The Totally Civil Covid Thread. (Closing 31/05)

  • Final proof of extensive vaxxine damage

    "

    health policy spokesman for the AfD parliamentary group, Martin Sichert, at the media conference.

    Until the reasons are clarified, he demands

    • Immediate suspension of vaccination with the corona vaccines until it can be ruled out that the massive increase in deaths is due to the vaccination
    • Autopsies on all those who died unexpectedly to determine where the massive increase came from"

    Ja,,, sicher..

  • Florida Announces Grand Jury Targeting mRNA COVID Vaccines Plus Public Health Integrity Committee to Counter Federal ‘Narratives’ & Agenda

    Florida Announces Grand Jury Targeting mRNA COVID Vaccines Plus Public Health Integrity Committee to Counter Federal ‘Narratives’ & Agenda
    Governor Ron DeSantis just convened a COVID-19 mRNA Vaccine Accountability Roundtable broadcast live on Twitter, announcing major measures to counter what…
    www.trialsitenews.com


    Governor Ron DeSantis just convened a COVID-19 mRNA Vaccine Accountability Roundtable broadcast live on Twitter, announcing major measures to counter what appears to be a growing concern that a confluence of federal, pharmaceutical industry, and medical establishment interests commandeered the health system to drive a one-sided, scientifically questionable agenda to mass vaccinate nearly the entire American population against SARS-CoV-2, the virus behind COVID-19. Bolstered by a sophisticated censorship regime involving direct federal agency (Department of Health and Human Services) and what is now proven instructions to Big Media and Big Tech ordering the censoring and even smear campaigns of those with alternative opinions (think Anthony Fauci and Francis Collins' efforts to destroy the authors behind the Great Barrington Declaration), a devastating decline in confidence in public health agencies and even the federal government ensues. In fact, even standard vaccination rates are in decline, some fear because of a lack of trust in what has been the world’s most prominent health agencies. At this roundtable, Governor DeSantis announced three major initiatives, including 1) the creation of a statewide grand jury to investigate any and all wrongdoing associated with the COVID-19 vaccination program, from data manipulation and misrepresentation to potential fraudulent practices. Likely to be impaneled in the Tampa Bay area, this effort reports DeSantis will lead to a series of legal processes and potential actions against Pfizer and Moderna; 2) Florida Surgeon General Joseph Ladapo will commission a study similar to one undertaken in a German university surveilling persons that died shortly after receiving COVID-19 vaccines. That university study found a disturbing linkage between mRNA vaccine and myocarditis-linked death. Partnered with the University of Florida and state medical examiners, Ladapo reports their study will likely keep the CEOs of Pfizer and Moderna awake at night with concern, and 3) Gov. DeSantis announced the formation of the Florida Public Health Integrity Committee, a body that assembles all of the researchers, doctors, and scientists will critically assess the various health policies, findings and recommendations emanating from federal agencies such as the Centers for Disease Control and Prevention (CDC). Surgeon General Joseph Ladapo will also spearhead the Committee. It would appear the State of Florida, under the leadership of Gov. DeSantis, is taking serious steps to counter the policies and measures, many considered draconian, since the onset of the COVID-19 pandemic.


    The vaccines were used in a futile bid to get the disease to go away. This was clear from the science it wasn’t going to work early on. While the COVID-19 vaccines were useful as a prophylactic therapeutic measure during the early surges of the pandemic, it was clear that durability issues and a mutating pathogen would cause significant problems for these products.


    Yet even when it was widely known that the vaccines would not stop viral transmission, the Biden administration ordered unprecedented mandates across American society by September 2021. Those that spoke out against such mandates were censored, slandered, and even destroyed professionally. TrialSite, as an example, started publishing unfolding studies revealing that the vaccines would not stop viral transmission. Announcing these on YouTube led to censorship, as did any news around the world about repurposed drugs such as ivermectin.


    There was a systematic attempt to censor any critical discussion, even among the highest qualified experts. TrialSite went on the record early on when the vaccines were released that the eradication of a dynamic, mutating RNA virus like SARS-CoV-2 via the mRNA vaccines was most likely not feasible. And science started to back that position, but it was suppressed and censored. The highest levels of the federal government used the power of state apparatus to compel media and society to suppress any critical discussion. Reform is most definitely needed. This is not a political or partisan, or anti-vaccine position.


    Florida’s state leadership apparatus now takes aim at COVID-19 and the interests that are identified as likely distorting or even perverting science to achieve particular gains, such as mass vaccination and monetary gain for the pharmaceutical companies.


    This roundtable included a group of medical, health academia specialists, and vaccine injured who discussed the risks of the COVID-19 vaccines, for example, not commonly covered by federal agencies or the mainstream media. The group expressed great concern about the politicization of medical science throughout the pandemic. One contributor even suggests a public health bureaucrat coup unfolded during the crisis.


    Clearly, DeSantis is quite serious about holding the pharmaceutical makers accountable. The controversial Florida Governor cited several studies pointing to a heightened risk of myocarditis and pericarditis in adolescents and young men, for example, when receiving the mRNA COVID-19 vaccines.


    On the contrary, while the CDC, FDA, and NIH acknowledge a very rare risk of these cardiovascular problems associated with the mRNA vaccines, they position that these incidences are so rare when compared to the risk of more severe COVID-19 or long COVID that the majority of the population should be vaccinated. Yet the safety signals surged with mass vaccination. Part of this was understandable—all drugs and vaccines have some side effects. But what occurred over the last couple of years was far from normal or healthy. Yet the standard party line continued—the vaccines are safe and effective, period, and everyone down to six-month-old babies should be inoculated.


    But a counter-narrative mounted: one that was based on a growing number of studies pointing to concern. One such study author present at the roundtable, Joseph Fraiman, who, along with Peter Doshi and others, investigated the true risks of myocarditis and pericarditis after the COVID-19 vaccines. According to their investigations, there is a 1 in 800 chance for an adverse event with the COVID-19 mRNA vaccines meaning according to this body of evidence, the vaccines potentially represent a higher risk than the actual virus, except for perhaps select higher risk cohorts such as the elderly or severely immunocompromised for example.


