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Posts by Fm1

    Catecholamines Are the Key Trigger of COVID-19 mRNA Vaccine-Induced Myocarditis: A Compelling Hypothesis Supported by Epidemiological, Anatomopathological, Molecular, and Physiological Findings


    https://www.cureus.com/article…nes,cause%20%5B21%2D23%5D.


    Abstract

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine-induced myocarditis is a rare but well-documented complication in young males. The increased incidence of sudden death among athletes following vaccination has been reported and requires further investigation. Whether the risk of myocarditis, a known major cause of sudden death in young male athletes, also increases after coronavirus disease 2019 (COVID-19) infection is unknown. The severity and implications of these critical adverse effects require a thorough analysis to elucidate their key triggering mechanisms. The present review aimed to evaluate whether there is a justification to hypothesize that catecholamines in a “hypercatecholaminergic” state are the key trigger of SARS-CoV-2 mRNA vaccine-induced myocarditis and related outcomes and whether similar risks are also present following COVID-19 infection.


    A thorough, structured scoping review of the literature was performed to build the hypothesis through three pillars: detection of myocarditis risk, potential alterations and abnormalities identified after SARS-CoV-2 mRNA vaccination or COVID-19 infection and consequent events, and physiological characteristics of the most affected population. The following terms were searched in indexed and non-indexed peer review articles and recent preprints (<12 months): agent, “SARS-CoV-2” or “COVID-19”; event, “myocarditis” or “sudden death(s)” or “myocarditis+sudden death(s)” or “cardiac event(s)”; underlying cause, “mRNA” or “spike protein” or “infection” or “vaccine”; proposed trigger, “catecholamine(s)” or “adrenaline” or “epinephrine” or “noradrenaline” or “norepinephrine” or “testosterone”; and affected population, “young male(s)” or “athlete(s).” The rationale and data that supported the hypothesis were as follows: SARS-CoV-2 mRNA vaccine-induced myocarditis primarily affected young males, while the risk was not observed following COVID-19 infection; independent autopsies or biopsies of patients who presented post-SARS-CoV-2 mRNA vaccine myocarditis in different geographical regions enabled the conclusion that a primary hypercatecholaminergic state was the key trigger of these events; SARS-CoV-2 mRNA was densely present, and SARS-CoV-2 spike protein was progressively produced in adrenal medulla chromaffin cells, which are responsible for catecholamine production; the dihydroxyphenylalanine decarboxylase enzyme that converts dopamine into noradrenaline was overexpressed in the presence of SARS-CoV-2 mRNA, leading to enhanced noradrenaline activity; catecholamine responses were physiologically higher in young adults and males than in other populations; catecholamine responses and resting catecholamine production were higher in male athletes than in non-athletes; catecholamine responses to stress and its sensitivity were enhanced in the presence of androgens; and catecholamine expressions in young male athletes were already high at baseline, were higher following vaccination, and were higher than those in non-vaccinated athletes.


    The epidemiological, autopsy, molecular, and physiological findings unanimously and strongly suggest that a hypercatecholaminergic state is the critical trigger of the rare cases of myocarditis due to components from SARS-CoV-2, potentially increasing sudden deaths among elite male athletes.



    The Relationship Between Vitamin D Status and Adrenal Insufficiency in Critically Ill Children

    Relationship Between Vitamin D Status and Adrenal Insufficiency in Critically Ill Children
    Context:. Recent studies in critically ill populations have suggested both adrenal insufficiency (AI) and vitamin D deficiency to be associated with worse clini
    academic.oup.com


    Relationship between Vitamin D Status and Autonomic Nervous System Activity

    Relationship between Vitamin D Status and Autonomic Nervous System Activity
    Vitamin D deficiency is associated with increased arterial stiffness. However, the mechanisms underlying this association have not been clarified. The aim was…
    www.ncbi.nlm.nih.gov

    and another coincidence


    Striking Drop in Stress Hormone Predicts Long Covid in Study

    Cortisol could be used with other biomarkers for diagnosis

    Research identifies three potential causes of chronic symptoms


    https://www.bloomberg.com/news/articles/2022-08-11/striking-drop-in-stress-hormone-predicts-long-covid-in-study


    Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study

    Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study
    Evidence suggests associations between vitamin D deficiency and cardiovascular disease (CVD) risk factors, including hypertension and excessive cortisol…
    www.ncbi.nlm.nih.gov


    Discussion

    This pilot study found that healthy adults supplemented with vitamin D had both lower blood pressure and lower levels of the stress hormone cortisol in their urine compared with those given a placebo.

