The Totally Civil Covid Thread.

  • If Pfizer and Moderna can do that from a finished vaccine, I suppose their competitors can too.

    Pfizer had never done vaccine research the same for Biontec. The Pfizer crap can contain up to 30% random RNA so you get a random gene therapy. Pfizer is part of the dark empire that kills people for money. Pfizer indices 5x more often immune suppression than Moderna that at least tried ti emulate a kind of vaccine.

    But only full blown idiots use the spike RNA in a gene therapy.

  • Unravelling the role of the mandatory use of face covering masks for the control of SARS-CoV-2 in schools: a quasi-experimental study nested in a population-based cohort in Catalonia (Spain)

    Unravelling the role of the mandatory use of face covering masks for the control of SARS-CoV-2 in schools: a quasi-experimental study nested in a population-based cohort in Catalonia (Spain)
    Objective To assess the effectiveness of mandatory use of face covering masks (FCMs) in schools during the first term of the 2021–2022 academic year. Design A…
    adc.bmj.com


    Abstract

    Objective To assess the effectiveness of mandatory use of face covering masks (FCMs) in schools during the first term of the 2021–2022 academic year.


    Design A retrospective population-based study.


    Setting Schools in Catalonia (Spain).


    Population 599 314 children aged 3–11 years attending preschool (3–5 years, without FCM mandate) and primary education (6–11 years, with FCM mandate).


    Study period From 13 September to 22 December 2021 (before Omicron variant).


    Interventions A quasi-experimental comparison between children in the last grade of preschool (5 years old), as a control group, and children in year 1 of primary education (6 years old), as an interventional group.


    Main outcome measures Incidence of SARS-CoV-2, secondary attack rates (SARs) and effective reproductive number (R*).


    Results SARS-CoV-2 incidence was significantly lower in preschool than in primary education, and an increasing trend with age was observed. Six-year-old children showed higher incidence than 5 year olds (3.54% vs 3.1%; OR 1.15 (95% CI 1.08 to 1.22)) and slightly lower but not statistically significant SAR (4.36% vs 4.59%; incidence risk ratio 0.96 (95% CI 0.82 to 1.11)) and R* (0.9 vs 0.93; OR 0.96 (95% CI 0.87 to 1.09)). Results remained consistent using a regression discontinuity design and linear regression extrapolation approaches.


    Conclusions We found no significant differences in SARS-CoV-2 transmission due to FCM mandates in Catalonian schools. Instead, age was the most important factor in explaining the transmission risk for children attending school

  • NHS & Ambulance overload is due to the ~30% increase in Cat. 1 heart attacks and strokes --- Vaxx damage

    How do you know this is damage from the vaccine? Is the incidence greater per capita in vaccinated people? I doubt it! Someone would have noticed. Someone other than trialsitenews, I mean.

  • People Are Dying. Don’t Ask. Don’t Tell.

    People Are Dying. Don’t Ask. Don’t Tell.
    Censorship has ruled covid. But emerging data on injury and death may be too big to ignore. This article is part of a publishing collaboration…
    www.trialsitenews.com


    37-year-old mountain biker Rab Wardell died of cardiac arrest days after winning Scotland’s national senior cross-country biking championship. (Instagram)

    After months of skirting YouTube censors, the ax fell on medical educator Dr. John Campbell when he spent fourteen minutes on August 20 parsing figures on two disturbing trends in the United Kingdom. First, UK deaths in 2022 were an alarming 14 percent higher than the prior five years, with 1,480 excess deaths—not attributed to covid-19—in the week ending August 5 alone.


    Second, figures on deaths after covid vaccinations were wildly uninformative. One government document put them as low as 10—“incredulous,” Campbell said—while another official report put them as high as 21,000 when underreporting was considered.


    A careful, evidence-based analyst with 2.4 million subscribers, Campbell wanted to know: “Why is no one talking about this in the UK?”


    YouTube provided an answer: “This video has been removed for violating YouTube’s Community Guidelines.”


    Indeed, but for a small cadre of brave doctors and researchers, few dare discuss the aftermath of covid management in the UK, US, and elsewhere—and chiefly the wisdom of repeated vaccinations. Instead, the questionable “safe and effective” mantra infuses media reports and, remarkably, science publishing that sometimes indicates quite the opposite.