    Meanwhile, Surgeon General Ladapo commissioned a study of the COVID-19 vaccines demonstrating their boost risk for myocarditis as much as 86% for patients in the 18 to 39 cohort who received mRNA vaccines from either Pfizer-BioNTech or Moderna. Ladapo was trashed in the mainstream media, and he admits that the data is preliminary and more investigation is needed. Because of that study, the Florida Department of Health guidance now recommends against COVID-19 vaccination for healthy children.


    In addition to the Governor and Surgeon General Ladapo, participants today included Dr. Joseph Fraiman, an emergency doctor and researcher; evolutionary biologist Bret Weinstein; Jay Bhattacharya, professor of medicine, economics, and health research at Stanford; Martin Kulldorf, a Swedish biostatistician at Harvard University; Tracy Høeg, physician and researcher; Christine Stabell Benn, Ph.D., MD, a doctor and investigator from Denmark; and persons representing vaccine-injured, including Steven A. Ordonia and Michelle Utter. Ordonia, a retired air force veteran and law enforcement officer, discussed his experience with the mRNA vaccines. Ordonia’s life has been turned upside down” since receiving the Pfizer mRNA vaccine. Ms. Utter, a sixth-generation Floridian, works in healthcare and was injured from the Pfizer vaccine. Before the vaccine, she was very active and now struggles with post-COVID-19 vaccine injury. She was forced to get the jab as her three sons are in the armed forces; her travel abroad to see them necessitated vaccination against COVID-19.


    External Content twitter.com
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    Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults
    In 2020, prior to COVID-19 vaccine rollout, the Brighton Collaboration created a priority list, endorsed by the World Health Organization, of potentia…
    www.sciencedirect.com


    Great Barrington Declaration and Petition
    As infectious disease epidemiologists and public health scientists we have grave concerns about the damaging physical and mental health impacts of the…
    gbdeclaration.org

  • fear mongering continues. Look at this bullshit study. The Researchers should be ashamed of themselves


    COVID Vaccine Hesitancy and Risk of a Traffic Crash

    COVID Vaccine Hesitancy and Risk of a Traffic Crash
    Coronavirus disease (COVID) vaccine hesitancy is a reflection of psychology that might also contribute to traffic safety. We tested whether COVID vaccination…
    www.amjmed.com


    Abstract

    Background

    Coronavirus disease (COVID) vaccine hesitancy is a reflection of psychology that might also contribute to traffic safety. We tested whether COVID vaccination was associated with the risks of a traffic crash.

    Methods

    We conducted a population-based longitudinal cohort analysis of adults and determined COVID vaccination status through linkages to individual electronic medical records. Traffic crashes requiring emergency medical care were subsequently identified by multicenter outcome ascertainment of all hospitals in the region over a 1-month follow-up interval (178 separate centers).

    Results

    A total of 11,270,763 individuals were included, of whom 16% had not received a COVID vaccine and 84% had received a COVID vaccine. The cohort accounted for 6682 traffic crashes during follow-up. Unvaccinated individuals accounted for 1682 traffic crashes (25%), equal to a 72% increased relative risk compared with those vaccinated (95% confidence interval, 63-82; P < 0.001). The increased traffic risks among unvaccinated individuals extended to diverse subgroups, was similar to the relative risk associated with sleep apnea, and was equal to a 48% increase after adjustment for age, sex, home location, socioeconomic status, and medical diagnoses (95% confidence interval, 40-57; P < 0.001). The increased risks extended across the spectrum of crash severity, appeared similar for Pfizer, Moderna, or other vaccines, and were validated in supplementary analyses of crossover cases, propensity scores, and additional controls.

    Conclusions

    These data suggest that COVID vaccine hesitancy is associated with significant increased risks of a traffic crash. An awareness of these risks might help to encourage more COVID vaccination.

  • It is much more like that the vaxxine victims did/could no longer drive a car....

    Now you might begin to understand why the US lost over a million people to Covid and has the 37th ranked healthcare system in the world. Research money being wasted on bullshit studies instead of early treatment options. Money wasted on nothing more than a politically motivated conclusion.

  • Now you might begin to understand why the US lost over a million people to Covid

    This is just the official number... Now you have to add about 1-200000/year that died to early due to vaxxines, drug abuse (remdesivir, opiodes > 100'000 etc..) Did you note that certain sudden deaths did increase up to 750% in Germany??

    US live expectancy lost >2 years during the last 2 years only...


    US population 334 mio. Deaths/ 334/78 about 4.25 mio. with 76 years this is about 4.3 mio. what only tells that COV-19 deaths did not add to the reduction in US live expectancy as this results from opiodes... So CoV-19 deaths are fake figures that tell nothing about reduction of live expectancy. But its is very low compare to CH/Japan.


    In reality the third world country USA has no working statistics that is close to actual.. See: https://www.cdc.gov/nchs/data-visualization/


    Best what you can get is 2020 data Here/UK 2 weeks back... UK has about 50'000 excess vaxxine deaths/year this would mean that the real US live expectancy should be much lower that the claimed 76.

  • Microbiome-focused Key Opinion Leader Hypothesizes Ivermectin’s Role in Inhibiting SARS-CoV-2

    Microbiome-focused Key Opinion Leader Hypothesizes Ivermectin’s Role in Inhibiting SARS-CoV-2
    Recently published in Frontiers of Microbiology, Dr. Sabine Hazan looked into a generic drug used by hundreds of millions of people every year, mostly in the…
    www.trialsitenews.com


    Recently published in Frontiers of Microbiology, Dr. Sabine Hazan looked into a generic drug used by hundreds of millions of people every year, mostly in the tropics to combat parasitic-born disease—ivermectin and its connection to SARS-CoV-2. A physician-scientist, Hazan both runs a successful clinic, a trial site, and a microbiome sequencing lab in Malibu, California. She and other researchers from Chinese University of Hong Kong have produced some evidence that SARS-CoV-2 can persist in human stool. In her most recent research, Hazan investigates the implication of decreased Bifidobacterium levels associated with persons “in COVID-19 susceptibility states, including old age, autoimmune disorder, and obesity”, hypothesizing that because the drug ivermectin is a by-product of Streptomyces fermentation, that it’s capable of not only feeding Bifidobacterial and thus potentially strengthening human defenses against SARS-CoV-2, the virus behind COVID-19, but also bolstering natural immunity, introducing a potentially protective capability against the coronavirus. Dr. Hazan’s recent lab-based study results concord with the hypothesis. Undoubtedly, a controversial topic given the levels of scrutiny directed at ivermectin, but Hazan isn’t deterred.


