Posts by axil

    A NEW STUDY On Vitamin D

    A very creative study published on April 30th 2020

    “We show that the risk of severe COVID-19 cases among patients with severe Vit D deficiency is 17.3% while the equivalent figure for patients with normal Vit D levels is 14.6% (a reduction of 15.6%)”

    A new strain of flu that has the potential to become a pandemic has been identified in China by scientists.

    It emerged recently and is carried by pigs, but can infect humans, they say.

    The researchers are concerned that it could mutate further so that it can spread easily from person to person, and trigger a global outbreak.

    While it is not an immediate problem, they say, it has "all the hallmarks" of being highly adapted to infect humans and needs close monitoring.…id-19-drug-111703247.html

    Gilead prices COVID-19 drug remdesivir at $2,340 per patient in developed nations


    In an open letter, Gilead Chief Executive Daniel O'Day said the price is well below the value it provides given that early hospital discharges could save around $12,000 per patient in the United States.

    Patient advocates have argued that the cost should be lower since remdesivir was developed with financial support from the U.S. government.

    18 Coronavirus Autopsies (This is what they found in the Brain) | COVID-19

    If you’ve seen my previous videos on autopsies that were done on COVID-19 patients, it's pretty clear by now that when patients do die of this coronavirus, it's because of the lungs. Either because of all the inflammation in the lungs, with pneumonia and cytokine storm and ARDS, sometimes with multiorgan failure….or because of the major blood clot that develops in the lungs. Sometimes though, blood clots show up in other parts of the body as well. For example, in some cases, clots can travel to the brain, and lodge in the blood vessels there, causing decreased blood flow to certain regions of the brain, and this is known as a stroke.

    But this virus, in a different manner, can cause neurologic symptoms in some people, such as headache, confusion, and anosmia, meaning loss of taste and smell. But we don’t really know why this coronavirus sometimes causes these symptoms. Is it because the coronavirus travels in the bloodstream to the brain? Maybe. After all, there are ACE2 receptors that are located in the brain. Is it because the virus gets in our nose, and used the olfactory nerves that are there to gain entry into our brain? Or are these symptoms more related to the effects of the cytokine storm, which is actually pretty common with infections in general, whether that be from pneumonia or something else? In a recent study in NEJM, they looked at brain findings from autopsies done on 18 patients who died from COVID-19, in a single teaching hospital. All 18 of these patients had nasopharyngeal swab samples that were positive for SARS-CoV-2 on RT-PCR.

    Eleven COVID 19 patients required mechanical ventilation, meaning a breathing tube. Interestingly, it was noted that all of the ventilated patients had a confusional state or decreased arousal from sedation for ventilation. The way that I interpret this is that when they paused the sedation, meaning they temporarily stopped the sedation to assess their mental status, the patient was able to follow commands during that time. This, in general, is not uncommon, but this does seem to occur more often with COVID 19 patients, and this is something that I’ve been finding with my COVID 19 patients in the ICU.

    On average, these COVID-19 patients died about 10 days after being admitted to the hospital.

    When they did the autopsies, they looked at the brain as a whole, and they also sampled 10 different areas of the brain, and then looked at those samples underneath the microscope. Microscopic examination showed acute hypoxic injury in some regions of the brain. Acute hypoxic injury means tissue was damaged as a result of not getting enough oxygen. There was an acute hypoxic injury in the cerebrum, which is the part of the brain that allows us to think, and be conscious. There was also an acute hypoxic injury in the cerebellum in all the patients. There were no blood clots in the brain, or vasculitis, meaning inflammation of blood vessels. So another thing we want to know, is, is the virus actually invading the cells of the brain? In this study, they actually tested the brain tissue for the virus with RT-PCR.

    Coronavirus HOROR: Experts only discovering vast long-term health issues of covid-19

    SCIENTISTS are only starting to grasp the vast array of health problems caused by the novel coronavirus, some of which may have lingering effects on patients and health systems for years to come, according to doctors and infectious disease experts.

    Besides the respiratory issues that leave patients gasping for breath, the virus that causes COVID-19 attacks many organ systems, in some cases causing catastrophic damage. Dr Eric Topol, a cardiologist and director of the Scripps Research Translational Institute in La Jolla, California said: ”We thought this was only a respiratory virus. Turns out, it goes after the pancreas.

    “It goes after the heart. It goes after the liver, the brain, the kidney and other organs. We didn't appreciate that in the beginning.”

    In addition to respiratory distress, patients with COVID-19 can experience blood clotting disorders that can lead to strokes, and extreme inflammation that attacks multiple organ systems.

    The virus can also cause neurological complications that range from headache, dizziness and loss of taste or smell to seizures and confusion.

    And recovery can be slow, incomplete and costly, with a huge impact on quality of life.

    The broad and diverse manifestations of COVID-19 are somewhat unique, said Dr Sadiya Khan, a cardiologist at Northwestern Medicine in Chicago.

    With influenza, people with underlying heart conditions are also at higher risk of complications, Khan said. What is surprising about this virus is the extent of the complications occurring outside the lungs.

    Kahn believes there will be a huge healthcare expenditure and burden for individuals who have survived COVID-19.

    Patients who were in the intensive care unit or on a ventilator for weeks will need to spend extensive time in rehab to regain mobility and strength.

    "It can take up to seven days for every one day that you're hospitalided to recover that type of strength," Kahn said. "It's harder the older you are, and you may never get back to the same level of function."

