Quote from Wyttenbach

In USA there are just the free masons and the JF mafia that rule the state. There is no real government. May be just the FBI is left over... But for how long?

This was no problem until the 1980-ties, but since then the lodges have been filled with extreme dumb but greedy people. So basically dilettantes and high criminals (Biden,Schulz,Putin,Xsi, "Erdowahn", Urban,..... ) rule most states.

Two insightful articles:

The Argumentum Hystericum

The Argumentum Hystericum

The Daily Sceptic has now settled down to fight a battle on three fronts: against COVID-19 policies, against climate change,

dailysceptic.org

Mencken’s words of contempt have never rung so true

'The most dangerous man to any government is the man who is able to think things out for himself.’

‘A fool who, after plain warning, persists in dosing himself with dangerous drugs should be free to do so, for his death is a benefit to the race in general.’

Mencken’s words of contempt have never rung so true - The Conservative Woman

Mencken’s words of contempt have never rung so true

www.conservativewoman.co.uk

Blood abnormalities found in people with Long Covid

Study implicates lack of key hormone, battle-weary immune cells, and reawakened viruses

Science | AAAS

An ambitious study of people with Long Covid, the mysterious, disabling symptoms that can trail a SARS-CoV-2 infection, has turned up a host of abnormalities in their blood. The clues add to a body of evidence hinting at drivers of the condition and potential treatments worth testing. They also suggest that, as many scientists and patients have suspected, Long Covid shares certain features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), another condition thought to follow an infection.

The new study, posted as a preprint last week, was modest in size, examining just 99 people with Long Covid. “But it went very deep, it went into granular aspects of the T cells, the antibody response,” says Eric Topol, director of the Scripps Research Translational Institute, who was not involved in the work. “This is exploratory, but it’s the foundation for much bigger studies.”

Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders

Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study

https://www.ncbi.nlm.nih.gov/p…20effect%20on%20cortisone.

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies

Background: This study was designed to investigate the vitamin D (vit-D) and vitamin B12 (vit-B12) levels and their correlation with anti-thyroid peroxidase…

www.karger.com

Mahidol University Finds Disturbingly Frequent Incidence of Cardiovascular Events in Adolescents Post Pfizer-BioNTech mRNA-based COVID-19 Vaccine

Mahidol University Finds Disturbingly Frequent Incidence of Cardiovascular Events in Adolescents Post Pfizer-BioNTech mRNA-based COVID-19 Vaccine

Recently, investigators from Thailand studied the cardiovascular effects of myocarditis as well as pericarditis post vaccine administration with the…

www.trialsitenews.com

Recently, investigators from Thailand studied the cardiovascular effects of myocarditis as well as pericarditis post vaccine administration with the Pfizer-BioNTech mRNA vaccine called BNT162b2 in Thai adolescents. Led by Chayasin Mansanguan at Mahidol University, one of Thailand’s top-ranked public research-focused universities, the study team designed the prospective cohort study involving participants between the ages of 13 to 18 years old and above who received their second dose of the BNT162b2 product. What was the cardiac manifestation among these subjects? As reported in a preprint upload, the team collected various data from demographics, symptoms, vital signs, ECG, echocardiography, and cardiac enzymes at baseline, Day 3, Day 7, and Day 14 (optional) using case record forms. Overall the study team enrolled 314 participants; of these, 13 participants were lost to follow-up, leaving 301 participants for analysis. The most common cardiovascular effects were tachycardia (7.64%), shortness of breath (6.64%), palpitation (4.32%), chest pain (4.32%), and hypertension (3.99%). Seven participants (2.33%) exhibited at least one elevated cardiac biomarker or positive lab assessment. Cardiovascular effects were found in 29.24% of patients, including tachycardia, palpitation, and myopericarditis. Myopericarditis was discovered in one patient post the mRNA jab, while two subjects were diagnosed with suspected pericarditis, and four of the participants were diagnosed with suspected subclinical myocarditis. The authors concluded that significant cardiovascular events ensue after mRNA COVID-19 vaccination with the Pfizer-BioNTech product. Overall, any cases of myopericarditis post the jab were most often mild in nature—all cases were fully recovered within two weeks. The authors do recommend continued monitoring of adolescents receiving the Pfizer-BioNTech mRNA vaccine.

