Fm1 Member
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Posts by Fm1

    Are the ‘Vulnerable’ and Aboriginals in Australia to be Rounded up in COVID-19 Quarantine Camps?


    Are the ‘Vulnerable’ and Aboriginals in Australia to be Rounded up in COVID-19 Quarantine Camps?
    With the advent of the new Omicron variant of the coronavirus, additional travel restrictions are being imposed. Travel has been banned
    trialsitenews.com



    With the advent of the new Omicron variant of the coronavirus, additional travel restrictions are being imposed. Travel has been banned from some African countries to Europe and the United States. Some countries may begin to overreact to not only the new variant but the current state of the pandemic. One of those countries may be Australia, which has seemingly imposed Chinese-style authoritarian measures across select states. Reports of Aboriginals rounded up and placed in military guarded quarantine camps raised considerable alarms based on past injustices to this vulnerable population.


    Are Reports of COVID-19-Positive Camps Authentic?

    Several news outlets, including Zerohedge.com, are reporting the Australian Defense Force is now physically transferring non vaccinated indigenous people in Northern Australia to a quarantine center located in Howard Springs. Could this be the case? If so, the rounding up of anyone, let alone indigenous Aboriginal Australians seems like a completely unethical if not illegal action for this modern age.


    Themanews.com is reporting the move to force residents to quarantine camps comes after “hard lockdowns” in the towns of Binjari and Rockhole didn’t stop the spread of the virus. The residents being forced into quarantine camps are already infected with covid; however, according to the article, more residents may be transferred who are not infected but have been identified as “close contacts”.


    But Australian Broadcasting Corporation (ABC News) doesn’t appear to be as alarmed as other news outlets. ABC is reporting Australian troops are being brought into the territories simply to help boost covid testing numbers because of a growing outbreak. The article repeats the fact that the outbreak is among aboriginal people. But ABC News says the troops are there in a “supporting role” to Northern Territory police.



    According to a InDaily report, South Australia state health officials are on the record defending the rapid set up of COVID quarantine camps to “house hundreds in Renmark, Port Augusta, Port Lincoln and M. Gambier,” yet are silent on details from location and cost to staffing.


    The Australian media discovered that this particular Australian state had issued a tender—a request for interest to manage 100-resident quarantine facilities in four regions to concerns of vulnerable and Indigenous people who will be “unable to quarantine at home during a COVID-19 outbreak.”


    Apparently, the document indicates a rush job—”mandatory criteria for the successful tenderer would be an “ability to mobilize on or before December 10, 2021.” It would appear that this particular state government is planning for what could be a forced quarantine from November 30 to June 30.


    A FactCheck organization, however, denies these claims. The Poynter Institute’s PolitiFact did acknowledge that the State of Queensland is building a quarantine facility for arriving travelers, whether vaccinated or not, that state authorities plan to use for fully vaccinated students upon their arrival in the country, as well as possible use for unvaccinated travelers.


    Moreover, leaving the door open, the fact-checker declared, “in the future, the Australian government might impose different quarantine requirements on vaccinated and unvaccinated travelers, but unvaccinated people living in the country would not be put in camps.” This contradicts to an extent the aforementioned claims. However, TrialSite suggests that if these fact-checkers are admitting to the camps, they are most certainly representative of an ominous movement in what has been one of the world’s most open, democratic of nations—that is, until COVID-19.


    Just as concerning, at one point, America was contemplating militarized camps. TrialSite sought out the point of view of the USA Today Fact Check operation to elicit their point of view. According to that account, the Department of Defense was considering military facilities for quarantine use, but several people on social media took great liberty to apply all sorts of conspiracy theories.


    But around the world, it would appear authoritarian and even totalitarian-like impulses manifest based on visceral, fear-based responses to the pandemic. TrialSite has reported on violence in Europe because of COVID-19 lockdowns. Now there are reports of possible forced internment in Australia. Even though this is among “indigenous people,” what will happen if forced quarantine spreads to the general population? Considering past injustices to Australia’s first peoples, we here at TrialSite cannot help but raise concern. COVID-19-based protests, some leading to violence, have spread even to small islands in the French Caribbean. Will the violence in Europe spread to other continents


    Australian army transfers contact cases to quarantine camp - RT en français
    38 residents of an indigenous community in contact with nine people who tested positive for Covid-19 were taken on November 21 to the Howard Springs
    newsnetdaily.com

    Merck and Ridgeback Report Full Phase 3 Analysis for Oral Antiviral COVID Pill; Efficacy Plunges from Interim Analysis


    Merck and Ridgeback Report Full Phase 3 Analysis for Oral Antiviral COVID Pill; Efficacy Plunges from Interim Analysis
    Merck and Ridgeback Biotherapeutics provided an update on the MOVe-OUT study of molnupiravir (MK-4482, EIDD-2801), an oral antiviral medicine for
    trialsitenews.com


    Merck and Ridgeback Biotherapeutics provided an update on the MOVe-OUT study of molnupiravir (MK-4482, EIDD-2801), an oral antiviral medicine for COVID-19. The full data show molnupiravir reduced the risk of hospitalization or death for patients with mild or moderate COVID-19 by about 30%, based on a study of more than 1,400 adults. Last month, an interim analysis showed about 50% efficacy, based on data from 775 patients.