    Just another coincidence? Vitamin D is essential for proper immune response!!!!!!!!!


    Prognostic significance of complement factors in severely ill patients with COVID-19


    Prognostic significance of complement factors in severely ill patients with COVID-19
    Coagulopathy, cytokine release, platelet hyperactivity and endothelial activation are regarded as potential major contributors to COVID-19 morbidity.…
    jim.bmj.com


    Abstract

    Coagulopathy, cytokine release, platelet hyperactivity and endothelial activation are regarded as potential major contributors to COVID-19 morbidity. Complement activation might provide a bridge linking these factors in severe COVID-19 illness. In this study, we investigated the prognostic significance of selected complement factors in hospitalized patients with severe COVID-19 infection. The study included 300 hospitalized adults with severe COVID-19 infection. Complement factors (C3, C3a, C4, sC5b-9) were assessed by commercial ELISA kits. Outcome parameters included mortality, intensive care unit admission and duration of hospital stay. It was found that survivors had significantly higher serum C3 (median (IQR): 128.5 (116.3–141.0) mg/dL vs 98.0 (70.0–112.8) mg/dL, p<0.001) and C4 (median (IQR): 36.0 (30.0–42.0) mg/dL vs 31.0 (26.0–35.0) mg/dL, p<0.001) levels when compared with non-survivors. On the other hand, it was shown that survivors had significantly lower C3a (median (IQR): 203.0 (170.3–244.0) ng/mL vs 385.0 (293.0–424.8) ng/mL, p<0.001) and sC5b-9 (median (IQR): 294.0 (242.0–318.8) ng/mL vs 393.0 (342.0–436.5) ng/mL, p<0.001) levels when compared with non-survivors. Multivariate logistic regression analysis identified C3a (OR: 0.97 (95% CI 0.96 to 0.99), p<0.001) and C4 (OR: 0.92 (95% CI 0.86 to 0.98), p=0.011) levels as significant predictors of mortality. In conclusion, serum levels of complement factors are related to mortality in severely ill patients with COVID-19.



    Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

    Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China
    Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism,…
    www.frontiersin.org


    Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function. It is hypothesized that serum complement components may interact with vitamin D in respect of the physical activities of daily living (PADLs).


    Objective: To investigate if serum complement components 3 (C3), complement components 4 (C4), and 25-hydroxyvitamin D [25(OH)D] associate with PADLs, and to examine whether the association between 25(OH)D levels and PADLs varies at different complement component levels among Chinese centenarians.


    Methods: This study was conducted in a group of population-based centenarians. PADLs were evaluated using the Barthel Index. Multiple regressions were used to analyze the associations among 25(OH)D, complements C3 and C4, and PADLs.


    Results: Among 943 participants, 672 (71.3%) had physical dependence (PD). After adjusting for potential confounders, serum 25(OH)D and C3 levels were positively correlated with PADLs, while C4 levels were negatively correlated with PADLs (Ps < 0.05). Serum 25(OH)D levels significantly interacted with both C3 (P for interaction = 0.033) and C4 (P for interaction = 0.006) levels on PADLs. At lower complement component levels, the multivariate odds ratios (ORs) of the upper tertile of vitamin D for PD were 0.32 (95% CI: 0.18–0.55) in the C3 group and 0.29 (95% CI: 0.16–0.50) in the C4 group. At higher complement component levels, the ORs in the C3 and C4 groups were not statistically significant.


    Conclusions: In a group of population-based Chinese centenarians, we observed that serum complement C3 and 25(OH)D levels were positively associated with PADLs, while C4 was negatively associated with PADLs. The associations between 25(OH)D levels and PADLs were more pronounced in groups with lower serum complement component levels.

    Inhaled aprotinin reduces viral load in mild-to-moderate inpatients with SARS-CoV-2 infection

    https://onlinelibrary.wiley.com/doi/10.1111/eci.13850


    INTRODUCTION

    In the fight against COVID-19, great steps have been taken to recover pre-pandemic socioeconomic activity. Despite this, the inevitable unsustainability over time of epidemiological norms and in a scenario of ‘coexistence with the virus’ produces the appearance of new infections that, although less serious, affect a significant percentage of persons. Within this population, it is important to highlight the one that is vulnerable to suffering a more severe COVID-19. There are many causes that can make an individual vulnerable to a more life-threatening form of COVID-19 and, therefore, require hospitalization (i.e. comorbidities, ageing or being at risk of social exclusion). Therefore, vaccination as the single therapeutic measure is insufficient, and it is essential to develop antiviral drugs that help alleviate these problems.


