Lou Pagnucco Member

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  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    First, regarding ivermectin discussed above, it is also anti-malarial and being repurposed as anti-cancer.

    A new preprint --
    "In Silico Screening of Some Naturally Occurring Bioactive Compounds
    Predicts Potential Inhibitors against SARS-COV-2 (COVID-19)…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    A couple of very recent papers propose soluble angiotensin-converting enzyme 2 as a promising therapy --

    "Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2"
    Summary
    We have previously provided the first…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    For those who wish to follow the latest COVID-19 (non-peer-reviewed) preprints on medRxiv.org and bioRxiv.org, these are on the URL: https://connect.biorxiv.org/relate/content/181

    A few published in the last two days that I found interesting were ---

  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    Perhaps of interest -

    New COVID-19 HOPE Clinical Trial Recommendations Introduced Today May
    Reduce or Eliminate Mechanical Ventilation for Coronavirus Patients
    (a combination of FDA-approved drugs (nebulized Heparin-N-acetylcysteine
    in COVID-19 Patients by…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    More drug repurposing and nutraceutical for COVID-19 treatment

    SARS-CoV-2 main protease (Mpro) is a novel therapeutic drug target.
    Mpro is a key protein required for the proteolytic maturation of the virus

    Identification of Potent COVID-19 Main Protease…
  • This new preprint proposes an explanation for the solar corona temperature --

    "A possible explanation for the mysterious hot solar corona"

    Abstract:
    The coronal heating has remained a puzzle for decades since its observation in 1940. Several
    space missions…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    Jed,

    You wrote: You claimed that "Fauci is trying to stop a run on hydroxychloroquine" by claiming it does not work.

    I never said that or believed that.
    Fauci was trying to dampen down the enthusiasm which is causing a run on supplies.
    As a matter of fact, I…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    Calm down Jed,
    Sure millions of doses can be made, but when the statements were made supplies were insufficient - probably still are
    (Some countries are prohibiting export.) See -- "Chloroquine in short supply as hospitals buy in bulk"
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    New York Hospitals have been using chloroquine. Perhaps Cuomo and Fauci are unaware?

    WATCH: NY Doctor says his hospital already using Chloroquine for coronavirus patients and have had ZERO deaths

    https://therightscoop.com/watc…and-have-had-zero-deaths/

    Dr.…
  • Lou Pagnucco

    Replied to the thread New USPTO Patent Applications.
    Post
    A new USPTO Patent issued to Japanese university on LENR via cavitation --

    United States Patent 10,590,966 March 17, 2020

    Method for generating mechanical and electrochemical cavitation, method for changing geometric shape and electrochemical…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    A new (March 12) video from the MedCram team shows that quercetin, like chloroquine, increases intracellular zinc --

    Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments
    youtube.com/watch?v=vE4_LsftNKM

    Some other…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    Regarding chloroquine -- Since it is an zinc ionophore ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/ ), some other zinc-ionophores formed with natural substances may be less toxic, although that is uncertain.

    The following may be of interest --

  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    A new paper that identifies some promising anti-Covid-19 treatments ---

    "Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface"

    Abstract
    The novel Wuhan…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    A new paper on drug repurposing discussed at ---
    Existing drugs may offer a first-line treatment for coronavirus outbreak
    https://medicalxpress.com/news…coronavirus-outbreak.html

    The paper cited is ---
    Discovery and Development of Safe-in-man Broad-Spectrum…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    A recent paper identifies three flavonoids (herbacetin, , rhoifolin , pectolinarin) that may have anti-viral effects on COVID-19 ---
    "Inhibition of SARS-CoV 3CL protease by flavonoids"
    https://www.tandfonline.com/do…080/14756366.2019.1690480

    Generally hard…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    New related publications --
    "Research points the way toward a practical nutraceutical strategy for coping with RNA virus infections"
    https://medicalxpress.com/news…egy-coping-rna-virus.html

    "Nutraceuticals have potential for boosting the type 1 interferon…
  • Lou Pagnucco

    Replied to the thread Electron-assisted fusion.
    Post
    New Google USPTO patent --

    United States Patent 10,566,094 February 18, 2020

    Enhanced electron screening through plasmon oscillations

    Abstract
    Enhanced Coulomb repulsion screening around light element nuclei is achieved by way of utilizing…
  • Lou Pagnucco

    Replied to the thread Electron-assisted fusion.
    Post
    Another new USPTO patent application employing enhanced electron screening --

    United States Patent Application 20200051700 February 13, 2020

    SUBMICRON FUSION DEVICES, METHODS AND SYSTEMS

    Abstract
    Methods, apparatus, devices, and systems for creating,…
  • Lou Pagnucco

    Replied to the thread Electron-assisted fusion.
    Post
    New USPTO Patent Application, based on the Physical Review C paper ---

    "Nuclear fusion reactions in deuterated metals"
    https://journals.aps.org/prc/a…15597a86203c464d727b8de5b

    United States Patent Application 20200051701 February 13, 2020
    "METHODS AND…
  • Lou Pagnucco

    Replied to the thread Covid-19 (WuFlu) News.
    Post
    A very recent (Feb 10) Nature Reviews paper discusses some potential treatments --
    "Therapeutic options for the 2019 novel coronavirus (2019-nCoV)"

    Therapeutic options in response to the 2019-nCoV outbreak are urgently needed.
    Here, we discuss the…