This study was registered on clinicaltrials.gov (NCT05288231) titled “Cardiac Manifestation in Adolescent After Pfizer COVID-19 injection in Thailand.”

What was the impetus for the study?

The Thai investigators affiliated with Mahidol University remind the reader about a recent U.S. Centers for Disease Control and Prevention (CDC) advisory Committee on Immunization Practices which identified a likely association between the COVID-19 mRNA vaccines from both Pfizer-BioNTech and Moderna and cases of myocarditis and pericarditis.

The study team disclosed that associated with the CDC data 4,863 adverse events (AEs) were reported from the Pfizer vaccine. Common findings observed with vaccines under study were tachycardia(16.41%), flushing (12.17%), hypertension (5.82%), hypotension (3.6%), and increased heart rate (9.03%).

In the Thailand-based study, the Mahidol University-based investigators characterized, classified, and evaluated the dynamic of cardiac function and ECG abnormality after the Pfizer vaccine injection.

About Mahidol University

Mahidol University is an autonomous research institution in Thailand that goes back to 1888 as part of Siriraj Hospital. With over 32,000 students, the university first became the University of Medical Science in 1943. It was later renamed in 1969 by King Bhumibol Adulyadej after his father, Prince Mahidol of Songkhla, who is the “Father of Modern Medicine and Public Health of Thailand.

With an original focus on health science, Mahidol University expanded to include a range of other fields while the institute also hosted Thailand’s first medical school—the Siriraj Medical School.

With the highest university budget of any public university in this Southeast Asian nation at $430 million by 2019, the bulk of those funds is allocated to research. Mahidol University has been ranked as Thailand’s number one university in recent years

Quote from Fm1

Cardiovascular effects were found in 29.24% of patients, including tachycardia, palpitation, and myopericarditis.

This is exactly what a "vaccine" should do with children....

Metabolomic and gut microbiome profiles across the spectrum of community-based COVID and non-COVID disease: A COVID-19 Biobank study

Metabolomic and gut microbiome profiles across the spectrum of community-based COVID and non-COVID disease: A COVID-19 Biobank study

Whilst many with SARS-CoV-2 infection have mild disease, managed in the community, individuals with cardiovascular risk factors experienced often more severe…

www.medrxiv.org

Abstract

Whilst many with SARS-CoV-2 infection have mild disease, managed in the community, individuals with cardiovascular risk factors experienced often more severe acute disease, requiring hospitalisation. Increasing concern has also developed over long symptom duration in many individuals, including the majority who managed acutely in the community. Risk factors for long symptom duration, including biological variables, are still poorly defined.

We examine post-illness metabolomic and gut-microbiome profiles, in community-dwelling participants with SARS-CoV-2, ranging from asymptomatic illness to Post-COVID Syndrome, and participants with prolonged non-COVID-19 illnesses. We also assess a pre-established metabolomic biomarker score for its association with illness duration.

We found an atherogenic-dyslipidaemic metabolic profile, and greater biomarker scores, associated with longer illness, both in individuals with and without SARS-CoV-2 infection. We found no association between illness duration and gut microbiome in convalescence.

Findings highlight the potential role of cardiometabolic dysfunction to the experience of long illness duration, including after COVID-19.

Association between Cardiometabolic risk factor and responsiveness to vitamin D supplementation: a new approach using artificial neural network analysis

Association between Cardiometabolic risk factor and responsiveness to vitamin D supplementation: a new approach using artificial neural network analysis - BMC Nutrition

Background There are increasing data highlighting the effectiveness of vitamin D supplementation in the treatment of vitamin D deficiency. But individuals vary…

bmcnutr.biomedcentral.com

From the last free US journal:: https://www.thedesertreview.co…ed-8b51-870078598ae9.html

Thus, Dr. Kory and his team's discovery should have been welcomed with open arms by a world in the throes of death, lockdown, and destruction during the Winter Surge of the COVID-19 pandemic.

However, this brings me back to Lincoln's quote about fooling people. Those dark political forces that valued profits over lives and control over health decided to attack Dr. Kory and his message. Because at the same time as Kory's revelation, Big Pharma and the captured NIH, CDC, and FDA had other marching orders - the planned mRNA vaccine rollout.