    The final analysis is from all enrolled patients (n=1,433). In this study population, molnupiravir reduced the risk of hospitalization or death from 9.7% in the placebo group (68/699) to 6.8% (48/709) in the molnupiravir group, for an absolute risk reduction of 3.0% and a relative risk reduction of 30%. Nine deaths were reported in the placebo group, and one in the molnupiravir group. In October, the companies submitted an Emergency Use Authorization application to the FDA based on interim data from the MOVe-OUT study. At the planned interim analysis, molnupiravir significantly reduced the risk of hospitalization or death from 14.1% (53/377) in the placebo group to 7.3% (28/385) in the molnupiravir, for a relative risk reduction of 48%.


    The MOVe-OUT trial is a global Phase 3, randomized, placebo-controlled, double-blind, multi-site study of non-hospitalized adult patients with laboratory-confirmed mild-to-moderate COVID-19. Patients enrolled in the study were unvaccinated against SARS-CoV-2, had at least one risk factor associated with poor disease outcomes, and symptom onset within five days prior to randomization. The primary efficacy objective of MOVe-OUT was to evaluate the efficacy of molnupiravir compared to placebo as assessed by the percentage of participants who are hospitalized and/or die from the time of randomization through Day 29.


    About Molnupiravir

    Molnupiravir (MK-4482/EIDD-2801) is an orally administered form of a potent ribonucleoside analog that inhibits the replication of SARS-CoV-2, the causative agent of COVID-19. Molnupiravir has been shown to be active in several preclinical models of SARS-CoV-2, including for prophylaxis, treatment, and prevention of transmission. Additionally, pre-clinical and clinical data have shown molnupiravir to be active against the most common SARS-CoV-2 variants


    Merck and Ridgeback Biotherapeutics Provide Update on Results from MOVe-OUT Study of Molnupiravir, an Investigational Oral Antiviral Medicine, in At Risk Adults With Mild-to-Moderate COVID-19 - Merck.com
    Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Ridgeback Biotherapeutics today provided an update on the MOVe-OUT study of…
    www.merck.com

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    Delta is on its way to extinction!


    Biological Significance of the Genomic Variation and Structural Dynamics of SARS-CoV-2 B.1.617


    Biological Significance of the Genomic Variation and Structural Dynamics of SARS-CoV-2 B.1.617
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been emerging and circulating globally since the start of the COVID-19 pandemic, of…
    www.ncbi.nlm.nih.gov


    Meanwhile 22 positively selected sites were found in nine different proteins, with 14 (63.6%) sites distributed in the structural proteins, of which nine (41%) were located in the S protein. Additionally, six of these 22 sites were led by C-to-U transition (R134N in nsp10, A394V in nsp14, A222V and H1101D/Y in S, and P13T and T135I in N). As C-to-U transition is a preferred direction of nucleotide mutations in SARS-CoV-2 (Matyasek and Kovarik, 2020; van Dorp et al., 2020), we should pay more attention on the 16 positive selection sites that were mutations of other directions than C to U. Notably, seven sites, of which four (57%) were located in the S protein, were identified under strong positive selection (Table 1). No positive selection sites were found localized in the RBD.


    Delta Variant May Have "Mutated Itself Into Extinction" In Japan, Suggest Researchers

    Delta Variant May Have 'Mutated Itself Into Extinction' In Japan, Suggest Researchers
    In July, Japan was hit by its largest COVID-19 wave yet. Driven by the introduction of the more infectious Delta variant, cases surged to a record of nearl
    www.iflscience.com



    They found multiple genetic changes at a site within nsp14, called A394V. These mutations appear to contribute to a crippled virus that is unable to replicate, which could explain how the Delta variant simply vanished from Japan in a matter of months.

    Don't hold your breath on a study on Vaxer pregnancy for quite awhile. As of ten days ago the trials for ivermectin were only half enrolled here in the US. No rush to get real data or save lives! Jab jab jab till the bank vault is full!!!

    More Nursing Home Troubles in UK—Reports that Elderly are Left to Die


    More Nursing Home Troubles in UK—Reports that Elderly are Left to Die
    Reports of gross negligence in long -term care facilities (nursing homes) or worse—criminal conduct — on both sides of the Atlantic during the pandemic
    trialsitenews.com


    Reports of gross negligence in long -term care facilities (nursing homes) or worse—criminal conduct — on both sides of the Atlantic during the pandemic have raised alarm as to the safety of the elderly in both the United Kingdom (UK) as well as in North America. Recently in the UK the Commissioner for Older People called out for a public inquiry into how Northern Ireland overall has managed the care of the elderly in nursing homes during the pandemic. Troubling, Eddie Lynch, the Commissioner for Older People raised concerns of “disturbing” reports including “Do not resuscitate” (DNR) notices assigned to some elderly residents without any notice to them or their families. Whether in Northern Ireland or other parts of the UK to America and Canada, the elderly have been routinely exposed to gross negligence or even criminal neglect during this pandemic. Investigations must follow.


