Fm1 Member
  • Member since Mar 28th 2016
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Posts by Fm1

    this supports Wyttenbach theory on covid cold imunity


    Parental Guidance: Research suggests kids may have COVID-19 immunity predating pandemic


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    While researching new studies around the globe, I came across this interesting piece of information on Nature.com that was published in November. Nature carries a compilation of research from around the world and this one research said scientists at the Francis Crick Institute in London analysed blood samples—from adults and children—who had not been infected with the new virus and found they contained antibodies. Nature says: “Scientists have found antibodies that recognize SARS-CoV-2 in the blood of people who have never caught the virus. Children are particularly likely to harbour such antibodies, which might explain why most infected children have either mild illness or none at all.” The blood samples in question were collected before Covid began to wreak havoc worldwide or just when it started to, which means that immunity to it already existed in some people.

    The New U.K. Variant May Cause False Negatives on Some COVID-19 Tests, FDA WWarns


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    The genetic mutations in new strains of the coronavirus could affect the results of some COVID-19 tests, according to a warning from the Food and Drug Administration (FDA). Because the mutations affect the part of the virus's genetic material that these tests look for, the tests could end up giving a false negative result, meaning the results are negative but an infection is present.


    The FDA recently discovered that three particular COVID-19 tests could give a false negative result if the sample contains the B.1.1.7 variant of the virus, which triggered the London lockdown in December. It has since spread to other countries, including the U.S. The risk for a false negative in this situation is low, according to the letter. But the FDA is flagging the issue to health care workers and lab staff.


    N439k pathway?


    Treat early, treat often and treat all!

    interesting, but my main reason for posting is that it's the perfect example. Medicine is still in its infancy concerning the imune system.


    Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site


    https://www.news-medical.net/n…S-CoV-2-binding-site.aspx


    A shadow over the promising inhaled interferon beta COVID-19 therapy has been cleared with the discovery that although it appears to increase levels of ACE2 protein - coronavirus' key entry point into nose and lung cells - it predominantly increases levels of a short version of that protein, which the virus cannot bind to.

    Naturally occurring antiviral proteins called interferons have shown promise in treating COVID-19. However, previous studies have shown that interferons increase levels of ACE2 - casting doubts over the potential for such treatments, with the possibility that increased ACE2 could see these drugs actually worsen COVID-19 impacts.


    But this latest research shows that it is predominantly the short ACE2, which lacks the viral binding site, that is increased in response to interferons. Since levels of the longer form of ACE2 remain unchanged, interferons do not appear to boost entry points for the virus, supporting their use in treating COVID-19 patients.



    Treat early, treat often, and treat all!

    Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    Human naïve antibodies contain anti-SARS-CoV-2 RBD antibodies

    The virus elicits neutralizing antibodies that prevent viral entry into the host cells. Most of these antibodies are directed against the viral spike glycoprotein, specifically its receptor-binding domain (RBD), a small immunodominant region. Antibodies to the RBD are of several types, each type targeting a different epitope, though there is a degree of overlap. This indicates that neutralization can occur via multiple mechanisms occurring via inhibition of viral entry at more than one site on the RBD.


    The majority of RBD antibodies described so far are surprisingly similar to their germline precursors, a state called low somatic hypermutation. This means that not only is it easy to produce anti-SARS-CoV-2 RBD antibodies, it makes it convenient for researchers to use naïve antibody libraries to pick out novel therapeutic antibodies and to compare antibody clones selected by their ability to bind the viral antigens in vitro with those that arise during natural infection or vaccination.


    The researchers used yeast display techniques to isolate three novel neutralizing antibodies from one such library. Of these antibodies, ABP18 blocks RBD-ACE2 binding, while two (NBP10 and NBP11) do not. Thus, the technique proved to be capable of differentiating antibodies that blocked ACE2 and those that did not.



    Treat early, treat often, and treat all!

