The Totally Civil Covid Thread. (Closing 31/05)

Are Serum 25-Hydroxyvitamin D Deficiency and Insufficiency Risk Factors for the Incidence of Dynapenia

Are Serum 25-Hydroxyvitamin D Deficiency and Insufficiency Risk Factors for the Incidence of Dynapenia? - Calcified Tissue International

Epidemiological evidence showing the association between low 25(OH)D and age-related reduction in neuromuscular strength (dynapenia) is a paucity and…

link.springer.com

Abstract

Epidemiological evidence showing the association between low 25(OH)D and age-related reduction in neuromuscular strength (dynapenia) is a paucity and controversial and, to date, the effect of osteoporosis and vitamin D supplementation on these associations has not been measured. Thus, we analyze whether serum 25(OH)D deficiency and insufficiency are risk factors for the incidence of dynapenia in individuals aged 50 or older and whether osteoporosis or vitamin D supplementation modify these associations. For that, 3205 participants of the ELSA study who were non-dynapenic at baseline were followed for 4 years. Vitamin D was measured at baseline by the serum concentration of 25(OH)D and classified as sufficient (> 50 nmol/L), insufficient (≥ 30 and ≤ 50 nmol/L) or deficient (< 30 nmol/L). The incidence of dynapenia was determined by a grip strength < 26 kg for men and < 16 kg for women at the end of the 4-year follow-up. Poisson regression models were adjusted by sociodemographic, behavioral, clinical and biochemical characteristics. Serum 25(OH)D deficient was a risk factor for the incidence of dynapenia (IRR = 1.70; 95% CI 1.04–2.79). When only individuals without osteoporosis and those who did not use vitamin D supplementation were analyzed, both serum 25(OH)D deficiency (IRR = 1.78; 95% CI 1.01–3.13) and insufficiency (IRR = 1.77; 95% CI 1.06–2.94) were risk factors for the incidence of dynapenia. In conclusion, a serum level of 25(OH)D < 30 nmol/L is a risk factor for the incidence of dynapenia. Among individuals without osteoporosis and those who do not take vitamin D supplementation, the threshold of risk is higher (≤ 50 nmol/L

vitamin D could have saved 116,000 or more American lives

New research finds that 116,000 American deaths and 4 million COVID-19 cases could have been avoided with low-cost low-risk multiple-benefit vitamin D supplementation, especially at 50,000 units daily

Trump, Biden, Fauci, the entire CDC, NIH, AMA and AAFP failed to take action on data that was available, published, verified, confirmed, and known to the entire world

New research finds that 116,000 American deaths and 4 million COVID-19 cases could have been avoided with low-cost low-risk multiple-benefit vitamin D supplementation, especially at 50,000 units daily

Trump, Biden, Fauci, the entire CDC, NIH, AMA and AAFP failed to take action on data that was available, published, verified, confirmed, and known to the…

healthythinking.substack.com

Dr Alex Kennerly Vasquez

Nov 18

A new study published in the open-access peer-reviewed journal Scientific Reports (2022 November*) shows us anew what we have already known:

1. WE COULD HAVE AVOIDED MILLIONS OF COVID INFECTIONS: Vitamin D supplementation provides protection against Covid infections; we could have avoided 4 million American COVID-19 cases if American politicians and medical organizations had implemented vitamin D supplementation; obviously more worldwide cases would have been prevented if this vitamin D supplementation had been implemented globally

2. Vitamin D supplementation provides protection against Covid deaths; 116,000 American deaths could have been avoided with low-cost low-risk multiple-benefit vitamin D supplementation, especially at 50,000 IU per day

3. Vitamin D supplementation is safe, easy, inexpensive, and essentially without risks and drug interactions

Hilarious

it's all about vitamin D

The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein

The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein - Nature Communications

www.nature.com

The current Coronavirus global pandemic necessitates the search for novel targets and therapeutic avenues. Shaban et al.1 reported the use of an endoplasmic reticulum (ER) stress inducer thapsigargin (Tg) to block replication of Coronaviruses (CoVs), and that a key mechanism for the anti-viral activities of Tg is to counteract virus-mediated GRP78/BiP downregulation. This conclusion contradicts the widely observed upregulation of GRP78 by virus infection and the reported pro-viral roles of GRP782,3. In contrast to their findings which were based primarily on short term culture of infected cells, here we have documented the temporal increase of both GRP78 mRNA and protein levels as SARS-CoV-2 infection intensifies, and that GRP78 knockdown or inhibition of its activity suppresses SARS-CoV-2 replication and infectivity in vitro and in vivo, implying that GRP78 could be a valuable stable host target to combat COVID-19.