    In a recent entry in News Letter by Phillip Bradfield follows the truly troubling reports that the Commission now seeks an investigation into allegations that some of the deaths during the pandemic were associated with DNRs leading to the withholding of life saving treatments, unbeknownst to the senior resident nor their family members.


    Commissioner Lynch declared recently:


    “There has been a huge number of excess deaths in care homes with latest figures from the Northern Ireland Statistics and Research Agency revealing that the deaths of care home residents account for 30% [over 1000 deaths] of all COVID related deaths. COVID has impacted us all, but older people, and particularly care home residents, those impacts have been exceptionally arduous. Over the past year we witnessed the incorrect recording of care home deaths, families having no access to loved ones, personal protective equipment (PPE) supply problems, inappropriate use of do not attempt to resuscitation orders, the slow introduction of testing, the transfer of COVID-positive patients into care homes—the list goes on.”



    Bradfield notes that the Prime Minister’s UK-wide public inquiry looks across UK agencies’ particular attention and centers on Northern Ireland’s executive to accelerate an investigation into truly troubling reports. The Commissioner reminds all that “Families deserve an answer on why deaths in care homes were so extensive and why care home residents were disproportionately affected by this pandemic.”


    Problems Across the Atlantic

    TrialSite has chronicled the horrific track record of nursing homes in North America. Both in the United States and Canada nursing homes have been epicenters of pandemic death. By last June the New York Times reported that at least 33% of the pandemic deaths by that point occurred in long term care facilities.


    The Centers for Disease Control and Prevention (CDC) track data associated with nursing homes. If this data is accurate the graph clearly indicates huge numbers of cases until the start of the year potentially implicating the positive impacts of better infectious disease management as well as vaccination on the situation. See the graph


    Recently a group of researchers affiliated with Harvard University, UCLA and University of Minnesota reported that federal NHSN data understates the total number of COVID-19 cases and deaths in nursing homes.


    In September New York Times reported that aids to former Gov. Andrew Cuomo deliberate obscured the full scope of fatality in the Empire State’s nursing homes. Already reports from New York State Attorney General Laticia James reveal a scandal—from undercounted COVID-19 deaths to disastrous pandemic management in many of the state’s nursing homes. More reports are expected including inquiries into Mr. Cuomo’s activities.


    Earlier in the year a report came out by the Canadian Institute for Health Information (CIHI) which found that supports some estimates that 69% of Canada’s COVID-19 fatalities occurred in nursing homes. The elderly, a highly vulnerable population, must be treated with dignity and respect. They paid into the system and deserved the best care and treatment during the pandemic. Our healthcare system failed them. Real investigations with sharp consequences must follow any wrongdoing


    Public Inquiry call on Covid in care homes and DNR notices
    The Commissioner for Older People has called for a public enquiry into NI’s handling of care home residents in the pandemic, describing as “disturbing” the…
    www.newsletter.co.uk

    Antibodies mimicking the virus may explain long haul COVID-19, rare vaccine side effects


    Antibodies mimicking the virus may explain long haul COVID-19, rare vaccine side effects
    With around 256 million cases and more than 5 million deaths worldwide, the COVID-19 pandemic has challenged scientists and those in the medical field.…
    medicalxpress.com


    With around 256 million cases and more than 5 million deaths worldwide, the COVID-19 pandemic has challenged scientists and those in the medical field. Researchers are working to find effective vaccines and therapies, as well as understand the long-term effects of the infection.

    While the vaccines have been critical in pandemic control, researchers are still learning how and how well they work. This is especially true with the emergence of new viral variants and the rare vaccine side effects like allergic reactions, heart inflammation (myocarditis) and blood-clotting (thrombosis).


    Critical questions about the infection itself also remain. Approximately one in four COVID-19 patients have lingering symptoms, even after recovering from the virus. These symptoms, known as "long COVID," and the vaccines' off-target side effects are thought to be due to a patient's immune response.


    In an article published today in The New England Journal of Medicine, the UC Davis Vice Chair of Research and Distinguished Professor of Dermatology and Internal Medicine William Murphy and Professor of Medicine at Harvard Medical School Dan Longo present a possible explanation to the diverse immune responses to the virus and the vaccines.


    Antibodies mimicking the virus


    Drawing upon classic immunological concepts, Murphy and Longo suggest that the Network Hypothesis by Nobel Laureate Niels Jerne might offer insights.


    Jerne's hypothesis details a means for the immune system to regulate antibodies. It describes a cascade in which the immune system initially launches protective antibody responses to an antigen (like a virus). These same protective antibodies later can trigger a new antibody response toward themselves, leading to their disappearance over time.


    These secondary antibodies, called anti-idiotype antibodies, can bind to and deplete the initial protective antibody responses. They have the potential to mirror or act like the original antigen itself. This may result in adverse effects.


    Coronavirus and the immune system


    When SARS-CoV-2, the virus causing COVID-19, enters the body, its spike protein binds with the ACE2 receptor, gaining entry to the cell. The immune system responds by producing protective antibodies that bind to the invading virus, blocking or neutralizing its effects.

