Covid-19 News

    Sceletium looks interesting too, but there are just so many plant products to screen::)

    3.21. Sceletium tortuosum (L.) N.E. Brown (Aizoaceae)

    The ethanolic and ethyl acetate extracts prepared from the whole part of Sceletium tortuosum, distributed throughout southern Africa, were investigated for their inhibitory activity against HIV-1 enzymes including protease (PR), reverse transcriptase (RT) and integrase (IN) [172]. The HIV-1 RT inhibition testing had IC50 values of <50 and 121.7 ± 2.5 μg/mL for ethanol and ethyl acetate extracts, respectively. In addition, both extracts had also inhibited HIV-1 PR with IC50 values < 100 μg/mL. Sceletium tortuosum might be a potential source of new lead compounds in the development of new anti-HIV compounds [67].

    Quote from axil

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    Should Zinc Be Added To Treatment Protocols For Covid-19 Patients?


    220 mg Zinc adjunct with HCQ protocol giving good results

    We have just finished the analysis of a large panel of minerals in patients with COVID-19 and found that the serum levels of Zn were crazy low. Not only all patients were deficient but also the levels were up to several times less than the levels measured in a control group. Levels of Fe, Se and Cu were also found to be different. All other minerals (Na, K, Ca, Mg, I...) had similar levels in both groups.


    There is plenty of things that we still do not understand with this virus.

    Quote from JulianBianchi

    We have just finished the analysis of a large panel of minerals in patients with COVID-19 and found that the serum levels of Zn were crazy low. Not only all patients were deficient but also the levels were up to several times less than the levels measured in a control group. Levels of Fe, Se and Cu were also found to be different. All other minerals (Na, K, Ca, Mg, I...) had similar levels in both groups.

    Interesting but do we have some sort of paper or study for this? This report encompasses less than 100%. The good results are anecdotal and could be due to chance.

    Also, what does "220 mg" of zinc mean? zinc gluconate, zinc sulfate, or zinc acetate? Zinc sulfate 220 mg tabs are available OTC in the US but have just 50 mg of elemental zinc.

    Confusing video- typical of Dr. Oz. He is always interesting and challenging but often jumps to conclusions on grossly insufficient information. And he's had his head handed to him in the past on many of the silly things that appear on his silly (but highly remunerative) TV show.

    Social distancing seems to be working, but it seems to be taking longer than some models predict. The decline is not as dramatic. For example, at healthdata.org for Italy, the second graph shows "19 days since projected peak in daily deaths." It shows actual data up to April 12, when there were 431 deaths. From there, the model drops to 160 today, with a range of 71 - 321. Unfortunately, the total for today is 578.


    For April 13, 14 and 15 the actual totals are: 566, 602, 578. Projected: 261, 192, 160.


    Here is the projection for Italy:


    THE PECULIAR HISTORY OF THIS NEW DISEASEIn some patients, the clinical history of this disease occurs with particular characteristics. It foresees that the patient manifests above all fever, which is not very responsive to antipyretics, and a state of malaise. A dry cough is often associated. After 5-7 days, older patients with already impaired lung function begin to experience shortness of breath and increased respiratory rate. In more fragile patients, however, dyspnea may already appear at the onset of symptoms. On the other hand, in younger subjects and in those who do not have basic respiratory impairments or other comorbidities, dyspnea may appear later. In these patients experiencing worsening inflammatory-induced lung injury, there is a decrease in oxygen saturation (<93%). This seems to be the crucial phase of the disease, from this point onwards, there may be a rapid deterioration of respiratory functions. The scenario is truly incredible because for patients who are paucisymptomatic and slightly hypoxic, the first therapeutic approach is oxygen therapy. Although this strategy is effective, worsening of respiratory failure may occur in some patients. With the drive preserved, the next step, according to logic, is the NIV. This therapy has a rapid success by increasing the P/F. In some patients, however, there is a sudden, unexpected worsening of clinical conditions. Patients collapse under the operator's eyes and require rapid intubation and invasive mechanical ventilation. However, after 24-48 hours the patient can have a rapid improvement with an increase in P/F. Operators are therefore tempted to proceed with weaning. But very often, after an initial success there is a new worsening of respiratory conditions, such as to require a new invasive therapy. Therefore, mechanical ventilation has also been suggested for 1-2 weeks.