    In this sense, the recent introduction in antiviral therapy of the drugs molnupiravir (Lagevrio®), nirmatrelvir/ritonavir (Paxlovid®) and lopinavir/ritonavir (Kaletra®) has been viewed with great hope. However, these drugs have the handicap of interactions with other drugs, their economic cost, side effects, not acting on the inflammatory phase or not being effective in COVID-19 prophylaxis.1


    A solution to these problems could be aprotinin, a broad-spectrum inhibitor of host proteases, such as the kinin–kallikrein system and fibrinogen.2 These proteases are used by the virus through a two-step mechanism to cleave the viral ‘spike’ protein and subsequently be able to recognize surface receptors on epithelial cells to infect.3 Recently, in a phase III clinical trial called ATAC (Aprotinin Treatment Against COVID-19), we showed that aprotinin is effective and safe to treat moderate COVID-19 by nebulization.4 This route of administration centres aprotinin's action mainly to the lung, avoiding the appearance of systemic effects, which are common for other antiviral drugs used in COVID-19. Moreover, aprotinin has easy clinical handling, can be applied for infection prophylaxis and on an outpatient basis for mild cases and can be afforded by countries with low economic resources.

    Study: Pfizer COVID vaccine efficacy wanes 27 days after dose 2 in teens


    Study: Pfizer COVID vaccine efficacy wanes 27 days after dose 2 in teens
    The authors say the findings underscore maximizing vaccine coverage and consideration of boosters for teens, if research supports it.
    www.cidrap.umn.edu


    A new study finds waning Pfizer/BioNTech COVID-19 vaccine protection against symptomatic infection in Brazilian and Scottish teens starting 27 days after the second dose amid the Delta and Omicron variant waves, but protection against severe illness was still strong at 98 days in Brazil.


    The study, published yesterday in The Lancet Infectious Diseases, analyzed nationwide data from 503,776 COVID-19 tests of 2,948,538 adolescents aged 12 to 17 years from Sep 2, 2021, to Apr 19, 2022, in Brazil, and 127,168 tests of 404,673 adolescents from Aug 6, 2021, to Apr 19, 2022, in Scotland. Protection against severe illness, defined as hospitalization or death within 28 days, was estimated only in Brazil owing to the small number of such cases in Scotland

    Let's add another reason to not trust the CDC or the FDA and the media. This should be headline news!!!


    Wuhan Lab: From Nipah Virus to COVID-19

    Wuhan Lab: From Nipah Virus to COVID-19
    Nipah virus&nbsp;(NiV) is a zoonotic virus, i.e., it normally spreads between animals and people. The main culprit is the fruit bat, known colloquially as…
    www.trialsitenews.com


    Nipah virus (NiV) is a zoonotic virus, i.e., it normally spreads between animals and people. The main culprit is the fruit bat, known colloquially as flying foxes. Infection often leads to encephalitis and can cause mild illness to severe illness to death. Most outbreaks are annual in Asia, mainly in Bangladesh and India. In the hospital setting, there can be person-to-person transmission. In those infected between 1998 and 2018, deaths occurred in 40-70% of patients. On August 4, the Epoch Times took a look at NiV in the context of a Senate hearing. The headline is dramatic: “Wuhan Lab Was Genetically Manipulating Deadly Nipah Virus, Expert Testifies at Senate Hearing.” According to this piece, forensic study has shown that the Wuhan Institute of Virology (WIV) was genetically modifying the virus, violating the Biological Weapons Convention, per expert presentation to a US Senate subcommittee hearing August 3. The study is another sign that WIV was doing gain-of-function work, and CEO of Atossa Therapeutics Steven Quay argues that this de facto weapons program was responsible for the COVID-19 pandemic. Also, by 2018, the U.S. CDC had outsourced Nipah virus research improperly to an Indian lab that lacked the appropriate certification, drawing actions from the Indian government. However, this effort seemed to be intertwined with more general research and not gain-of-function.