    As a form of down-regulation, these protective antibodies can also cause immune responses with anti-idiotype antibodies. Over time, these anti-idiotype responses can clear the initial protective antibodies and potentially result in limited efficacy of antibody-based therapies.


    "A fascinating aspect of the newly formed anti-idiotype antibodies is that some of their structures can be a mirror image of the original antigen and act like it in binding to the same receptors that the viral antigen binds. This binding can potentially lead to unwanted actions and pathology, particularly in the long term," Murphy said.


    The authors suggest that the anti-idiotype antibodies can potentially target the same ACE2 receptors. In blocking or triggering these receptors, they could affect various normal ACE2 functions.


    "Given the critical functions and wide distribution of ACE2 receptors on numerous cell types, it would be important to determine if these regulatory immune responses could be responsible for some of the off-target or long-lasting effects being reported," Murphy commented. "These responses may also explain why such long-term effects can occur long after the viral infection has passed."


    As for COVID-19 vaccines, the primary antigen used is the SARS-CoV-2 spike protein. According to Murphy and Longo, current research studies on antibody responses to these vaccines mainly focus on the initial protective responses and virus-neutralizing efficacy, rather than other long-term aspects.


    "With the incredible impact of the pandemic and our reliance on vaccines as our primary weapon, there is an immense need for more basic science research to understand the complex immunological pathways at play. This need follows to what it takes to keep the protective responses going, as well as to the potential unwanted side effects of both the infection and the different SARS-CoV-2 vaccine types, especially as boosting is now applied," Murphy said. "The good news is that these are testable questions that can be partially addressed in the laboratory, and in fact, have been used with other viral models."

    A new variant of coronavirus can cause another wave of infections worldwide


    A new variant of coronavirus can cause another wave of infections worldwide
    Another variant of coronavirus has been identified, this time the particle named B.1.1.529 seems to have a dangerous potential to generate a new wave of
    trialsitenews.com


    Another variant of coronavirus has been identified, this time the particle named B.1.1.529 seems to have a dangerous potential to generate a new wave of infections not only in its place of origin, South Africa but worldwide. According to the bioinformatics Túlio de Oliveira, a professor who directs gene sequencing institutions in two South African universities, this variant, still unnamed proposed, as happened with the delta variant of coronavirus, accumulated a large number of mutations that had not yet been identified before. South Africa’s Health Minister Joe Phaahla was concerned about the future this discovery could bring. According to him, a new wave of cases of coronavirus, the fourth in the country, may not only remain restricted to the African continent but again break international barriers.


    Relationship between HIV and coronavirus

    Around 100 cases have been linked to the new variant B.1.1.529 in Africa, being predominantly located in South Africa according to Anne von Gottberg, a clinical microbiologist and head of the department of respiratory diseases of the National Institute of Communicable Diseases but also in Botswana as reported Kereng Masupu, coordinator of the Covid-19 Presidential Task Force. An important relationship has been proposed to better understand the appearance of cases of the new African variant of coronavirus. The continent is the region with the highest number of HIV infection cases worldwide with about 8.2 million cases. Chronically infected individuals progressively present immunosuppression states and it is precisely at this point that the relationship with coronavirus is established. The accumulation of mutations is more observed in patients chronically infected with coronavirus, with immunosuppressed populations such as those infected with the HIV most vulnerable to the permanence of SARS-CoV2, says François Balloux, director of the UCL Genetics Institute.


    Fourth wave on the way?

    A concern for the emergence of a fourth wave of infection on the African continent beckons closely with a key factor in the establishment, (or not) of new waves of coronavirus infections, vaccination. In contrast to countries on the European continent, which although it is presenting an increasing number of new cases of COVID-19 recently, already has on average 67% approximately 67% of people with a complete immunization scheme, either by Pfizer or Johnson & Johnson vaccines, South Africa has rates of 35% of fully vaccinated adults, with even worse numbers in other regions that reach 6.6% said the Director of the CDC of Africa, John Nkengasong. The sad reality becomes even more serious when revealed the reason behind the low rates, the lack of demand despite the supply of vaccines. Figures show 45% of doses delivered yet to be administered. The health department even asked Johnson and Johnson and Pfizer Inc. to postpone new deliveries due to the drop in demand.


    A high rate of new infections turns on red alert

    With the emergence of the new variant of coronavirus, local authorities are beginning to have premonitions of what may be to come, a new crisis in the public health sectors, especially in hospital admissions. In just a few days the number of cases of COVID-19 rose 6.5%, from just under 900 to almost 2,500 records of coronavirus infection in populous regions of South Africa. Another 2000 cases have been recorded in places such as Johannesburg and Pretoria. According to Professor Tulio, 75% of infections comprise genomes of the new viral variant and this number is expected to only increase, repeating last year’s crisis period

    Despite Controversy, Ivermectin Saves a Life


    Despite Controversy, Ivermectin Saves a Life
    In a follow up to a story TrialSite first ran on November 15, a Chicago area judge “stood up” to Edward Hospital and ordered the medical institution to
    trialsitenews.com



    In a follow up to a story TrialSite first ran on November 15, a Chicago area judge “stood up” to Edward Hospital and ordered the medical institution to administer ivermectin to a “dying man.”