The molecular chaperone GRP78/BiP or HSPA5 that in humans is encoded by the HSPA5 gene, and has recently been identified as a host auxiliary factor for SARS-CoV-2 entry4. For simplicity, this protein is referred to as GRP78 thereafter. Importantly, computer modeling including structural dynamics and binding analysis reveals that host-cell recognition through GRP78 is enhanced in the new variants of SARS-CoV-2 associated with increased transmissibility5,6. The study by Shaban et al.1 that was published in Nature Communications explored the use of the ER stress inducer Tg, a well-established inducer of GRP78, to block replication of CoVs by counteracting CoV-mediated suppression of IRE1α and GRP78. The authors concluded that Tg induced an anti-viral state by blocking the CoV-induced autophagic flux and reactivating the ER quality control (ERQC) or ER-associated degradation (ERAD) network of proteins that were suppressed by infection of CoVs. Furthermore, the authors stated that CoVs suppressed GRP78 expression in infected cells and Tg-induced GRP78 re-expression is a major mechanism for the anti-viral activities of Tg. While the anti-viral effects of Tg on multiple different CoVs in different cell types are clearly demonstrated by Shaban et al.1, in view of the emerging implications of GRP78 in enhancing SARS-CoV-2 and its variants for entry and subsequent function in viral protein production and infectivity2,3,4, some mechanistic explanations offered for the Tg effects based on the short-term culture of infected cells may need further consideration

Effects of exogenous vitamin D on endoplasmic reticulum stress-related factors in the vitamin D deficiency rats with cerebral ischemia

Effects of exogenous vitamin D on endoplasmic reticulum stress-related factors in the vitamin D deficiency rats with cerebral ischemia

We observed the potential neuroprotective effect of exogenous vitamin D on cerebral ischemia in vitamin D deficiency rats and explored its mechanism. …

www.sciencedirect.com

Abstract

We observed the potential neuroprotective effect of exogenous vitamin D on cerebral ischemia in vitamin D deficiency rats and explored its mechanism. Sixty Sprague Dawley rats were randomly divided into three groups including control (CON) group, vitamin D deficiency (VDD) group and vitamin D deficiency combined with exogenous vitamin D (VDD + VD) group, with 20 rats in each group. The rats in the CON group were fed with normal diet, while the rats in the VDD and VDD + VD groups with vitamin D-deficient diet for 8 weeks, and then underwent middle cerebral artery occlusion (MCAO). Six hours later, exogenous 25-hydroxyvitamin D (25-VD3) was intravenously injected into the rats of the VDD + VD group every 24 h for 4 times. Motor behaviors were significantly better and 25-VD3 level in the left brain tissue was significantly higher in the CON group than in the VDD and VDD + VD groups 102 h after MCAO (all P < 0.05). Although the motor behaviors, infarct volume and 25-VD3 level in brain tissue showed a good tendency in the VDD + VD group as compared with VDD group, the two groups were not significantly different (all P > 0.05). GPR78 was significantly higher, but apoptosis and CHOP significantly lower in the VDD + VD group than in the VDD group (all P < 0.05). The aggravation of cerebral ischemia caused by vitamin D deficiency is possibly due to up-regulating GRP78 and down-regulating CHOP in brain tissue.

another study indicating vitamin D deficency. Vitamin D is the key! When will health officials finally connect the dots????????

Experiments Show Infection of Visceral Fat Cells May Contribute to Severe COVID-19

Experiments Show Infection of Visceral Fat Cells May Contribute to Severe COVID-19

Two types of adipocytes (fat cells) were infected in the laboratory: one obtained from human stem cells isolated from subcutaneous tissue and the other differentiated from stem cells taken from visceral fatty tissue.

Experiments show that visceral fat – fat around the liver, intestines, and other organs, considered a risk factor for cardiovascular disease, diabetes, and high blood pressure – contributes more to severe COVID-19 than subcutaneous fat (under the skin, as in “love handles”). The experiments were conducted in Brazil by researchers at the State University of Campinas (UNICAMP) and the University of São Paulo (USP).

Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults

Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults

Visceral fat area (VFA), a novel sex-specific index for visceral fat obesity (VFO) might play a major role in the development of vitamin D deficiency. However,…

www.ncbi.nlm.nih.gov

Vitamin D deficiency is a surrogate marker for visceral fat content, metabolic syndrome, type 2 diabetes, and future metabolic complications

https://medcraveonline.com/JDM…s%20have,25(OH)D%20levels.

another study on raising vitamin D levels. Time for the NIH to take their heads out of its ass!!!