    “We have a million injuries and all these deaths,” Dr. Meryl Nass said in reference to figures from the US vaccine reporting system, “and there’s a combination of hiding information and misinterpreting data in the public domain by the CDC and FDA.”


    Nass, a Maine doctor and anthrax vaccine expert, knows the toll of challenging covid dogma. Her medical license was suspended last January over charges she did not support covid vaccines and used treatments that—while legal and off-label—were “not authorized or approved” for covid-19.


    “I prescribed ivermectin and hydroxychloroquine”—shown in many studies to save lives—“and advised against the vaccine,” she told me. In return, Maine’s medical board ordered a neuropsychological exam—essentially a test, she said, of her mental stability—for disseminating “misinformation regarding the SARS CoV2 pandemic and the official public health response calling for vaccinations.” A hearing will be held in coming months.


    Even as people like Campbell and Nass remain in the crosshairs, prominent experts in the alt-vaccine world have told me recently of a groundswell of movement. This view is not based on a distinct shift in the public perception or fixed official dogma. As a headline in the Wall Street Journal on August 28 stated: Latest Covid Boosters Are Set to Roll Out Before Human Testing Is Completed.


    Still, experts say the evidence of post-covid damage—from a vaccine-centered pandemic response that rejected early treatment—is becoming too big to ignore.


    “The dam wall is cracking,” said Dr. Paul Marik, a critical care expert and chairman of the Front Line Covid Critical Care Alliance. “The data is coming out,” he told me.


    “The excess mortality data, miscarriage data, and dropping birth rates are accumulating from numerous places around the world. All data timed in relation to vaccine rollouts,” agreed FLCCC’s president, Dr. Pierre Kory, when I asked his view on these trends. “It is an unmitigated humanitarian catastrophe that is being systematically censored.”


    Now, as covid recedes, these experts see vaccines as issue number one.


    “No sane person vaccinates the entire country with an experimental vaccine without trials,” Dr. Nass said. “Particularly since the whole country already has some immunity; the virulence is low, and”—the focus of this article—“the evidence supports higher all-cause mortality with an increasing number of vaccine doses.”


    More are dying, still

    As the Omicron chapter closes and covid deaths decline, another ominous trend, many months in the making, is coming into stark relief. People in the prime of life are dying in unexpected numbers.


    The trend was noticed in the third quarter of 2021, as I wrote last January, when the OneAmerica group of insurance companies reported a 40 percent increase in deaths in 18- to 64-year-olds. “Our data,” the company told me then, “shows an increase in death rates in our business across the U.S., which aligns with what we’re seeing in national industry data.” Of 250,000 deaths in that age group, the company statement said, just 20 percent, 50,600, were attributed to covid. The company refused to answer follow-up questions.


    What happened in Germany a month later may explain why.



    The chart above, labeled “Number of vaccinations versus excess mortality,” is from a German study on excess pandemic deaths. It states: “The red line shows the death deficit, respectively the excess deaths, the four dashed lines the number of vaccinations from January 2021 to June 2022.”

    In February 2022, the insurance giant BKK ProVita reported startling findings in a study of 10.9 million client records from the first seven months of 2021. Nearly 217,000 patients had sought medical attention after vaccination against covid, the study found, putting the company’s vaccine-injured figure more than ten times above official estimates and translating into a national rate of 4 to 5 percent of vaccinees.


    Company Director Andreas Schöfbeck wrote in a letter that the data indicated “significant underreporting of suspected side effects following Corona vaccinations” in the government tracking system.


    “We regard this as a significantly alarming signal that must be taken into account in the further use of vaccines,” he wrote.


    Nine days later, Schöfbeck was fired, amid assertions he was seeking attention and showed “embarrassing ignorance or insidious intent to deceive.” This is what happens when 11 million records come up with an answer that defies the vaccine narrative. “Danger to human life cannot be ruled out,” the disgraced official had warned in his missive.


    Some see that danger being realized.


    Dr. Eyal Shahar, a physician and retired public health professor at the University of Arizona, recently analyzed three datasets of United States deaths, including two from the Centers for Disease Control and one from Our World in Data.


    He observed that the share of excess deaths, above what would be considered normal and not accounted for by covid, grew over time, even as the nation’s supposed best method of controlling the pandemic—vaccines—was being rolled out. From April to December 2020, non-covid excess deaths ranged across the datasets from 11 percent to 27 percent of all excess deaths; by June to September 2021, they roughly doubled, to 26 percent to 43 percent, Shahar found. Some 47,000 to 82,000 unexplained, non-covid excess deaths occurred in those four months alone, he estimated.


