oldguy Sorry if I misunderstood. It is unconscionable for a governor to dictate the practice of medicine and to question with legal action the decisions of front line practitioners.

If you're gonna try HCQ and AZI, this is how to do it safely.

Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin

https://www.heartrhythmcaserep…-0271(20)30058-0/abstract (note PDF linked for full paper)

A methodical and careful critique of the original study from Marseilles known, I have no idea why, as the Raoult study (he was one a dozen or so authors and last listed).

https://www.redactionmedicale.…w_20_03_20_001%5B1%5D.pdf

Further in vitro study supporting use of HCQ and Azi against COVID-19 -- that's "nice" but what we need is a good clinical RCT type study.

Preprint scheduled for Aug 2020 publication

https://www.sciencedirect.com/…cle/pii/S0882401020305155

Once again, strong evidence that EKG monitoring is absolutely required when HCQ and AZI are given together:

https://www.medrxiv.org/conten…101/2020.04.22.20075671v1

Scientists Say New Strain of the Coronavirus Is More Contagious

Scientists at Los Alamos National Laboratory have identified the new strain that has dominated the world since mid-March, they say. In addition to spreading faster than the original version of the virus, it also makes people more vulnerable to a second infection.

https://www.newsmax.com/health…ain/2020/05/05/id/966205/

They expressed the most concern about the mutation called D614G, which is responsible for the virus’ change in spikes.

“D614G is increasing at an alarming rate, indicating a fitness advantage relative to the original Wuhan strain that enables more rapid speed,” …...But, according to the Times, another worry is that people who have become infected with the older version of the virus would not have immunity to the second strain. If this is the case, the authors wrote, it could make “individuals susceptible to a second infection.”

Quote from seven_of_twenty

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172803/

This is the only recent paper I could find about ivermectin. I found no clinical trials in Google scholar. Absent those, who knows what it does in actual clinical cases? If anyone has a good paper wherein clinical use is reported, please do us all a favor and post it.

The fist summary paper: Usefulness of Ivermectin in COVID-19 Illness.pdf

The compelling Japanese NHK report about Ivermectin was of today. I will ask my wife for the source or may be Jed can find it for us. But the chemo target software had it on the top position already 4 weeks ago just ahead of Heparin. Heparin for me is the most surprising find as it was never meant as an antiviral! (like the famous blue pill...) Also the hidden action of Nikotin is interesting as you just can glue a tape.

Quote from seven_of_twenty

Again, not a randomized clinical trial (RCT). Frankly, I am surprised at how long we are having to wait for a properly done, large scale, fully well designed and executed study of HCQ with and without Azi and perhaps zinc. And preferably from the US or Europe.

Novartis has the go of the CDC for a large US study. But is double blind really the thing you like to do with severely ill patients..?

Quote from Alan Smith

VERY serious issue

yes, and since it seems to be in the part that governs the spikes,

I would assume it will make vaccines harder to make.

Although I doubt there will be a vaccine anytime soon.

Early stage treatments should be tested.

An in vitro study appears to show that chloroquine, remdesivir, niclosamide and ciclesonide seem to have good anti-viral effects in fairly wide therapeutic windows that avoid significant toxicity (graphs depict the trade offs). Niclosamide appears to have the best risk/benefit profile --

"Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs"

https://www.biorxiv.org/content/10.1101/2020.03.20.999730v1

Also, for those perplexed by the NIH bureaucracy's antipathy toward HCQ, here is an MD who is also perplexed --

"UPDATE ON Covid-19 Treated with Hydroxychloroquine/Zpak VS Remdesivir FACTS AND EVIDENCE BASED"

(BTW, 9 of the NIH panel that recommended against HCQ work for Gilead)

Perhaps also interesting to note that U.S. hospitals have been buy HCQ in abnormally high volumes.

Also afflicted health care workers have been treated with HCQ, and just recently Israel has bought several tons of HCQ from India.

Wyttenbach

Quote

But is double blind really the thing you like to do with severely ill patients..