And part and parcel of this vaccine rollout relied upon achieving an Emergency Use Authorization (EUA) for the vaccines. This Emergency Use Authorization was very specific. Under Section III (B) (1d), there could be no effective alternative drug.

Some more::

In Uttar Pradesh, India, an area of comparable population size to the United States, where Ivermectin was widely employed, only 23,567 lives were lost to COVID-19, according to Johns Hopkins University CSSE COVID-19 data. This toll represents a 97% lower PER CAPITA death rate than the United States, which banned Ivermectin.

What is most apparent now, says Kory, is the massive rise in patients with vaccine injuries, sudden death, heart attacks, strokes, and cancers appearing in emergency rooms.
Something for vaxx cancer victims :: https://www.oncotarget.com/article/16723/text/

Report in SciTech Daily.

Research indicates republicans are dying at a higher rate than democrats.

A recent study shows how politics and health outcomes have become more intertwined over time. From 2001 to 2019, researchers from Brigham and Women’s Hospital looked at death rates and information on federal and state elections for all counties in the United States. The researchers discovered a “mortality gap,” or an increasing divergence in age-adjusted death rates in counties that had supported Democrats or Republicans in prior presidential and governor elections.

“In an ideal world, politics and health would be independent of each other and it wouldn’t matter whether one lives in an area that voted for one party or another,” said corresponding author Haider Warraich, MD, of the Division of Cardiovascular Medicine at the Brigham. “But that is no longer the case. From our data, we can see that the risk of premature death is higher for people living in a county that voted Republican.”

PSK

"A fool who votes against improvements to the health service is free to do so, but his death is still a tragedy" ZenoOfElea

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

https://www.pnas.org/doi/full/10.1073/pnas.2200960119

Significance

Neurological symptoms are among the most prevalent of the extrapulmonary complications of COVID-19, affecting more than 30% of patients. In this study, we provide evidence that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in the human brain, where it infects astrocytes and to a lesser extent, neurons. We also show that astrocytes are susceptible to SARS-CoV-2 infection through a noncanonical mechanism that involves spike–NRP1 interaction and respond to the infection by remodeling energy metabolism, which in turn, alters the levels of metabolites used to fuel neurons and support neurotransmitter synthesis. The altered secretory phenotype of infected astrocytes then impairs neuronal viability. These features could explain the damage and structural changes observed in the brains of COVID-19 patients.

Abstract

Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently characterized as part of “long COVID-19” syndrome) has been frequently observed after mild infection. We show the spectrum of cerebral impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, ranging from long-term alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety symptoms) to severe acute damage confirmed in brain tissue samples extracted from the orbitofrontal region (via endonasal transethmoidal access) from individuals who died of COVID-19. In an independent cohort of 26 individuals who died of COVID-19, we used histopathological signs of brain damage as a guide for possible SARS-CoV-2 brain infection and found that among the 5 individuals who exhibited those signs, all of them had genetic material of the virus in the brain. Brain tissue samples from these five patients also exhibited foci of SARS-CoV-2 infection and replication, particularly in astrocytes. Supporting the hypothesis of astrocyte infection, neural stem cell–derived human astrocytes in vitro are susceptible to SARS-CoV-2 infection through a noncanonical mechanism that involves spike–NRP1 interaction. SARS-CoV-2–infected astrocytes manifested changes in energy metabolism and in key proteins and metabolites used to fuel neurons, as well as in the biogenesis of neurotransmitters. Moreover, human astrocyte infection elicits a secretory phenotype that reduces neuronal viability. Our data support the model in which SARS-CoV-2 reaches the brain, infects astrocytes, and consequently, leads to neuronal death or dysfunction. These deregulated processes could contribute to the structural and functional alterations seen in the brains of COVID-19 patients.

Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes

Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes

Accumulating evidence indicates that the active form of vitamin D, 1,25(OH)2D3, can be considered as a neurosteroid. However, the cerebral expression …

www.sciencedirect.com

Highlights

•

In comparison to the kidney and liver, the brain produces low levels of the transcripts coding for Cyp27a1, Cyp27b1, Cyp24a1.