    THE MESSAGE FOR THOSE WHO TREAT THESE PATIENTS IS THEREFORE TO FOLLOW THE CLINICAL PERFORMANCE FOCUSING ESPECIALLY ON THE VALUES OF THE SATURIMETRY, RATHER THAN CONSIDERING THE TYPICAL P/F VALUES SUGGESTIVE OF ARDS


    S0 Anti viral therapy will be most effective at the initial fever & cough stage. Any later (after 5-7 days) when oxygen saturation declines to 93% is too late because excessive inflammatory lung damage has already occurred and can no longer be reversed by subsequenly killing off the virus with Z-pak Anti Bat (iV) or any other antiviral treatment for that matter. It simply could not be expected from the biochemical, histological or pathological evidence presented by the various groups. The basic difference between Raoult and Zelenko's positive results and all the other negative results including the Brazilian study is that in the former the antiviral therapy is given in the initial fever and cough stage whilst all the others are way too late after the 5-7 day stage from initial infection. Expecting this to work after the decrease in oxygen saturation to 93% is idiotic - the damage is already done and cannot be reversed, only ventilation and oxygen therapy over the next few weeks can gradually allow the lungs to recover from the damage caused by the viral load. At this level of pathology, as we all know, once on a ventilator in ICU survival rates are only 50% and no amount of our Z-pak Anti Bat (iV) at this late stage will alter that miserable out come. This is why I'm advocating an age-old tried and tested WHO technique used for malaria pandemics in the past,,,,,,,,,,,,,,,,,, Mass Fever Treatment (MFT) a slightly more selective form of Mass Drug Administration (where they actually added chloroquine to the table salt). This entails very early intervention in the illness at the first sign of fever developing. Its just common sense.:)

    Quote from Dr Richard

    Sutherlandia, an indigenous Southern African shrub commonly known as "cancer bush” has a traditional African and settler folklore history, but has recently been hyped as a treatment for a ridiculously long list of mostly improbable conditions and as a treatment, even cure, for cancer and AIDS, which action is specifically forbidden by law, for the good reason that it may raise false hopes and even lead to substitution for effective treatment of life-threatening illnesses. Sutherlandia moreover, contains significant concentrations of canavanine, an analogue of a conditionally essential amino acid, which in ill and or protein deficient individuals, erroneously enfolds into their proteins, only to have these tissues, even entire organs and or systems, eventually rejected and attacked by their own immune system. Canavanine moreover, is distinctively immunosuppressive of critical cellular immune responses against cancer cells and infectious organisms, including viruses, bacteria, protozoa, helminths and fungi. Sutherlandia is therefore potentially an extremely dangerous substance and ought not to be fraudulently sold as a safe and efficacious panacea.


    Thanks for reposting the pharma mafia disclaimer!


    They have all right to do this as Sutherlandia efficiently kills a large junk of their business. Sutherlandia is the oldest known herb of man-kind and is used since more than 6000 years. The above post is complete nonsense as it has been safely used by millions of infected in South Africa without any side effect. It can be used by children off all age etc.. Of course there are always people with certain gen-defects that show a bad reaction. I know people that are allergic to water...


    Some big pharma companies I know currently are heavily invested in Sutherlandia and certainly soon will launch a chemotherapeutic based plant extracts. This might be the main reason they spread false information.


    I think there is a reason for concern that while social distancing is beneficial, it has its limits, and can’t go on forever. Can the U.S. reopen the economy with a fairly constant number of 10,000 new cases per day?


