Apparently, for each muon (positive or negative) up to about 50 electron–positron pairs may be produced according to the energy-dissipation mechanism described here: https://www.researchgate.net/p…by_lepton_pair-production
The additional challenge is to slow down negative muons because they move at sub-light speed, meaning, with decay time taken into considerations, a very spacious reactor will be needed if not slowed down.
This seems to be possible using molecular protium (H2), with the additional advantage of emission of light due to scintillation.
I found this publication summary of which I have requested a copy since it may be interesting in the context of how to harvest the annihilation energy.