•

High levels of Pdia3 mRNA are found in cortex and hippocampus compared to kidney and liver.

•

The transcript coding for Vdr, the genomic vitamin D receptor, is mainly expressed in astrocytes.

•

The strongest expression of Pdia3 mRNA is observed in neurons, astrocytes and endothelial cells.

•

An increased production of Cyp24a1 is found in microglia and endothelial cells after treatment with 1,25(OH)2D3.

•

In the brain, Pdia3 may be considered as the main vitamin D receptor.

CYP24A1 gene

cytochrome P450 family 24 subfamily A member 1

https://medlineplus.gov/geneti…ailable%20in%20the%20body.

The CYP24A1 gene provides instructions for making an enzyme called 24-hydroxylase. This enzyme helps control the amount of active vitamin D available in the body. When active, vitamin D is involved in maintaining the proper balance of several minerals in the body, including calcium and phosphate, which are essential for the normal formation of bones and teeth. One of vitamin D's major roles is to control the absorption of calcium and phosphate from the intestines into the bloodstream. Vitamin D is also involved in several processes in addition to bone and tooth formation.

The 24-hydroxylase enzyme breaks down the active form of vitamin D, called 1,25-dihydroxyvitamin D3 or calcitriol, to an inactive form when the vitamin is no longer needed. The enzyme also breaks down 25-hydroxyvitamin D (also known as calcidiol), which is the form of vitamin D that is stored in the body.

The role of Pdia3-dependent 1α,25-dihydroxy vitamin D3 signaling on IgE-mediated mast cell activation

Quote from ZenoOfElea

From our data, we can see that the risk of premature death is higher for people living in a county that voted Republican.”

What is higher ????

75 year anniversary of Nüremberg Code is coming up at August 20th!

Quote from ZenoOfElea

From our data, we can see that the risk of premature death is higher for people living in a county that voted Republican

White collar jobs vs blue collar jobs is the reason

"A gullible fool who doesn't think is of no use"

Quote from PSK

White collar jobs vs blue collar jobs is the reason

The stats clearly show that people in counties that voted Republican have a lower vaccination rate and they die in greater numbers from COVID. That difference is not caused by blue collar jobs. In Democratic counties with many blue collar jobs, people die from COVID at lower rates than wealthy white collar GOP voters.

People in GOP counties die from other causes at higher rates than people in Democratic counties. See:

People in Republican Counties Have Higher Death Rates Than Those in Democratic Counties

A growing mortality gap between Republican and Democratic areas may largely stem from policy choices

www.scientificamerican.com

It may be that outside of COVID, blue collar jobs tend to shorten lifespans. I think it would depend on the industry. It is plausible, but when you look only at COVID deaths, Republicans die at higher rates than Democrats, and of course more of them suffer from severe cases leading to amputations, lung damage, inability to have sex, a higher likelihood of early death and other effects from COVID. The vaccine greatly reduces such outcomes.

NEJM:

https://www.nejm.org/doi/full/10.1056/NEJMoa2201662

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19

ABSTRACT

BACKGROUND

Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

METHODS

In this phase 3, double-blind, randomized, placebo-controlled trial, we used a 2-by-3 factorial design to test the effectiveness of three repurposed drugs — metformin, ivermectin, and fluvoxamine — in preventing serious SARS-CoV-2 infection in nonhospitalized adults who had been enrolled within 3 days after a confirmed diagnosis of infection and less than 7 days after the onset of symptoms. The patients were between the ages of 30 and 85 years, and all had either overweight or obesity. The primary composite end point was hypoxemia (≤93% oxygen saturation on home oximetry), emergency department visit, hospitalization, or death. All analyses used controls who had undergone concurrent randomization and were adjusted for SARSCoV-2 vaccination and receipt of other trial medications.