    “What’s the downside?’, asked Circuit Judge Paul Fullerton, according to an article in Substack. As reported in the article, Sun Ng, a retired contractor from Hong Kong traveled to Illinois to be with his family. Unfortunately, Ng contracted covid and was admitted to a hospital. After a few days in the hospital Ng was put on a respirator and had a 50% of dying.


    Ng’s daughter, Man Kwan Ng, who says she has a doctorate in Mechanical Engineering did research into ivermectin and concluded the hospital should administer the drug to her father. After the hospital’s refusal Man Kwan Ng sued. When the case was brought before Judge Fullerton, Edward Hospital insisted if ivermectin were administered “there could be side effects as well as ordering ivermectin would violate its (hospital) policies and forcing the issue would be ‘extraordinary’ judicial overreach.” Fullerton disagreed and insisted Edward Hospital let Dr. Alan Bain. Bain has been a proponent of ivermectin’s use to combat covid. Judge Fullerton pointed out since Sun Ng is basically “on his deathbed” the risk of administering ivermectin would be “minimal”.


    As pointed out in the TrialSite article, Dr. Bain is unvaccinated. Edward Hospital, citing the Illinois state rule against unvaccinated health care workers being allowed in the hospital and wouldn’t let Bain in to administer the drug. Judge Fullerton pointed out an exemption in the Illinois law allowing health care workers into the hospital if they test negative for covid. Bain was allowed in.



    TrialSite has done extensive coverage of lawsuits regarding the use of ivermectin in hospitals. Attorney Ralph Lorigo had been a leading advocate for patient’s rights and fighting for those infected with covid to gain access to ivermectin.


    As the Chicago Tribune https://www.chicagotribune.com…zil4q5g2mfjglq-story.html points out lawsuits over ivermectin have become common even though many hospitals say it doesn’t work against covid. As the article says curt decisions on ivermectin have varied.


    After Edward Hospital allowed Bain to administer a five-day course of ivermectin to Sun Ng, he was removed from a ventilator and left the ICU on November 16. The Daily Herald, a suburban Chicago paper also reported that Ng was better after being treated with ivermectin for 5 days. However, Edward Hospital claims Ng was recovering before the controversial drug was administered. Given the success ivermectin has had in treating covid it is puzzling the effectiveness of the drug has been delegitimized. Ivermectin is continually referred to as a “animal drug” and “horse de-wormer.” This has led to a political divide over its usage. When will politics be put aside for a drug that can possibly save lives


    Judge rules unvaccinated doctor can treat COVID-19 patient with ivermectin at Edward Hospital in Naperville
    A 71-year-old man, who came to the U.S. from Hong Kong to celebrate his granddaughter’s first birthday, contracted a severe case of COVID-19.
    www.chicagotribune.com


    https://pantagraph.com/lifestyles/health-med-fit/judge-rules-illinois-doctor-can-treat-covid-19-patient-with-ivermectin/article_f3cd50cc-ab04-592a-a17b-37ecf8678b27.html

    not much to talk about as no research to a cause and effect will be released "locked away" but from what I am aware of this is a radio runaway from med change.. I wish I could be more specific but you know its pointless without proof. hidden like most info needed is.

    Lots of research but nobody cares or like Huxley, don't believe. Remember the world experienced a flu pandemic from 1857-1859 and it was stop dead in its tracks 2 days after the Carrington Event


    Influence of Solar Minimum on Cosmic Ray Flux, Mutations in viruses and Pandemics Like COVID-19


    Is the 2019 novel coronavirus related to a spike of cosmic rays?
    WHO's pronouncement of the 2019 novel coronavirus outbreak as a pandemic disease came months after we published a warning that the present deepest minimum of…
    www.ncbi.nlm.nih.gov


    On The Occurrence of Historical Pandemics During The Grand Solar Minima | European Journal of Applied Physics


    What sunspots are whispering about covid-19? - PubMed
    Several studies point to the antimicrobial effects of ELF electromagnetic fields. Such fields have accompanied life from the very beginning, and it is possible…
    pubmed.ncbi.nlm.nih.gov


    Revealing the relationship between solar activity and COVID-19 and forecasting of possible future viruses using multi-step autoregression (MSAR)
    The number of sunspots shows the solar activity level. During the high solar activity, emissions of matter and electromagnetic fields from the Sun make it…
    www.ncbi.nlm.nih.gov

    No relationship between solar activity and virus mutation rate. That is kooky.


    Solar flares do alter background solar radiation but that is only one (tiny) component of what can mutate viruses. With an RNA virus in particular the main component is imperfect replication.

    Read Hope Simpson

    Silicon Valley Knowledge Workers Sign Manifesto Against Widened COVID Vaccine Mandate

    Silicon Valley Knowledge Workers Sign Manifesto Against Widened COVID Vaccine Mandate
    Several hundred Google employees have signed and circulated a manifesto opposing the company’s Covid vaccine mandate, posing the latest challenge for
    trialsitenews.com


    Several hundred Google employees have signed and circulated a manifesto opposing the company’s Covid vaccine mandate, posing the latest challenge for leadership as it approaches key deadlines for returning workers to offices in person.