Excellent question. I saw Dr. Fauci asked it. His response was you have to do a "multi-armed" study which compares one or more drugs believed to have effect to the drug you are testing. Patients must be matched and assigned at random. For example, you can ethically test HCQ+AZI against Remdesivir for safety and effectiveness and against the combination of Remdesivir and HCQ+AZI. These are difficult studies which use lots of patients and cost more than placebo controlled studies. Trials are always stopped if one method is obviously superior to another or to placebo from early or ongoing data analysis.

Propaganda. You may have been sleeping your entire life. Time to wakeup. Once you are awake, teach kids to be very critical of what they read. They also are vulnerable.

This is just a few of the recent articles. In each article you should be able to find something that is suspicious in its framing, and the overall perspective should be obvious deep-state doesn't want this drug.

Now if you were a physician would you say - hmmm looks good to me with 'birth defects', 'early death', 'fox news trumpted', 'ignoring expert opinion'.

That is why Trump calls it the "fake news media". Cause it is.

Francis Collins NIH Director...

Pursuing Safe and Effective Anti-Viral Drugs for COVID-19

Questions for Francis Collins

1. Have you put all NIH's eggs in one basket?

You mentioned Remdesivir 19 times.. Are you implying that

THE only Safe and Effective Anti-Viral Drugs Drug =Remdesivir?

.. are there any other drugs ? Francis?

https://directorsblog.nih.gov/…gs-for-covid-19/#comments

""Over the past several weeks, a mind-boggling array of possible therapies have been considered.

None have yet been proven to be effective in rigorously controlled trials, but for one of them, it’s been a busy week.

So let’s focus on an experimental anti-viral drug, called remdesivir, that was originally developed for the deadly Ebola virus.

"One of the goals of the NIH is to "expand the base in medical and associated sciences in order to ensure a continued high return on the public investment in research." Taxpayer dollars funding NIH are from the taxpayers, making them the primary beneficiaries of advances in research.

WOW!

White House Plans to Disband Virus Task Force

Mr Pence earlier on Tuesday told reporters in a briefing that the task force could soon be disbanded.

He said the Trump administration was "starting to look at the Memorial Day [late May] window, early June window as a time when we could begin to transition back to having our agencies begin to manage, begin to manage our national response in a more traditional manner".

He said it was "a reflection of the tremendous progress we've made as a country".

The president was also asked on Tuesday if White House task force experts Dr Deborah Birx and Dr Anthony Fauci would still be involved in efforts to address the coronavirus.

"They will be and so will other doctors and so will other experts in the field," the president answered.

As I said before in a previous post there is a problem attaining a sufficiently high therapeutic dose (at least 5 uM) of ivermectin. At these high levels it activates CNS inhibitory pathway GABA pathways, causing coordination problems in dogs. Healthy volunteers have taken up to 120 mg doses per day in one study without adverse side effects but this obviously needs more research. Possibly a high concentration could be delivered to respiratory tract and lungs with an asthmatic-type inhaler, this avoiding systemic toxicity? Hydroxychloroquine could be applied in this way too, so a high dose is transiently applied to the afflicted region early on in the illness. Supplemented with Anti Bat pills.

Quote from RobertBryant

Navid .. by the the FASB study.. do you mean the Veterans Affairs hospital records study preprint(Magagnoli)

which was alleged to have shown that HCQ was ineffective?

I'm surprised you don't remember - it was this review.

It does not include that May 1st Wuhan data.