RESULTS

A total of 1431 patients underwent randomization; of these patients, 1323 were included in the primary analysis. The median age of the patients was 46 years; 56% were female (6% of whom were pregnant), and 52% had been vaccinated. The adjusted odds ratio for a primary event was 0.84 (95% confidence interval [CI], 0.66 to 1.09; P=0.19) with metformin, 1.05 (95% CI, 0.76 to 1.45; P=0.78) with ivermectin, and 0.94 (95% CI, 0.66 to 1.36; P=0.75) with fluvoxamine. In prespecified secondary analyses, the adjusted odds ratio for emergency department visit, hospitalization, or death was 0.58 (95% CI, 0.35 to 0.94) with metformin, 1.39 (95% CI, 0.72 to 2.69) with ivermectin, and 1.17 (95% CI, 0.57 to 2.40) with fluvoxamine. The adjusted odds ratio for hospitalization or death was 0.47 (95% CI, 0.20 to 1.11) with metformin, 0.73 (95% CI, 0.19 to 2.77) with ivermectin, and 1.11 (95% CI, 0.33 to 3.76) with fluvoxamine.

CONCLUSIONS

None of the three medications that were evaluated prevented the occurrence of hypoxemia, an emergency department visit, hospitalization, or death associated with Covid-19. (Funded by the Parsemus Foundation and others; COVID-OUT ClinicalTrials .gov number, NCT04510194.)

A NEJM editorial:

https://www.nejm.org/doi/full/10.1056/NEJMe2209017

Time to Stop Using Ineffective Covid-19 Drugs

QUOTE:

In practicing evidence-based medicine, physicians use the best evidence currently available on safety and efficacy in making decisions on treatment choices for their patients. During the Covid-19 pandemic, some of the early treatment trials were rushed, leading to studies that were badly conducted¹ or had too few patients.² As a result, initial evidence of the efficacy of some Covid-19 treatments could not be replicated,^3,4 but these drugs were already in widespread use by then, and some clinicians have been reluctant to change to proven efficacious alternatives. Ivermectin and fluvoxamine, in particular, are still widely prescribed, even though evidence has been steadily accumulating to indicate that both treatments at acceptable doses are not effective for Covid-19.^3-5

In this issue of the Journal, Bramante et al.⁶ report the results of the COVID-OUT randomized, controlled trial of oral metformin, ivermectin, and fluvoxamine for the early treatment of SARS-CoV-2 infection in 1323 outpatients. The investigators found no reductions in hypoxemia, emergency department visits, hospitalization, or death associated with any of the three drugs. . . .

Wyttenbach "What is higher ????"

It is published in the BMJ so you probably should just ignore it

JedRothwell

The paper is based on data collected from 2001 to 2019 so no Covid effect in this research.

PSK

The fact that you say "A gullible fool who doesn't think is of no use" while at the same time dismissing the results as “White collar jobs vs blue collar jobs is the reason” without saying “maybe” or “it might be possible that white collar jobs vs blue collar jogs is the reason” is ironic.

Nonetheless it is a good point. Maybe you are correct.

It is a piece of research and should rightly be critiqued, hopefully by people smarter than us.

It may turn out to be seriously flawed.

White collar vs blue collar was not specifically mentioned in the paper.

The nearest that the paper comes to dealing with your point is a data split into metropolitan and rural;

“Given that Democratic rural counties fared much better than Republican rural counties, it is likely that political environment has an important role to play in the widening urban-rural mortality gap.”

The paper goes on to say;

“One potential explanation may be related to underlying differences in access to healthcare. Recent evidence suggests that the values and beliefs about whether health insurance coverage should be provided by the federal government vary markedly by political environment, and Republican states tend to have higher uninsurance rates, in part because many elected to not expand Medicaid over the past decade. Lack of health insurance coverage is associated with lower rates of screening, identification, and treatment of important risk factors (eg, diabetes, hypertension) and chronic conditions (heart disease, cancer). ”

Personally I would guess that this is a more significant factor than “white collar vs blue collar” but that is only my slightly informed position.

***

In respect of your posting above Dr Alexander James says;

“This is a politics of tar and feather, and it is being conducted through a pseudo-logic of coercive dichotomies, all of which have the form of the argumentum hystericum.

Until we collectively restore some sort of sense of proportion to our entire culture, there is nothing to be done. But at least, for the moment, we can identify the problem.”

I have two thoughts to share;

Hysteria; you refer to “hysteria” in the areas of Covid, climate change and wokeism.

