impact has been "profound,"
on the authority of
Lieutenant-General Dr Shaikh Mohamed Abdullah Al Khalifa.
data data data? how profound?
and did Abdullah use antiviral X..virs concomitantly? or azithromycin?
the best evidence so far is the French trial on medrxiv.
HCQ PLUS azithromycin( Zithromax)
both old cheap drugs.. but probably in short supply recently
Display Moreon the authority of
Lieutenant-General Dr Shaikh Mohamed Abdullah Al Khalifa.
data data data? how profound?
and did Abdullah use antiviral X..virs concomitantly?
Even in the more developed countries, Doctors on the front lines are ahead of the controlled studies. Priority one; save the patient with what works best, and then if it was not the normal standard protocol, follow up with the data, data, and then more data.
That said, describing the outcomes as "profound", with nothing else to add, may have more to do with the title of author they quoted:
Supreme Council of Health chairman Lieutenant-General Dr Shaikh Mohamed Abdullah Al Khalifa.
Gupta: The truth about using chloroquine to fight coronavirus pandemic
Dypyridamole??? tantalising results for an old antiplatelet drug..
reduces hypercoagulation?
Overcoagulation of blood is one adverse result of Covid
Dipyridamole has been approved for clinical studies by
Dawu County People's Hospital and the First Affiliated Hospital of Guangzhou Medical University.
Clinical trial (C) was registered.
As a result, we has finished its first-round clinical
trials including 31 patients with COVID-19 and it demonstrated markedly improved clinical outcomes
More drug repurposing and nutraceutical for COVID-19 treatment
SARS-CoV-2 main protease (Mpro) is a novel therapeutic drug target.
Mpro is a key protein required for the proteolytic maturation of the virus
Identification of Potent COVID-19 Main Protease (Mpro) Inhibitors from
Natural Polyphenols: An in Silico Strategy Unveils a Hope against CORONA
(Four Potent Hits: Hesperidin, Rutin, Diosmin, Apiin)
https://www.preprints.org/manuscript/202003.0333/v1
FEP-based screening prompts drug repositioning against COVID-19
(15 of the 25 FDA approved drugs tested showed potent Mpro inhibition.
See pages 14-15 for drugs and potencies. Note chloroquine is potent.
Montelukast sodium[AKA Singulair] and omeprazole[AKA Prilosec] are also.)
Looks like the evidence for using hydroxychloroquine with azithromycin and Zn supplement is overwhelming now. Wake up NHS and WHO - I guess we will have to 're-purpose veterinary grade fish tank cleaner now all the pharmaceutical supplies have been stockpiled! Too little too late
all the pharmaceutical supplies have been stockpiled!
Nonsense: Sanofi (France) long time ago > 2 weeks ramped up production. Bayer certainly did the same. This drug has been produced in the Billion dose amount for 100's of Million people exposed to Malaria.
Cluster outbreak in Tokyo Inaricho (Taito-Ku). In a local hospital 10 people were tested positive. (Its close to our home place in Asakusa.) Now they have to track hundreds of visitors, doctor family members etc..
We (Switzerland) just found 10 Mio additional masks that have been stock piled by industry for emergency cases. They had to re-certify them as they are over the expiration date... They work better than expected, 4 hours...
This is good news as the EU forces companies to break contracts for covid-19 used material...
Thus I guess Trump has to "ask" for plaquenil. May be he can trade in the old - post war - espionage contract, that allows the US to read all German communication...
...
Décret n° 2020-314 du 25 mars 2020 complétant le décret n° 2020-293 du 23 mars 2020 prescrivant les mesures générales nécessaires pour faire face à l'épidémie de covid-19 dans le cadre de l'état d'urgence sanitaire
Here is a New York Times article with a model showing what happens if we end social distancing and reopen the U.S. sooner, rather than later:
https://www.nytimes.com/intera…trump-reopen-america.html
It shows the effects of social distancing for 14 days versus 2 months. 14 days produces 128 million total infections by October 1, with a sharp peak in late May. 2 months produces 14 million infections, with a rising number on October 1. You may think that a rising number is bad news, but it would be good because by then we should have enough masks, hazmat suits, ventilators and so on. (Ventilators especially if James Dyson can make them, as he thinks he can.)
Some quotes from the article:
By Nicholas Kristof and Stuart A. Thompson
Model created with Gabriel Goh, Steven De Keninck, Ashleigh Tuite and David N. Fisman
MARCH 25, 2020
. . . .
