Covid-19 (WuFlu) News

  • From the BBC new site;

    UK, residents are now only allowed to leave their homes for “very limited purposes” like shopping for necessities.

    The direction of travel is clear, but the restrictions announced by the UK prime minister still fall short of the measures in place in many European countries, where most people can’t now leave their houses without a special permit.

    In Italy and Spain even outdoor exercise is banned.

  • UK now officially on lockdown from tonight.

    Briefing at work today NHS is looking at 12 weeks minimum for this.


    Wow! Boris Johnson has guts, doing this.


    I am glad people are taking this seriously.


    As I have said -- too many times -- I only wish the UK and the U.S. had learned from Japan . . . Last night there was an in-depth documentary and interview with the team of epidemiologists in Japan who are finding clusters of cases, and identifying links. There are only about 30 of them! It is extraordinary. It is surely the most amazing accomplishment in the history of public health. Of course there are thousands of other people doing field work such as asking patients where they have been. Maybe they look at cell phone records? I don't know. Anyway, this small group is doing the most important job of spotting clusters, and patients who are not connected with anyone else which may indicate a hidden cluster. The head of the effort is middle-aged prof. He said what is most needed for this work is "to be afraid, very afraid." They cannot let down their guard for even an hour. He said he deeply regrets that the situation has gotten out of control in the EU and the U.S.

  • Brave New World - none of this would have been necessary if the authorities had acted at the same time as China in mass distribution of anti-viral medicines. The total number of deaths curve in China begins to flatten out on 20 Feb just after chloroquine delivery from Pakistan. Just as Italy was erupting in an exponential rise. Hopefully the three day decrease following chloroquine/azithromycin therapy begun on 20 March will continue in Italy and then can be extended to the rest of us. The question arises though could all of this and the devastating economic meltdown have been avoided if Bayer along with all other big pharma had responded immediately on 20 Feb flooding pharmacies across the World with supplies of hundreds of millions of Chloroquine doses? Why was it just China? Instead of the opposite reaction of UK pharmacies telling everyone that it would never work and trying to restrict people from any access to it and insidiously stockpiling it anyway by restricting any exports?

  • Some possibly better news on the post-infection immunity problem - short-term at least.. https://www.nature.com/articles/s41591-020-0819-2


    We report the kinetics of immune responses in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) that required hospitalization. Increased antibody-secreting cells (ASCs), follicular helper T cells (TFH cells), activated CD4+ T cells and CD8+ T cells and immunoglobulin M (IgM) and IgG antibodies that bound the COVID-19-causing coronavirus SARS-CoV-2 were detected in blood before symptomatic recovery. These immunological changes persisted for at least 7 d following full resolution of symptoms.

  • Brave New World - none of this would have been necessary if the authorities had acted at the same time as China in mass distribution of anti-viral medicines. The total number of deaths curve in China begins to flatten out on 20 Feb just after chloroquine delivery from Pakistan. Just as Italy was erupting in an exponential rise. Hopefully the three day decrease following chloroquine/azithromycin therapy begun on 20 March will continue in Italy and then can be extended to the rest of us. The question arises though could all of this and the devastating economic meltdown have been avoided if Bayer along with all other big pharma had responded immediately on 20 Feb flooding pharmacies across the World with supplies of hundreds of millions of Chloroquine doses? Why was it just China? Instead of the opposite reaction of UK pharmacies telling everyone that it would never work and trying to restrict people from any access to it and insidiously stockpiling it anyway by restricting any exports?


    There’s a lot to unpack with what you are arguing. South Korea went right into chloroquine too, and they had 7 recorded deaths today. China has had recorded deaths over the last week as well.


    I hope chloroquine is the answer to all of this. But perhaps it doesn’t alway work for everyone in all cases. We will know a lot more in the coming weeks now that it is being put to widespread use in the West. If it brings the death rate down substantially it will be a huge sigh of relief. Not a home-free by any means, but a better wait to a vaccine.


    But Dr. Richard you have been banging the chloroquine drum from early on here. So if it works in a meaningful way, credit to you.

  • Brave New World - none of this would have been necessary if the authorities had acted at the same time as China in mass distribution of anti-viral medicines. The total number of deaths curve in China begins to flatten out on 20 Feb just after chloroquine delivery from Pakistan.


    We are 32 days later, and tomorrow New York Doctors have been given official approval to start with the Chloroquine. Not bad at all IMO, but since you were on this so early, and kept "banging the drum" as Deleo said..even taking a few arrows in the process, you are more than welcome to have your own opinion. :)


    If the drug combo does not work though, I take that back.

  • Oh really. He said that measles, in America, is a "very, very serious disease."

    Please excuse me if I don't trust the dude.

    Last year, the measles killed 140,000 people worldwide, most of them children. When pregnant women get it, it can severely damage the baby. It is one of the most contagious diseases. The mortality rate among children is 0.3, three times worse than the flu, and the lifelong complications are much more common, and far worse. If you don't think that is a very, very serious problem, you have no knowledge of medical science, and no common sense.

  • Re-infection of recovered patients is already happening in Italy, though there is scant data yet.