    Shahar was so disturbed by his findings that he examined death statistics in his home state of Arizona. The trend was the same. Twenty-two percent of excess deaths in the eighteen months through September 2021—more than 5,000 Arizonans—were not from covid, he found. Asked why non-covid excess deaths were soaring, he told me, “I wish I knew.”


    Theories for the increase focus on two complex dynamics:


    Lockdown effects related to untreated disease, economic deprivation, violence, suicide, and overdose.


    The role of covid vaccines.


    While the first dynamic is generally recognized, the second has been minimized and dismissed. It cries out for more honest scientific study. Indicative, perhaps, of a turning tide, a new peer-reviewed study in Vaccine journal analyzed the aftermath of jabs, finding serious and under-studied injuries: “These results raise concerns that mRNA vaccines are associated with more harm than initially estimated at the time of emergency authorization.”


    Lives lost too soon—and in utero

    In perhaps the most exhaustive analysis yet, posted online on August 18, researchers at two German universities found disturbing trends in death data. “Something must have happened in April 2021 that led to a sudden and sustained increase in mortality in the age groups below 80 years,” the study states. “[N]o such effects on mortality had been observed during the COVID-19 pandemic so far.”


    Unlike covid, which disproportionately kills older people, the explosion of non-covid deaths in Germany was across the board—“almost entirely due to an increase in deaths in the age groups between 15 and 79,” the report said. The group with the largest share of unexplained excess deaths, 9.3 percent above expected, was 40- to 49-year-olds; but even 15- to 29-year-olds had 3.5 percent more unexplained deaths.


    When the researchers charted the numbers, they saw eerie parallels, called “covaries,” between four covid inoculation campaigns and tandem surges in deaths. As they put it, “the strong increase in mortality in April 2021 and the further development of the excess deaths covaries [correlates] with the strong increase of the number of vaccinations.” In other words, more shots aligned with more deaths.



    The chart above, labeled “Monthly stillbirths in the years 2020 to 2022 in Germany,” is from a German study on excess pandemic deaths. It states: “The upper panel shows the number of live births per quarter since 2019; the middle panel the number of stillbirths per quarter since 2019; and the lower panel the number of stillbirths per 1000 births per quarter since 2019.”

    If this wasn’t bad enough, the study, performed by an actuary-mathematician and psychologist, picked up a 10.9 percent increase in stillborn babies from 2020 to the second quarter of 2021. The uptick, also “sudden and sustained,” the study said, continued through the first quarter of 2022, when 9.9 percent more stillbirths were recorded as a share of births. “In the year 2021, starting in April, a striking excess [stillbirth] mortality is observed,” they wrote.


    Study author Matthias Reitzner, a widely published mathematician based at University of Osnabrück, told me he was surprised by the dearth of research on excess deaths using standard actuarial models long employed by insurance companies and pension funds.


    “Maybe the outcome of the computations does not fit into the official COVID19-narrative,” he wrote in an email. “In all major German media this issue is totally ignored as it does not fit into the storytelling-line the government wants to be published.”


    Uncounted, underreported

    Although the problem is not acknowledged, many analysts, physicians and scientists are expressing growing alarm over the effects of covid vaccines on pregnancy.


    Pfizer documents released under a judge’s order showed an astronomical 87.5 percent fetal and neonate death rate after maternal vaccination: In 32 pregnancies, there were 25 miscarriages and three neonatal deaths. The documents were inscrutable, perhaps intentionally so, stating that “no outcome was provided” for another 238 pregnancies, according to an article by FLCCC’s Dr. Kory.


    It’s tempting to dismiss such figures, as an AP “fact-check” did, as lacking context. Based on its own study, the CDC calls vaccination in pregnancy “safe and effective.” But that “preliminary” study used data tracked through online surveillance systems in selective ways, researchers found.


    Among 827 women vaccinated during pregnancy, rates of miscarriage were comparable to pre-pandemic levels, the CDC study said. But among 127 women vaccinated before 20 weeks gestation, 104 pregnancies—82 percent—ended in spontaneous abortion, according to a critique in Science, Public Policy and the Law.