Overcoming Infections Including COVID-19, by Maintaining Circulating 25(OH)D Concentrations Above 50 ng/mL

Vitamin D and COVID-19 | PLMI

Described herein are cost-effective strategies using vitamin D to achieve D3 and 25(OH)D concentrations crucial for maintaining a robust immune system.

www.dovepress.com

Abstract: The elderly and those with underlying chronic diseases (i.e., comorbidities) such as pulmonary, cardiovascular, metabolic, and renal diseases, increase their susceptibility to sepsis, including COVID-19. The SARS-CoV-2 virus damages pulmonary cells, causing acute respiratory distress syndrome (ARDS) and hypoxia. It further damages endothelial cells, altering clotting mechanisums causing intravascular hemolysis, microvascular thrombosis, and micro-embolization, contributing to the risk of death. Approximately 75% of the immune system functions of humans depend on vitamin D and the availability of sufficient amounts of vitamin D metabolites [vitamin D and 25(OH)D] concentrations to enter immune cells from the bloodstream. Such concentrations are achievable through sun exposure, targeted food fortification programs, and adequate daily or weekly vitamin D supplements. That would allow for generating 1,25(OH)2D (non-hormonal form of calcitriol) intracellularly in peripheral target cells like immune cells. This enables immune cells’ physiological functions, including intracrine/autocrine and paracrine signaling processes. This initiates and maintains robust immune functions, such as forming antibodies and antimicrobial peptides, suppressing inflammation, and increasing the expression of anti-inflammatory and antioxidant genes, thus, strengthening immune functions. The opposite occurs in hypovitaminosis D, increasing vulnerability to infections and dying from it. Therefore, governments should make the population sufficient with immunoceuticals—micronutrients, especially vitamin D, and other micronutrients: the most cost-effective intervention to keep the population healthy. The cost of such interventions are minuscule compared to the expenses related to increased hospitalizations and premature deaths. Supposed such a program was implemented in mid-2020 as the author proposed, we estimated that 50% of hospitalizations (and the associated healthcare costs) and a third of deaths from COVID could have been prevented. Described herein are cost-effective strategies using vitamin D to achieve and sustain serum D3 and 25(OH)D concentrations crucial for maintaining a robust immune system, improving general health, minimizing disease severities and deaths, and reducing healthcare costs.

Quote from Fm1

When will health officials finally connect the dots?

You again and again ask the wrong question.

Health officials (FM/R/F/B-mafia) since >10 years try to block people from taking adequate quantities of V-D. So when will people sue these Dr. Mengeles.

The free mason run Swiss TV did run a health session > 1 hour where a JF-mafia (Dr. UNI Zürich) supporter explained why people should not take more V-D....

Switzerland :: Omicron on decline :: https://www.covid19.admin.ch/de/overview

Still 8:1 vaxx:unvaxx in hospital. :: https://www.covid19.admin.ch/d…accineBreakthroughRel=abs

There are more unvaxx in hospital because all the RSV kids that fill the clinic are mostly unvaxx....

Myocarditis NHS advice....

carte blanche to vaccinate everyone over five,,

despite documented myocarditis risk for young men..

"some might think this appalling"

John Campbell 2.69 million subscribers,,

Here a link to the European momo (realtime mortality monitoring) page : https://www.euromomo.eu/

It is obvious that the large excess mortality started in September 2021 but the CoV-19 wave started much later in December...Also the peak of the Cov-19 wave was in March and then still ongoing e.g. in Germany.

So its clear that only the first wave (first half 2020) of deaths is 100% correlated with CoV-19. The other waves are way more vaxx excess deaths driven.

Same story in winter 20/21. France reports high numbers of CoV.19 death but no excess mortality.

Conclusion: As we know form US data. CoV-19 deaths did not change the mortality. I think main death reason in USA was care to death and neglecting patients then the biggest cause : vaxx excess mortality as proven by Australia data.

Swiss momo page : https://www.experimental.bfs.a…n/home/projects/momo.html

Age > 64 are dying in large quantities = out of band. There is also more flu, RSV, rhinovirus and the vaxx = immune suppressed really suffer.

So still no relaxing time for the vaxx folks.

The other reason for US excess deaths (From https://www.srf.ch/news/intern…-millionen-dosen-fentanyl)

Fentanyl has been first -under cover - sythesized at ETH Zürich around my chemistry time (1980). The first victim was a Caribinieri who finger tested/tasted it. The test package has been sent to the Italian mafia...

I think it was a secrete for about 30 years and then somebody could no longer resist the money.

