The vaccine terrorists talk of vaccines because these gen therapies have a similar effect. But the gen therapy is not a vaccination that strengthens your immune system. The gen therapy just produces more or less monoclonal antibodies. This was also the original name for this therapy in cancer. Mono clonal antibody therapy.
So THH's arguments are fake and based on mediocre understanding what science is.
W as is his style is lying again (I was going to say exagerrating - but it is a bit more than that).
The mRNA vaccines code for spike protein sequences - it is true. In that sense the proteins that are generated by the vaccine are less varied than what the body gets when a whole load of COVID viruses enter it.
The antibodies generated are not monoclonal. A given protein will raise varied antibodies (different for each person). It is ironic - the anti-vaxers here paint a picture of mRNA vaccines as being artificial and dangerous, but actually all they are doing is introducing to your immune system in a very safe way a subset of the exposed virus proteins. Those proteins do not stick around for long, and the change comes from your bodies natural immune response. Just like what would happen with the virus except then you gte a larger number of proteins, around for longer. The mRNA vaccine generates T and B memory cells, enough for a long-term response, though how long-term is another issue. It seems likley teh T cell response will stick around a good deal longer than the B-cell reponse.
B-cell response not monoclonal
These latter cross-reactive B cell clones had higher levels of somatic hypermutation as compared to those that recognized only the SARS-CoV-2 S protein, which suggests a memory B cell origin. Our studies demonstrate that SARS-CoV-2 mRNA-based vaccination of humans induces a persistent germinal centre B cell response, which enables the generation of robust humoral immunity.
T-cell response not monoclonal
Two doses of 1–50 μg of BNT162b1 elicited robust CD4+ and CD8+ T cell responses and strong antibody responses, with RBD-binding IgG concentrations clearly above those seen in serum from a cohort of individuals who had recovered from COVID-19. Geometric mean titres of SARS-CoV-2 serum-neutralizing antibodies on day 43 were 0.7-fold (1-μg dose) to 3.5-fold (50-μg dose) those of the recovered individuals. Immune sera broadly neutralized pseudoviruses with diverse SARS-CoV-2 spike variants. Most participants had T helper type 1 (TH1)-skewed T cell immune responses with RBD-specific CD8+ and CD4+ T cell expansion. Interferon-γ was produced by a large fraction of RBD-specific CD8+ and CD4+ T cells. The robust RBD-specific antibody, T cell and favourable cytokine responses induced by the BNT162b1 mRNA vaccine suggest that it has the potential to protect against COVID-19 through multiple beneficial mechanisms.
Six epitopes from the spike protein and 12 epitopes from non-spike proteins were selected to measure T cell responses. The comparison of T cell response after infection or vaccination revealed no significant difference in magnitudes of response, memory phenotypes, T cell receptor repertoire diversity, and αβ T cell receptor sequence motifs in memory T cells generated by natural SARS-CoV-2 infection and vaccination. These findings indicate that the BNT162b2 is capable of boosting pre-existing vaccine-induced as well as infection-induced immunity after the prime-boost immunization.
Importantly, the study identified T cell responses to a spike-derived epitope that is cross-reactive to common cold coronaviruses. Moreover, the analysis of longitudinal samples from COVID-19 recovered participants before and after vaccination identified a subset of T cells, including differentiated effector cells or actively proliferating T cells, which was transient and could not be observed in the same donor at later timepoints. However, the expanded clones from which these transient T cells were derived persisted in other T cell subsets with long-lived memory phenotypes. This indicates that robust T cell memory can be generated by both natural infection and vaccination.
None of which is to say that immune response to mRNA vaccines is as good or as long lasting as response to the full virus - if you are lucky enough to have a strong immune system that can generate it.
W, as always, seizes onto some hotel shampoo bottle larceny and turns it into a major bullion heist.