I would agree with that. The media and certain fringe elements do try to stir up a level of hysteria. In my opinion this is partly because the media has much more competition with social media and new media such that they try to attract attention by making every headline one of “outrage”, “alarm”, “shock”. I stopped reading newspapers years ago for the good of my blood pressure. Such hysteria does not make for good policy. But this effect is across the media, not just one side or another. For example while one side is accused of hysteria on Covid and climate change, another side is predicting an economic apocalyse or stockpiling weapons for a civil war.

Which leads onto …

Dichotomy; sadly, IMO, we are not well served by our political classes, whose interest is in making everything black and white and stirring up one side against the other side (who often are portrayed as a bogeyman figure). “Coercive dichotomies” abound along with tribalism. In my view this is one of the key strategies to stop people thinking for themselves.

In the real world simple dichotomies are not the answer to most issues.

When people stop focusing on their differences they may find that they have a lot in common.

So if I ultimately want to think for myself then I reject being put into one side or another.

These damn coincidences just keep piling up or maybe vitamin D is the key!

Myelitis Following COVID-19 Illness

Myelitis Following COVID-19 Illness

COVID-19 occurs due to infection by the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2), which has caused havoc globally. It presents with a…

www.cureus.com

Abstract

COVID-19 occurs due to infection by the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2), which has caused havoc globally. It presents with a wide range of symptoms, mainly respiratory symptoms, but with time various neurological manifestations of the disease have also been noted, like myelitis. This case report aims to shed light on COVID-19-associated myelitis so that potential neurological complications of COVID-19 can be identified and treated timely. We report a case of a 41-year-old male who presented with weakness of all limbs with urinary complaints. He also had a cough and sore throat for the past few days. The MRI scan of the spine showed long segment myelitis in the cervical cord extending from the cervicomedullary junction to the upper end of the C4 vertebral body. COVID-19 myelitis is a rare but severe complication of COVID-19 infection and needs to be discussed.

Low serum vitamin D levels and recurrent inflammatory spinal cord disease

Low serum vitamin D levels and recurrent inflammatory spinal cord disease - PubMed

This study provides a basis for a prospective trial of measuring 25-hydroxyvitamin D levels in these patient populations and assessing the influence of vitamin…

pubmed.ncbi.nlm.nih.gov

Background: Low 25-hydroxyvitamin D levels have been associated with a higher risk of developing multiple sclerosis and increased relapse rates in patients with multiple sclerosis. As a sterol hormone involved in multiple immunologic pathways, vitamin D may play a role in preventing monophasic immune-mediated central nervous system attacks from developing into recurrent disease.

Objective: To investigate the association between low serum vitamin D levels and recurrent spinal cord disease.

Design, setting, and patients: We performed a retrospective analysis at Johns Hopkins Transverse Myelitis Center, Baltimore, Maryland, evaluating 25-hydroxyvitamin D levels in 77 patients with monophasic and recurrent inflammatory diseases of the spinal cord.

Main outcome measure: Levels of 25-hydroxyvitamin D.

Results: Vitamin D levels are significantly lower in patients who developed recurrent spinal cord disease, adjusting for season, age, sex, and race.

Conclusions: This study provides a basis for a prospective trial of measuring 25-hydroxyvitamin D levels in these patient populations and assessing the influence of vitamin D supplementation on the frequency of relapses in those with recurrent inflammatory spinal cord disease.

Guess what....... Still waiting for that prospective study 11 years later.

Long COVID and the Systemic Effects of Post-Viral Syndromes Part I: The Central Nervous System

Long COVID: Immune and Systemic Effects of Post-Viral Infection Part II: Ongoing Inflammation and Autoimmunity

Part III: Long COVID and Mitochondrial Dysregulation

Parts 1,2, and 3 all scream, vitamin D deficency!!!

It Doesn't Add Up! Pfizer’s mRNA Injections Dosage is Probabilistic. Conformity with Label Cannot Be Verified.

It Doesn't Add Up! Pfizer’s mRNA Injections Dosage is Probabilistic. Conformity with Label Cannot Be Verified.

Pfizer’s mRNA injections are supplied in multiple dose vials.  There are several versions available today, however the most widely used is the…

www.trialsitenews.com

Pfizer’s mRNA injections are supplied in multiple dose vials. There are several versions available today, however the most widely used is the “purple cap” vial. This version has been supplied from the beginning of the injections roll out globally. Both, the EUA BNT162b2 product and the “fully FDA approved” (but strangely unavailable in the US) version of COMIRNATY come in the purple cap format. The image below shows both products. Did you spot the difference?