    Ivermectin—does it work?

    With 93 ivermectin studies conducted covering over 134,000 patients during the pandemic, one would think that there was sufficient data to make a conclusion one way or another. But it’s not that simple. There are three general schools of thought associated with this question.


    One branch is associated with opponents of ivermectin use against COVID-19. Encompassing pretty much all of the medical establishment, that is the dominant institutions directing health in America—from federal institutions under the Department of Health and Human Services (DHSS) such as the FDA, CDC, or NIH, to thought leaders in major academic medicine to health systems and hospitals and, of course, industry. This group benefits from mass media coverage and declares that the high profile studies led by academic medical centers that fail to show ivermectin efficacy against SARS-CoV-2 is more than enough to close the door, and a chapter in history.


    But there is another branch of what this media would refer to as ivermectin supporters. They point to the fact that the key major ivermectin studies used to discredit the drug as useful against COVID-19 exhibited significant flaws, such as obvious underdosing. They also point to real-world data such as mass ivermectin use in India’s most populated state Uttar Pradesh during the Delta surge in the spring to summer 2021. It was an aggressive campaign involving that state’s public health apparatus, pairs of health outreach workers that spread across the state, pervasive testing, and other non-pharmaceutical interventions plus the now famous home medicine kit which included ivermectin.


    This health outreach campaign was so effective that even the World Health Organization issued a press release highlighting the effort—but they omitted what was in those home medicine kits. Plenty of other examples apply, and dozens of countries temporarily authorized the drug on a provisional emergency basis during the pandemic—that news, covered in TrialSite, was completely censored in U.S. media. This group believes that was an orchestrated campaign to smear doctors who prescribed the drug off label. It was part of an information war that included censorship and a relentless behind the scenes collaboration between aforementioned federal agencies the Federation of State Medical Boards (FSMB) and even industry players to delegitimize the drug’s use. The FDA sent letters to the FSMB alerting that umbrella group to instruct their members to monitor doctors at the state level for propagating “misinformation” including any talk that ivermectin can bring benefits to persons with COVID-19. A climate of absolute fear grew among physicians. The FDA went after the drug directly in an information war, including questionable tactics.


    Finally, a third group is unsure about ivermectin’s use, citing evidence in some cases that the drug seems to work, and in other cases it does not. TrialSite perhaps falls in this category. For example, it could as be the case in Bangladesh that the drug must be combined with doxycycline, zinc, and perhaps other regimen for some effect but perhaps not by itself.


    Hazan Hypothesis Breakdown

    In an effort to attempt to simplify the Hazan hypothesis we include a breakdown below.


    What is ivermectin?

    Coming from a class of compound called macrocyclic lactones—namely Avermectins, the drug was discovered over three decades ago that led to a Nobel Prize award for game-changing impacts on the field of antiparasitic agents. The drug is approved by the FDA for treating parasitic infections.


    What are Avermectins?

    Found naturally, they are a fermented strain of Streptomyces avermitilis. So, they are a series of drugs and pesticides involved in the treatment of worms and insect-based parasites and include 16-membered macrocyclic lactone derivatives with strong anthelmintic and insecticidal properties. Again, naturally occurring compounds, they are the result of fermentation by Streptomyces avermitilis, a soil actinomycete. The discoverers isolated eight different Avermectins in four pairs of homologue compounds involving both a major (a-component) and a minor (b-component) typically in ratios of 80:20 to 90:10. Ivermectin was one of a handful of anthelmintics derived from Avermectins.


    According to Dr. Hazan, are the mechanisms of action for ivermectin’s ability to inhibit SARS-CoV-2 well known?

    No. While the mechanisms of action against antiparasitic agents are well known, the drug’s potential to be used in the fight against SARS-CoV-2 is not well understood.


    So, what’s ivermectin’s connection to the microbiome?

    Hazan writers in her peer reviewed piece that “Strepomyces spp. belong to the same phylum as a critically important constituent of the gut microbiome and common ingredient of probiotics, Bifidobacterium.”


    Interestingly Hazan shares a body of research evidencing a possible link between abundant levels of Bifidobacterium and known decreases in SARS-CoV-2 infections. Hazan refers to her group’s own work plus the following:


    Tao et al., 2020

    Xu et al., 2020

    Reinold et al., 2021

    Yeoh et al, 2021

    Zuo et al., 2021

    Hazan et al., 2022b

    Also, the Malibu physician-scientists reports real-world observations in the clinic involving patient pre-and post-FCT experiences that “certain bacteria in the same phylum may be able to replace each other’s function.” Among other things Hazan and colleagues hypothesized that Streptomyces spp. could possibly be used to replace Bifidobacterium loss.


    What is Bifidobacterium and why are they important?

    A group of bacteria known as probiotics that normally reside in the human intestines and stomach, they help the body execute essential activities from digestion to resisting harmful bacteria. Hazan cites them as “microaerotolerant anaerobes that degrade monosaccharides, such as glucose and fructose, via the bifid shunt, or the fructose-6-phosphate phosphoketolase pathway and produce more ATP than traditional fermentative pathways.”


    The use of probiotics has exploded among the health conscious. Think about all the drinks sold at places like Whole Foods. But that’s a far cry from robust evidence for the benefits across therapeutic areas. Frankly, Hazan is part of a movement of scientists working to diligently generate what is hoped will be robust evidence based on high quality studies. There is a growing interest with more capital flowing into this research space.


    Hazan does point toward studies pointing to evidence for the importance of increased Bifidobacterium levels to human health including the potential promotion of anti-inflammatory activity including:


    Arboleya et al., 2016

    Hughes et al., 2017

    Tao et al., 2020

    As mentioned above, abundant Bifidobacterium levels are associated with less SARS-CoV-2 infection.


    Study Background

    Hazan tested the hypothesis that ivermectin can potentially reduce SARS-CoV-2 infection due to its anti-inflammatory attributes associated with enhanced replication of Bifidobacterium. This leads to inhibition of TNF- α.


