Quote from Alan Smith

Well, there are 1.45 Bn + people in China. 21,Mn is a tiny number compared with that, especially when you consider that many of those a/cs would have been business accounts belonging to shut down operations. Places like China pretty much run on wireless phones, the old 'twisted pair'technology never got very deep into the countryside.

But then on the other hand..... here is what happens to people who publish reality in China that goes against the agenda......

https://nypost.com/2020/04/01/…or-mysteriously-vanishes/

China is to be believed and one to emulate as is sometimes posted here?

Quote from JedRothwell

If there is social destruction in the U.S., it will be the fault of the Congress and the administration. It is easily avoidable.

The poor countries can do little..

their recovery is totally dependent on the early recovery of the rich countries and subsequent charity

Quote from Bob#2

China is to be believed and one to emulate as is sometimes posted here?

The WHO holds up China as an example.. but cannot utter the word " Taiwan"

Critics say the WHO is too deferential to Beijing, which under the so-called One China policy considers Taiwan part of its territory.

Wen-Ti Sung, a political scientist from the Australian National University,

told the ABC China's funding for UN agencies such as WHO made it relatively immune to criticism.

https://www.abc.net.au/news/20…us-response-data/12101512

https://www.taiwannews.com.tw/en/news/3908633

Quote from Shane D.

Does anyone believe the communist Chinese version of the story about the whistle blower, and *hero*: "Dr. Zhongming, 57, died at Jinyintan Hospital on Tuesday after “all-out rescue efforts failed,” ?

Yup, I am sure that is what happened. There were many eye-witnesses who told the public. Thousands of people blamed the government, despite the danger of doing so. The way the story was reported was a blow to the government. They would have framed it some other way if they could have hidden the facts.

Quote from RobertBryant

https://www.bloomberg.com/news…lion-users-as-virus-bites

While the drop in users is unusual, the total is small relative to total wireless subscriptions

which have risen to a combined 1.6 billion for the three carriers.

1%?

Display More

Robert,

I guess my 1st concern is that they all died from this virus and no one is using the phones.

Regarding the argument that we cannot shut things down and doing so will cause social disruption . . .

Imagine the U.S. were invaded by a foreign army, rather than viruses. Imagine this army was killing 1,000 people a day, and in 3 days it would start killing 2,000. It was likely to kill at least a few hundred thousand, according to government estimates. Image that the only way to defeat it was to put the entire nation on a war footing, as in WWII, shutting down the civilian economy, and converting auto factories into weapons manufacturing. No one would say: "It isn't worth it. We need the economy. Let them kill as many as they like. Besides, if we fight them, they may kill even more people. The cure may be worse than the disease." That would not only be treasonous, it would be insane. You can't have a regular economy and a normal life when soldiers are rampaging through the nation killing thousands of people a day. No one will go to work when there are soldiers machine gunning thousands of people in the streets every day. And no one will go to work when a virus is killing thousands of people.

You cannot have a normal life or a normal economy during a major epidemic such as 1918 Spanish flu, or today. No country ever did that. An epidemic paralyzes the entire nation with fear, and shuts everything down, until it passes.

For those who wish to follow the latest COVID-19 (non-peer-reviewed) preprints on medRxiv.org and bioRxiv.org, these are on the URL: https://connect.biorxiv.org/relate/content/181

A few published in the last two days that I found interesting were ---

Clinical observations of low molecular weight heparin in relieving inflammation

in COVID-19 patients: A retrospective cohort study

( - low molecular weight heparin has potential antiviral effects and can help delay or

block inflammatory cytokine storms. It can also increase the lymphocytes (LYM%)of

patients and has the potential for treatment of COVID-19.)

https://www.medrxiv.org/conten…101/2020.03.28.20046144v1

Azithromycin and ciprofloxacin have a chloroquine-like effect on respiratory epithelial cells

https://www.biorxiv.org/content/10.1101/2020.03.29.008631v1

(However, cipro is a fluoroquinolone with some serious side effects.)

Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro

https://www.biorxiv.org/conten…0.03.29.014407v1.full.pdf

HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

https://www.biorxiv.org/content/10.1101/2020.03.29.014183v1

The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Directly Decimates Human Spleens and Lymph Nodes

https://www.medrxiv.org/conten…101/2020.03.27.20045427v1

No Evidence for Temperature-Dependence of the COVID-19 Epidemic

https://www.medrxiv.org/conten…101/2020.03.29.20046706v1

Then there is the case of Ai Fen.. whose 'social credit ' also seems to have run out

"

two weeks ago Dr Ai Fen, director of the emergency at Wuhan Central hospital, went public in the Chinese magazine, Renwu, saying she had been disciplined and silenced in December 2019 after alerting her superiors to the unknown virus afflicting her patients.

"If I had known what was to happen," she said. "I would not have cared about the reprimand. I would have f**king talked about it to whoever, wherever I could."

President Xi ordered her interview erased from the internet. Dr Ai Fen herself has disappeared, whereabouts unknown.

https://9now.nine.com.au/60-mi…b3-4439-9089-b733b8e4a6c5

Why bats are not kosher..

Leviticus 11:13-19

"

Bats' fierce immune systems drive viruses to higher virulence, making them deadlier in humans

https://www.sciencedaily.com/r…/2020/02/200210144854.htm

Here is a projection cited by Dr. Birx at a White House briefing. Many experts agree with this. It is easy to understand, and it has real data up to today.

https://covid19.healthdata.org/projections

Quote from Shane D.

That said; can we trust the "many eye witnesses"? And if so, where are the Chinese investigations to prove he died as claimed?

We can trust them because what they said was terrible news to the Chinese government. It caused a large public outcry against the government. He is seen as a victim of the government. A martyr. The last thing the government wants is an investigation.

If he had died some other way, or just vanished, it would have been better for the Chinese government. If they wanted to get rid of him quietly for some reason, they would have. They often do that to people.

Quote

The exit strategy is obvious! Everyone knows what it is. Keep the numbers down by following up on every case, and quarantining every patient, until a vaccine is deployed. That's all there is to it.

Shane D.

JedRothwell is precisely correct on the above. The only thing that will end the crisis in the US and the developed world is a fast test, preferably done without a machine like a pregnancy test. Then, meticulous case tracing and quarantining positive cases. We will probably also know from immunoglobulin studies who has sufficient immunity. That is now commonplace in measles and chickenpox.

A big problem will be the undeveloped countries. WTF will they do? They will need a lot of help. But a good motive for helping them apart from the obvious humanitarian one is that they could serve as an endless reservoir for the virus.

This looks promising

Quote from Alan Smith

The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15

Shutoku Matsuyama, Miyuki Kawase, Naganori Nao, Kazuya Shirato, Makoto Ujike, Wataru Kamitani, Masayuki Shimojima, Shuetsu Fukushi
doi: https://doi.org/10.1101/2020.03.11.987016This article is a preprint

Abstract

Steroid compounds, which are expected to have dual functions in blocking host inflammation and MERS-CoV replication, were screened from a chemical library. Within this library, ciclesonide, an inhaled corticosteroid, suppressed human coronavirus replication in cultured cells, but did not suppress replication of respiratory syncytial virus or influenza virus. The effective concentration of ciclesonide to block SARS-CoV-2 (the cause of COVID-19) replication (EC90) was 6.3 μM. After the eleventh consecutive MERS-CoV passage in the presence of ciclesonide, a resistant mutation was generated, which resulted in an amino acid substitution (A25V) in nonstructural protein (NSP) 15, as identified using reverse genetics. A recombinant virus with the mutation was also resistant to ciclesonide suppression of viral replication. These observations suggest that the effect of ciclesonide was specific to coronavirus, suggesting this is a candidate drug for treatment of patients suffering MERS or COVID-1.

From "Corriere della Sera", Italy, via Google Translate

Francesco Scaglione, professor of Pharmacology at the University of Milan and clinical pharmacologist at the Niguarda Hospital, is among the experts in charge of putting firm points on the therapies that have shown, to date, evidence of efficacy against the pathology triggered by SARS-CoV-2.

Professor Scaglione, can you anticipate something?