    The Biden administration has ordered U.S. companies with 100 or more workers to ensure their employees are fully vaccinated or regularly tested for Covid-19 by Jan. 4. In response, Google asked its more than 150,000 employees to upload their vaccination status to its internal systems by Dec. 3, whether they plan to come into the office or not, according to internal documents viewed by CNBC.


    The Manifesto

    The manifesto within Google, which has been signed by at least 600 Google employees, asks company leaders to retract the vaccine mandate and create a new one that is “inclusive of all Googlers,” arguing leadership’s decision will have outside influence in corporate America. It also calls on employees to “oppose the mandate as a matter of principle” and tells employees to not let the policy alter their decision if they’ve already chosen not to get the Covid vaccine.


    The company has also said that all employees who work directly or indirectly with government contracts must be vaccinated — even if they are working from home


    Several hundred Google employees sign manifesto against widened Covid vaccine mandate
    Google employees are circulating a manifesto opposing a widened Covid vaccine mandate as a return-to-work deadline nears.
    www.cnbc.com

    I guess you mean you or may be your fellows. I know nobody that takes flue vaccines...Strange people...


    These folks ignore reality. FM/R/J/B governments run a private company for their buddies profits. How can you believe that the state works for the public ?? This only happens under pressure. But now we have a Covid totalitarian state that ignores all your rights and benefits. That is what I say since one year. You/we are just cattle!

    You have it backwards, they are giving you present day reality and asking that governments be more transparent with the public on how they spend mine and your money. In other words, they agree with you, just more in a politically correct way.

    While breakthrough infections seem the norm, reinfection from previous infection IS rare!!!


    Reinfection from Covid-19 is rare, severe disease is even rarer, a study of people in Qatar finds


    https://www.nejm.org/doi/full/10.1056/NEJMc2108120


    Qatar had a first wave of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from March through June 2020, after which approximately 40% of the population had detectable antibodies against SARS-CoV-2. The country subsequently had two back-to-back waves from January through May 2021, triggered by the introduction of the B.1.1.7 (or alpha) and B.1.351 (or beta) variants.1 This created an epidemiologic opportunity to assess reinfections.


    Using national, federated databases that have captured all SARS-CoV-2–related data since the onset of the pandemic (Section S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org), we investigated the risk of severe disease (leading to acute care hospitalization), critical disease (leading to hospitalization in an intensive care unit [ICU]), and fatal disease caused by reinfections as compared with primary infections in the national cohort of 353,326 persons with polymerase-chain-reaction (PCR)–confirmed infection between February 28, 2020, and April 28, 2021, after exclusion of 87,547 persons with a vaccination record. Primary infection was defined as the first PCR-positive swab. Reinfection was defined as the first PCR-positive swab obtained at least 90 days after the primary infection. Persons with reinfection were matched to those with primary infection in a 1:5 ratio according to sex, 5-year age group, nationality, and calendar week of the PCR test date (Fig. S1 and Table S1 in the Supplementary Appendix). Classification of severe, critical, and fatal Covid-19 followed World Health Organization guidelines, and assessments were made by trained medical personnel through individual chart reviews.

    Of 1304 identified reinfections, 413 (31.7%) were caused by the B.1.351 variant, 57 (4.4%) by the B.1.1.7 variant, 213 (16.3%) by “wild-type” virus, and 621 (47.6%) were of unknown status (Section S1 in the Supplementary Appendix). For reinfected persons, the median time between first infection and reinfection was 277 days (interquartile range, 179 to 315). The odds of severe disease at reinfection were 0.12 times (95% confidence interval [CI], 0.03 to 0.31) that at primary infection (Table 1). There were no cases of critical disease at reinfection and 28 cases at primary infection (Table S3), for an odds ratio of 0.00 (95% CI, 0.00 to 0.64). There were no cases of death from Covid-19 at reinfection and 7 cases at primary infection, resulting in an odds ratio of 0.00 (95% CI, 0.00 to 2.57). The odds of the composite outcome of severe, critical, or fatal disease at reinfection were 0.10 times (95% CI, 0.03 to 0.25) that at primary infection. Sensitivity analyses were consistent with these results (Table S2).


    Reinfections had 90% lower odds of resulting in hospitalization or death than primary infections. Four reinfections were severe enough to lead to acute care hospitalization. None led to hospitalization in an ICU, and none ended in death. Reinfections were rare and were generally mild, perhaps because of the primed immune system after primary infection.


    In earlier studies, we assessed the efficacy of previous natural infection as protection against reinfection with SARS-CoV-22,3 as being 85% or greater. Accordingly, for a person who has already had a primary infection, the risk of having a severe reinfection is only approximately 1% of the risk of a previously uninfected person having a severe primary infection. It needs to be determined whether such protection against severe disease at reinfection lasts for a longer period, analogous to the immunity that develops against other seasonal “common-cold” coronaviruses,4 which elicit short-term immunity against mild reinfection but longer-term immunity against more severe illness with reinfection. If this were the case with SARS-CoV-2, the virus (or at least the variants studied to date) could adopt a more benign pattern of infection when it becomes endemic.4


    Laith J. Abu-Raddad, Ph.D.