    “We hypothesize that IVM treats SARS-CoV-2 infection by decreasing inflammation through enhanced replication of Bifidobacterium, leading to inhibition of TNF- α. Does the anti-parasitic drug feed Bifidobacterium and thus promote the growth of that good bacteria? Note there are other suggested possible mechanisms of action explored. Follow the source to the journal for a full review.”


    (A) Bifidobacterium inhibits inflammation via binding of TNF-α. (B) Expansion of the right side of panel (A), showing IVM contains monosaccharide oleandrose moieties that could feed Bifidobacterium, thereby increasing replication and increased inhibition of TNF-α and inhibition of inflammation





    Source: Frontiers in Microbiology


    So, what does the research show thus far according to Dr. Hazan?

    Bifidobacterium has a protective role in SARS-CoV-2 infection possibly explained by calling out immune functions of the “good” bacteria. Hazan and her ProgenaBiome team contribute to what is still early, but growing research suggesting the gut microbiome, especially Bifidobacterium levels, associates with both positive and adverse COVID-19 infection.


    In this literature review, Hazan points to Tao et al. (2020) arguing that “changes in gut microbiota composition might contribute to SARS-CoV-2-induced production of inflammatory cytokines in the intestine, which may lead to cytokine storm onset.”


    Other bodies of research (Hughes et al., 2017 & Dyakov et al. 2020) suggest heightened levels of Bifidobacterium may reduce not only inflammation levels but also TNF- α function thus contributing to “calming the cytokine storm of SARS-CoV-2 infection.” The argument here is based on a premise that Bifidobacterium not only binds to TNF-α, but also reduces the paracrine and endocrine mediator of inflammatory and immune functions in the bloodstream; eventually absorbing it from what Cervantes and Hong, 2017 refer to as the “gut-lung” axis---completely absorbing the matter from lungs and other impacted areas.


    Based on this hypothesis, does ivermectin pose any risk due to its known antibacterial effects against Staphylococcus aureus and other gram-positive bacteria?

    Possibly contradictory for its purported ability to trigger growth of other gram-positive bacterium—Bifidobacterium—one study (Lazarenko et al, 2012) revealed in laboratory mice that “Bifidobacterium spp. can have protective effects against S. aureus infection in mice, thereby acting in an antagonistic relation with S. aureus.” Thus, Hazan assumes it unlikely that the drug would counter the “good” bacteria.


    Does Hazan make absolute claims that she has proven her hypothesis?

    Absolutely not. The physician-scientist acknowledges that this is all early-stage research and acknowledges in the language of the literature review results that she cannot be certain of the true function of ivermectin and the microbiome.


    She does articulate that assuming her hypothesis was true this would impact the timing of how ivermectin would be administered, for example. Suggesting the data thus far (again assuming one isn’t in the camp that believes ivermectin just doesn’t work against SARS-CoV-2) implies that ivermectin should be used right before the onset of cytokine storm (typically seriously ill COVID-19 patients present cytokine storm along with hypoxemia by Day 10-14), often referred to as the “second week crash.”


    What study data does Hazan have on use of ivermectin combination therapy on COVID-19 patients?

    Using ivermectin combination therapy starting at Day 10 post the initial onset results in successful treatment with all 24 severely hypoxic patients recovering without hospitalization. Hazen writes, “In short, ivermectin should be typically administered at the point of an SpO2 drop, the cytokine storm onset, and/or approximately Days 10-14.”




    Source: ProgenaBiome


    Who is Dr. Sabine Hazan?

    Profiled before on the TrialSite CureSeekers pilot series, Dr. Sabine Hazan heads up a Ventura, California-based trial site called Ventura Clinical Trials as well as a Malibu based laboratory ProgenaBiome touted as leading the way into the future of medicine via deep foundational knowledge in the microbiome today.


    Hazan’s work has focused on the human microbiome and its impact on our health. Connected with a group of physician-investigators focusing Clostridioides difficile infection (CD) and an associated procedure called the fecal microbiota transplantation (FMT), involving the delivery of healthy human donor stool to the patient via colonoscopy, enema, nasogastric (NG) tube or in capsule form. Over the years Hazan discovered that in real world scenarios FMT could treat other conditions such as Crohn's disease, psoriasis and more.


    But there is much investigation to produce the medical evidence for more broader acceptance. Her pursuit for knowledge led her to an infectious disease specialist and early microbiome research pioneer Dr. Sydney Finegold—he was pursuing investigation into whether gut bacteria could even be associated with Autism. Key to the health of the future Finegold once told Dr. Hazan, was to sequence the microbiome, classifying, analyzing and labeling bacteria, features and functions in what could become a suite of biomarkers for better health. Along the way Hazan, who in Malibu California counts as part of her patient panel some of the top actors, musicians and entertainment industry executives, discovered that FMT increases conditions such as Crohn’s disease, restoring balance to their microbiome. She started working with Thomas Borody in Australia, considered a major pioneer in FMT.


    For example, he pioneered what Hazan deems the first effective triple antibiotic therapy for Helicobater pylori which led to hundreds of patients’ relief from peptic ulcers. Borody’s Center for Digestive Diseases (CDD) has completed over 30,000 FMT treatments and the doctor-investigator filed over 165 patents. In the meantime, Feingold entrusted all of this legacy work (papers, books, etc.) to Hazan to pursue the ongoing link between the microbiome and Autism. Shortly after in 2019 Hazan launched the research company ProgenaBiome, a state-of-the-art genetic research laboratory with sophisticated onsite whole genome sequencing. Leading what Hazan terms a healthcare revolution, she formed the Malibu Microbiome Meeting, bringing together a wide range of healthcare professionals from investigators to nutritionists to pursue pragmatic microbiome-related research.


    Microbiome-Based Hypothesis on Ivermectin’s Mechanism in COVID-19: Ivermectin Feeds Bifidobacteria to Boost Immunity

    Microbiome-Based Hypothesis on Ivermectin’s Mechanism in COVID-19: Ivermectin Feeds Bifidobacteria to Boost Immunity
    Ivermectin is an anti-parasitic agent that has gained attention as a potential COVID-19 therapeutic. It is a compound of the type Avermectin, which is a…
    www.frontiersin.org

  • Steroids: Too Little Too Late in COVID-19 Respiratory Illness

    Steroids: Too Little Too Late in COVID-19 Respiratory Illness
    To this day, the Infectious Disease Society of America and the National Institutes of Health Guidelines do not advise prehospital use of corticosteroids in…
    www.trialsitenews.com


    To this day, the Infectious Disease Society of America and the National Institutes of Health Guidelines do not advise prehospital use of corticosteroids in COVID-19 illness. Conversely oral and or nebulized steroids have been a part of the FLCCC and McCullough protocols since 2020. Justification for early steroids sadly now comes from an autopsy study of fatal cases by Kato et al who evaluated 61 cases from the NIH, Cornell, and University of North Carolina Chapel Hill.