If you are wondering whether the vials simply contain different amounts of finished drug product and different quantities of each ingredient to account for the different number of doses, I have the answer – they do not. Indeed, it would be a bad pharmaceutical practice to have identical looking vials containing different dosage of the same product.

Review of Pfizer’s Chemistry Manufacturing and Controls module from EMA materials obtained via a data leak at the end of 2020 revealed the following information about the ingredients, dosage, and the total volume of the finished product in the vials:

Clearly, this means a 0.45 mL of drug product, when diluted with 1.8 mL of saline is supposed to deliver 5 doses of 30 mcg of mRNA each. The same dosage information, was provided in Pfizer’s briefing document for the FDA VRBPAC meeting on December 10, 2020, requesting the initial Emergency Use Authorization.

The label dosage information for Pfizer COMIRNATY currently available on the FDA website. Section 11 lists the ingredients in text form. The quantities per dose listed are the same as were provided in the FDA and EMA documents at the end of 2020. The total supplied volume of product in the vial is also the same – 0.45ml and calls for the same amount of the dilutant to arrive at the individual doses.

"COMIRNATY […] supplied as a frozen suspension in multiple dose vials with purple caps […]; each vial must be diluted with 1.8 mL of sterile 0.9% Sodium Chloride Injection, USP […]. Each 0.3 mL dose of COMIRNATY supplied in multiple dose vials with purple caps […]contains 30 mcg of a nucleoside-modified messenger RNA (mRNA) encoding the viral spike (S) glycoprotein of SARS-CoV-2. Each 0.3 mL dose of the COMIRNATY […] also includes the following ingredients: lipids (43 mg ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 0.05 mg 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide, 0.09 mg 1,2-distearoyl-sn-glycero-3-phosphocholine, and 0.2 mg cholesterol), 0.01 mg potassium chloride, 0.01 mg monobasic potassium phosphate, 0.36 mg sodium chloride, 0.07 mg dibasic sodium phosphate 20 dihydrate, and 6 mg sucrose. The diluent (sterile 0.9% Sodium Chloride Injection, USP) contributes an additional 2.16 mg sodium chloride per dose."

The math clearly doesn’t add up: 225 mcg of the active mRNA substance in a vial equals to 50 mcg in a 5-dose vial and 38 mcg in a 6-dose one.

The explanation of this apparent mystery is that the mRNA injection ingredients are specified by weight while the dose administration is by liquid volume. No direct translation is possible. At the injection administration site, the untrained and unsupervised vaccinators who, no doubt, will be thrown under the proverbial bus first when this scam fully unravels, are involved in the last phase of mRNA product manufacturing – the making of the individual doses, outside of any possibility of quality control by the pharmaceutical company. If you are wondering if this violates the FD&C Act – yes, it does. This is like the illicit drug dealers cutting cocaine by hand in a basement lab, however, much less precise.

The vials, after dilution, contain 7.5 doses by liquid volume, and they always did. Pfizer relabeled vials from 5 to 6 doses without making any changes to the product but rewarding themselves with 20% more revenue while selling the same vials with the same effective number of doses. Genius. The dose therefore is probabilistic. Assuming the ingredients, and especially mRNA distribute absolutely evenly in the vial after someone manually injects saline into it, turns it over 10 times, and then leaves it in the fridge for 6 hours, then each dose may be 30 mcg of mRNA. However, that’s a silly assumption. Of course, they do not. A technician draws a dose, lets the vial sit for 6 hours, draws some more doses, forgets it’s 6 hours, or forgets to put the vial into the fridge, and then decides that they too should make an extra buck by drawing the 7th dose from what is supposed to be only 5 or 6 doses – there are numerous scenarios that can be imagined (and are documented in VAERS database and other sources).