    “Our re-analysis indicates a cumulative incidence of spontaneous abortion 7 to 8 times higher than the original authors’ results,” the November 2021 study concluded.


    As of August 19, 2022, Vaccines Adverse Events Reporting System listed 1,769 miscarriages in the United States and its territories, among a total of 4,963 including foreign reports.


    Government and media routinely dismiss these figures as anecdotal and lacking foundation.


    In reality, public reporting systems were widely acknowledged before covid to suffer from vast undercounting of harm. A 2009 US study estimated that just 1 percent of vaccine injuries were reported, while in the UK “only 10% of serious reactions, and between 2 and 4% of non-serious reactions are reported,” a 2018 government report found.


    This suggests that those 1,769 doomed pregnancies reported in the US are but the tip of the iceberg.



    “The reasons behind these horrific numbers [of overall excess deaths] are complicated and none of us fully understand them,” London GP Charles Levinson said in a rare UK media report. “That is exactly why there should be an urgent and comprehensive government inquiry.” Instead, he saw “total silence” on the issue.


    The German scientists, similarly, called for “a reassessment of the mortality burden brought about by the COVID-19 pandemic.”


    That, of course, is the point. Find out what is going on. Instead, Dr. Campbell asked the question on YouTube and was censored. As a journalist, I espoused early covid treatment and was suspended for life from Twitter—for tweeting on Nobel Prize-winning ivermectin, which could have saved hundreds of thousands from covid death.


    One singular study

    Leave it to researchers in Thailand to do what the United States and others countries have not: Follow a group of healthy adolescents double-vaccinated for Covid-19 and see how they fared. Dr. Marik said their effort is the first prospective study since the vaccine rollout on anyone, let alone youngsters. “It’s really important,” he said.


    The Thai study, of 301 adolescents from 13 to 18 years old, found significant cardiac and other anomalies after getting the Pfizer vaccine. Nearly 18 percent had abnormal electrocardiograms; 7.6 percent suffered tachycardia; 4 percent had high blood pressure, and 4.3 percent each had palpitations and chest pain. Moreover, chemical markers of heart inflammation were found in 2.3 percent, among them one teenager who suffered myocarditis; two with suspected pericarditis, and four with likely “subclinical myocarditis.”


    In a comment posted on the study’s preprint, Dr. Rosamund Jones, a British pediatrician and critic of covid vaccines for children, called the findings “hugely concerning” and challenged the weak conclusion, as did others, that teens be monitored after covid vaccination. That’s typical of the concessions such studies make to get published.


    “In normal times, the conclusion would have been to withdraw this drug urgently,” Dr. Jones wrote.


    Another physician, Dr. Paul Spradbery said the study’s characterization of myopericarditis cases as “usually mild,” was “dangerous.” The condition “leads to cardiac tissue scarring and hence impaired ability to pump blood,” he wrote.


    While other studies have found post-vaccination heart injury in adolescents—one reported a 133-fold higher rate of myocarditis in vaccinated teenage boys—the Thai research suggests the damage may be far more common than retrospective studies found.


    One among many

    On August 22, a 37-year-old Scottish mountain biker, Rab Wardell, went into cardiac arrest while lying in bed with his partner, Olympic cyclist Katie Archibald. She tried desperately to revive him. The athlete’s death came two days after Wardell won Scotland’s national senior cross-country biking championship, having won the junior title two decades earlier. “Stoked to be able to take the win,” he wrote on Instagram, where, just hours before his death, he posted a photograph of his appearance on The Nine, a Scottish BBC sports program.


    Statistically, Wardell most certainly fits into the category of the moment: unexplained, early, non-covid death.


    Of note, the Scottish Parliament launched an inquiry last January into a growing trend of above-average deaths that emerged in mid-2021. Last May, the nation’s health secretary issued a response to the concerns of the COVID-19 Recovery Committee of The Scottish Parliament that revealed little about why Scots were dying.


    “We have recently reviewed the content and frequency of all COVID-19 data reporting, working in partnership with Public Health Scotland and National Records of Scotland,” Humza Yousef wrote, “and will continue to closely monitor excess deaths.”


    The word vaccine was not mentioned.

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  • Unexplained excess deaths in UK still at 1500/week :: https://www.ons.gov.uk/peoplep…al/weekending26august2022


    So in Europe we have about 15% excess deaths among people of age > 64 ! The only thing all have in common is the exceptional joy after a dead promotion RNA gene therapy...

