we would hear similar stories played out all over the world,
Currently there is a drama btw the NSW government, health department and Carnival cruises
about " a ship of shame"
Ruby Princess
which the media are making a meal of
..
Posts by RobertBryant
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India, Pakistan, Bangladesh, Africa, Malaya, Phillipines, S. America -.... previous N1H1 pandemics wiped out 50 million mainly in these countries
wiped out 50 million
When? 2009 1920?
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ivermectin reduced Covid-19 viral RNA
the main problem with ivermectin ( a derivative of becterial defense molecule)
is toxicity..
and then there is the perennial problem of how much drug gets to the target,
the present maintenance dosing rates via the oral route for parasites such as threadworm/scabies
are ~ ten times lower than the dosing rate to give an IC50 of ~ 2.5 microMolar
perhaps a modified ivermectin would work better
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The inside gossip..from the White House
Trump versus expertise over HCQ
https://www.axios.com/coronavi…42-9bfe-890413c6220d.html
". "People speak up and there's robust debate, but there's never been a confrontation."
Yesterday was the first confrontation."
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What shall I tell him??
Social distance from lions is advisable... vorsicht.
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New Zealand radio jockies
encouraging PM Ardern to physically punish her Minister of Health for going mountain biking.
the problem was not isolation..but the possibility of burdening the hospitals with an accident
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Virus are dust, but "evil" dust.
For Coronavirus all flesh is grass
but bats are least tasty..
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We'll meet again .. some sunny day
Channelling the Cliffs of Dover.
unfortunately this cannot be fought on the beaches..
Winston Churchill
the virus crossed into Poland long ago..
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Scotland’s chief medical officer, Catherine Calderwood, has quit after facing intense criticism
for breaking her own rules to twice visit her second home during the coronavirus outbreak.
https://www.theguardian.com/uk…vice-catherine-calderwood
Maybe she she should change the rules..
We went to the beach yesterday
3 family members plus a dog
NSW state rules: maximum stranger group S=s+s ... n=2
but family group (F= f+f+f..) is unrestricted.. +d??
F+s ? .. maximum s=1
When S=1 then things are getting really bad.
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I am used to seeing on this site
Perception bias..replication?
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as posted this long read about Safire's work
Where there is lack of data
there is endless room for Directed EVOlutionary speculation..
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WHO= CHO
New math from
Japan's Deputy PM Taro Aso
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Ivermectin might work..used for Scabies in much of world
Recent evidence of in vitro efficacy in Australia
IC50 = 2,5 micro molar...(2.2 mg/kg) is too high.
https://www.sciencedirect.com/…cle/pii/S0166354220302011
Cheap drug widely used against River Blindness
in Africa Nigeria Uganda DRC Cameroon
https://onlinelibrary.wiley.co…/j.1365-3156.2011.02735.x
Also has in silico activity against yellow fever flavivirus
https://www.researchgate.net/p…prospects_for_an_old_drug
Next step.. Clinical trial..?
The exact toxicity level is unknown but
the IC50 of 2.2 mg/kg is way above that
achievable with Scabies/river blindness dosing levels.(02 mg/kg
(.. unfortunately
Perhaps if it was nebulised into the lungs it might be less toxic.
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But these guys are ready for take-off!
North Texas is a long way from Cape Canaveral..
Arturo Tossini is a long way from testable with his 4D psyche
and a long way from physics with his pediatrician training
"I do not like to be on focus. Looking for unexpected, hidden multidisciplinary relationships,
I publish in rather different Journals (e.g., nuts in Nature, New England Journal of Medicine, Physics of Life Reviews, PLOS Biology, Cognitive Neurodynamics, etc) and fields (biology, physics, math, philosophy, history, medicine, and, above all, neuroscience). ---http://arturotozzi.webnode.it/ --- https://orcid.org/0000-0001-8426-4860 ---
I would term my method "testable rationalism": experimental previsions arising from top-down,
deductive mathematical/topological approaches.
Arturo T is leveraging off Oded Zilberberg's 4D/2D quantum hall results
but probably Oded would not view this stuff as kosher..
maybe it is pork..