    Just so people understand, mitochondrial and metabolic dysfunction is directly related to a vitamin d deficenccy. Here's a study that addresses the issue


    Prevailing vitamin D status influences mitochondrial and glycolytic bioenergetics in peripheral blood mononuclear cells obtained from adults


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097975/


    Abstract

    Background

    Circulating peripheral blood mononuclear cells (PBMCs) are exposed to metabolic and immunological stimuli that influence their functionality. We hypothesized that prevailing vitamin D status [25(OH)D] would modulate the bioenergetic profile of PBMCs derived from humans.



    Treat early, treat often and treat all

    New findings help explain how COVID-19 overpowers the immune system


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    you already have mitochondrial and metabolic dysfunction, then you may, as a result, have a poor first line of defense against COVID-19. Future work should consider mitochondrial biology as a primary intervention target for SARS-CoV-2 and other coronaviruses," he said.


    The study, published in the Nature journal Scientific Reports, expands on recent findings that COVID-19 mutes the body's innate inflammatory response and reports that it does so by diverting mitochondrial genes from their normal function.


    "We already knew that our immune response was not mounting a successful defense to COVID-19, but we didn't know why," said lead author Brendan Miller, a senior doctoral student at the USC Leonard Davis School. "What we did differently was look at how the virus specifically targets mitochondria, a cellular organelle that is a crucial part of the body's innate immune system and energy production."

    Study identifies genetic changes likely to have enabled SARS-CoV-2 to jump from bats to humans


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    A new study, involving the University of Cambridge and led by the Pirbright Institute, has identified key genetic changes in SARS-CoV-2—the virus that causes COVID-19—that may be responsible for the jump from bats to humans, and established which animals have cellular receptors that allow the virus to enter their cells most effectively.

    The genetic adaptions identified were similar to those made by SARS-CoV—which caused the 2002-2003 SARS epidemic—when it adapted from bats to infect humans. This suggests that there may be a common mechanism by which this family of viruses mutates in order to jump from animals to humans. This understanding can be used in future research to identify viruses circulating in animals that could adapt to infect humans (known as zoonoses) and which potentially pose a pandemic threat.

    A Mild COVID-19 Case May Still Result in Long-Term Symptoms


    https://www.healthline.com/hea…ult-in-long-term-symptoms


    Since last spring, experts have been sounding the alarm about COVID-19 “long-haulers,” people who experience lasting symptoms for months after being diagnosed with COVID-19.


    A new study published in the Annals of the American Thoracic Society adds to a growing body of research on this phenomenon.


    The authors of the study invited patients who had been diagnosed with COVID-19 to attend a follow-up appointment months after their diagnosis.



    Treat early, treat often and treat all!

    This clown talking of vitamin d is absolute bullshit. Saying you store vitamn d during the summer and use it in winter is lunacy. The half life of vitamin d Calcitriol in the body is 15 hours, D3 is 15 days. Did he get his medical degree at walmart?

    Oh boy


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    i guess this a reflection of our 37th ranked healthcare system, research seems to be lacking also


    Much of US data to catch newest coronavirus variants is several months old


    https://amp.cnn.com/cnn/2021/0…irus-sequences/index.html


    (CNN)As part of the hunt for new coronavirus variants, an international database shows the United States ranks 61st in how quickly virus samples are collected from patients, analyzed and then posted online.


    Countries with far fewer resources, including Bangladesh, Sri Lanka and Suriname, process samples more quickly than the United States does.


    "It's pathetic," said Dr. Peter Hotez, a virologist at Baylor College of Medicine.

    Noch ein Kraut! Now we have at least two herbs that work: Sutherlandia & "Cistus incanus" and may be Nigella Sativa. There will for sure be more!

    This is known since more than 6 months now and long term data shows that some symptoms decrease other not. Most likely all these patients need a post infection clearing with 3 does of Ivermectin. The same for the "testes pain" of man that can last much longer than other symptoms.

    Here a clearing is mandatory!

    Nicotine, Cannabis sativa, green tea, Sutherlandia, nigella sativa, cistus incanus all show promsng results. However, none will ever be adopted as a treatment n the United States. The FDA has no control over these plants except nicotine patches and they surely will not go there. So just go home and hope you get better


    Treat early, treat often and treat all

    The scientists found that 76 % of patients reported at least one ongoing symptom during the follow up tests.


