Fm1 Member
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    Virtual session: Dr Fauci expresses fear about COVID-19 vaccine’s efficacy against South African variant


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    LAHORE: The world-renowned physician and immunologist from the US Dr Anthony Fauci expressed fear about COVID-19 vaccine’s efficacy against South African variant of coronavirus, which seems slightly more complex than the UK variant.


    “Since British scientists noted the UK variant tends to increase transmissibility than its virulence, the South African variant is little bit complicated that may render vaccine’s effectiveness vulnerable,” Dr Fauci said while speaking to a group of global health reporters ahead of “HIV Research for Prevention” (HIVR4P) conference. An International AIDS Society’s (IAS) virtual conference, which was originally scheduled for Cape Town last November, is now taking place online over the last week of January and the first week of February.


    So by continuing to jab the world population, are we helping the virus to become vaccine resistant ?

    beware it's still flu season with little to no known local transmission, but it's out there!


    Iraqi authorities detect bird flu outbreak in Salahudin province


    http://outbreaknewstoday.com/i…salahudin-province-40256/


    The laboratory tests proved that poultry in Samarra, some 120 km north of the Iraqi capital Baghdad, was infected with bird flu,” Ammar Khalil, governor of the province, said.


    Over 60,000 chickens in the province were detected to have acquired the bird flu, as authorities are advising citizens to be on ‘high alert’ in confronting the virus.


    All the chickens in the fields infected with the virus were culled, and the fields’ halls were sanitized, in addition to blocking and scanning 3 km of areas surrounding the fields.

    Covid tongue' among Covid symptoms you need to know


    https://www.southwalesargus.co…covid-symptoms-need-know/


    He wrote: “One in five people with Covid still present with less common symptoms that don’t get on the official PHE list - such as skin rashes.


    “Seeing increasing numbers of Covid tongues and strange mouth ulcers. If you have a strange symptom or even just a headache and fatigue, stay at home!”

    If Covid-19 Did Start With a Lab Leak, Would We Ever Know?


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    instance, both investigations include Peter Daszak, disease ecologist and president of the EcoHealth Alliance, a research nonprofit with a history of conducting research into SARS-related coronaviruses and their effects on humans, including collaborative work done at the Wuhan Institute of Virology. The Wuhan Institute happens to be the only laboratory in China that is allowed to work with the world’s most dangerous pathogens, and it’s located at the apparent ground zero of the current outbreak.


    If there were a lab leak—and, again, most experts do not believe that the available evidence points in this direction—then both the Wuhan Institute and its US partner would be on a short list of candidates to investigate. It should be obvious that no one with any connection to either organization can play a formal role in any truly independent investigation into the pandemic’s origins. (Of course their expert input could and should be solicited through other means.)


    It’s also worth noting that Daszak expressed certainty, very early in the crisis, that the disease originated in the wild. Last winter, just after the WHO first named the virus, he drafted a formal statement to “strongly condemn conspiracy theories suggesting that Covid-19 does not have a natural origin,” and to “stand with” colleagues in Wuhan and across China. More than two dozen other scientists would sign that letter, which was published by The Lancet on Feb. 19, 2020. Emails obtained via Freedom of Information Act suggest that Daszak organized the effort from the start.

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    Many scientists citing two scandalous COVID-19 papers ignore their retractions


    https://www.sciencemag.org/new…-ignore-their-retractions


    COVID-19 “is such a hot topic that publishers are willing to publish without proper vetting,” even in the face of retractions that made global headlines, says Elizabeth Suelzer, a reference librarian at the Medical College of Wisconsin who has written about problematic citations to a retracted 1998 study in The Lancet falsely linking vaccination to autism.


    Both of the retracted COVID-19 papers, one in The New England Journal of Medicine (NEJM) and the other in The Lancet, were based on what appeared to be a huge database of patient records compiled from hospitals worldwide by Surgisphere, a small company operated by vascular surgeon Sapan Desai, who was a co-author on each article. The 22 May 2020 Lancet paper ostensibly showed that hydroxychloroquine, an antimalarial drug promoted by President Donald Trump and others, could harm rather than help COVID-19 patients. Its publication led to a temporary halt in a major clinical trial and inflamed an already-divisive debate over the drug, which has proved to be no help against COVID-19. The 1 May NEJM article corroborated other evidence that people already taking certain blood pressure medicines did not face a greater risk of death if they developed COVID-19.


    Questions soon arose about the validity, and even existence, of the Surgisphere database, however, and the retractions followed on 4 June. But of the 200 papers examined by Science—all published after the retractions—105 inappropriately cited one of the disgraced studies. In several cases it was a primary source for a meta-analysis combining multiple studies to draw overarching conclusions. In most, the studies were cited as scientific support or context. Science also found a handful of articles that uncritically cited an influential April preprint based on the same Surgisphere data set, which described the antiparasitic drug ivermectin as beneficial in critical COVID-19 cases. (There is no standard way to retract preprints, however.)