"
29) Zilberberg O, Huang S, Guglielmon J, Wang M, Chen KP, et al. 2018. Photonic topological boundary pumping as
a probe of 4D quantum Hall physics. Nature, 553(7686):59-62. doi: 10.1038/nature25011.16) Lohse M, Schweizer C, Price HM, Zilberberg O, Bloch I. 2018. Exploring 4D quantum Hall physics with a 2D
topological charge pump. Nature 553, 55–58. doi:10.1038/nature25000. -
Origin of Safire.. looks to be Las Vegas January 2012..
They have made inspiring videos since then..
This is the latest
we just need the published data...
Montgomery Childs idea of "tranformative technology"
is much more inspiring than "disruptive technology"
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Black cumin..Nigella Sativa
an ancient panacea..from the deserts
The oil is not so expensive ...yet. and not toxic at two tablespoons a day
from personal experience awhile back
No clinical studies on covid
but the in silico modeling shows better binding with the main protease(6lu7) in Covid..than CQ and hydroxyCQ
of nigellicine etc there are over 100 potentially active chemicals
Algeria chemrxiv
'Identification of Compounds from Nigella Sativa as New Potential Inhibitors
of 2019 Novel Coronavirus (Covid-19): Molecular Docking Study.
https://chemrxiv.org/ndownloader/files/22154187
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Now I need two 500mg 3D panadol
I have now found what my 4D recurrent headache looks like
in orthographic projection..
bioxriv paper... 4D thought
https://www.biorxiv.org/conten…0.03.05.979062v1.full.pdf
"QUATERNIONIC ASSESSMENT OF EEG TRACES ON NERVOUS MULTIDIMENSIONAL HYPERSPHERES "
"
pave the way to test an intriguing hypothesis: the recently-proposed claim that the
brain activity takes place in multidimensional spaces. It is noteworthy that, apart from the quaternionic maps described in
this paper, another method is available to assess higher dimensional activities of nervous networks. Indeed, it has been
recently suggested (Tozzi 2019) that hidden spatial dimensions of nervous activity could be tackled in terms of oscillations
inside a two-dimensional superlattice equipped with quantum Hall effects" -
There are Not many people like this on this forum but if you are acquainted with them please attempt education..remotely
"results also showed that about 20% of the participants were reluctant to implement proper prevention measures.
The statistical analysis indicated that the typical characteristics of those people were
male,
younger (under 30 years old),
unmarried, from lower-income households,
with a drinking or smoking habit
and a higher extraversion score.
https://www.medrxiv.org/conten…101/2020.03.31.20048876v1
Japanese sociological study re: Covid and self-restraint.
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What’s in it for them?
Academic progress.= $ + altruism +status?
there are a bunch of aspiring PhD's etc in China
maybe some will get to work for BigPharma
maybe some will help their neighbours..
maybe some will get imprisoned
human motivations are variable..and change with age.. kids.. trials..food availabiilty .. alcohol...lovers..sildenafil
https://shennongproject.com:11…dingEnergy=-5.4&rank=3266
That research question is harder to answer for these 18 researchers than in silico binding..
Chi Xu Zunhui Ke Chuandong Liu Zhihao Wang Denghui Liu Lei Zhang Jingning Wang Wenjun He Zhimeng Xu Yanqing Li Yanan Yang Zhaowei Huang Panjing Lv Xin Wang Dali Han Yan Li Nan Qiao Bing Liu
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From chemrxiv... interesting in silico resource... unfortunately can't find azithromycin modelling yet..
https://chemrxiv.org/articles/…ctive_Web_Server/12058143
interesting mix of contactshttps://shennongproject.com:11443/#/contacts
https://shennongproject.com:11443/#/methods
"We prepared a large-scale library consisting of 8,506 small molecular compounds from DrugBank
. It covers all FDA-approved drugs, compounds in midst of clinical trials and molecules under experimental investigations.
The SDF files were downloaded for each compound from DrugBank, whereas the SMILES files were downloaded for compounds without 3D SDF files, for example Saquinavir, Lopinavir, Ritonavir and Carfilzomlib.
We converted the SMILES files to 3D SDF files for the four drugs using python rdkit library."
I've despised pharmaceutical company attempts to bribe
I think there might be some agreement at least on this point..
my feeling is that Bigpharma is too set in its ways
to provide much benefit to the Covid situation .at least for new drugs.
which is a pity.. they have good labs..