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    More than three quarters of COVID-19 patients hospitalised for treatment have at least one ongoing symptom six months after initially becoming unwell, according to a study published in The Lancet journal.


    The research looked at the long-term effects of the novel coronavirus infection in 1,733 patients first diagnosed in Wuhan, China between January and May followed to June and September.


    In the study, scientists interviewed the patients face-to-face using questionnaires to evaluate their symptoms and health-related quality of life. The discharged patients also underwent physical examinations, lab tests, and a six-minute walking test to gauge their endurance levels.


    Is this a direct result of no early outpatient treatment? Ancient aliens theorist say YES!


    Treat early treat often and treat all

    This Strange Symptom Could Be a Sign of COVID, the Mayo Clinic Says


    https://bestlifeonline.com/news-strange-covid-symptom/


    Most of us can rattle off the basic COVID symptoms on command at this point: cough, fever, shortness of breath, fatigue to name a few. But according to a recent interview with Stacey Rizza, MD, an infectious disease expert at the Mayo Clinic, there are also many COVID symptoms flying under patients' radars, obscuring diagnoses. Among them, says Rizza, is one particularly strange and surprising symptom: inflammation of the testes in men.


    Ouch, it's really getting personal!


    Treat early treat often and treat all

    The Disturbing New Symptom of Long COVID Doctors Want You to Know


    https://bestlifeonline.com/symptom-long-covid-hands-news/


    My hands would peel. I would wake up one day and my hands would feel like sandpaper, and they would peel in their entirety," she said. Her fingernails will also turn purple every so often. Siniscalchi says her doctor refers to this as "COVID hands."


    My guess? Zinc and iron deficenccy


    Treat early treat often and treat all

    Coronavirus cases pass 90 million worldwide, doubling in just 10 weeks


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    Coronavirus infections have now surpassed 90 million confirmed cases, as more countries braced for wider spread of more virulent strains of a disease that has now killed nearly 2 million worldwide. The number of infections worldwide has doubled in just 10 weeks, according to a tally by Johns Hopkins University on Sunday. Covid-19 infections had hit 45 million as recently as late October. As of early Monday, Johns Hopkins counted 90,260,464 infections confirmed by government and other entities tracking cases


    Treat early, treat often and treat all

    New evidence that U.K. coronavirus variant spreads more easily has scientists really worried


    https://www.latimes.com/scienc…-really-worried?_amp=true


    The coronavirus variant that emerged in the United Kingdom belongs to the world now, and mounting evidence is confirming some scientists’ early suspicions: It is a super spreader capable of turbocharging the pandemic and muscling less transmissible strains of the virus into oblivion.


    Now that the new variant has established a beachhead in the United States and more than 40 other countries, the race to contain it is on. That contest pits humans armed with vaccine, masks and hand sanitizer against a viral strain with a handful of genetic changes that has raised fears from the moment they were detected.


    Treat early, treat often and treat all

    Surprisingly, or maybe not so :) , today I ran across that local Physician prescribing HCQ for COVID. Asked him how he got his prescriptions filled, and he said he does not list a diagnosis. Said: "I am not stupid".

    He is using the same playbook as the doctors who prescribed oopioid, undiagnosed pain. Eventually he will be called on this and if he tells the truth will have his licence revoked. Brave man!

    Coronaviruss: Chinese study finds most patients still show signs of ‘long Covid’ six months later


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    Most patients who received hospital treatment for Covid-19 developed long-term health problems, according to a large-scale study from China. Researchers found that 76 per cent of those discharged from one hospital in Wuhan, the city at the centre of the outbreak, still showed at least one symptom associated with the disease six months later.


    Another example for early outpatient treatment.


    Treat early, treat often and treat all

    Japan has found a new Covid variant. Here's how it compares to virus strains in the UK, South Africa


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    Japan's National Institute of Infectious Diseases (NIID) on Sunday said it had detected a new variant of the coronavirus in four travelers arriving from Brazil.


    The newly-discovered mutant strain of Covid-19 was found to share some of the mutations in common with those of concern for increased infectivity, the institute said, referring to highly infectious strains recently discovered in the U.K. and South Africa.