    60 Times More Deadly Than COVID-19?

    Per Quay, he and others looked at COVID patient sample specimens and data provided by the WIV. Their work is still in preprint. Quay found, “20 unexpected contaminants that they believe are evidence of other research conducted at the lab.” In written testimony, he says, “For 19 of the 20 unexpected contaminants, we then found published research from the previous two years, confirming that the lab had indeed been working on these unexpected genes.” One contaminant not accounted for by WIV, “was cloning vectors of the Nipah virus,” according to Quay. He noted in written testimony, “This is the most dangerous research I have ever encountered….” Experts at the hearing said that it is less transmissible than Ebola “since it isn’t airborne.” “If we posit a 60% mortality rate, Nipah is 60 times more deadly than COVID-19. [A] laboratory-acquired infection with a modified Nipah virus would make the COVID-19 pandemic look like a walk in the park,” one expert said.


    And this particular type of synthetic biology is against international law, arguably. “It’s actually against the biological weapons treaty to take the Nipah virus apart and then put it back together again,” Quay said.


    Data Memory-Holed

    At the hearing, Quay listed evidence which pointed to a lab-leak hypothesis for COVID-19. WIV’s open database of, “22,00 samples and viral sequences” was removed from the internet on September 19, 2019, prior to COVID-19. WIV said the removal was due to cyber-attacks, but Quay maintains that the deletions are suspicious and that, “the database was taken offline to remove evidence of close precursors to COVID-19, which would have been a ‘smoking gun’ showing that the virus leaked from the lab.”


    He pointed out that WIV was the world center of coronavirus research, and that prior to 2019, it was home to 65% of published materials on this topic. “For almost a decade, they were going into bat caves throughout China and … back into Africa as well, 20 visits a year in bringing these samples back to the laboratory.”


    TrialSite has chronicled a timeline of events, milestones and other goings on at WIV that raises the specter of at least a significant probability pointing to the lab leak theory. But the evidence isn’t sufficiently conclusive for any final declarations. There is no doubt that the U.S. began outsourcing research to WIV via the EcoHealth Alliance partnership.


    Research on SARS-C0V-2 Cousin in 2016

    Quay offered, “They had the largest collection of raw material backbones from nature to then do gain-of-function research on--I believe it’s the confluence of those two activities … bringing things back from bat caves and gain-of-function research that led to the pandemic.” WIV has long denied being the source of COVID-19, but their government has also long refused efforts to open the lab and records to independent analysts, “making an independent investigation of the hypothesis nearly impossible.” Per a 2021 State Department fact sheet, experiments on RaG13, a SARS-CoV-2 cousin, were ongoing at WIV as far back as 2016. Again, as far as SARS-CoV-2, the activities with U.S. contractor EcoHealth Alliance and the National Institutes of Health involvement with coronavirus research should also be investigated further.


    CDC Outsourcing Research to Indian Labs?

    It would appear the U.S. had its own Nipah virus research program occurring in India. In February 2020, The Hindu reported that the U.S. CDC was collaborating with Indian labs for Nipah virus research potentially considered a bioweapon. This news was covered by multiple media in India.


    Apparently, interest in Nipah virus research intensified during an outbreak in Kerala, India in 2018. The CDC initially got involved to train partners at the Manipal Centre for Virus Research (MCVR), but the latter apparently lacked the certifications as well as approval from the National Indian Council of Medical Research (ICMR)/Health Ministry Screening Committee (HMSC) for permissions.


    According to this account from India, their government “sharply censured the U.S. government’s Centers for Disease Control and Prevention (CDC) for funding an ‘unapproved’ Indian laboratory in Manipal, and not securing the necessary permissions for undertaking in India for work on Nipah virus, considered a potential bioweapon.”


    What? This snippet of news didn’t get much attention given the emerging pandemic at the time. But why would the CDC be outsourcing Nipah virus research to an Indian lab that lacked BSL4 credentials?


    The CDC responded to the Hindu’s outreach, acknowledging the program didn’t have the proper authorizations “due to some confusion about clearance for private institutions,” and that it didn’t commission the research directly.


    Months earlier, the India’s Ministry of Health and Family Welfare communicated in a written letter to both the CDC and the MCVR, “ordering them to shut down the study.” An immediate demand: “Transfer the Nipah virus samples to the certified ICMR-National Institute of Virology in Pune,” as well as insisting that the American public health agency cease all unauthorized sponsorship for Nipah virus research

    Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study


    Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
    AbstractBackground. Low vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We i
    academic.oup.com


    Abstract

    Background

    Low vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.