    The Japanese epidemiologist on national TV and Dr. Larry Brilliant say we shouldn't worry about this. They say it might happen, but it is probably so rare it makes no difference. QUOTE:


    There are cases where people think that they've gotten it again, [but] that's more likely to be a test failure than it is an actual reinfection. But there's going to be tens of millions of us or hundreds of millions of us or more who will get this virus before it's all over, and with large numbers like that, almost anything where you ask “Does this happen?” can happen. That doesn't mean that it is of public health or epidemiological importance.


    https://www.wired.com/story/co…-smallpox-epidemiologist/


    https://www.wired.com/story/di…scientists-are-skeptical/

  • Nigeria advises caution...

    after several overdose on CQ... it might be good to check Trump's medical expertise

    https://edition.cnn.com/2020/0…p-nigeria-intl/index.html


    No, I get it. Chloroquine is a powerful drug. People with certain conditions can have very negative reactions to it. Here is another story that sounds unrelated to the one you are mentioning.


    http://bannerhealth.mediaroom.com/chloroquinephosphate

  • Last year, the measles killed 140,000 people worldwide, most of them children. When pregnant women get it, it can severely damage the baby. It is one of the most contagious diseases. The mortality rate among children is 0.3, three times worse than the flu, and the lifelong complications are much more common, and far worse. If you don't think that is a very, very serious problem, you have no knowledge of medical science, and no common sense.

    Indeed measles is extremely contagious. But Jed you weren't listening. He said *America*, not countries where people lack for proper nutrition and hygiene, where yes measles can even be deadly. (Give them vitamin A and it would not be like that!) Even I would recommend the measles vaccine in certain countries, for certain populations. That is because it is a live, attenuated vaccine. But inactivated vaccines like DTaP is another story. Those vaccines kill many times more children than they save, killed from non specific conditions (ie, disease not targeted for by the vaccine). Watch a health worker in the field, an MD and PhD, share her team's findings from African villages.


    Relating this to covid19. I've heard advice that people should get their yearly flu vaccine, that it will offer some protection against covid19. Wrong. It may do exactly the opposite, with a phenomenon known as 'virus vaccine interference', increasing the odds of corona virus infection by over 30 percent. See

    https://www.nogeoingegneria.co…k-36-says-military-study/

    or

    https://www.ncbi.nlm.nih.gov/pubmed/31607599

  • https://nypost.com/2020/03/23/…ate-to-treat-coronavirus/


    Man dies after self-medicating with chloroquine phosphate to treat coronavirus


    A man died after ingesting an additive used to clean fish tanks — the pharmaceutical drug version of which has been touted by President Trump as a potential coronavirus cure.


    Within 30 minutes of taking chloroquine phosphate, the man in his 60s experienced “immediate effects” and had to be admitted to a nearby Banner Health hospital, the medical system in Arizona said in a press release Monday.


    His wife, also in her 60s, is in critical condition after taking the additive, which is used in aquariums to kill some organisms, like algae, that may harm fish.


    Prices of the product on eBay skyrocketed after some studies found that the pharmaceutical version, the anti-malarial drug chloroquine, and a derivative of it called hydroxychloroquine, were effective in killing the virus in laboratory experiments.

  • Ciclesonide...Alvesco .. existing asthma inhaled steroid prodrug

    may be effective against Covid,

    Less side effects than chloroquine


    1. In vitro action against CV RNA ....biorxiv..

    2. S. Korea..Drug modelling shows it to have much promise

    3....3 patients in Japan had good results


    https://www.biorxiv.org/content/10.1101/2020.03.11.987016v1

    http://www.ajudaily.com/view/20200323122525195

    https://mainichi.jp/english/ar…00317/p2a/00m/0na/026000c

    Trials are in progress..soon

    Japan Plans Alvesco Clinical Trial for Coronavirus

    Japan’s National Center for Global Health and Medicine (NCGM) is planning a clinical trial for Teijin’s Alvesco (ciclesonide), for the treatment of pre-symptomatic patients infected with the Covid

    .. whether Alvesco is effective in preventing virus-infected patients with no pneumonia symptoms from developing COVID-19 pneumonia, Norio Omagari, head of the NCGM’s Disease Control and Prevention Center, said at a press conference on March 23. The center is currently compiling a protocol, aiming to start the trial as soon as possible.

    Note.. Ciclesonide forms desisobutyrylciclesonide DIBC...

    DIBC appears to bind with one of the twenty NSPs(nonstructural proteins..)

    which have been sequenced

    -NSP15-which is an enzyme -- an endoribonuclease.

    http://www.rcsb.org/3d-view/6W01/1


  • Axil,


    Interesting story, but It was the Daily Mail that first made the connection between Hydroxychloroquine, and the fish tank cleaner 3 days ago:


    https://www.dailymail.co.uk/he…tested-COVID-19-drug.html


    Although one of their typical political hit pieces, I do give them credit for at least warning readers: "Sellers of the fish tank product warn it is not for human consumption".


    Now think about it; this bright idea to drink a cleaning product was the wife's. The husband is dead, while she is still alive...although she claims to have gotten sick also. Although not too sick to talk to the news, and make it a point to drag Trump into this. What does that tell you?


    Tells me, either this story is better suited for "True Detective" magazine (if that is still in print), and if not, is a candidate for this years Darwin Award.

  • My order of chloroquine from 24x7 pharma that SOT suggested earlier is still held up in customs for 5 or so days. Do the bureaucrats realize they are costing lives holding up these deliveries? Anyone have any suggestion to help remedy this situation? Call a Senator? And the some stupid article about one patient overdosing. Thanks media.