mRNA and LNPs are known to be highly unstable and to degrade rapidly. They also will not distribute evenly in a vial as this is a manually made water-fat mixture with fat tending to float to the top, especially after several hours. The doses are extremely uneven in composition of ingredients, some will contain 50%+ more mRNA and would this introduce 5-6 trillion extra mRNA molecules in the injection which will distribute all over the body in minutes, rapidly make toxic spikes, and may kill a person quickly. Pfizer’s internal pharmacovigilance report obtained by FOIA had thousands of severe adverse events and deaths documented in 2 months after roll-out with median onset below 48 hrs. Some doses will end up containing mostly water. We are all familiar with the fact that lots of people have no adverse events after the injections, while many thousands have died, got severely injured and permanently disabled by these injections. My own educated guess on this topic is that the doses from freshly opened and stirred vials would be the deadliest ones. The doses that were drawn from the vials that set on a shelf for a while, especially if the syringe is taking the liquid from the bottom of the container first will tend to be mostly harmless.

This was never tested by any regulator as no acceptance criteria for vials/doses exist. Batches of the product are released based on self-declared testing of the bulk products by the manufacturer. Nobody can know the composition of the shots as they are administered to people with catastrophic consequences. These products are fraudulent by design and product conformity with its label cannot be verified

Quote from ZenoOfElea

White collar vs blue collar was not specifically mentioned in the paper.

In Germay the term social mortality has been defined. Bankers,dealers, IT professionals,... making tons of money in average live 10 years longer than the blue color workers.

This means: Blue color workers pay into retirement funds and the fig fish eat it.

In Switzerland this trick did not work out as we have only a few blue color folks left, that live far to long. So the fat guys had to change the law and now (since > 15 years) steal every year 2% of the funds money to pay the big fish rents...

Quote from JedRothwell

NEJM:

https://www.nejm.org/doi/full/10.1056/NEJMoa2201662

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19

ABSTRACT

BACKGROUND

Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

METHODS

In this phase 3, double-blind, randomized, placebo-controlled trial, we used a 2-by-3 factorial design to test the effectiveness of three repurposed drugs — metformin, ivermectin, and fluvoxamine — in preventing serious SARS-CoV-2 infection in nonhospitalized adults who had been enrolled within 3 days after a confirmed diagnosis of infection and less than 7 days after the onset of symptoms. The patients were between the ages of 30 and 85 years, and all had either overweight or obesity. The primary composite end point was hypoxemia (≤93% oxygen saturation on home oximetry), emergency department visit, hospitalization, or death. All analyses used controls who had undergone concurrent randomization and were adjusted for SARSCoV-2 vaccination and receipt of other trial medications.

RESULTS

A total of 1431 patients underwent randomization; of these patients, 1323 were included in the primary analysis. The median age of the patients was 46 years; 56% were female (6% of whom were pregnant), and 52% had been vaccinated. The adjusted odds ratio for a primary event was 0.84 (95% confidence interval [CI], 0.66 to 1.09; P=0.19) with metformin, 1.05 (95% CI, 0.76 to 1.45; P=0.78) with ivermectin, and 0.94 (95% CI, 0.66 to 1.36; P=0.75) with fluvoxamine. In prespecified secondary analyses, the adjusted odds ratio for emergency department visit, hospitalization, or death was 0.58 (95% CI, 0.35 to 0.94) with metformin, 1.39 (95% CI, 0.72 to 2.69) with ivermectin, and 1.17 (95% CI, 0.57 to 2.40) with fluvoxamine. The adjusted odds ratio for hospitalization or death was 0.47 (95% CI, 0.20 to 1.11) with metformin, 0.73 (95% CI, 0.19 to 2.77) with ivermectin, and 1.11 (95% CI, 0.33 to 3.76) with fluvoxamine.

CONCLUSIONS

None of the three medications that were evaluated prevented the occurrence of hypoxemia, an emergency department visit, hospitalization, or death associated with Covid-19. (Funded by the Parsemus Foundation and others; COVID-OUT ClinicalTrials .gov number, NCT04510194.)

Did you write that conclusion?

Trial suggests metformin effective at reducing odds of serious outcomes for COVID-19 patients seeking early treatment

Trial suggests metformin effective at reducing odds of serious outcomes for COVID-19 patients seeking early treatment

In work published in the New England Journal of Medicine, researchers—led by the University of Minnesota Medical School and School of Public Health—have found…

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