    Methods

    MR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] and CRP concentrations were instrumented using 35 and 46 genome-wide significant variants, respectively.


    Results

    In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ∼50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, confirming the inverse association between 25(OH)D and CRP in the deficiency range (P = 1.10E-05) but not with higher concentrations. Neither linear or non-linear MR analysis supported a causal effect of serum CRP level on 25(OH)D concentration (Plinear = 0.32 and Pnon-linear = 0.76).


    Conclusion

    The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency. Correction of low vitamin D status may reduce chronic inflammation.

    The only vaccine like reaction is antibodies that are useless against BA5. It has no more resemblance to a real vaccine than say asprin

    You have slammed vitamin d studies from the beginning to the present. Covid severity, long COVID and rebound Covid is a direct result of vitamin deficency, starting with vitamin d leading to depletion of vitamins B1, B3, B12 and iron. I have provided the studies pointing to this over and over. Here is one more that relates to long COVID, but I'm pretty sure you won't see the relationship.


    Effect of vitamin D3 on self-perceived fatigue

    A double-blind randomized placebo-controlled trial


    Effect of vitamin D3 on self-perceived fatigue: A... : Medicine
    y persons with low serum 25-hydroxyvitamin D (25(OH)D) levels. We enrolled 120 individuals (mean age 29 ± 6 years, 53% women) presenting with fatigue and…
    journals.lww.com


    Abstract

    Background:

    Vitamin D deficiency is frequent and has been associated with fatigue in uncontrolled trials.


    Methods:

    This is the first double-blind placebo-controlled clinical trial to investigate the efficacy of per os vitamin D3 (cholecalciferol) in treating fatigue among otherwise healthy persons with low serum 25-hydroxyvitamin D (25(OH)D) levels. We enrolled 120 individuals (mean age 29 ± 6 years, 53% women) presenting with fatigue and vitamin D deficiency (serum 25(OH)D < 20 μg/L). Participants were randomized to a single oral dose of 100,000 units of vitamin D or placebo. The primary endpoint was intra-individual change in the fatigue assessment scale (FAS) at 4 weeks after treatment.


    Result:

    The mean age of the participants was 29 ± 6 years, 53% were women. Mean FAS decreased significantly more in the vitamin D group (−3.3 ± 5.3; 95% confidence interval [CI] for change −14.1 to 4.1) compared with placebo (−0.8 ± 5.3; 95% CI for change −9.0 to 8.7); (P = 0.01). Amelioration of fatigue was reported more frequently in vitamin D than in placebo group (42 [72%] vs. 31 [50%]; P = 0.01; odds ratio [OR] 2.63, 95% CI for OR 1.23–5.62). Among all participants, improvement in fatigue score correlated with the rise in 25(OH)D level (R = −0.22, P = 0.02).


    Conclusion:

    Vitamin D treatment significantly improved fatigue in otherwise healthy persons with vitamin D deficiency.


    This study was registered at the http://www.ClinicalTrials.gov Protocol ID NCT02022475.

    COVID’s second death toll damns our ‘experts’


    COVID’s second death toll damns our ‘experts’
    COVID has killed a million-plus Americans, but the disastrous US policy response — blunt-instrument shutdowns and endless fear-mongering — has inflicted its…
    nypost.com


    A million died, largely among the elderly and the immunocompromised. Our smashing of every social bond did nothing to save them. It did do massive harm to everyone else, especially young people.


    Numbers don’t lie — and on COVID’s second toll they damn our expert class.

    Ok we can forget Barcelona in the spring of 2018 and northern Italy in August of 2019 and again in china in October of 2019 during military games. But ya evidence for wet market is overwhelming, NOT!

    I think studies like this one show that narrative to be bullshit!!!


