an individual that’s been infected. But with delta, is that what the vaccines actually do, lower viral load?
The Study
That’s the heart of this study, which again must be peer-reviewed, or formally vetted by panels of disinterested, objective, critical reviewers. This study team accessed test-positive specimens collected between June 28, 2021, and July 24, 2021, from 83 people in Dane County, Wisconsin. As it so happens, this is one of the most vaccinated places in America, combined with high test rates (about 67.4% fully vaccinated, according to the authors). Here the study team compared what is called “threshold cycle (Ct) value in test-positive specimens.
The study team used self-reported vaccine status and dates of final vaccination to stratify the study population into two groups, including A) fully vaccinated (n=32) and B) those who were unvaccinated (n=51).
The authors noted that they used the Ct measure as “a convenient proxy for estimating viral loads.” They had to because Ct values don’t offer the scientist absolute virus quantification. The study protocol did call for standardization as the team used one contract laboratory and a unified protocol to eliminate sources of variability.
Results
Unfortunately, the study team failed to detect any differences in Ct values in the specimens from fully vaccinated versus unvaccinated specimens. While the study authors couldn’t confirm the presence of the delta lineage, they did emphasize the “high prevalence of delta variants in the sequenced specimens suggests many, if not most are delta.”
After expanding the number of samples to include another 208 from other counties in Wisconsin (using the same lab), the study now had in its possession 291 samples. The authors report finding 79 infections among those who were fully vaccinated and found that 66 of the 79 specimens (84%) had high Ct values (≤30) while 177 of 212 (83%) unvaccinated specimens also had similar viral load ranges. The team wrote that within the fully vaccinated cohort, 26 of 79 (33%) of these were associated with individuals with breakthrough infections and very low Ct values of <20, consistent with high viral loads. The authors concluded that “Taken together, these data suggest that a substantial proportion of individuals with SARS-CoV-2 vaccine breakthrough infections during our study period have levels of SARS-CoV-2 RNA in nasal secretions that are consistent with the ability to transmit the virus to others.”
Limitations
The study isn’t peer-reviewed and hence preliminary, meaning it cannot convey any evidential force at this point. Some commenters are not happy that the media picks up on such preliminary research. TrialSite takes the view that transparency and accessibility are good. In a dynamic, intellectual society, the marketplace for ideas, research, and the like will be sorted for what’s high quality versus not. Of course, this is what the peer review process helps enforce, hence why we emphasize the limitations. But we can also note that the peer review process during the pandemic has opened up many questions involving bias, money, and influence.
But regardless, the authors here emphasize that their findings “need to be substantiated in larger cohorts” and are susceptible to skewing elements. Moreover, emphasizing a recent study suggesting that the Pfizer-BioNTech vaccine could wane ineffectiveness, the authors declared, “it’s difficult to determine whether this represents waning levels of vaccine-induced immunity, increased circulation of variants like delta with partial immune escape, and/or bias in the timing of vaccination.”
The authors continued on the difficulties of accuracy with this study, declaring, “The ‘true’ proportion of breakthrough infections with high viral loads would require comprehensive, frequent surveillance testing of vaccinated populations to identify these individuals.” TrialSite, in respect to those concerned about publishing preliminary preprint data, shares a comment published in medRxiv, declaring, “They compare raw Ct values which are meaningless in qPCR testing and must be correlated with something, e.g. a dilutions series of positive control COVID RNA at the very least.” But is it irresponsible and borderline unethical to publish data like this?
Lead Research/Investigators
· Kasen K. Riemersma, PhD, University of Wisconsin-Madison
· Brittany E. Grogan, MPH, Public Health Madison & Dane County
· Amanda Kita-Yarbo, MPH, Epidemiologist, Public Health Madison & Dane County
· Gunnar E. Jeppson, Exact Sciences
· David H. O’Connor, PhD, University of Wisconsin-Madison
· Thomas C. Friedrich, PhD, University of Wisconsin-Madison
· Katarina M. Grande, MPH, Public Health Madison & Dane County
“95% of the severe patients are vaccinated. 85%-90% of the hospitalizations are in Fully vaccinated people. We are opening more and more COVID wards. The effectiveness of the vaccine is waning/fading out.”
Other sources: https://thebl.com/health/top-i…vid-hospitalizations.html
Same picture in Singapore, Australia... https://www.globalresearch.ca/…-fully-vaccinated/5752476
One more summary with sources: https://www.algora.com/Algora_…-vaccines-are-ineffective
The popular wisdom to date is that vaccinated people will largely avoid any hospitalization or worse. The idea was that, at least with the delta variant, herd immunity wouldn’t be possible due to transmissibility. At least those who were vaccinated could rest a little easier. Then came this hospitalization report by the Jerusalem Post that revealed 58% of those patients were fully vaccinated, while only 39% were unvaccinated.
This wasn’t supposed to happen. Maayan Jaffe-Hoffman reported that even though there were more vaccinated than unvaccinated in the hospital with breakthrough infections, the actual percentage of those who required invasive treatment was low. Only three fully vaccinated people needed ventilation.
We've been through this so many times...
Israel has high vaccination rates with those most at risk vaccinated
58% of hospital patients are vaccinated
It is expected to happen, unless efficacy of vaccine against serious infection is 100%. We know from other more reliable data that it is (for delta) > 90% but not 100%.
For delta, two worldwide variants on from original, the original vaccine still works. But not as well., It will not prevent infection completely (looks like 50% better than unvaccinated). It will not prevent hospitalisation completely (looks like 95% better than unvaccinated at least in UK where vaccine doses were widely separated). Finally, the vaccine will not protect equally well forever. Likely it will always give some protection (those memory T and B cells formed). But good immediate protection enough to prevent sometime serious symptomatic infection - no.