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    Best post of the whole thread !

    New coronavirus variants could cause more reinfections, require updated vaccines


    https://www.sciencemag.org/new…-require-updated-vaccines


    When the number of COVID-19 cases began to rise again in Manaus, Brazil, in December 2020, Nuno Faria was stunned. The virologist at Imperial College London and associate professor at the University of Oxford had just co-authored a paper in Science estimating that three-quarters of the city’s inhabitants had already been infected with SARS-CoV-2, the pandemic coronavirus—more than enough, it seemed, for herd immunity to develop. The virus should be done with Manaus. Yet hospitals were filling up again. “It was hard to reconcile these two things,” Faria says. He started to hunt for samples he could sequence to find out whether changes in the virus could explain the resurgence.


    On 12 January, Faria and his colleagues posted their initial conclusions on the website virological.org. Thirteen of 31 samples collected in mid-December in Manaus turned out to be part of a new viral lineage they called P.1. Much more research is needed, but they say one possibility is that in some people, P.1 eludes the human immune response triggered by the lineage that ravaged the city earlier in 2020.

    Some countries, including the U.S., have focused heavily on the use of vaccines to combat their outbreaks. While vaccines are a useful tool, they will not end the pandemic alone, Mike Ryan, executive director of the WHO's health emergencies program, said at the news conference.


    "We warned in 2020 that if we were to rely entirely on vaccines as the only solution, we could lose the very controlled measures that we had at our disposal at the time. And I think to some extent that has come true," Ryan said, adding the colder seasons and the recent holidays also may have also played a role in the spread of the virus.

    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen

    As reported yesterday a form of the south african mutation is now spreading in the US southwest rapidly. Months ago I posted concerns of a mutation seen in China in April, N439k, that made the virus harder to detect through testing. The strain seemed to be donated by the D614 mutation and petered out, but instead mutated to the 501Y.V1 south african strain along the N439k protein pathway.


    Why new coronavirus variants 'suddenly arose' in the U.K. and South Africa


    https://www.nationalgeographic…k-and-south-africa/#close


    A few case studies hint at this kind of rapid evolution for chronically ill SARS-CoV-2 patients. In a recent preprint article, Gupta and his colleagues document mutation of the virus after a patient received three treatments of convalescent plasma starting at day 63 of their illness. Two of the viral mutations developed in genes that code for the spike protein. Something similar happened inside a 65-year-old cancer patient who survived after 105 days with the virus. And one of the mutations recently spotted in the South African variant—N439K—may allow the virus to bypass monoclonal antibody drugs, according to a preprint released by the COVID-19 Genomics Consortium in November.



    Without rapid full vaccination, which we know is impossible with the 2 dose 28 day wait, early treatment is the only way out of this. Millions are going to die or suffer life long complications if we continue to follow present protocol of go home and wait. Treat early, treat often, treat all, do something!!!

    C.D.C. Warns the New Virus Variant Could Fuel Huge Spikes in Covid-19 Cases


    https://www.nytimes.com/2021/0…th/covid-cdc-variant.html


    Federal health officials warned on Friday that a far more contagious variant of the coronavirus first identified in Britain could become the dominant source of infection in the United States by March, and would likely lead to a wrenching surge in cases and deaths that would further burden overwhelmed hospitals.


    This dire forecast from the Centers for Disease Control and Prevention made plain what has been suspected for weeks now: The nation is in an urgent race to vaccinate as many Americans as possible before the variant spreads across the country.


    Could become the dominate strain? guess what guys, it already has. CDC, always a few weeks late!


    Treat early, treat often and treat all!

    Covid-19: US says it has new evidence coronavirus may have come from a Chinese laboratory


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    The US said on Friday it had new information suggesting the Covid-19 pandemic could have emerged from a Chinese laboratory and not through contact with infected animals, the latest salvo in the Donald Trump administration’s efforts to pressure Beijing over the virus’s origins. Specifically, the US Department of State said it had obtained evidence that researchers at the Wuhan Institute of Virology became sick in the autumn of 2019 – before the first identified case was identified in the city – with symptoms it said were consistent with either Covid-19 or common seasonal illnesses.

    C.D.C. Warns the New Virus Variant Could Fuel Huge Spikes in Covid-19 Cases


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    Federal health officials warned on Friday that a far more contagious variant of the coronavirus first identified in Britain could become the dominant source of infection in the United States by March, and would likely lead to a wrenching surge in cases and deaths that would further burden overwhelmed hospitals.


    This dire forecast from the Centers for Disease Control and Prevention made plain what has been suspected for weeks now: The nation is in an urgent race to vaccinate as many Americans as possible before the variant spreads across the country.


    Again they forget the people now infected, vaccine, vaccine, vaccine


    Treat early, treat often and treat all!