    Kato T, Asakura T, Edwards CE, Dang H, Mikami Y, Okuda K, Chen G, Sun L, Gilmore RC, Hawkins P, De la Cruz G, Cooley MR, Bailey AB, Hewitt SM, Chertow DS, Borczuk AC, Salvatore S, Martinez FJ, Thorne LB, Askin FB, Ehre C, Randell SH, O'Neal WK, Baric RS, Boucher RC. Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1336-1352. doi: 10.1164/rccm.202111-2606OC. PMID: 35816430.n...


    The bottom line is that after 20 days, SARS-CoV-2 is gone from the trachea and the big problem is mucus plugging and congestion. Within the small blood vessels of the lungs, blood clots are forming. Kato showed the only factor associated with reduced mucus in these fatal cases was dexamethasone most commonly used at 6 mg a day in the IDSA and NIH protocols.


    For reference, dexamethasone is routinely administered for brain swelling at 10 mg intravenously every 4-6 hours. In respiratory inflammation (asthma, allergic pneumonitis), the most commonly administered steroid is intravenous solumedrol 60-125 mg every 6 to 12 hours. In the McCullough protocol, I did not hesitate to initially recommend oral prednisone 60 mg a day and later come into the practice of using 20 mg every 12 hours with a 5–10-day taper. It is interesting to note none of these deceased patients received the FLCCC or McCullough protocols prior to admission. If they did, they wouldn’t be on the autopsy table.


    Kato T, Asakura T, Edwards CE, Dang H, Mikami Y, Okuda K, Chen G, Sun L, Gilmore RC, Hawkins P, De la Cruz G, Cooley MR, Bailey AB, Hewitt SM, Chertow DS, Borczuk AC, Salvatore S, Martinez FJ, Thorne LB, Askin FB, Ehre C, Randell SH, O'Neal WK, Baric RS, Boucher RC. Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1336-1352. doi: 10.1164/rccm.202111-2606OC. PMID: 35816430.


    Follow the link and check out more from Dr. Peter McCullough at “Courageous Discourse.”


    References

    Steroids: Too Little Too Late in COVID-19 Respiratory Illness
    Autopsy Study Shows Steroids Cut Down on Mucus Plugging of Airways
    petermcculloughmd.substack.com

  • These data suggest that COVID vaccine hesitancy is associated with significant increased risks of a traffic crash. An awareness of these risks might help to encourage more COVID vaccination.

    There might be another causal link - In the eyes of most people getting vaccinated is the safe thing to do. Perhaps those who chose not to be vaccinated are less risk-averse than those who did. Thus they get involved in more accidents.


    Or maybe they have more cats, as this study might suggest.


    "In their July 2018 publication, Stefanie Johnson and her colleagues cautiously link Toxoplasma gondii with increased entrepreneurial behavior. They studied university students, business professionals and global entrepreneurial tendencies, and found: business students are 1.4 times more likely to be infected with Toxoplasma gondii than non-business students; amongst business professionals, the odds of starting a business successfully is 1.8 greater if infected with the parasite; and globally there was a positive correlation between infection and entrepreneurial activity.


    Entrepreneurial behavior is linked with infected individuals having less ‘fear of failure’ and more ‘entrepreneurial intent’. Entrepreneurs display more ‘risk taking’ and less ‘risk-avoidance’ behaviors. The authors caution that just because infection does seem to correlate with entrepreneurship, it does not follow that increased risk taking will lead to high rewards, as the ‘quality’ of the decision or action is hard to predict. You are not more likely to become rich [so don’t go out and seek infection to get wealthy].


    To me, it is clear that Toxoplasma gondii can influence behaviors, although we should exercise caution when attributing how much influence and what the outcomes of the influence are without further study. One aspect of Stefanie Johnson’s study is that they looked at global trends as well as smaller niche groups, and that got me pondering how much of an influence Toxoplasma gondii (and even other parasites) could have had on human and societal evolution. Did infection cause our ancestors to take risks such as harnessing fire for the first time, developing hunting strategies or even domesticating animals? And, if so, where would we be without such risk taking behaviors?"


    https://blogs.biomedcentral.co…:text=Toxoplasma%20gondii's%20definitive%20hosts%20are,front%20of%20their%20predators%20%E2%80%93%20cats.

  • Stay away from cats and litter box

  • Heidelberg University Hospital Autopsy Examination Reveals Disturbing Data—5 of 20 Deceased Likely Linked to mRNA COVID-19 Vaccines

    Heidelberg University Hospital Autopsy Examination Reveals Disturbing Data—5 of 20 Deceased Likely Linked to mRNA COVID-19 Vaccines
    German researchers from the esteemed Heidelberg University Hospital Institute of Pathology led by corresponding authors Thomas Longerich Deputy Director…
    www.trialsitenews.com


    German researchers from the esteemed Heidelberg University Hospital Institute of Pathology led by corresponding authors Thomas Longerich Deputy Director University Hospital Heidelberg and Peter Schirmacher, acting chairman of the German Society of Pathology, director of the Institute of Pathology also at Heidelberg University Hospital, and president of the German Association for the Study of the Liver, recently had their investigation published in the journal Clinical Research in Cardiology titled “Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination.” The real-world analysis examined 25 persons who died unexpectedly and within 20 days of the COVID-19 vaccination. The authors report that five of the total or 20% evidenced signs of myocarditis, a type of cardiovascular condition that likely had no other explanation other than the COVID-19 jabs. The authors declared, based on their results, “myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination.” Their findings may aid in adequately diagnosing unclear cases after vaccination and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases. The State of Florida’s Surgeon General recently announced that the American state would conduct a similar study examining persons that die within 20 days after COVID-19 vaccination. Importantly, this study has limitations, and any broad-based epidemiological claims wouldn’t be appropriate.