TSN is a news site - not a science site - and it has an agenda.
It first sets up a straw man "it is expected that vaccines designed for original COVID will provide 100% protection against delta
It then highlights figures (58% patients fully vaccinated) that cannot be evaluated without information about what proportion of older at risk population are vaccinated
Finally it says "this is not expected".
Well, for anyone reading the data, it is expected. We are very lucky still to be mostly protected against delta by the original vaccine. The next variant - maybe not.
The mRNA vaccine providers can generate a vaccine specific to delta in 100 days once given the go-ahead. Personally I think they should have been told to do this already.
THH
PS - there are newer vaccine technologies that promise better protection across variants. We will gte better drugs eventually - though it is tougher than vaccines. But we need to get through things now.
What we face now is the waning protection of an experimental gen therapy that never should have been allowed among younger an healthy people. Of course you should not believe figures of 95/99% severely ill are fully vaccinated are already real. But the play book of nature points in this direction!
The last lie that is uphold (by CDC & Fauci) to force people into vaccination is that only 11 % get a severe illness or 9% end up in ICU.
In fact this data was the first alarming signal that in fact vaccinated people develop 4-10 times more severe illness than unvaccinated people. Unvaccinated people end up in hospital at most in 2-3% of all PCR+ cases. In ICU < 1%.
Also keep in mind that the vaccine protection of the older is 2x better than for the younger (recent linked paper) and age is not the driving factor. The driving factor is always the same. Comorbidity! & Missing preparation = zinc, V-D.
Despite evidence of breakthrough infections on the rise, the current Biden Administration has declared the current surge a “pandemic of the unvaccinated.” But is this a true statement or just another form of government misinformation?
Well I guess you could call it government misinformation if you view that statement as meaning "only the vaccinated can get seriously ill", rather than "the high hospitalisation rate and fast spread is due to the unvaccinated". Given lower vaccination rates in America, and the protection form vaccination, the vast majority of those in hopsital will be unvaccinated. As vaccination + post-infection immunity covers more of the population the hospital population will shift more to vaccinated. They will still be 10X safer than the unvaccinated. Just most of those will be vaccinated, post-COVID, or dead.
TSN's spin on this is definitely a form of TSN misinformation. No question there.
Our best information now is that even with 100% vaccination and delta we cannot stop spread without lockdown. Delta is more than 2X more transmissable than original, and vaccination efficacy is 50%. Admittedly there is quite a bit of uncertainty in this - but it is what we now expect.
Therefore everywhere with high vaccination will see spikes in COVID. These can be managed without lockdown just as Flu is - some people die but not enough to destroy health systems. Specific variants will burn themselves out, as with Flu.
In fact this data was the first alarming signal that in fact vaccinated people develop 4-10 times more severe illness than unvaccinated people. Unvaccinated people end up in hospital at most in 2-3% of all PCR+ cases. In ICU < 1%.
This sounds counterfactual to me. Do you have any data to support it? And are you sure you are not making a similar statistics mistake to what you have done twice before? 
Wyttenbach I was looking for your old post on the Pfizer data - you linked it but I couldnt find it. I looked at the FDA and Pfizer study for the people who may have had ~200 symptoms that were been excluded. I couldnt tell where that was. I know both arms had 1000+ people who had suspected but not confirmed stuff going on which could sway the results right away.
The FDA study said this:
Among 3410 total cases of suspected but unconfirmed COVID-19 in the overall study
population, 1594 occurred in the vaccine group vs. 1816 in the placebo group. Suspected
COVID-19 cases that occurred within 7 days after any vaccination were 409 in the vaccine
group vs. 287 in the placebo group. It is possible that the imbalance in suspected COVID-19
cases occurring in the 7 days postvaccination represents vaccine reactogenicity with symptoms
that overlap with those of COVID-19.
I found this image on the protocol which doesnt talk about that.
Maybe you can help me find out what happened...
I wanted data of suspected infections in the first dose and after the 2nd but could not see it
an interesting read - from a we have not a clue but don't worry cases will go up and then down perspective. I sort of agree with a lot of it.
Maybe you can help me find out what happened...
Once more the official Pfizer report: Emergency Use Authorization (EUA) for an Unapproved ProductReview Memorandum Pfizer BNT162.pdf
The problem is that Pfizer did kick out all early COV-19 cases from the vaccine groups. The study was the biggest cheat ever as Pfizer had the supervision what is 100% against the rules.
an interesting read - from a we have not a clue but don't worry cases will go up and then down perspective.
This is what I say since 3 weeks. Delta will end the pandemic. But the real danger is the vaccinated. Pfizer more than Moderna that for certain reasons get much more sick in a higher rate, what can be explained by the fact that the gen therapeutic antibodies are highly immune suppressive but inadequate to fight delta.
I did advise already many people that got Pfizer to make all precautions we know with zinc,V-D and get some Ivermectin, just in case it hits you. This is mandatory for all "vaccinated" with > 1 comorbidity and age > 50 - latest 5 months after "vaccination".
Just watch the share prices...
Once more the official Pfizer report: Emergency Use Authorization (EUA) for an Unapproved ProductReview Memorandum Pfizer BNT162.pdf
The problem is that Pfizer did kick out all early COV-19 cases from the vaccine groups. The study was the biggest cheat ever as Pfizer had the supervision what is 100% against the rules.
In the attached image is the 311 people with "protocol deviations" -- how did you know what the deviations are? The study has obscured all data about what happened between dose 1 and 2 and the actual cases happening there.