    Study indicates that cross-reactive immunity against SARS-CoV-2 N protein was present in Africa prior to the pandemic

    Study indicates that cross-reactive immunity against SARS-CoV-2 N protein was present in Africa prior to the pandemic
    Researchers assessed the pre-existing cross-protective immune responses against SARS-CoV-2 nucleocapsid protein and spike protein before the COVID-19 pandemic…
    www.news-medical.net

    Dr. James Thorp Interview VAERS Expert: Disturbing COVID-19 Vaccine Data


    Dr. James Thorp Interview VAERS Expert: Disturbing COVID-19 Vaccine Data
    Recently, a contributor to TrialSite, Dr. James Thorp, recently interviewed Albert Benavides, a world expert on the CDC Vaccine Adverse Event Reaction System…
    www.trialsitenews.com


    Recently, a contributor to TrialSite, Dr. James Thorp, recently interviewed Albert Benavides, a world expert on the CDC Vaccine Adverse Event Reaction System (VAERS). Dr. Thorp suggests that the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), and more continue to reject the very purpose of VAERS in the first place—a vital database used to identify safety signals. But how could VAERS data signals be rejected when the very system was designed for this very purpose?


    According to Dr. Thorp, there is irrefutable evidence that this rejection of VAERS is based on an absolutely false narrative. During the interview, these experts speculate on what could be considered the unthinkable: groups and participants deeply embedded in organized medicine are deleting cases with adverse events, delaying reporting for months, and throttling the results to minimize vaccine-induced adverse events.


    With over 20 plus independent sources not only verifying VAERS but that there may even be some form of manipulation and throttling. As an example of some potentially illicit activity, Pfizer’s own documentation should be referenced—specifically on page 7’s associated tables review. Dr. Thorp told TrialSite, “Do 1,223 deaths in the first 90 days of the COVID-19 vaccine program sound safe?


    Thorp wonders aloud if the CDC’s Tommy T. Shimabukuro’s arguments are reliable—the position published in the New England Journal of Medicine that the COVID-19 vaccine is safe for pregnant women? Again, reviewing Pfizer’s own documents on page 12, Thorp shares “Does the 45% complication rate in the 274 pregnant women sound safe to you (75 "serious" and 49 "non-serious complications)?


    Thorp noted that Mr. Shimabukuro’s name surfaces in emails accessed via the Freedom of Information Act (FOIA) requests associated with actions by both the FDA and CDC extinguishing a death that happened to have not been reported. Disturbing allegations.


    TrialSite suggests the vaccines were highly effective early on but with SARS-CoV-2 mutations, durability issues surfaced that have impacted overall efficacy. Safety issues appear to be actively suppressed based on several data sources. An accurate safety profile remains absolutely essential for a proper risk-benefit analysis ongoing.


    Dr. James Thorp Interviews Albert Benevides - The World Expert on VAERS
    The Medical Industrial Complex of World-Wide Globalists attempt to invalidate VAERS. Dr. James Thorp interviews Albert Benevides the World Expert on VAERS.…
    rumble.com

    Low vitamin D common in chronically anticoagulated children

    Low vitamin D common in chronically anticoagulated children
    SAN DIEGO – Consider testing for vitamin D deficiency to optimize bone health in children receiving frequent anticoagulation.
    www.mdedge.com


    Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C)

    Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C)
    Multisystem Inflammatory Syndrome in children (MIS-C) is a rare but devastating complication of coronavirus disease 19 (COVID-19). The development of…
    www.ncbi.nlm.nih.gov


    PREVALENCE OF VITAMIN D DEFICIENCY IN IRON DEFICIENT AND NORMAL CHILDREN UNDER THE AGE OF 24 MONTHS


    https://www.researchgate.net/publication/346942571_PREVALENCE_OF_VITAMIN_D_DEFICIENCY_IN_IRON_DEFICIENT_AND_NORMAL_CHILDREN_UNDER_THE_AGE_OF_24_MONTHS


    ABSTRACT Objective: To elucidate the potential association between iron status and vitamin D levels in infants. Methods: A cross sectional study was conducted on patients who presented in Consultant Clinics, Department of Pediatrics, The Indus Hospital, Karachi from 1st November 2015 till 31st April 2016. Medical records of infants aged three to 24 months were analyzed retrospectively. Data was entered and analyzed using SPSS version 21.0. Results: A total of 87 patients were enrolled in the study, out of which 47 (54%) patients had iron deficiency anemia, 23 (26.4%) had iron deficiency and 17 (19.5%) had no anemia. Out of 87 patients, 43 (49.4%) had vitamin D deficiency, 8 (9.2%) were vitamin D insufficient and 36 (41.4%) were vitamin D sufficient. Iron deficient anemic patients had significantly higher proportion of vitamin D deficiency as compared to iron deficient and normal patients (57.4% vs 47% and 29.4% respectively. Significant difference in median hemoglobin was found between vitamin D deficient patients and vitamin D insufficient patients. P-value of <0.05 was considered as significant. Conclusion: Iron-deficient children are more prone to vitamin D deficiency. Therefore, every child with IDA should also be evaluated for vitamin D deficiency. Educational efforts are needed to increase compliance with iron and vitamin D supplementation guidelines.