From a European Medicines Agency report in 2004:

Ivermectin is widely used in humans for treatment of onchocerciasis and other parasitic diseases
at single or repeated doses of 0.15 to 800 mg/kg bw. Tolerance to the compound has been
assessed in healthy volunteers and in patients; adverse effects are usually mild and transient. In
particular, no effects on the central nervous system were observed. The main effects noted in field
and community based trials have been those arising from the death of the parasites, the so-called
Mazzotti reaction, which is characterised by arthralgia, pruritis, fever, hypertension, tachycardia,
headache and ocular changes. Neither in these studies nor during treatment for other parasitic
diseases has a subset of atypically sensitive individuals been detected. Furthermore, the adverse
effects experienced by the small number of persons accidentally exposed to doses (often of
veterinary preparations) higher than customary human doses are in keeping with those noted in
test animals.
A double blind, randomised, placebo controlled clinical trial was conducted to assess the safety
and tolerability of oral subacute repeat doses of up to 1.2 mg/kg bw and an acute dose of
2.0 mg/kg bw in 68 healthy adult male and female human subjects as a treatment for headlice. No
treatment related signs of toxicity were observed and in particular, there were no signs of
neurotoxicity such as emesis, mydriasis (measured by pupillometry) or ataxia, that were predicted
to be the most sensitive potential adverse effects based on the laboratory animal studies. A
conservative NOEL of 420 µg/kg bw was identified.

Quote from ZenoOfElea

WOW!

White House Plans to Disband Virus Task Force

The president was also asked on Tuesday if White House task force experts Dr Deborah Birx and Dr Anthony Fauci would still be involved in efforts to address the coronavirus.

"They will be and so will other doctors and so will other experts in the field," the president answered.

I expect people on this board to be competent enough now to realize this story is about a war inside the administration. Trump is surrounded by deep-staters and they started this.

The WHO is Gates. The CDC is Gates and Fauci. Gates is Vaccines. Fauci is virus. Fauci is vaccines. You have to respect a guy, no matter how much attention seeking, willing to take this shit on. If he does it he will go down as one of the greatest presidents since JFK. Most of you need to learn American history before you can understand what I am saying so don't parrot a response (noo that can't be I don't agree---dark journalist on youtube is one of the most competent tellers)

Quote from oldguy

Scientists Say New Strain of the Coronavirus Is More Contagious

Scientists at Los Alamos National Laboratory have identified the new strain that has dominated the world since mid-March, they say. In addition to spreading faster than the original version of the virus, it also makes people more vulnerable to a second infection.

https://www.newsmax.com/health…ain/2020/05/05/id/966205/

They expressed the most concern about the mutation called D614G, which is responsible for the virus’ change in spikes.

“D614G is increasing at an alarming rate, indicating a fitness advantage relative to the original Wuhan strain that enables more rapid speed,” …...But, according to the Times, another worry is that people who have become infected with the older version of the virus would not have immunity to the second strain. If this is the case, the authors wrote, it could make “individuals susceptible to a second infection.”

Display More

This is always something to watch - but the mutation rate is already well studied, and relatively slow: slower than flu.

These strains are tiny changes, and while you can worry about differing immune reponses and lack of immunity it is likely most immune responses (natural or vaccine) to one will protect against others.

Any tiny change that increases reproduction number will tend to dominate, even if it does this by only a small amount. the real issue is whether such a change alters the mortality of the virus.

https://www.biorxiv.org/conten…29.069054v2.full.pdf+html (the preprint on which these reports are based)

So if we don't use higher than 2 mg/Kg ie 140 mg dose for a 70 Kg adult we might derive some benefit with Ivermectin, but this needs more pharmacokinetic study to be certain.

Behind the curtain:

Quote from Dr Richard

A double blind, randomised, placebo controlled clinical trial was conducted to assess the safety
and tolerability of oral subacute repeat doses of up to 1.2 mg/kg bw and an acute dose of
2.0 mg/kg bw in 68 healthy adult male and female human subjects as a treatment for headlice. No
treatment related signs of toxicity were observed and in particular, there were no signs of
neurotoxicity such as emesis, mydriasis (measured by pupillometry) or ataxia, that were predicted
to be the most sensitive potential adverse effects based on the laboratory animal studies. A
conservative NOEL of 420 µg/kg bw was identified.

Display More

This is the US lab study about Ivermectin: https://www.sciencedirect.com/…cle/pii/S0166354220302011

As said: Ivermectin is more or less side effect free and the antiviral mechanism has been decoded.