Perhaps of interest --
COVID-19 and Ivermectin, We Finally Have Some Clinical Trial Data!
Hopefully, ivermectin will not be politicized by The Media.
Display MorePerhaps of interest --
COVID-19 and Ivermectin, We Finally Have Some Clinical Trial Data!
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Hopefully, ivermectin will not be politicized by The Media.
Thanks for the video. I am not sure ivermectin will get politicized. It’s a pretty straightforward drug that people use for head lice and has been around a long time.
I like how the study shows a reduction in mortality with people on ventilators. Working drugs should show some benefit at all stages of illness. The question is what dosage of ivermectin is needed to really be effective, and is it so much that it could produce severe side effects? It just needs more clinical trials and testing, which is happening now.
I think we will see a large amount of clinical trial results on different drugs in late May and early June - including some NIH studies. That’s going to be an interesting time.
Usefulness of Ivermectin in COVID-19 Illness - "virtual" reduction in mortality rate
smoking
A French study found that only 4.4% of 350 coronavirus patients hospitalized were regular smokers and 5.3% of 130 homebound patients smokedThis pales in comparison with at least 25% of the French population that smokes A French study found that only 4.4% of 350 coronavirus patients hospitalized were regular smokers and 5.3% of 130 homebound patients smokedThis pales in comparison with at least 25% of the French population that smokes
A Chinese study found a similar mismatch with the general population. Fumigation?
Awake to find The POTUS has floated the idea of injecting bleach into the body to cure Coronavirus. Perhaps we could try injecting Alphabet Soup into all politicians to see if they can start forming coherent sentences.
It's not quite clear at the moment, but it may not have been an original thought.
Display MorePerhaps of interest --
COVID-19 and Ivermectin, We Finally Have Some Clinical Trial Data!
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Hopefully, ivermectin will not be politicized by The Media.
Although we report a strong potential signal for
benefit in COVID-19, these data must not be considered conclusive since unknown confounders cannot
always be reliably accounted for, even when propensity score matching techniques are emplooyed in
developing control groups. There is no substitute to a properly conducted randomized clinical trial.
However, ass the tempo of COVID-19 rages and aggressively so, we believe that even this preliminary
information is important to communicate so that clinicians can consider this therapy for appropriate
testing in this setting. We conclude that administration of ivermectin during COVID-19 illness in
hospitalized patients is associated with a lower mortality and hospital length of stay. These findings
require confirmation in randomized controlled trials.
The signal here is VERY STRONG.
However, these cautious conclusions are correct. They tried hard to match subjects, but all that is needed is a confounder not considered that correlates strongly with the use of Ivermectin, and these results will not hold.
EDIT
Here is the argument against ivermectin. Basically the in vitro activity is at levels 20X higher than highest reasonable clinical dose. So either there is some unexpected in vivo effect, or the above study signal is caused by some unconsidered confounding variable.
https://www.medrxiv.org/conten….20061804v1.full.pdf+html
Still, this evidence is much more convincing than the evidence so far for Hydrochloroquine. It is reported properly here, as something that may not hold but deserves very urgent RCT investigation.
disinfectant / bleach - the terms are used similarly in common parlance. Are you saying the quote above (BBC) is misleading?
Yes, and trying to characterize what he said as "recommending injecting bleach" is at best, extremely artistic. There is a UV light treatment that makes tremendous sense. It is not a stretch to think about trying to disinfect the body through this and other means. From what I understand, COVID is basically a surface infection. If we can disinfect the surface of our hands, why not explore it in other ways. Folks who lean strongly enough to the left like to look down their noses at Trump and people who like him, which makes them like Trump even more. It also seems to be a tribal affirmation to Trump-bash--you let the tribe know you are one of them.
Looks like we were correct in adding ivermectin to the Anti Bat combo. A dose of 10 mg would be appropriate, and much higher doses up to 120 mg have been tested in volunteers without significant adverse effects. Kills parasitic bugs by acting on chloride channels paralyzing them with a single dose. Is thought to prevent viral cargo proteins from disrupting nuclear viral defence mechanisms (nuclear as in the cell nucleus which holds the DNA not as in cold fusion). A single ivermectin dose works well on parasites but may need a more prolonged treatment to be 100% effective against coronavirus. No harm in maintaining a 10 mg dose for 5 days minimum in a clinical trial?
Better order some Ivermectin before it is embargoed like HCQ!
Yes, and trying to characterize what he said as "recommending injecting bleach" is at best, extremely artistic. There is a UV light treatment that makes tremendous sense. It is not a stretch to think about trying to disinfect the body through this and other means. From what I understand, COVID is basically a surface infection. If we can disinfect the surface of our hands, why not explore it in other ways. Folks who lean strongly enough to the left like to look down their noses at Trump and people who like him, which makes them like Trump even more. It also seems to be a tribal affirmation to Trump-bash--you let the tribe know you are one of them.
Trump was taking about injecting (or in some other way getting inside the body) disinfectant. In what alternate reality do his words not mean that?