    more to the point the study shows 1 in 8 around 12% of the population, whereas early reports were in the 1 in 3 or 30% suffered from long COVID. Brings it into better perspective. Covid severity as well as long COVID and Covid kick back from remdesivir and Paxcrap are a result of vitamin d deficency leading to low B1,B3,B12 and iron.

    Symptomatic Bradycardia Manifesting as Acute Hypothyroidism Following COVID-19 Infection: A Case Report


    Symptomatic Bradycardia Manifesting as Acute Hypothyroidism Following COVID-19 Infection: A Case Report
    The role of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and associated autoimmune phenomenon behind pathology development has been a…
    www.cureus.com


    Abstract

    The role of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and associated autoimmune phenomenon behind pathology development has been a scientific mystery since the onset of the pandemic in 2020. Early on, scientific studies showed coronavirus disease 2019 (COVID-19) being linked to many pathological consequences including blood clots, neurocognitive dysfunction, and cardiomyopathy. We present a case of acute hypothyroidism in an 88-year-old female with no previous history of thyroid dysfunction or disease. The eventual workup revealed a thyroid-stimulating hormone (TSH) of greater than 100,000 milli-international units per liter (mlU/L) and a thyroxine (free T4) level of less than 0.10 nanograms per deciliter (ng/dl). At the time of presentation, she was found to have a positive COVID-19 test despite being vaccinated. She was started on a levothyroxine injection, which led to eventual symptom resolution. Our aim of this case report is to highlight the possibility of her acute hypothyroidism being triggered by the onset of COVID-19.


    Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012


    https://bmcendocrdisord.biomed…%20in%20the%20long%2Dterm.


    Abstract

    Purpose

    Many smaller studies have previously shown a significant association between thyroid autoantibody induced hypothyroidism and lower serum vitamin D levels. However, these finding have not been confirmed by large-scale studies. In this study, we evaluated the relationship between hypothyroidism and vitamin D levels using a large population-based data.


    Methods

    For this study, we used National Health and Nutrition Examination Survey (NHANES) during the years 2007–2012. We categorized participants into three clinically relevant categories based on vitamin D levels: optimal, intermediate and deficient. Participants were also split into hypothyroid and hyperthyroid. Weighted multivariable logistic regression analyses were used to calculate the odds of being hypothyroid based on vitamin D status.


    Results

    A total of 7943 participants were included in this study, of which 614 (7.7%) were having hypothyroidism. Nearly 25.6% of hypothyroid patients had vitamin D deficiency, compared to 20.6% among normal controls. Adjusted logistic regression analyses showed that the odds of developing hypothyroidism were significantly higher among patients with intermediate (adjusted odds ratio [aOR], 1.7, 95% CI: 1.5–1.8) and deficient levels of vitamin D (aOR, 1.6, 95% CI: 1.4–1.9).


    Conclusion

    Low vitamin D levels are associated with autoimmune hypothyroidism. Healthcare initiatives such as mass vitamin D deficiency screening among at-risk population could significantly decrease the risk for hypothyroidism in the long-term.


    Torsade de Pointes with severe vitamin D deficiency, an unusual presentation of a common problem

    Torsade de Pointes with severe vitamin D deficiency, an unusual presentation of a common problem
    Torsade de Pointes (TdP) is a rare cardiac arrhythmia that is associated with prolonged QTc interval. Hypocalcemia is a common cause of prolonged QTc. Although…
    www.ncbi.nlm.nih.gov


    <Learning objective: Severe vitamin D deficiency is common especially in elderly patients. The diagnosis and treatment of this disorder are simple, but the consequences of severe depletion of vitamin D storage can lead to deep electrolyte abnormalities and life-threatening arrhythmia such as Torsade de Pointes. A simple screening test is effective in preventing a dreadful outcome.>

    One in 8 patients seen to have long covid symptoms', says study


    Covid symptoms: 'One in 8 patients seen to have long covid symptoms', says study - The Economic Times


    According to the study, of adults who have had Covid-19, 21.4% experienced at least one new or severely increased symptom three to five months post-infection compared to before infection. This was against 8.7% of uninfected people in the same time period, suggesting that one in eight Covid-19 patients (12.7%) in general population experience long-term symptoms due to Covid-19.