    In UK many of the excess deaths are in <65 as in 2020/21 most dry tinder removed and many old deaths brought forward


    NHS & Ambulance overload is due to the ~30% increase in Cat. 1 heart attacks and strokes --- Vaxx damage

    How do you know this is damage from the vaccine? Is the incidence greater per capita in vaccinated people? I doubt it! Someone would have noticed. Someone other than trialsitenews, I mean.

    Yes, world wide and Gov't data not trialsite

  • A sad day - An obviously really concerned Dr. Cambell analysis excess deaths in UK...


    I guess he has an opinion, but he can't express it due to YouTube rules.


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  • US study shows that vaccination gives no advantage against severe disease !!!! https://jamanetwork.com/journa…ntent=olf&utm_term=090822



    The proportion of vaccinated persons admitted to the ICU was similar to that among unvaccinated persons (505 [19.5%] vs 1961 [21.7%], respectively; P = .13), as were proportions for in-hospital death (216 [10.1%] vs 802 [9.9%], respectively; P = .89). Median length of stay in vaccinated persons was shorter (median, 4.3 days [IQR, 1.9-8.9] vs 4.6 days [IQR 2.3-9.3], respectively) (Table 1). On multivariable analysis, vaccination was not significantly associated with a reduced risk of severe disease (ie, ICU admission or death) (aRR, 0.83; 95% CI, 0.65-1.07; P = .16) (eTable 5 in the Supplement). The sensitivity analysis using the propensity score–matched cohort included 2000 vaccinated and 2000 unvaccinated patients (eTable 6 in the Supplement). Results from the analysis of this cohort were similar to the primary model; vaccination was not significantly associated with reduced risk of severe disease (aRR, 0.80; 95% CI, 0.59-1.10; P = .16; full model not shown).



    But claims less hospitalization...So fact is: Vaccine have no positive value for your final health.

  • doubt it. Please cite a public health agency document that says there is an increase and it is caused by the vaccine, not the disease or some other cause.

    No public health agency I'm aware of will admit there is an increase and it is caused by the vaccine. However, the data is clear and Gov'ts rowing back on jabs, first in young, pregnant shows they know. See UK Green Book

  • A sad day - An obviously really concerned Dr. Cambell analysis excess deaths in UK...


    I guess he has an opinion, but he can't express it due to YouTube rules.


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    Yes, in Dr. John Campbell - The eight sick mice jabs he says

    "I have to be very careful what I say or I will be censored"

    In an earlier one, after censored the V word now never mentioned - excess a mystery, nobody knows and closing with "That's all I'm Allowed To Say"

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    Why?


    UK vaccination, adverse reactions

    Excess deaths remain high - Dr. John Campbell, Published on Aug 20, 2022

    Note: Until about three months ago Dr. John Campbell was hugely pro-jab. Unlike many Docs, he looks at emerging data


    Watch Censored Video:

    UK vaccination, adverse reactions
    Excess deaths remain high…
    altcensored.com


    And


    John Campbell Shares Some Truth, YouTube Deletes His Video
    Dr. John Campbell is a retired English nurse trainer and accident and emergency nurse with a doctorate in philosophy.  He started uploading videos 15 years ago…
    expose-news.com

  • Assessment of Kidney Involvement in COVID-19 Patient

    Assessment of Kidney Involvement in COVID-19 Patient
    Background and aim: Physicians need to be aware of the difficulties that SARS-CoV-2 infection brings to other regions of the body, such as the kidneys, even…
    www.cureus.com


    Abstract

    Background and aim: Physicians need to be aware of the difficulties that SARS-CoV-2 infection brings to other regions of the body, such as the kidneys, even though the key emphasis is on pulmonary characteristics. The most frequent kidney complication among COVID-19 hospitalized patients is considered acute kidney injury (AKI). This study aimed to describe overall different aspects of acute kidney injury (AKI) in COVID-19 patients admitted to JLNMCH during the COVID-19 pandemic and to determine the prevalence of AKI among COVID-19 hospitalized patients.


