Why vaccination makes things worse.
https://science.sciencemag.org/content/sci/373/6555/648.full.pdf
See Kerala/Israel/USA California
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in
California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal
domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated
with a Wuhan-1 isolate–based messenger RNA vaccine or from convalescent individuals exhibited
neutralizing titers that were reduced 2- to 3.5-fold against the B.1.427/B.1.429 variant relative to
wild-type pseudoviruses. The L452R mutation reduced neutralizing activity in 14 of 34 RBD-specific
monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization
for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the
signal peptide cleavage site and the formation of a new disulfide bond, as revealed by mass
spectrometry and structural studies.
For gamma the reduction was just 70% in average here we talk of factors 3 after an already vanning protection for Pfizer. Only 1.3.5.1 was worst so far. But now we have W152C that clears all vaccines...
It is common medicine knowledge since 100 years. Never vaccinate into a pandemic. This may be works for circuit boards...
Some differences among the mutations:
https://www.medrxiv.org/content/10.1101/2021.08.19.21262139v1.full.pdf
In general infection protects much better than vaccination. Some rare mutations are slightly worse for some combination of infected e.g. by alpha then epsilon.xyz
Alpha was the only non-resistant variant
associated with breakthrough infection in vaccinated cases. Overall, fully vaccinated cases were significantly
more likely than unvaccinated cases to be infected by resistant variants (77.6% versus 47.7%, p=1.96e-08)
(Figure 2B, top and Table 1), but not by variants associated with increased infectivity (84.7% versus 76.8%, p
0.092) (Figure 2B, bottom and Table 1). The distribution of variants in immunocompetent and
immunocompromised patients was similar (Figure 2A). Infections by the gamma and delta variants, which
cause more pronounced decreases in Ab neutralization relative to most of the other resistant VOCs12,21 (Figure
2A, left) were increased in fully vaccinated breakthrough infections as compared to unvaccinated infections. In
contrast, variant distribution in unvaccinated cases, with alpha and epsilon predominant (Figure 2B, right), was
similar to estimates of prevalence locally in the community and in the state of California during the study
period1