Note: “Social distancing” also includes a reduction in large gatherings; some school closures and working from home; and efforts to support hospitals and diagnostic testing. Based on a simulation between January and late October using an epidemic model. See full methodology for details.
President Trump says he wants the United States “raring to go” in two and a half weeks, on Easter, with “packed churches all over our country.” He and many other political conservatives suggest that we are responding to something like the flu with remedies that may be more devastating than the disease.
We created this interactive model with epidemiologists to show why quickly returning to normal could be a historic mistake that would lead to an explosion of infections, hospitalizations and deaths.
Instead, health experts advise giving current business closures and social distancing a month to slow the pandemic, buying time to roll out mass testing and equip doctors with protective equipment. Then, depending on where we are, we can think about easing up — while prepared for a new burst of infections that will then require a new clampdown.
Play with this model below by moving the slider to change the length of time that controls are in effect, and you’ll see the impact on lives lost. . . .
Wyttenbach OK try getting hold of some then, then you will see the problem.
Managed to find some clarithomycin which is very similar to azithromycin today. Anyone know how to source RNA dependent RNA polymerase inhibitors like remdesivir? Might as well acquire the full battery of anti-virus compounds and have it ready if needed. I'm sure Prince Charles will be taking no chances with the 'Oh just self isolate and hope you get better' approach to date of the NHS. Or maybe he's a false positive since there are so many. Thought! If testing is so unreliable why not spend the money on medicines instead?
Great news! The NHS has just bought millions of antibody test kits which nobody really knows work. (BBC news at six on NOW) And coughing at police officers is now a criminal offence! One of my distant ancestors Jonathan Swift, the great political satirist, would be laughing in his grave.
Décret n° 2020-314 du 25 mars 2020 complétant le décret n° 2020-293 du 23 mars 2020 prescrivant
They (French) also will use Lopinavir/Kaletra what Swiss (use it since one month) doctors found is sub-optimal for younger. They should ask Japan/China for Favipiravir!
demographic study from death certificate in France.
in the Eastern cluster, mortality have increased by 75% compare to normality.
Upper is all France, lower is East (big cluster)
The bump above around weak 5 is the end of flu. the huge peak is Covid19.
Note 017 flu was terrible, but covid is already above in the east.
About distribution of people in ospital, in ICU, back home, or dead
America No 1.
The eagle edges out the dragon..in the Year of the Rat
.
robert bryant Very interesting, the dipyridamole clinical study but awGads it's small. Much sketchier even than the Raoult study of HCQ and Azi! Dipyridamole is sold as Persantine in the US, for use as an adjunct to anticoagulants in preventing clots in such things as artificial heart valves. Surprisingly, it seems to have a low incidence of adverse effects as per prescription information. The usual dose for the anticoagulant role is 200 mg of extended release twice a day or up to 400 mg of the rapid release three times a day (PLEASE! never take anything or decide on dose without advice of your physician!!!!!!). That makes it expensive. A bottle of 100 x 50 mg tablets at McGuff is $90 US for the generic. You don't want to know the cost of the brand product ($600+).
On the other hand, Montelukast (Singulair brand in the US) is very inexpensive. Less than $5 for 100 tabs from a medical supply house. It is used to treat bronchospasm and asthma (chronically, never for rescue) and seems pretty safe. You can Google prescribing information for dose and side effects and again: NEVER without advice from your physician.
Thanks for the info- every little bit helps. I only wish they had studied a larger group. The controls for the dipyridamole were only ten patients and they had wildly diverse outcomes.
QuoteEven in the more developed countries, Doctors on the front lines are ahead of the controlled studies. Priority one; save the patient with what works best, and then if it was not the normal standard protocol, follow up with the data, data, and then more data
No. Putting the cart ahead of the horse. Testing a rocket by firing it into the ground.
No. Not with ethical doctors. It is always possible to get a terrible surprise. A promising drug may, when the data are sorted, may do more harm than good, even killing people. Without a controlled study, even at least a sketchy one, you know nothing. Anecdotes of individual cases and small, uncontrolled studies tell you virtually nothing. At best, they can point to the need for a study. Might as well reach into a pharmaceutical warehouse and pick something up at random and give that. There is a small, rare exception for anecdotal data and that is when a patient is irrevocably terminal and you thus can do little or no harm.