    While much of the focus has been on the minority of patients who experience severe disease, doctors increasingly are looking to the needs of patients who were not sick enough to require hospitalization, but are still suffering months after first becoming infected.

    Studies are just getting underway to understand the long-term effects of infection, Jay Butler, deputy director of infectious diseases at the U.S. Centers for Disease Control and Prevention, told reporters in a telephone briefing on Thursday.

    "We hear anecdotal reports of people who have persistent fatigue, shortness of breath," Butler said. "How long that will last is hard to say."

    While coronavirus symptoms typically resolve in two or three weeks, an estimated 1 in 10 experience prolonged symptoms, Dr Helen Salisbury of the University of Oxford wrote in the British Medical Journal on Tuesday.

    Salisbury said many of her patients have normal chest X-rays and no sign of inflammation, but they are still not back to normal.

    "If you previously ran 5k three times a week and now feel breathless after a single flight of stairs, or if you cough incessantly and are too exhausted to return to work, then the fear that you may never regain your previous health is very real," she wrote.

    Dr Igor Koralnik, chief of neuro-infectious diseases at Northwestern Medicine, reviewed current scientific literature and found about half of patients hospitalized with COVID-19 had neurological complications, such as dizziness, decreased alertness, difficulty concentrating, disorders of smell and taste, seizures, strokes, weakness and muscle pain.

    Koralnik, whose findings were published in the Annals of Neurology, has started an outpatient clinic for COVID-19 patients to study whether these neurological problems are temporary or permanent.

    Kahn sees parallels with HIV, the virus that causes AIDS.

    Much of the early focus was on deaths.

    "In recent years, we've been very focused on the cardiovascular complications of HIV survivorship," Kahn said.

    from the express

    Oxford investigator on virus drug that offers hope

    (16 Jun 2020) A British trial organised at Oxford University has discovered a drug called Dexamethasone reduces fatalities among severely ill coronavirus patients.
    Peter Horby, the co-chief investigator of the Recovery Trial - Randomised Evaluation of COVID-19 Therapy - said about 75% of patients in hospital will receive a mortality benefit from using the drug.
    Over three months, the university enrolled over 11,000 patients, Horby says making it "by far the biggest clinical trial in the world".
    Trialing 6 different types of drugs, in the last week it was discovered steroid drug Dexamethasone had a "significant effect" on patients with breathing difficulties. In ventilated patients with COVID-19, the drug reduced risk of death by about 35%.
    In patients needing oxygen treatment, it reduced risk of death by about 20%.
    Horby said the drug itself is stocked in "every pharmacy", it is available throughout the world and is "extremely cheap".…ue&recirc=taboolainternal

    One in five people worldwide is at risk of developing ‘severe’ cases of Covid-19, scientists claim.

    Scientists also estimated that 349 million people worldwide, or 4% of the global population, were at “high risk” of developing severe Covid-19 if infected with the virus. Individuals who fell into the high risk category were defined as those who would require hospital admission if they fell ill with the virus, and included people who may not have any underlying health conditions.

    Covid 19 could be the answer to global warming if the death toll would eventually climb into the billions.…=en-US&gl=US&ceid=US%3Aen

    Coronavirus antibodies may last only two to three months after infection, study suggests

    Researchers in the Wanzhou District of China compared the antibody response of 37 asymptomatic people with that of 37 symptomatic people. The researchers found people without symptoms had a weaker antibody response than those with symptoms.

    Additionally, within eight weeks, antibodies fell to undetectable levels in 40% of asymptomatic people, compared with 12.9% of symptomatic people, according to the study’s findings.

    A person can get Covid 19 as frequently as he can get the common cold.

    “When you look at the history of coronaviruses, the common coronaviruses that cause the common cold, the reports in the literature are that the durability of immunity that’s protective ranges from three to six months to almost always less than a year,” he said during an interview on June 2 with JAMA Editor Howard Bauchner. “That’s not a lot of durability and protection.”

    But we already know that late stage use does little. The study was on those hospitalized.

    I thought the issue was early application of HCQ to decrease the replication of the virus at the early stages. not to repair damage already done. My understanding (as limited as it is) is that HCQ is claimed to help Zn interfere with replication to decrease the viral load early to limit damage and having lots of those nasty little things in you. That is keep the numbers down so your body can "do its thing".

    HCQ without zinc has no significant preventive effects on Covid development.

    New Data on Adding Zinc to Hydroxychloroquine + Azithromycin

    A new pre-print study from NYU Grossman School of Medicine shows that the addition of zinc to a hydroxychloroquine and azithromycin COVID-19 treatment regimen may result in a statistically significant reduction in mortality. Dr. Seheult discusses the interesting results and possible confounders of this retrospective observational study. (This video was recorded May 15th, 2020)

    Hydroxychloroquine and azithromycin + zinc study on medRxiv -…f&event=video_description

    COVID-19 Therapeutics: Computational Screenings Show A Variety Of Natural Phytochemicals Could Have Efficacy Against SARS-CoV-2 Including EGCG From Green Tea.

    The computed activity of EGCG From Green Tea. was found to be higher than that of both reference drugs, Remdesivir and Chloroquine.

    May 11, 2020…2-including-egcg-from-gre

    Phenol-Explorer is the first comprehensive database on polyphenol content in foods. The database contains more than 35,000 content values for 500 different polyphenols in over 400 foods. These data are derived from the systematic collection of more than 60,000 original content values found in more than 1,300 scientific publications. Each of these publications has been critically evaluated before inclusion in the database. The whole data on the polyphenol composition of foods is available for download.