OK, so hydroxychloroquine not quinine. These are very different drugs and the differences are not that subtle. I would never take quinine unless specifically for a condition it was specific for-- if there were less dangerous alternative.
Covid-19, Your health and that of your community
- Alan Smith
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Splitting hairs - analogous molecular structures have similar pharmacological properties - add a chloride here, move a hydroxyl there you end up with a family of compounds which have slightly different effects. When there is time all the analogues primaquine, mefloquine, quinine and others should all be tested for anti-COVID-19 activity. Nothing wrong with quinine, it's been used for centuries.
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The malaria drug chloroquine, which is being trialled as a potential treatment for COVID-19, has long been used in nanomedicine for studying nanoparticle uptake by cells. Three nanomedicine researchers share their insights into how, exactly, chloroquine might affect the virus SARS-CoV-2. (Nature Nanotechnology | 8 min read)
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Splitting hairs - analogous molecular structures have similar pharmacological properties - add a chloride here, move a hydroxyl there you end up with a family of compounds which have slightly different effects. When there is time all the analogues primaquine, mefloquine, quinine and others should all be tested for anti-COVID-19 activity. Nothing wrong with quinine, it's been used for centuries.
Mostly bullshit. What did you say your "Dr." was from?
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(Nature Nanotechnology | 8 min read)
Behind paywall, in US anyway.
Not quite clear on what nanomedicine is. Very short doctors?
https://en.wikipedia.org/wiki/Nanomedicine (not sure how those methods might apply... and paywall)
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Nothing wrong with quinine, it's been used for centuries.
The main drawback of quinine is its tolerability.. the subject of historical anecdotes
and the lethal adverse reactions of allergic patients
Quinine is a bit like some posters here..best to take with a bit of gin or not orally
the good thing is that Japan and China don't have much bigPharma
and are testing the cheaper drugs ciclesonide.CQ... hydroCQ.. fa ....vir ....
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sad: Grim find: Bodies of virus victims in Spanish nursing homes
...Spanish army troops disinfecting nursing homes have found, to their horror, some residents living in squalor among the infectious bodies of people suspected of dying from the new coronavirus, …..
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As bodies piled up, Madrid took over a public skating rink as a makeshift morgue after the city facility overflowed.
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seven_of_twenty: Sorry about the paywall - maybe a regional thing. Try this instead, same meat different gravy.
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any Canadians here?
any word on the strat of the trial of colchicine to reduce the "storm"?
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"that he hopes to know if colchicine is effective in coronavirus patients within three months."
Trials take time..
the turnaround on the Chinese trials seems to be quicker. i month..
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https://www.dailywire.com/news…-schools-restaurants-open
Sweden is not jumping on the shut-it-all-down bandwagon, and doing a little better than their neighbors. With Brazil resisting also, we will be able to make comparisons when this is over with. That will help establish more reasonable policy for the next pandemic.
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https://www.dailywire.com/news…-schools-restaurants-open
Sweden is not jumping on the shut-it-all-down bandwagon, and doing a little better than their neighbors. With Brazil resisting also, we will be able to make comparisons when this is over with. That will help establish more reasonable policy for the next pandemic.I
it won't take much to end this.bravado. Boris tried and failed under internal and external pressure
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I was sent by a friend this paper from a Chilean epidemiologist that discusses the rationale for enforcing quarantine based on the observed growth of the contagion. Published yesterday.
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Sweden is not jumping on the shut-it-all-down bandwagon, and doing a little better than their neighbors. With Brazil resisting also, we will be able to make comparisons when this is over with. That will help establish more reasonable policy for the next pandemic.
Nope. It doesn't work that way. Japan and Korea have not shut it all down either, because they never had to. They tested thousands of people. They kept close track of all cases, and connected as many as possible to others. They tracked down infected people. They kept the numbers from increasing exponentially out of hand. Sweden has done the same thing. (I don't know about Brazil.) This method is far better than shutting it down. Shutting it down is the last resort when all else has been tried and has failed. Or -- in the case of the U.S. -- when nothing was tried before the exponential increase began, and the leaders' policy was to pretend the epidemic was not happening.
The reasonable policy is obvious. Test widely. Keep track of every case. Quarantine any sick person. Do not let it grow exponentially. This has now been proven beyond doubt, by China, Korea, Japan, Sweden, Ireland and other countries. The unreasonable policy is to wait until it is too late, and then shut things down. The third, genocidal policy is to stand aside and do nothing, letting the disease run its natural course, killing millions of people. That is the de facto Federal government policy.
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Boris tried and failed under internal and external pressure
I am as interested in how they (Sweden) are able to resist the intense pressure from the western media to conform, as to how they fare with the virus compared to others.
And BTW; Boris got a boost from Oxford College today. If I read it right, they claim millions were already exposed without knowing it, thereby inoculated (herd immunity) before the first case surfaced.
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Another reason to give up smoking.. medrxiv
Smoking or COPD doubles the amount of attachment points(Ace2 receptor) for Covid.. on the bronchial surface..
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Conclusions:
CE-2 expression in lower airways is increased in patients with COPD and with current
smoking. These data suggest that these two subgroups are at increased risk of serious COVID-19
infection and highlight the importance of smoking cessation in reducing the risk.https://www.medrxiv.org/conten…03.18.20038455v1.full.pdf
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Great line in a letter to the Guardian today. 'Now is the time to be unseen and not herd.'
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And BTW; Boris got a boost from Oxford College today. If I read it right, they claim millions were already exposed without knowing it, thereby inoculated (herd immunity) before the first case surfaced.
tell that to Italians
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