Covid-19 News

    A new paper that identifies some promising anti-Covid-19 treatments ---


    "Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface"


    Abstract

    The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares substantial similarity with SARS-CoV. Here, using a computational model of the spike protein (S-protein) of SARS-CoV-2 interacting with the human ACE2 receptor, we make use of the world's most powerful supercomputer, SUMMIT, to enact an ensemble docking virtual high-throughput screening campaign and identify small-molecules which bind to either the isolated Viral S-protein at its host receptor region or to the S protein-human ACE2 interface. We hypothesize the identified small-molecules may be repurposed to limit viral recognition of host cells and/or disrupt host-virus interactions. A ranked list of compounds is given that can be tested experimentally.


    https://chemrxiv.org/articles/…ACE2_Interface/11871402/3


    Table 3 lists the top candidates - some are fairly easy to obtain.

    Worth noting is that the readily available flavonoid quercetin (designated as 'quercetol;quercitin') is highly ranked, so is luteolin-monoarabinoside which I believe is found in dark colored berries, perhaps responsible for their alleged anti-viral effects


    Some speculation - Furin protease inhibitors are also being investigated to reduce Covid-19 infectivity.

    Several flavonoids - baicalein, chrysin, rutin appear to inhibit furin.

    • Official Post

    This link is an analysis of information I was already aware of since about 7 weeks ago but is the first time I see it published in a properly sourced way.


    Basically, It suggests the Covid-19 surge started at least 1 month before than officially acknowledged (I think it started at least two months earlier to spike that way in China) and that the spread begun much earlier, and this caused a spike in “flu” elsewhere and in “flu fatalities”. You can say this is wild speculation, but the data is known and the speculation based in this data does not leave much room for alternative explanations.


    https://medium.com/@sesrenacon…e-suspicious-68d4e2b6be6d

    It could explain why there is no coronavirus outbreaks in Africa because of widespread use of antimalarial drugs like chloroquine, quinine or quinidine- supplies of these drugs can't have been embargoed - what about every traveller on their way to mosquito infested regions? The normal stocks of these must be pretty big. Failing ordering it over the internet I suppose we could all just drink excessive quantities of tonic water which contains quinine/quinidine to get that bitter taste. Schweppes will be pleased if everyone starts stockpiling it instead of loo - rolls.:)

    Quote from Dr Richard

    Why on earth isn't chloroquine being routinely prescribed as a prophylactic in coronaravirus outbreaks? Such a safe cheap remedy effective in micro - molar concentrations against viral entry into cells.:) Pandemic solved?


    Let me take a wild guess: there's hardly any money to be made?


    Dr Didier Raoult of France, among the top infectious disease specialists in the world, has said the following recently about covid19, translated:


    Quote

    Ultimately, this infection is perhaps the simplest and cheapest to treat of all viral infections.


    He was referring to the use of chloroquine phosphate, something that has been around for about 70 years.


    https://translate.google.com/t…-efficace.php&prev=search

    • Official Post
    Quote from Dr Richard

    Or there's always hydroxychloroquine used to treat malaria,lupus and rheumatoid arthritis possibly just as effective?


    1- don't try to make a clinical test yourself with hydroxychloroquine...

    2- Chinese have done such test and Pr raoult reports that one of the observation is that infections last for 4 days with that. The report is not clear, not quantified, but said very positive... which raises incredulity.

    3- Pr Raoult explained that he was not surprised, and even advised to test Chloroquine, because he used that medication to cure bacterial infection inside cells, that anre technically not so different from big viruses (used same vacuole, that HCQ make more acidic). he used much higher doses than used agains malaria. It is know to work in vitro agains many coronaviruses, but yest in vivo may be different.

    4- Recently some noticed that Chinese authorities have launched a plan to push production of hydroxychloroquine and another known antiviral (I forgot... maybe Remdesivir)

    5- some article reports that agains Chloroquine and another antiviral are officially on "guidelines" in china

    6- there is an article in nature about "repositioning", which is a strategy that Pr Raoult push (since hardest point in making a medication, is testing it's toxicity, and that for a known medication used in another indication, that job is done).

    7- recognized virologist in FR,CH,QC, all reported the chineses scientits have communicated since the beginning, in December... Chinese are said very good , if not leader in virology in the world.

    8- another medication, against arthitis (an antiinflamatory) is interesting Chineses https://www.fiercepharma.com/p…-new-treatment-guidelines


    Don't use it alone it is a medication that have a lethal dose not far from the effective dose. The disease will probably not be serious for most of you... If you are young, don't smoke, have good lungs... anyway, wash your hands, avoid big events, to visit the elderly, in order to slow the propagation, so that the hospital are not flooded by people needing a respirator.

    Washing hands&alike may also push usual flu to extinguish faster, making room in emergency care hospital.


    It is a great moment in humanity. See the speed to sequence ARN, provides tests, try vaccines, tray antiviral, high communications, huge public awarenes, beside the conspiracy theories, great advices (wahing hands, avoiding meetings...), and great tools (hydroalcoholic fluid, remote work, teleconference tools) are available...


    The curves of infection grow, but more and more country are in linear if not logistic shape, with logistic limit quite low...

    The hardes will be to convince the careless majority to calm down propagating the virus by shaking hands and going to the disco or to visit the elderly... Percolation theory rules.

    another chemrxiv article ..re: chloroquine possible action

    by Liu and Li from Sichuan..


    According to the validation analysis of these finds, Chloroquine

    could prevent orf1ab, ORF3a and ORF10 to attack the heme to form the porphyrin, and inhibit the

    binding of ORF8 and surface glycoproteins to porphyrins to a certain extent. Therefore, this research is

    of high value to contemporary biological experiments, disease prevention and clinical treatment.


    https://chemrxiv.org/articles/…ing_to_Porphyrin/11938173

    I got both chloroquine and amantadine without prescription here: http://24x7globalmed.com/search?q=chloroquine

    It took about two weeks.


    CAUTION: the source is India and there is no way to judge whether it is real or counterfeit. It does look a bit rough but generally OK (I will add images). You can judge the web site for itself. You can check the internet archives to see if it's been around for a while.


    I strongly suggest *not* taking this preparation from this source prophylactically. I am keeping it on hand in case things get really bad and I can't get treated with it through usual USA channels should I get sick. Chloroquine is serious medicine with potential side effects which also can be serious. Same with Amantadine and of course Remdesivir even more so. Remember that many Covid-19 infections are asymptomatic (percentage unknown). It has been theorized that up to 80% of patients have no more than a brief elevation of temperature (103 F or so) which lasts less than a day. The exception seems to be those more than 65 year old and those with immune suppression for whatever reason or serious other illness like uncontrolled diabetes and congestive heart failure. Even for those people, the risk of chloroquine may exceed the benefits. However, if you do get symptoms and test positive, I would suggest using it rapidly, in consultation with your physician.

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