I do not know enough about medicine to follow this discussion of hydroxychloroquine. I could not judge whether it might be effective. However, since it has been approved for other uses, I suppose it is reasonably safe in the correct dosage. Even if it does no good, I don't suppose it would do much harm. If doctors feel it helps, I would encourage them to use it. I would ask that it be used on me if I were sick. I understand that in normal circumstances you have to do double-blind testing and you have to be careful when deploying a new drug. You even have to be careful when using an old drug in new ways. But these are not normal circumstances. In this situation, I think we should put aside the rules and use whatever the doctors think is best. They may be judging by intuition, but the intuition of a professional is often a good thing to go by. You want ship captains and airplane pilots to pay close attention to their intuition.
We can always do double blind tests for a reserved set of people while many doctors outside the study go ahead and use the drug before the test results are in.
Since this situation is so extraordinary, I think we should skip some steps in the development of a vaccine, too. Or accelerate steps, even to the point of recklessness. As reported the other day, tests of vaccines on human volunteers has already begun. This might hurt the test subjects, but they are willing to take that risk. I would be willing too, even if they told me there is a significant risk of harm. In this case, the harm of delaying far outweighs the harm that a few dozen volunteers might suffer.
I believe in normal circumstances, they would not have started the human tests so soon. I guess they would still be inoculating mice or primates?