    Influenza drug enisamium a potential COVID-19 treatment


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    Researchers in Europe and the United States have demonstrated the potential of the influenza drug enisamium as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).


    Aartjan te Velthuis from the University of Cambridge in the UK and colleagues showed that enisamium prevented SARS-CoV-2 replication in human cell lines and stopped viral RNA synthesis in vitro.


    Furthermore, in a double-blind, randomized, placebo-controlled trial of adults hospitalized with COVID-19, enisamium significantly reduced recovery time among patients who required supplementary oxygen.


    The drug is already clinically approved for use against influenza in eleven different countries. Furthermore, enisamium does not require intravenous administration and could be used outside of the hospital setting.



    Treat early, treat often and treat all!

    Norway Warns of Vaccination Risks for Sick Patients Over 80


    https://www.bloomberg.com/news…for-sick-patients-over-80


    Norway said Covid-19 vaccines may be too risky for the very old and terminally ill, the most cautious statement yet from a European health authority as countries assess the real-world side effects of the first shots to gain approval.


    Norwegian officials said 23 people had died in the country a short time after receiving their first dose of the vaccine. Of those deaths, 13 have so far been autopsied, with the results suggesting that common side effects may have contributed to severe reactions in frail, elderly people, according to the Norwegian Medicines Agency.

    U.S. potentially facing ‘perpetual infection’ of Covid in spring as new variants spread, warns Dr. Scott Gottlieb


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    Dr. Scott Gottlieb emphasized the importance of getting as many people vaccinated as possible, and warned of a potentially dire spring and summer without protective immunity as new Covid variants appear across the globe.


    "If we can't get more protective immunity into the population, we could be facing a situation where we have, sort of, a perpetual infection heading into the spring and summer as these variants get a foothold here," said the former FDA chief in the Trump administration in an interview on CNBC's "The News with Shepard Smith" on Thursday evening.


    Without approval of early outpatient treatment the death toll will be enormous rivaling the second wave of the spanish flu pandemic.


    Treat early, treat often and treat all

    COVID’s toll on smell and taste: what scientists do and don’t know


    https://www.nature.com/articles/d41586-021-00055-6


    How many people with COVID-19 lose their sense of smell?

    The exact percentage varies between studies, but most suggest that smell loss is a common symptom.


    One review published last June1 compiled data from 8,438 people with COVID-19, and found that 41% had reported experiencing smell loss. In another study, published in August2, a team led by researcher Shima T. Moein at the Institute for Research in Fundamental Sciences in Tehran, Iran, administered a smell-identification test to 100 people with COVID-19 in which the subjects sniffed odours and identified them on a multiple-choice basis. Ninety-six per cent of the participants had some olfactory dysfunction, and 18% had total smell loss (otherwise known as anosmia).


    Anosmia is a common symptom in the northern hemisphere during flu and cold season, it's usually treated with zinc and vitamin B1 by most primary care doctors. Why now that covid has the same symptom have medicine think it needs to be treated differently?


    Treat early, treat often and treat all

    Headline should read without early treatment....


    Surgeon: Post-COVID lungs ‘look worse’ than any awful smokers’ lungs


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    A trauma surgeon says X-rays from her COVID-19 patients often come back with scarring and that they “look worse than any type of terrible smoker’s lung.”


    Dr. Brittany Bankhead-Kendall, an assistant professor of surgery with Texas Tech University, recently tweeted, “I don’t know who needs to hear this, but ‘post-Covid’ lungs look worse than ANY type of terrible smoker’s lungs we’ve ever seen.”


    Treat early, treat often and treat all

    Researchers test common drugs in quest for treatments for early COVID-19


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    A little-noticed group of medical researchers is racing to find treatments for COVID-19 in its early stages, hoping to keep infected people out of the hospital with everyday medications like antidepressants or vitamins.


    Instead of seeking new drugs, the researchers are pulling common generics off pharmacy shelves, and even eyeing the nutritional-supplement aisles, in search of agents with proven safety and, perhaps, hidden superpowers.


    And they’re pioneering a new approach to medical research — mail-order clinical trials, in which patients can take the medication and monitor its effects without leaving home.

    SIU researchers discover new COVID-19 variant


    https://news.google.com/articl…=en-US&gl=US&ceid=US%3Aen


    It’s here. We found it,” Gagnon said in a press release. “It’s definitely home-grown and widespread, and we’re the first to characterize it.”


    The team’s work traced the earliest appearance of the U.S. variant to Texas in May. Since then, Gagnon said the variant has acquired two new mutations.


    “We predict that 20C-US may already be the most dominant variant of SARS-CoV-2 in the U.S.,” said Gagnon in an article on the discovery titled, “Emergence and Evolution of a Prevalent New SARS-CoV-2 Variant in the United States.”


    Gagnon’s research looked at genomic surveillance of the virus as it works its way through a population. A press release from SIU says this type of research can lead to the early identification of new variants and help health authorities formulate appropriate responses.