    Methods and materials: All adult patients (over the age of 18 years) who screened positive for COVID-19 in a swab specimen from areas of nasopharyngeal by reverse transcriptase polymerase chain reaction and then hospitalized were included in the study. Information was gathered on the patient's demographics, general medical history, and drugs prescribed. From past medical information, associated comorbidities and home pharmaceuticals were identified. We gathered hospitalization information, such as duration of stay in ICU, details about the application of mechanical ventilation, information regarding extracorporeal membrane aeration, details of the use of vasopressor administration, and baseline results of laboratory test along with baseline clinical information during 48 hours of hospitalization.


    Results: The percentage of patients with no history of AKI requiring traumatic mechanical ventilation was 79.4%, while the percentage of patients with no history of AKI not requiring traumatic mechanical ventilation was 11.5%. The difference was relevant statistically (p<0.001). The percentage of patients with AKI of any stage requiring traumatic mechanical ventilation was 22.8%, while the percentage of patients with no history of AKI not requiring traumatic mechanical ventilation was 76.8%. The difference was relevant statistically (p<0.022).


    Conclusion: We discovered that AKI was a rather typical finding among hospitalized COVID-19 patients. Patients hospitalized for COVID-19 had a poor prognosis if they developed AKI



    Vitamin D and Acute Kidney Injury: A Two-Way Causality Relation and a Predictive, Prognostic, and Therapeutic Role of Vitamin D

    https://www.ncbi.nlm.nih.gov/p…%20hydroxylation%20occurs.


    Abstract

    Background: Acute kidney injury (AKI) constitutes a multi-factorially caused condition, which significantly affects kidney function and can lead to elevated risk of morbidity and mortality. Given the rising scientific evidence regarding vitamin D's (VitD's) multisystemic role, the connection between AKI and VitD is currently being studied, and the complex relation between them has started to be unraveled.


    Methods: A systematic review had been conducted to identify the pathogenetic relation of VitD and AKI and the potential role of VitD as a biomarker and therapeutic–renoprotective factor.


    Results: From 792 articles, 74 articles were identified that fulfilled the inclusion criteria. Based on these articles, it has been found that not only can VitD disorders (VitD deficiency or toxicity) cause AKI but Frontiers in Nutrition

    Frontiers Media SA

    Vitamin D and Acute Kidney Injury: A Two-Way Causality Relation and a Predictive, Prognostic, and Therapeutic Role of Vitamin D

    Spyridon Graidis, Theodosios S. Papavramidis, and Maria Papaioannou


    Additional article information


    Associated Data

    Supplementary Materials

    Data Availability Statement

    Abstract

    Background: Acute kidney injury (AKI) constitutes a multi-factorially caused condition, which significantly affects kidney function and can lead to elevated risk of morbidity and mortality. Given the rising scientific evidence regarding vitamin D's (VitD's) multisystemic role, the connection between AKI and VitD is currently being studied, and the complex relation between them has started to be unraveled.


    Methods: A systematic review had been conducted to identify the pathogenetic relation of VitD and AKI and the potential role of VitD as a biomarker and therapeutic–renoprotective factor.


    Results: From 792 articles, 74 articles were identified that fulfilled the inclusion criteria. Based on these articles, it has been found that not only can VitD disorders (VitD deficiency or toxicity) cause AKI but, also, AKI can lead to great disruption in the metabolism of VitD. Moreover, it has been found that VitD serves as a novel biomarker for prediction of the risk of developing AKI and for the prognosis of AKI's severity. Finally, animal models showed that VitD can both ameliorate AKI and prevent its onset, suggesting its renoprotective effect.


    Conclusion: There is a complex two-way pathogenetic relation between VitD disorders and AKI, while, concomitantly, VitD serves as a potential novel predictive–prognostic biomarker and a treatment agent in AKI therapy

  • SARS-CoV-2 requires acidic pH to infect cells

    https://www.pnas.org/doi/10.1073/pnas.2209514119


    Significance

    Infection by SARS-CoV-2 depends upon the large spike (S) protein decorating the virions and is responsible for receptor engagement and subsequent fusion of viral and cellular membranes allowing release of virion contents into the cell. Using new single-particle imaging tools to visualize and track the successive steps from virion attachment to fusion, combined with chemical and genetic perturbations of the cells, we provide direct evidence for the cellular uptake routes of productive infection in multiple cell types and their dependence on proteolysis of S by cell surface or endosomal proteases. We show that fusion and content release always require the acidic environment from endosomes, preceded by liberation of the S1 fragment which depends on angiotensin converting enzyme receptor engagement.