"First of all, these are indications - which will be constantly updated - whose aim is to clarify doubts about the daily management of the patient with Covid-19".

So what are the drugs that really work?

«We started from a reflection: a key role is that of the mechanism of excessive inflammation associated with a cytokine release syndrome. Based on this survey, and with a view to preventing serious forms in patients in home isolation, we have developed a proposal for therapy to be followed at home, inexpensive and that could easily be prescribed by family doctors. The combination is as follows: hydroxychloroquine (an old antimalarial drug), azithromycin (antibiotic with immunomodulating effect) and celecoxib, anti-inflammatory with activity against type 2 cyclo-oxygenase (COX-2, enzyme that determines the release of cytokines). Two different dosages of hydroxychloroquine were hypothesized for those under 65 without risk factors and for subjects over 65 and / or with concomitant pathologies. All patients should take potassium and magnesium supplements to avoid the risk of cardiac arrhythmias, a possible side effect of the combined hydroxychloroquine-azithromycin ".

Anti-HIV drugs, which are talked about a lot, are not mentioned.

"It was a clear choice: the experience gained in the Lombard clinical centers regarding the use of lopinavir / ritonavir (and other medicines that act in a similar way) shows, in a relevant percentage of patients, a poor tolerability of therapy and moreover there is a widespread perception of ineffectiveness. Lopinavir, as well as darunavir, are drugs designed to target a typical target of the HIV virus, which is not present in Sars-CoV-2 ".

https://www.corriere.it/salute…838fa.shtml?refresh_ce-cp

Quote from Lou Pagnucco

For those who wish to follow the latest COVID-19 (non-peer-reviewed) preprints on medRxiv.org and bioRxiv.org, these are on the URL: https://connect.biorxiv.org/relate/content/181

...

No Evidence for Temperature-Dependence of the COVID-19 Epidemic

https://www.medrxiv.org/conten…101/2020.03.29.20046706v1

On the other hand there is this study:

Causal empirical estimates suggest COVID-19 transmission rates are highly seasonal

https://www.medrxiv.org/conten…101/2020.03.26.20044420v1

Quote

This paper provides the first plausibly causal estimates of the relationship between COVID-19 transmission and local temperature using a global sample comprising of 166,686 confirmed new COVID-19 cases from 134 countries from January 22, 2020 to March 15, 2020. We find robust statistical evidence that a 1°C increase in local temperature reduces transmission by 13% [-21%, -4%, 95%CI]. In contrast, we do not find that specific humidity or precipitation influence transmission. Our statistical approach separates effects of climate variation on COVID-19 transmission from other potentially correlated factors, such as differences in public health responses across countries and heterogeneous population densities. Using constructions of expected seasonal temperatures, we project that changing temperatures between March 2020 and July 2020 will cause COVID-19 transmission to fall by 43% on average for Northern Hemisphere countries and to rise by 71% on average for Southern Hemisphere countries.

The evidence for temperature dependence reducing spread is thin. Sure viruses survive best below 5 Deg C but that won't make transmission between hot bodies in an igloo more or less likely would it? More likely lowered immunity in cold weather coupled with seasonally low vitamin D. Then it you include data from hot malarial regions where previous flu epidemics (1918) decimated 2 million people in 3 months- well nothing like that has happened yet, say compared to an advanced country like Italy which is also quite hot. Oh yes it must be the anti malarial drugs they're taking unless they are genetically immune? Unlikely because this is a new virus unlike H1N1 which caused previous pandemics. But it's always possible.

Quote from Roseland67

That 21.000,000 cell phone accounts have gone inactive?

No money (shop closed laid off) no phone - very simple!

Quote from Ahlfors

the experience gained in the Lombard clinical centers regarding the use of lopinavir / ritonavir = Kaletra

This has been used as a last resort in Switzerland. May reduce virus count up to 20% what can help in certain cases but mortality at this stage is around 50% anyway.

Avigan the Japanese anti flue drug has one more serious side affect as reported by German news papers. Blood carbamide level can strongly raise up to kidney damaging levels. Definitely more studies for combined medication is needed.

Only advise: Do not enter any shop where masks are not mandatory!!