Covid-19, Your health and that of your community

Quote from RobertBryant

there was so much more money to be made in Viagra and Statins than in malaria..

malaria was a disease of the poor .. not the rich.

The first was a lucky side effect as heart patients did ask for extra packages....

Statins are generally of no use even for patients that had a recent infarct (1% significant in a 1 year study less than homeopathy )

Even worse: The latest Chinese study shows that low LDL is related with dementia and high LDL is related with lower dementia!!

Possibly Millions of people that took statins will get early dementia. Thats how big pharma works. Self proliferation of new high income victims.

Quote from Wyttenbach

The first was a lucky side effect as heart patients did ask for extra packages....

Statins are generally of no use even for patients that had a recent infarct (1% significant in a 1 year study less than homeopathy )

Even worse: The latest Chinese study shows that low LDL is related with dementia and high LDL is related with lower dementia!!

Possibly Millions of people that took statins will get early dementia. Thats how big pharma works. Self proliferation of new high income victims.

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Wht,

Nice to know that someone else on planet earth has reached my level of cynicism

Nature article about using salt to increase anti-viral efficiency of masks

https://www.nature.com/articles/srep39956#further-reading

Quote from Dr Richard

Deleo It has been mass prescribed since 1940 for malaria already. It was only restricted here on 2.02.2020 Please explain?

Believe me, I want HCQ to work as much as you do. Anything that works is great news, I don’t care what it is as long as it works and is safe. We need drugs to keep people off ventilators. Until that happens we are essentially in no man’s land.

I think the medical community has a history of being too conservative at times. Too many studies that take too long to do. And the one thing we don’t have right now is time. So hopefully they are moving as fast as humanly possible with their studies. Below is an article by a Doctor (who sounds too slow and conservative with his approach in my opinion). But it’s the other side of the argument for it, and worth a read.

https://www.newyorker.com/news…r-against-the-coronavirus

It seems some here believe more in Chinese studies...what about this one: https://www.sciencedaily.com/r…/2019/05/190528120558.htm ?

That seems to have a contrary outcome...the question is who is right....but the problem is that most, if not all large studies are somehow "sponsored" by your big mafia pharma, so it may depend on what medicine they want to sell in the end...

Quote

The first was a lucky side effect as heart patients did ask for extra packages....

Statins are generally of no use even for patients that had a recent infarct (1% significant in a 1 year study less than homeopathy )

Even worse: The latest Chinese study shows that low LDL is related with dementia and high LDL is related with lower dementia!!

Possibly Millions of people that took statins will get early dementia. Thats how big pharma works. Self proliferation of new high income victims.

COMPLETE BULLSHIT!

It is irritating to read crap like that, obviously written without the slightest attempt to find the facts. It took me about thirty seconds to locate this:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078755/

This is a metastudy of three million patients:

"Previous studies have indicated that statins use is associated with risk of dementia, but presented controversial results. Medline, Embase, Web of Science, and the Cochrane Database were searched update to November 2017 to identify the potential relationship between statins use and dementia. Thirty-one eligible studies involving a total of 3332,706 participants with 184,666 incident cases were included in this meta-analysis. Statins use was associated with dementia risk decrement (relevant risk [RR]: 0.85; 95% confidence interval [CI], 0.80–0.89). Subgroup analysis showed statins use was associated with Alzheimer disease (AD) (RR: 0.81; 95% CI, 0.73–0.89) and non-AD dementia (RR: 0.81; 95% CI, 0.73–0.89) risk decrement. Furthermore, statins use was associated with dementia risk decrement in female (RR: 0.89; 95% CI, 0.80–0.98) and male (RR: 0.88; 95% CI, 0.83–0.93). In addition, a dose–response showed per 1 year of duration of statins use incremental increase was associated with 20% dementia risk decrement (RR: 0.80; 95% CI, 0.73–0.87), and per 5-mg mean daily dose incremental increase in statins use was associated with 11% dementia risk decrement (RR: 0.89; 95% CI, 0.83–0.96).

Statins use was associated with dementia risk decrement. The potency and the cumulative duration of statin utilized played critical roles."

There is also this (and many more):

https://www.sciencedaily.com/r…/2019/05/190528120558.htm

Quote

Researchers found a link between high LDL cholesterol and early-onset Alzheimer's disease. The results could help doctors understand how the disease develops and what the possible causes are, including genetic variation.

Wyttenbach 's credibility seems to be reaching for all time lows.

Quote from Wyttenbach

Roche Switzerland

Roach Switzerland

Quote from seven_of_twenty

COMPLETE BULLSHIT!

Statins

...dementia metastudies are debatable,, exclusions inclusions.. dementia diagnoses.. comorbidities

the accuracies of the conclusions are low..

I'd go with little evidence any way for statins +,- or 0 effect on dementia

Cochrane group is my first point of call

https://www.cochrane.org/CD003…atins-prevention-dementia

"

There is good evidence that statins given in late life to people at risk of vascular disease do not prevent cognitive decline or dementia.

Viagra... a phosphodiesterase inhibitor designed for reducing blood pressure.. a lucky shot...not a fizzer .for Pfizer

Either drug is not a goer in Nigeria where the average life expectancy is 55.

Another lucky shot may be ITI-24.

It is also a phosphodiesterase inhibitor.. with the best binding to the Covid spike so far..

Maybe John Hopkins U is trialing it right now?

https://www.shennongproject.co…dingEnergy=-7.4&rank=2118

https://www.labroots.com/trend…ts-heart-failure-patients

Quote from seven_of_twenty

COMPLETE BULLSHIT!

It is irritating to read crap like that, obviously written without the slightest attempt to find the facts

https://medicalxpress.com/news…term-bad-cholesterol.html No correlation between LDL and heart stroke risk....