    10k new cases is a major improvement over where we are now. But I could see a scenario where we kind of get stuck there for months.


    The only two things that I think could significantly lower the number of new cases beyond that are:


    1. A general requirement that people wear masks outside their homes. This wouldn’t just be for the grocery store, but people would have to wear them at their places of business, and kids would wear them in school etc. I am not sure Western society is ready for something like this. But I won’t be surprised if it becomes more of the conversation soon because it may be impossible to reopen the economy in a meaningful way without having everyone wear a mask.


    2. The Governor of each State needs to create testing SWAT teams. So if someone tests positive in a particular place they can go in fast and test everyone and do contact tracing.


    call me pessimistic but I don’t think the outbreak is going to fade down to a negligible number on its own. This could just be how life goes for the next couple of years.

    Wyttenbach oh come off it Jurg, allergic to water?? Go ahead. and try a large dose of Sutherlandia and Don 't blame me if it makes you as sick as a dog. The canavanine in it will gradually substitute for arginine in all your enzymes in your important metabolic pathways and you will slowly grind to a halt!! Just keep a large dose of L- arginine handy to neutralise its competitive toxicity!:) Also the Gaia website is pro-herbal remedies and anti pharma so how can this be pharma mafia propaganda? Your other two suggestions make sense.

    Quote from Dr Richard

    The basic difference between Raoult and Zelenko's positive results and all the other negative results including the Brazilian study is that in the former the antiviral therapy is given in the initial fever and cough stage whilst all the others are way too late after the 5-7 day stage from initial infection.


    The symptoms of coivid-19 are thankful clear. Treatment should latest start at day 3, better day 2 (36 hours) when symptoms have been confirmed. At day two you can start the well known herbal antiviral combo treatment this allows you if no progress is seen to switch to a stronger more risky drug latest at day 5.


    I personally (+ family) do use this combo (Sutherlandia, Sceletium) since about 15 years what usually keeps away all flue, colds etc.. I also did take it after surgery to avoid hospital infections. But for corona it might be helpful to add Archangelica.

    Deleo The whole course of this pandemic can be reversed by Mass Fever Treatment which the WHO has used before in malaria epidemics. If they put out a directive to all developed countries to do this it would be pandemic over. We have enough effective anti viral drugs now to do this it's just a matter of convincing the relevant health authorities that this is the way forward. Give the mass population 100% a seven day course of antivirals to be taken at the first sign of fever. This is precisely what happens in third world countries - do you think they wait around on developing a fever which they know will kill them unless they take something for it? No they immediately take anything they can that's available to survive, anti-malarials, anti HIV, antibiotics anything they can find that might help. They don't have a problem with side effects. Spoilt western democracies do which is why we are dying in droves. The third world is not.

    Quote from Dr Richard

    canavanine


    Toxicity is dose dependent.. plenty of approved cancer drugs have toxicity which is over the moon,,

    as mentioned before.. paracetamol will kill one's liver in high enough dose


    Lessertia (Sutherlandia frutescens), a bush of the Kalahari Desert belonging to the Fabaceae family,

    is named “Pethora” by San Bushmen—“this which modifies” the evolution of disease.

    The Sotholas call it “Motlepelo”—’which brings the heart back to life”,

    and the Zulus have named it “Insiswa”—“which disperses darkness”.

    It has been used by white settlers as an adaptogene, and they called it “cancerbush”—“a bush against cancer”.

    It is hardly known in western countries.

    Its main compounds are L-canavanine, pinitol, GABA and at first a glucoside of triterpenoid.

    This drug has been used without any controlled assay in therapy for AIDS patients.

    We noticed some effectiveness in treating tiredness, so we made an oral preparation with Lessertia powder,

    which was given to 16 cancer patients at a dosage of 600 mg a day, in order to study its effect in asthenia


    https://www.researchgate.net/p…a_fatigue_en_cancerologie

    https://www.researchgate.net/p…ia-frutescens-extract.pdf

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