    Hiam Chemaitelly, M.Sc.

    Weill Cornell Medicine–Qatar, Doha, Qatar

    [email protected]


    Roberto Bertollini, M.D., M.P.H.

    Ministry of Public Health, Doha, Qatar


    for the National Study Group for COVID-19 Epidemiology


    Supported by the Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core at Weill Cornell Medicine–Qatar; the Ministry of Public Health; Hamad Medical Corporation; and Sidra Medicine. The Qatar Genome Program supported the viral genome sequencing.


    Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.


    This letter was published on November 24, 2021, at NEJM.org.


    Members of the National Study Group for COVID-19 Epidemiology are listed in the Supplementary Appendix, available with the full text of this letter at NEJM.org.

    Authors Argue COVID-19 Vaccine Makers Must Share Pricing for Public Good


    Authors Argue COVID-19 Vaccine Makers Must Share Pricing for Public Good
    An American Osteopath as well as a Canadian public health researcher recently secured a publishing slot in the Journal of the Royal Society of Medicine
    trialsitenews.com


    An American Osteopath as well as a Canadian public health researcher recently secured a publishing slot in the Journal of the Royal Society of Medicine making the case for more cost transparency with the COVID-19 vaccines. The paper correlates pharmaceutical pricing to real-world vaccine inequity. Their core driving principle: a vaccine with high costs is essentially the equivalent to no viable vaccine for a great number of low-and-middle-income (LMICs). The authors propose that these vaccines should be a “public good” given the globally integrated, public nature of the pandemic not to mention the extensive public underwriting. Reports that Pfizer could generate $100 billion in the first two years of monetization clearly indicate not only windfall profits but also ethical, moral, and even legal implications. Enforcing secrecy can reinforce a lack of trust. Does the overall public health benefit?


    The authors argue that governments shouldn’t stand for vaccine producer secrecy—particularly in cost. Already inequality of access grows, and reinforced secrecy worsens the situation.


    Donald Wright with the School of Osteopathic Medicine, Rowan University in New Jersey and Joe Lexchin, Faculty of Health, York University in Toronto wrote:


    “Governments must stop being partners in secrecy, and as purchasers, they should demand public, verifiable reports on net costs, after direct and indirect taxpayers’ subsidies, in order to set globally affordable cost-plus prices for these global public health goods. Until that happens, the question will be raised about whether both governments and companies are committing ‘crimes against humanity.’


    Lead Research/Investigator

    Donald Wright, PhD, School of Osteopathic Medicine, Rowan University


    Joe Lexchin, MD, MS, Faculty of Health, York University in Toronto


    Call to Action: TrialSite Community—what do you think?


    SAGE Journals: Your gateway to world-class research journals
    Subscription and open access journals from SAGE Publishing, the world's leading independent academic publisher.
    journals.sagepub.com

    Growth, reproduction numbers and factors affecting the spread of SARS-CoV-2 novel variants of concern in the UK from October 2020 to July 2021: a modelling analysis


    Growth, reproduction numbers and factors affecting the spread of SARS-CoV-2 novel variants of concern in the UK from October 2020 to July 2021: a modelling analysis
    Objectives Importations of novel variants of concern (VOC), particularly B.1.617.2, have become the impetus behind recent outbreaks of SARS-CoV-2. Concerns…
    bmjopen.bmj.com


    Abstract

    Objectives Importations of novel variants of concern (VOC), particularly B.1.617.2, have become the impetus behind recent outbreaks of SARS-CoV-2. Concerns around the impact on vaccine effectiveness, transmissibility and severity are now driving the public health response to these variants. This paper analyses the patterns of growth in hospitalisations and confirmed cases for novel VOCs by age groups, geography and ethnicity in the context of changing behaviour, non-pharmaceutical interventions (NPIs) and the UK vaccination programme. We seek to highlight where strategies have been effective and periods that have facilitated the establishment of new variants.


    Design We have algorithmically linked the most complete testing and hospitalisation data in England to create a data set of confirmed infections and hospitalisations by SARS-CoV-2 genomic variant. We have used these linked data sets to analyse temporal, geographic and demographic distinctions.


    Setting and participants The setting is England from October 2020 to July 2021. Participants included all COVID-19 tests that included RT-PCR CT gene target data or underwent sequencing and hospitalisations that could be linked to these tests.


    Methods To calculate the instantaneous growth rate for VOCs we have developed a generalised additive model fit to multiple splines and varying day of the week effects. We have further modelled the instantaneous reproduction number Rt for the B.1.1.7 and B.1.617.2 variants and included a doubly interval censored model to temporally adjust the confirmed variant cases.