    Anti-Covid-19 groups pounced on the findings to make broad, sweeping declarations while fact checkers systematically refuted such claims. Typically, the truth lies somewhere in the middle.


    Context

    The German study authors acknowledge several cases of myocarditis following anti-SARS-CoV-2 vaccination, with symptoms typically occurring within the first three days following the second dose of mRNA COVID-19 vaccines (Comirnaty and Spikevax, respectively) and young male patients presenting with chest pain are predominantly affected.


    Typically, the authors report:


    “Clinical findings like elevated troponin serum levels, abnormal ST-elevations in ECG and altered ventricle movement in echocardiogram or late enhancement in cardiac MRI suggested the development of myocarditis. Most of the reported cases showed clinically mild courses with resolution of symptoms without treatment. However, in rare instances, individuals required intensive care support or even died from acute heart failure as described in an early report by Verma et al. “


    While the German authors point out that although the studies include different diagnostic modalities applied, they establish a link between vaccination and myocarditis. Many of these studies lack extensive testing for infectious agents, especially the study of autopsy cohorts, as well as information about potential long-term outcomes, which are not available yet.


    While the study doesn’t offer conclusive evidence sufficient that other causes couldn’t be ruled out, the authors appear very clear based on their writing that the vaccine is suspect.


    The Study

    Examining autopsies associated with the COVID autopsy and biomaterial registry Baden-Württemberg containing autopsy, clinical and pathological data as well as tissue samples, the study team initially included 54 persons who died within 20 days after a COVID-19 vaccine. Each autopsy was conducted in one of the five University hospital sites in this German state.


    This particular network in the state of Baden-Württemberg collaborates with various other state functions and national German networks (E.g., the German Center for Infection Research (DZIF), the German Center for Lung Research (DZL) and the national academic research network NUM (Network of University Medicine; DEFEAT PANDEMics) with results consistently reported to the Paul Ehrlich Institute (PPEI), the German Federal Institute for Vaccines and Biomedicines.


    In this particular study, only 35 autopsies were included, all done at Heidelberg University Hospital, in a bid to ensure all medical documents and associated findings were present.


    What was examined?

    The German examiners evaluated the hearts of the deceased macroscopically—measuring key attributes from weight and thickness of the left, right, and interventricular walls to the dissension of coronary arteries to look for arteriosclerosis and exclusion of thrombi. Also, the team examined inflow and outflow tracts as well as other relevant procedures.


    How did the team define myocarditis?

    Based on what’s known as the Dallas criteria as well as specifications based on Caforio et al. as an inflammatory infiltrate with ≥ 14 leucocytes/mm2 including up to 4 monocytes/mm2 with the presence of CD3 positive T-lymphocytes ≥ 7 cells/mm2 and signs of myocyte degeneration and necrosis of non-ischemic origin.


    What were the results?

    Out of 35 cases reviewed at the University of Heidelberg, the researchers wrote that the autopsies revealed other causes of death (e.g., pre-existing illness) in 10 patients and thus fit into exclusion criteria.


    They found cardiac autopsy findings consistent with (epi-) myocarditis were observed in five cases of the remaining 25 deceased—those who died unexpectedly within 20 days of receiving a COVID-19 vaccine.


    Four of the five were vaccinated with Pfizer-BioNTech Comirnaty and one with Moderna’s Spikevax; of course, both are mRNA-based vaccines. What follows are some basic facts of the deceased:

    3 of the deceased persons were women, two men

    4 of the deceased died after the first vaccine jab with the remaining post the second dose

    All 5 of the 25 died within the first week post mRNA vaccination (mean 2.5 days, median 2 days)

    None of the deceased had COVID-19 infections prior to vaccination and all were tested negative for SARS-CoV-2 prior to vaccination

    Conclusion

    The study team communicated fairly conclusive language, sharing:


    “Based on the autopsy findings and all available data, no other cause of death except (epi-)myocarditis was identified in any of the cases presented here. Hence, myocarditis has to be considered the likely cause of death. From a functional point of view, myocardial damage in our cases is not sufficient to postulate contractile failure as terminal cause of death; thus, arrhythmic failure, either by cardiac arrest or by ventricular fibrillation, has to be assumed as the mechanism leading to the patients’ death. Myocarditis-related acute cardiac arrest due to either asystoly or ventricular fibrillation is a well-established pathomechanism in other causes of acute myocarditis as well.”

    How do the authors rationalize the linkage to the vaccines?

    a close temporal relation to vaccination; all cases were found dead within one week after vaccination

    (B) absence of any other significant pre-existing heart disease, especially ischemic heart disease or cardiomyopathy

    (C) negative testing for potential myocarditis-causing infectious agents

    (D) presence of a peculiar CD4 predominant T-cell infiltrate, suggesting an immune mediated mechanism. The latter criterion is supported by demonstration of a phenotypically identical T-cell infiltrate at the deltoidal injection site in one of the cases. It has to be emphasized, that a comparable (epi-)myocardial infiltration was neither found in any of the other 20 autopsies performed on bodies found dead within 20 days following an anti-SARS-CoV-2 vaccination nor in the age- and sex-matched cohorts from three independent periods from our autopsy-files.

    Other considerations?

    The findings support some other considerations. For example, aside from pneumonia, myocarditis is another manifestation reported during SARS-CoV-2 infection. Thus, it’s up for debate if myocarditis and COVID-19 is primarily caused by the viral infection or if it occurs. as a secondary consequence of the host immune response.


    It’s possible that “molecular mimicry between the SARS-CoV-2 spike and self-antigens could trigger an anti-myocytic immune response in predisposed persons. The authors also report the prospect of “A vaccine-induced activation of the immune system in persons with otherwise peripheral tolerance due to regulatory T cells might promote CD4 + effector T cell expansion and myocarditis.”


    Limitations

    This study has numerous limitations, including:


    Small sample size

    Inherits the bias of an endpoint analysis

    Descriptive data in terms of quality—the study doesn’t allow for epidemiological conclusions in terms of incidence or risk estimation

    The study team rehashes narrative talking points that the incidence of myocarditis is low after vaccination while risks of COVID-19 are higher—some studies refute this risk-benefit analysis

    Infectious agents may also trigger myocarditis

    The authors point out that this study “cannot provide a definitive functional proof or a direct causal link between vaccination and myocarditis.”