May be next time you will take 2 minutes....Or may be avoid going to pharma paid meetings...

Here about LDL and dementia...

https://www.frontiersin.org/ar…389/fneur.2018.00952/full

Wyttenbach

It would take too long but basically your inference is wrong. Virtually everything you post is wrong or you draw the wrong conclusions. Statins emphatically do not cause dementia and they certainly do reduce initial and repeat myocardial infarctions (heart attacks).

"Pharma paid meetings?" Insulting! Screw you! I don't go to those. I've despised pharmaceutical company attempts to bribe doctors since medical school.

From now on, I will ignore you. I don't have the time. But I want to warn others to be careful and independently vet anything they get from your posts.

Quote from Shane D.

When the books are written after this all over, many will focus on HCQ, and how, because it became associated with one man, it took longer to be fully accepted than it should have taken.

Hardly surprising though. Ever heard the story of the Boy Who Cried Wolf?

From chemrxiv... interesting in silico resource... unfortunately can't find azithromycin modelling yet..

https://chemrxiv.org/articles/…ctive_Web_Server/12058143

interesting mix of contactshttps://shennongproject.com:11443/#/contacts

https://shennongproject.com:11443/#/methods

"We prepared a large-scale library consisting of 8,506 small molecular compounds from DrugBank

. It covers all FDA-approved drugs, compounds in midst of clinical trials and molecules under experimental investigations.

The SDF files were downloaded for each compound from DrugBank, whereas the SMILES files were downloaded for compounds without 3D SDF files, for example Saquinavir, Lopinavir, Ritonavir and Carfilzomlib.

We converted the SMILES files to 3D SDF files for the four drugs using python rdkit library."

Quote from seven_of_twenty

I've despised pharmaceutical company attempts to bribe

I think there might be some agreement at least on this point..

my feeling is that Bigpharma is too set in its ways

to provide much benefit to the Covid situation .at least for new drugs.

which is a pity.. they have good labs..

Quote from RobertBryant

From chemrxiv... interesting in silico resource... unfortunately can't find azithromycin modelling yet..

https://chemrxiv.org/articles/…ctive_Web_Server/12058143

interesting mix of contactshttps://shennongproject.com:11443/#/contacts

https://shennongproject.com:11443/#/methods

"We prepared a large-scale library consisting of 8,506 small molecular compounds from DrugBank

. It covers all FDA-approved drugs, compounds in midst of clinical trials and molecules under experimental investigations.

The SDF files were downloaded for each compound from DrugBank, whereas the SMILES files were downloaded for compounds without 3D SDF files, for example Saquinavir, Lopinavir, Ritonavir and Carfilzomlib.

We converted the SMILES files to 3D SDF files for the four drugs using python rdkit library."

I think there might be some agreement at least on this point..

my feeling is that Bigpharma is too set in its ways

to provide much benefit to the Covid situation .at least for new drugs.

which is a pity.. they have good labs..

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What’s in it for them?

A pat on the back from the president?

a big “attaboy” from Congress?

a Laurel and Hardy handshake from America?

Like congressmen, they want $$$$$$$$$,

they found a legal, (kinda), path to do it.

Quote from Roseland67

What’s in it for them?

Academic progress.= $ + altruism +status?

there are a bunch of aspiring PhD's etc in China

maybe some will get to work for BigPharma

maybe some will help their neighbours..

maybe some will get imprisoned

human motivations are variable..and change with age.. kids.. trials..food availabiilty .. alcohol...lovers..sildenafil

https://shennongproject.com:11…dingEnergy=-5.4&rank=3266

That research question is harder to answer for these 18 researchers than in silico binding..

Chi Xu Zunhui Ke Chuandong Liu Zhihao Wang Denghui Liu Lei Zhang Jingning Wang Wenjun He Zhimeng Xu Yanqing Li Yanan Yang Zhaowei Huang Panjing Lv Xin Wang Dali Han Yan Li Nan Qiao Bing Liu

There are Not many people like this on this forum but if you are acquainted with them please attempt education..remotely

"results also showed that about 20% of the participants were reluctant to implement proper prevention measures.

The statistical analysis indicated that the typical characteristics of those people were

male,

younger (under 30 years old),

unmarried, from lower-income households,

with a drinking or smoking habit

and a higher extraversion score.

https://www.medrxiv.org/conten…101/2020.03.31.20048876v1

Japanese sociological study re: Covid and self-restraint.

Quote from Shane D.

Not following you. Of course I know the story. Who doesn't? But please go ahead and explain yourself. This is a unique opportunity on LF to bring up politics, as long as it relates to COVID.

I don't really think its political to acknoledge that Donald Trump constantly tells lies... That's just fact*. Problem is, when a fair percentage of what a person says in public is made up (like the boy in the story), the public, quite rightly, will ignore the bullshitter on the rare occasion that a wolf does turn up.

And no, I'm not some libtard who's been watching too much "Fake News Media", or whatever gaslighting counts as political debate these days. I actually find the guy far more entertaining than Hillary would have been, and slyly hoped he would win... There's a certain nihilistic satisfaction that comes from watching turkeys vote for Christmas (ie. the working classes voting against Obamacare). Possibly only because it confirms a few European prejudices about the state of the USA.

Third paragraph self-censored, to avoid the requirement of a right to reply. Now settle down and lets get back to COVID, you swivel-eyed Fox News watching paranoiacs!

* An average of 15 per day, according to the fact checkers (and he's been in office for >1000 days)...

Hopefully the US will have to create their own cheaper national insurance funded NHS system to combat future virus pandemics. Medicine for all is a basic human right.