    Results We observed a clear replacement of the predominant B.1.1.7 by the B.1.617.2 variant without observing sustained exponential growth in other novel variants. Modelled exponential growth of RT PCR gene target triple-positive cases was initially detected in the youngest age groups, although we now observe across all ages a very small doubling time of 10.7 (95% CI 9.1 to 13.2) days and 8 (95% CI 6.9 to 9.1) days for cases and hospitalisations, respectively. We observe that growth in RT PCR gene target triple-positive cases was first detected in the Indian ethnicity group in late February, with a peak of 0.06 (95% CI 0.07 to 0.05) in the instantaneous growth rate, but is now maintained by the white ethnicity groups, observing a doubling time of 6.8 (95% CI 4.9 to 11) days. Rt analysis indicates a reproduction number advantage of 0.45 for B.1.617.2 relative to B.1.1.7, with the Rt value peaking at 1.85 for B.1.617.2.


    Conclusions Our results illustrate a clear transmission advantage for the B.1.617.2 variant and the growth in hospitalisations illustrates that this variant is able to maintain exponential growth within age groups that are largely doubly vaccinated. There are concerning signs of intermittent growth in the B.1.351 variant, reaching a 28-day doubling time peak in March 2021, although this variant is presently not showing any evidence of a transmission advantage over B.1.617.2. Step 1b of the UK national lockdown easing was sufficient to precipitate exponential growth in B.1.617.2 cases for most regions and younger adult age groups. The final stages of NPI easing appeared to have a negligible impact on the growth of B.1.617.2 with every region experiencing sustained exponential growth from step 2. Nonetheless, early targeted local NPIs appeared to markedly reduced growth of B.1.617.2. Later localised interventions, at a time of higher prevalence and greater geographic dispersion of this variant, appeared to have a negligible impact on growth.

    Incorrect. It goes to midnight GMT, 11/23/2021.

    Well I guess this is just bluster to promote more jabs!


    Health minister suggests fourth vaccine dose amid rising fears of fifth COVID wave


    chrome-distiller://ac2295d2-c85f-49b2-bf60-6447370f2f96_f4a7892f9c0d9bafbb03fbcfb7299ed90ef642cc48e66532e58e2ada6428ebda/?title=Health+minister+suggests+fourth+vaccine+dose+amid+rising+fears+of+fifth+COVID+wave+%7C+The+Times+of+Israel&time=113858859&url=https%3A%2F%2Fwww.timesofisrael.com%2Fhealth-minister-suggests-fourth-vaccine-dose-amid-rising-fears-of-fifth-covid-wave%2F


    Health Minister Nitzan Horowitz said Wednesday that Israelis may need to get a fourth COVID-19 vaccine dose at some point if cases climb again, as the country’s top coronavirus official warned that the country may already be seeing the start of a fifth infection wave.


    “It’s not unreasonable [to think] we’ll need a fourth vaccine,” said Horowitz in an interview with Channel 12, after Health Ministry data indicated that 9 percent of the new cases diagnosed Tuesday had received the third booster dose.


    Most concerns, however, have revolved not around triply-vaccinated adults, but children who have yet to be vaccinated. Israel began giving shots to kids as young as 5 this week, amid signs pointing to increasing infection rates among kids.


    Some commentators have referred to the current rise in infections as the “children’s wave.”


    Coronavirus czar Salman Zarka, who is spearheading the national response to the pandemic, said he believes Israel is already in a new wave of infections.


    “We’re not in between waves, we’re at the start of a new wave,” Zarka told the Kan public broadcaster Wednesday.


    “When we thought about the fifth wave, we didn’t think about an increase in cases like this one. We thought about a new variant imported from abroad, about what’s happening now in Europe,” Zarka said. “The increase now is too early and too fast. I don’t want to call it the fifth wave, or a new wave at all.”


    There were 605 new infections on Tuesday, around 76% of which were unvaccinated people. It wasn’t clear if the 9% of people who were infected after receiving a booster shot caught the disease after the two weeks needed for the dose to fully take effect.

    Horowitz said he doesn’t think Israel is entering a new wave of infection, despite the rising number of cases.


    “If we are entering a fifth wave, our strategy is to vaccinate as many people as possible and live alongside COVID,” he said.


    Channel 12 reported that the campaign to vaccinate children was off to a slow start, with just four percent of parents setting up appointments.


    Ilana Gans, chief of staff of the public health services department at the Health Ministry, said Wednesday that around 30,000 young children in Israel are booked in to receive coronavirus vaccines. Some 1 million children are eligible for the shots.


    “There’s no reason to wait with the children’s vaccination. The virus doesn’t wait. It can be dangerous to children,” Horowitz said, citing the virus’s acute symptoms and potential long-term effects, including concentration problems, anxiety and breathing difficulties.

    Also known as the “R-number,” the figure represents the number of people each confirmed patient infects, on average. Any number over 1 signifies that case numbers are rising. The infection rate had been below 1 for two months before hitting that threshold several days ago.


    At a meeting of the coronavirus cabinet Tuesday, the first in some two months, Prime Minister Naftali Bennett reportedly warned of possible restrictions to stem COVID-19 infections during the upcoming Hanukkah holiday.


    As of Wednesday evening, there were 6,606 active cases, including 122 people in serious condition. There have been 14 fatalities in the past week, bringing the toll since the start of the pandemic to 8,180.