    Lead Research/Investigators

    Thomas Longerich


    Prof. Dr. Peter Schirmacher


    Call to Action: More studies, as well as an extended registry, are required to identify persons at risk for this potentially fatal class of adverse event of interest. Additional analysis (clinical, serological, and molecular) may contribute to a deeper understanding. Note that this study was the inspiration for the recently announced State of Florida study. They will study persons who die in Florida within 20 days of receiving the mRNA COVID-19 vaccines.

  • Mirror, Mirror 2021: Reflecting Poorly

    Health Care in the U.S. Compared to Other High-Income Countries

    https://www.commonwealthfund.o…res%20of%20care%20process.



    Abstract

    Issue: No two countries are alike when it comes to organizing and delivering health care for their people, creating an opportunity to learn about alternative approaches.

    Goal: To compare the performance of health care systems of 11 high-income countries.

    Methods: Analysis of 71 performance measures across five domains — access to care, care process, administrative efficiency, equity, and health care outcomes — drawn from Commonwealth Fund international surveys conducted in each country and administrative data from the Organisation for Economic Co-operation and Development and the World Health Organization.

    Key Findings: The top-performing countries overall are Norway, the Netherlands, and Australia. The United States ranks last overall, despite spending far more of its gross domestic product on health care. The U.S. ranks last on access to care, administrative efficiency, equity, and health care outcomes, but second on measures of care process.

    Conclusion: Four features distinguish top performing countries from the United States: 1) they provide for universal coverage and remove cost barriers; 2) they invest in primary care systems to ensure that high-value services are equitably available in all communities to all people; 3) they reduce administrative burdens that divert time, efforts, and spending from health improvement efforts; and 4) they invest in social services, especially for children and working-age adults.

  • The U.S. ranks last on access to care, administrative efficiency,

    Thanks to the neglected public schools that feed the basic (damn cheap) personal into boring administration...

    Could also bee that the average working ethics is very random in USA.

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  • Setting the Record Straight on Ivermectin ⋆ Brownstone Institute


    Setting the Record Straight on Ivermectin

    BY David R. HendersonDAVID R. HENDERSON, Charles L. HooperCHARLES L. HOOPER   DECEMBER 14, 2022   HISTORY, POLICY   5 MINUTE READ


    The COVID-19 pandemic brought us a panoply of lies and evidence-light declarations that were less intended to inform Americans than to consolidate power and buy time. Among these were Anthony Fauci’s famous shift from arguing against wearing masks, to recommending wearing one, and, finally, to wearing two.


    Fauci also tried to convince us that the SARS-CoV-2 virus was not manipulated in a lab even though his inner circle had emailed him about “unusual features” of the virus that looked “potentially engineered.” And, of course, we had “fifteen days to stop the spread,” an evergreen concept that dragged on for two years. Lest readers fault us for forgetting, there was also the “gain of function” controversy, the focused protection battle, school closures, lockdowns, vaccine mandates, and vaccine misrepresentations.


    These topics have received much public attention. The one pandemic topic that hasn’t, and is nonetheless important, is the maligned ivermectin. It’s time to set the record straight.


    If you’ve followed the news closely over the last two years, you’ve probably heard a few things about ivermectin. First, that it’s a veterinary medicine intended for horses and cows. Second, that the FDA and other government regulatory agencies recommended against its use for COVID-19. Third, that even the inventor and manufacturer of ivermectin, Merck & Co., came out against it. Fourth, that one of the largest studies showing that ivermectin worked for COVID-19 was retracted for data fraud. And, finally, that the largest and best study of ivermectin, the TOGETHER trial, showed that ivermectin didn’t work.


    Let’s consider the evidence. Ivermectin has a distinguished history, and it may have benefits comparable to those of penicillin. The anti-parasitic’s discovery led to a Nobel Prize and subsequent billions of safe administrations around the world, even among children and pregnant women. “Ivermectin is widely available worldwide, inexpensive, and one of the safest drugs in modern medicine.”


    The FDA put out a special warning against using ivermectin for COVID-19. The FDA’s warning, which included language such as, “serious harm,” “hospitalized,” “dangerous,” “very dangerous,” “seizures,” “coma and even death,” and “highly toxic,” might suggest that the FDA was warning against pills laced with poison, not a drug the FDA had already approved as safe. Why did it become dangerous when used for COVID-19? The FDA didn’t say.


    Because of the FDA’s rules, if it were to make any statement on ivermectin, it was obliged to attack it. The FDA prohibits the promotion of drugs for unapproved uses. Since fighting SARS-CoV-2 was an unapproved use of ivermectin, the FDA couldn’t have advocated use without obvious hypocrisy. Ivermectin’s discoverer, Merck & Co., had multiple reasons to disparage its own drug.

    Merck, too, couldn’t have legally “promoted” ivermectin for COVID-19 without a full FDA approval, something that would have taken years and many millions of dollars. Plus, Merck doesn’t make much money from cheap, generic ivermectin but was hoping to find success with its new, expensive drug, Lagevrio (molnupiravir).


    A large study of ivermectin for COVID-19 by Elgazzar et al. was withdrawn over charges of plagiarism and faked data. Many media reports seem fixated on this one dubious study, but it was one of many clinical studies. After the withdrawn studies have been removed from consideration, there are 15 trials that suggest that ivermectin doesn’t work for COVID-19 and 78 that do.


    The TOGETHER trial received significant positive press. The New York Times quoted two experts who had seen the results. One stated, “There’s really no sign of any benefit [from ivermectin],” while the other said, “At some point it will become a waste of resources to continue studying an unpromising approach.”


    While the Elgazzar paper was quickly dismissed, the TOGETHER trial was acclaimed. It shouldn’t have been. Researchers who have analyzed it have found 31 critical problems (impossible data; extreme conflicts of interest; blinding failure), 22 serious problems (results were delayed six months; conflicting data), and 21 major problems (multiple, conflicting randomization protocols) with it.