You are the one bringing left/right politics into this. How about just consider what he says, without politics. I note the aberration.
Today he says what he said yesterday was meant sarcastically. Do you believe that?
THH
smoking
A French study found that only 4.4% of 350 coronavirus patients hospitalized were regular smokers and 5.3% of 130 homebound patients smokedThis pales in comparison with at least 25% of the French population that smokes A French study found that only 4.4% of 350 coronavirus patients hospitalized were regular smokers and 5.3% of 130 homebound patients smokedThis pales in comparison with at least 25% of the French population that smokes
Maybe smokers die younger, hence the age profile is younger?
CDC puts the deficit at 10 years for smokers.
The age dependence of COVID means that those last 10 years (found only in non-smoking population) will have much higher mortality. Mortality roughly doubles for every 7 years.
Better order some Ivermectin before it is embargoed like HCQ!
it comes in apple flavor. (horses)
Alan Smith no politics please!
It's not quite clear at the moment, but it may not have been an original thought.
There is no bottom to the media in the US,
none. They will twist, turn and pervert anything to fit their political ends.
Antibody Studies.
Coronaviruses: An Overview of Their Replication and Pathogenesis
".....Second, the propensity of the viruses to recombine may pose a problem by rendering the vaccine useless and potentially increasing the evolution and diversity of the virus in the wild [108]……"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/
Iit may mean that any attempt at a vaccine for cov-19 may make things worse.
This is how ivermectin works - surprising it has not been used clinically before now having such a wide spectrum of action. Seems rather too good to be true - but used with HCQ, Avigan, azithromycin/doxycycline, Zn and herbals in Anti Bat could spell the end for this nasty little coronavirus (covering all bases):
From
by SNY Yang - 2020 - Cited by 7
Epub 2020 Mar 3. The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer. Yang SNY(1), Atkinson SC(2), Wang ...
'merits closer consideration as a broad spectrum antiviral' would definitely be an understatement. Seems like a wonder drug but why has it not been used against flu? Maybe in vivo or in clinical trials it will be not so effective.
Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and dengue virus (DENV) represent a major burden for human health worldwide. Although RNA viruses replicate in the infected host cell cytoplasm, the nucleus is central to key stages of the infectious cycle of HIV-1 and influenza, and an important target of DENV nonstructural protein 5 (NS5) in limiting the host antiviral response. We previously identified the small molecule ivermectin as an inhibitor of HIV-1 integrase nuclear entry, subsequently showing ivermectin could inhibit DENV NS5 nuclear import, as well as limit infection by viruses such as HIV-1 and DENV. We show here that ivermectin's broad spectrum antiviral activity relates to its ability to target the host importin (IMP) α/β1 nuclear transport proteins responsible for nuclear entry of cargoes such as integrase and NS5. We establish for the first time that ivermectin can dissociate the preformed IMPα/β1 heterodimer, as well as prevent its formation, through binding to the IMPα armadillo (ARM) repeat domain to impact IMPα thermal stability and α-helicity. We show that ivermectin inhibits NS5-IMPα interaction in a cell context using quantitative bimolecular fluorescence complementation. Finally, we show for the first time that ivermectin can limit infection by the DENV-related West Nile virus at low (μM) concentrations. Since it is FDA approved for parasitic indications, ivermectin merits closer consideration as a broad spectrum antiviral of interest.
Coronaviruses: An Overview of Their Replication and Pathogenesis
Iit may mean that any attempt at a vaccine for cov-19 may make things worse.
".....Second, the propensity of the viruses to recombine may pose a problem by rendering the vaccine useless and potentially increasing the evolution and diversity of the virus in the wild [108]……"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/
That narrows down our options in fighting COVID to; facilitate herd immunity, get skinny, never grow old (Peter Pan), or crossbreed with a bat. Other than the no-brainer option to lose weight, that leaves herd immunity as the best weapon against. They do say these coronaviruses run their course, so that is good news since they also say there are no drugs 100% effective against them.
What really peeves me, is that this could be largely prevented in the future, if only some cultures would stop eating bats. What will it take to stop them? I was thinking a good way is to ban international flights from any city, or region with a wet market that offers bats. If passengers from banned areas fly here indirectly through connections, take their temp when they arrive. High temp, and off to quarantine with them.
Another way is for the media to report on them like Australia 60 Minutes did. That is hard to do though, as many are in communist countries like CHINA, and Vietnam. Plus, I don't think they care much about what the rest of the world thinks of their dirty habits, or what endangered species they eat into extinction.
Another one to add to the list....Nitazoxamide effective against MERS Cov,,,,
clinicaltrials.gov › show › NCT04341493
10 Apr 2020 - Hydroxychloroquine vs Nitazoxanide in Patients With COVID-19 ... Syndrome (SARS) and Middle East respiratory syndrome (MERS). Problem ...
only some cultures would stop eating bats.
we were warned Leviticus 11:13-19 “'These are the birds you are to regard as unclean and not eat because they are ……. and the bat."