    Abstract

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with membrane attachment and ends with spike (S) protein–catalyzed membrane fusion depending on two cleavage steps, namely, one usually by furin in producing cells and the second by TMPRSS2 on target cells. Endosomal cathepsins can carry out both. Using real-time three-dimensional single-virion tracking, we show that fusion and genome penetration require virion exposure to an acidic milieu of pH 6.2 to 6.8, even when furin and TMPRSS2 cleavages have occurred. We detect the sequential steps of S1-fragment dissociation, fusion, and content release from the cell surface in TMPRRS2-overexpressing cells only when exposed to acidic pH. We define a key role of an acidic environment for successful infection, found in endosomal compartments and at the surface of TMPRSS2-expressing cells in the acidic milieu of the nasal cavity.


    The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?

    https://www.hindawi.com/journals/jeph/2012/727630/

  • Powerful new antibody neutralizes all known SARS-CoV-2 variants

    Powerful new antibody neutralizes all known SARS-CoV-2 variants
    As SARS-CoV-2 has evolved and mutated, therapeutic antibodies that worked early in the pandemic have become less effective, and newer variants, especially…
    medicalxpress.com



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  • Sustained, as-yet unheard of excess mortality trend strikes Switzerland


    Neither heat waves nor Corona mortality are sufficient to explain the excess deaths, which are concentrated in the 65+ age bracket. Maybe it's wasp stings!

    Sustained, as-yet unheard of excess mortality trend strikes Switzerland
    Neither heat waves nor Corona mortality are sufficient to explain the excess deaths, which are concentrated in the 65+ age bracket.
    www.eugyppius.com



    Australian Excess Deaths


    Carl Heneghan and Tom Jefferson note that Australia is seeing significant excess mortality, and it´s not all down to Covid.

    Australian Excess Deaths
    Australia is seeimg significant excess mortality, and it's not all down to COVID.
    trusttheevidence.substack.com

  • Covid-19 vaccine boosters for young adults: A risk-benefit assessment and five ethical arguments against mandates at universities

    Covid-19 vaccine boosters for young adults: A risk-benefit assessment and five ethical arguments against mandates at universities


    Abstract

    Students at North American universities risk disenrollment due to third dose Covid-19 vaccine mandates. We present a risk-benefit assessment of boosters in this age group and provide five ethical arguments against mandates. We estimate that 22,000 - 30,000 previously uninfected adults aged 18-29 must be boosted with an mRNA vaccine to prevent one Covid-19 hospitalisation. Using CDC and sponsor-reported adverse event data, we find that booster mandates may cause a net expected harm: per Covid-19 hospitalisation prevented in previously uninfected young adults, we anticipate 18 to 98 serious adverse events, including 1.7 to 3.0 booster-associated myocarditis cases in males, and 1,373 to 3,234 cases of grade ≥3 reactogenicity which interferes with daily activities. Given the high prevalence of post-infection immunity, this risk-benefit profile is even less favourable. University booster mandates are unethical because: 1) no formal risk-benefit assessment exists for this age group; 2) vaccine mandates may result in a net expected harm to individual young people; 3) mandates are not proportionate: expected harms are not outweighed by public health benefits given the modest and transient effectiveness of vaccines against transmission; 4) US mandates violate the reciprocity principle because rare serious vaccine-related harms will not be reliably compensated due to gaps in current vaccine injury schemes; and 5) mandates create wider social harms. We consider counter-arguments such as a desire for socialisation and safety and show that such arguments lack scientific and/or ethical support. Finally, we discuss the relevance of our analysis for current 2-dose Covid-19 vaccine mandates in North America.

  • Students at North American universities risk disenrollment due to third dose Covid-19 vaccine mandates.

    How could USA grow to a Dr. Mengele concentration camp based on capitalist forces? The RNA therapy is one of the most deadly illness we know today. Currently 1500 people/week die of it in UK. So in all vaxx countries this makes 60'000/week or 3 million a year.


    The prove is 100% clear as the excess mortality in all places started short after the completion of the first vaxxx round. It got higher after the booster round. Australia is the perfect control group as there the effect can be seen with no CoV-19 interplay at work.


    The press world wide has now noted it and tries to invent explanations based non counted COV-19 deaths and neglected cancers what is a big fake of course.


    Booster = death sentence ore suicide as the US liven insurance industry warns you.