    While the popular narrative is that the TOGETHER trial showed that ivermectin didn’t work for COVID-19, the actual results belie that conclusion: ivermectin was associated with a 12 percent lower risk of death, a 23 percent lower risk of mechanical ventilation, a 17 percent lower risk of hospitalization, and a 10 percent lower risk of extended ER observation or hospitalization. We have calculated that the probability that ivermectin helped the patients in the TOGETHER trial ranged from 26 percent for the median number of days to clinical recovery to 91 percent for preventing hospitalization. The TOGETHER trial’s results should be reported accurately.


    Based on the clinical evidence from the 93 trials that ivermectin reduced mortality by an average of 51 percent, and on the estimated infection fatality rate of COVID-19, about 400 infected Americans aged 60-69 would need to be treated with ivermectin to statistically prevent one death in that group. The total cost of the ivermectin to prevent that one death: $40,000. (Based on the GoodRx website, a generic prescription for ivermectin is priced at approximately $40. Roughly 2.5 prescriptions would be needed per person to receive the average dose of 150 mg per patient.)

    How much is your life worth? We’re betting it’s worth far more than $40,000.


    When the next pandemic strikes, by necessity we’ll rely on older drugs because newer ones require years of development. Ivermectin is a repurposed drug that helps, and could have helped so much more. It deserves recognition, not disparagement. What we really need, however, is a way to inoculate ourselves against the lies and misrepresentations of powerful public figures, organizations, and drug companies. Sadly, there are no such vaccines for that contagion.

  • When the next pandemic strikes, by necessity we’ll rely on older drugs because newer ones require years of development. Ivermectin is a repurposed drug that helps, and could have helped so much more. It deserves recognition, not disparagement.

    Although Hooper /Henderson write "we'll rely on older drugs" The authors well know..

    Nothing would change the FDA stance on ivermectin. or other generic drug

    ..if there was a next pandemic ..as explained here..


    "The FDA waits for a deep-pocketed sponsor to present a comprehensive package that justifies the approval of a new drug or a new use of an existing drug.

    For a drug like ivermectin, long since generic, a sponsor may never show up.

    The reason is not that the drug is ineffective; rather, the reason is that any expenditures used to secure approval for that new use will help other generic manufacturers that haven’t invested a dime. "

    the FDA hands are in the pockets of Merck Pfizer...etc...

    that's the way the system is set up... to work .. or not.

    The FDA’s War Against the Truth on Ivermectin
    "The FDA spreads lies and alarms Americans while preventing drug companies from providing us with scientific explorations of existing, promising, generic…
    www.aier.org



  • It all about vitamin D! Its over! THE CURE for Covid 19

    Salen: Insight into the Crystal Structure, Hirshfeld Surface Analysis, Optical Properties, DFT, and Molecular Docking Studies

    https://www.tandfonline.com/doi/abs/10.1080/10406638.2022.2097281?journalCode=gpol20


    Abstract

    We report on a known Schiff base dye salen. The crystal structure of salen is in the enol–enol tautomer. Molecules are packed into a 3D supramolecular framework through C–H···π interactions. The absorption spectrum of salen in CH2Cl2 exhibits three bands in the UV region, while the spectrum in MeOH contains an additional band at 403 nm and a shoulder at 280 nm, corresponding to the cis-keto tautomer. The emission spectrum of salen in MeOH exhibits a band at 435 and 457 nm upon irradiation at 280 and 400 nm, respectively, arising from the enol–cis-keto* and/or cis-keto–cis-keto* tautomers. The solution of salen in CH2Cl2 showed dual emission with the bands at 349 and 462 nm upon irradiation at 290 nm with the low-energy emission band arising from the enol–cis-keto* and/or cis-keto–cis-keto* tautomers, while the high-energy band corresponds to the enol–enol* tautomer. The emission spectrum of salen in CH2Cl2 exhibits a single band at 464 nm upon irradiation at 380 nm, arising from the different conformers of the enol–cis-keto* and/or cis-keto–cis-keto* tautomers. The DFT calculations revealed that the enol–enol tautomer is the most favorable, followed by the enol–cis-keto tautomer. The global chemical reactivity descriptors were estimated from the HOMO and LUMO. The DFT calculations were also applied to probe salen as a potential corrosion inhibitor for some important metals used in implants. The enol–cis-keto and enol–trans-keto tautomers exhibit the best electron charge transfer from the molecule to the surface of all the studied metals, of which the most efficient electron charge transfer was established for Ni, Au, and Co. Molecular docking was applied to study interaction of tautomers of salen with a series of the SARS-CoV-2 proteins, of which the best binding affinity was found toward nsp14 (N7-MTase).


    And the reason why

    Ligand Access Channels in Cytochrome P450 Enzymes: A Review

    Ligand Access Channels in Cytochrome P450 Enzymes: A Review
    Quantitative structure-activity relationships may bring invaluable information on structural elements of both enzymes and substrates that, together, govern…
    www.ncbi.nlm.nih.gov

  • While the Elgazzar paper was quickly dismissed, the TOGETHER trial was acclaimed.

    The El Gazzar paper data (in fact an old version) has been "hacked" by a junior Aussi free mason, that headed an medical startup company. It was his entry job to sell the old data as actual to be accepted in the field. The paper had to be retracted by El Gazzar to be able to continue his work as the FM/R/F/B mafia dominates most governments and the value of a live in Egypt is pretty low...


    The world market price for Ivermectin is 10 cents for 12mg or about 1$ a cure. We here can get it without prescription for about 80cents/12mg.


    Look at the mortality rate of India that did treat at least 200 million people with the Ziverdo kit. For the last 1.5 years (Ziverdoo time) India had only 100'000 deaths thereof more than 30'000 from the vaxxine or ziverdo-late only states.

    So the USA FM/R/F/B mafia killed 40x more people than India during the same time.... = Pre-inheritance promotion...


    With the proper treatment Ziverdo + iodine nose/throat tincture you can reduce CoV-19 mortality 100x !!!!!


    With a vaxxine you shorten your live time by at least 15% and now contribute to the largest cold epidemic ever seen. All European children hospitals are all over full. Germany cancels surgeries to help children.


    So please to not complain about Putin that kills some 100'000 by gun mincing them, the USA FM/R/JF/B mafia killed wqay more people than Putin for teh same reason = personal profit and fame.


    So next time when you believe that you have a democratic right to vote for a criminal - what is a precondition today - into the parliament then replace his name by a famous animal.

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