Quote from Wyttenbach

I think it was a secrete for about 30 years and then somebody could no longer resist the mone

Not hard to get. I had an email from a Chinese Pharma company awhile back offering to sell me Fentanyl by the kilo.

Quote from Alan Smith

I had an email from a Chinese Pharma company awhile back offering to sell me Fentanyl by the kilo.

The synthesis is damn simple as heroin is in the textbooks. Just exchange one attachment...Has been done by a third year student that obviously never finished his studies in jail. But he certainly works (worked..) for some criminals since a long time if he survived...

Mission Impossible: Unvaccinated Blood Banking

Unrealistic, Unfeasible, Impractical

Mission Impossible: Unvaccinated Blood Banking

Unrealistic, Unfeasible, Impractical

petermcculloughmd.substack.com

By Peter A. McCullough, MD, MPH

On virtually every interview I am asked about the market demand for unvaccinated blood transfusion. Early in 2021, myself and two prominent pathologists wrote to the American Association of Blood Banks, American Red Cross, and other blood banking authorities about the possibility of COVID-19 vaccinated persons donating blood contaminated with mRNA and Spike protein. Our letter was answered months later with acknowledgement of the potential problem but with no action taken. Now nearly two years later, the seroprevalence for sensitive antibodies against the Spike protein (whether by natural infection, vaccination, or both) is nearly universal in American populations. This means Spike protein could be within a small number CD16 monocytes in virtually every blood donation. This leaves the remaining issue of of circulating lipid nanoparticles containing mRNA which are circulatory after vaccination for 15 days and probably longer.

Quote from Fm1

Mission Impossible: Unvaccinated Blood Banking

Unrealistic, Unfeasible, Impractical

https://petermcculloughmd.subs…substack&utm_medium=email

By Peter A. McCullough, MD, MPH

On virtually every interview I am asked about the market demand for unvaccinated blood transfusion. Early in 2021, myself and two prominent pathologists wrote to the American Association of Blood Banks, American Red Cross, and other blood banking authorities about the possibility of COVID-19 vaccinated persons donating blood contaminated with mRNA and Spike protein. Our letter was answered months later with acknowledgement of the potential problem but with no action taken. Now nearly two years later, the seroprevalence for sensitive antibodies against the Spike protein (whether by natural infection, vaccination, or both) is nearly universal in American populations. This means Spike protein could be within a small number CD16 monocytes in virtually every blood donation. This leaves the remaining issue of of circulating lipid nanoparticles containing mRNA which are circulatory after vaccination for 15 days and probably longer.

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Never got the jab but got "covid". So I do have the antibodies for the spiky thingy (at least in theory).

A ‘Cover-Up of Evidence of Mass Murder’: The CDC Appears to Be Removing VAERS Records

A ‘Cover-Up of Evidence of Mass Murder’: The CDC Appears to Be Removing VAERS Records - DailyClout

Something strange is going on with the VAERS system. Reports that were present three months ago are now inexplicably missing.

dailyclout.io

Something strange is going on with the VAERS system. Reports that were present three months ago are now inexplicably missing. And fewer than 4% of adverse events recorded in V-Safe have made their way to VAERS. This is the CDC’s database; Dr. Rochelle Walensky is in charge of it. And the agency’s failure to properly manage VAERS is suppressing the already-alarming safety signal of the Covid-19 shots.

US live expectancy down by 2.4 years since 2019.... https://www.bbc.com/news/world-us-canada-64067436

Officials claim 75% is from CoV-19. But bitter reality at least 50% is from vaxx damage /cure to death. 25% from drug abuse.

Here I still get many messages of sudden deaths (= turbo cancer/organ failure) of 2-3x vaxx folks at age around 65...

Quote from Wyttenbach

US live expectancy down by 2.4 years since 2019.... https://www.bbc.com/news/world-us-canada-64067436

Officials claim 75% is from CoV-19. But bitter reality at least 50% is from vaxx damage /cure to death. 25% from drug abuse.

Here I still get many messages of sudden deaths (= turbo cancer/organ failure) of 2-3x vaxx folks at age around 65...

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75% of excess deaths is from a shitty piss poor healthcare system drawn up by an incompetent NIH and supported by big pharma. I'm sure the secret motto is " let's keep em on the edge of healthy" ! Corrupt from top to bottom!

Moderna plus the UK

a match made in heaven.

Roll up your sleeves... Brits

Company to establish a global clinical trials base, endorsing UK as a science superpower

"The company has now committed to invest substantial funding in UK-based research and development (R&D) activities over a 10-year period. This will include running a significant number of clinical trials in the UK and it has also pledged to fund grants for UK universities, including PhD places and research programmes".