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    Genome-wide association study reveals class I MHC–restricted T cell–associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations


    Genome-wide association study reveals class I MHC–restricted T cell–associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations
    It has recently been shown that vitamin D deficiency can increase asthma development and severity and that variations in vitamin D receptor genes are …
    www.sciencedirect.com


    Background

    It has recently been shown that vitamin D deficiency can increase asthma development and severity and that variations in vitamin D receptor genes are associated with asthma susceptibility.


    Objective

    We sought to find genetic factors that might interact with vitamin D levels to affect the risk of asthma exacerbation.


    Methods

    We conducted a genome-wide study of gene–vitamin D interaction on asthma exacerbations using population-based and family-based approaches on 403 subjects and trios from the Childhood Asthma Management Program. Twenty-three polymorphisms with significant interactions were studied in a replication analysis in 584 children from a Costa Rican cohort.


    Results

    We identified 3 common variants in the class I MHC–restricted T cell–associated molecule gene (CRTAM) that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level. These results were replicated in a second independent population (unadjusted combined interaction, P = .00028-.00097; combined odds ratio, 3.28-5.38). One variant, rs2272094, is a nonsynonymous coding polymorphism of CRTAM. Functional studies on cell lines confirmed the interaction of vitamin D and rs2272094 on CRTAM expression. CRTAM is highly expressed in activated human CD8+ and natural killer T cells, both of which have been implicated in asthmatic patients.


    Conclusion

    The findings highlight an important gene-environment interaction that elucidates the role of vitamin D and CD8+ and natural killer T cells in asthma exacerbation in a genome-wide gene-environment interaction study that has been replicated in an independent population. The results suggest the potential importance of maintaining adequate vitamin D levels in subsets of high-risk asthmatic patients.



    A subgroup of lupus patients with nephritis, innate T cell activation and low vitamin D is identified by the enhancement of circulating MHC class I-related chain A

    Relationship between Lymphocyte Subpopulations and Vitamin D Levels in COVID-19 Pneumonia Patients


    Relationship between Lymphocyte Subpopulations and Vitamin D Levels in COVID-19 Pneumonia Patients - PubMed
    This preliminary study confirms the high prevalence of vitamin D deficiency in patients with COVID-19 pneumonia and that vitamin D deficiency is associated…
    pubmed.ncbi.nlm.nih.gov


    Abstract

    Background: Some studies have shown that patients who are hospitalized with severe COVID-19 also have low levels of vitamin D. It is known that vitamin D can reduce the risk of infections and down regulate the immune/inflammatory reaction.


    Objectives: To investigate the association between vitamin D status and lymphocyte subpopulations in hospitalized pneumonia COVID-19 patients.


    Methods: In 33 positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients with radiologic evidence of interstitial pneumonia and in 16 healthy control subjects matched for age, sex, and seasonality lymphocyte subpopulations and vitamin D levels were evaluated.


    Results: The majority of patients with COVID-19 pneumonia (70.8%) presented vitamin D deficiency. The percentages of neutrophils presented a negative correlation (r = -0.74; P < 0.001), whereas the percentages of lymphocytes presented a positive correlation (r = 0.43; P < 0.01) with 25(OH)D. Moreover, vitamin D levels were positively correlated with CD3+ (r = 0.37, P < 0.05), CD4+ (r = 0.41, P < 0.05), CD8+ (r = 0.32, P < 0.07), and CD19+ (r = 0.38, P < 0.05).


    Conclusions: This preliminary study confirms the high prevalence of vitamin D deficiency in patients with COVID-19 pneumonia and that vitamin D deficiency is associated with a reduction of lymphocyte subsets and altered T-lymphocyte activation. This finding may contribute to clarify the mechanisms by which vitamin D influences the course and outcome of COVID-19 pneumonia.


    Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions

    Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions
    Class II invariant chain peptide (CLIP) expression has been demonstrated to play a pivotal role in the regulation of B cell function after nonspecific…
    www.ncbi.nlm.nih.gov