So expert THH has reasons why the experience with HIV is not applicable to SARS MERS?
what experts in coronavirus vaccine development (SARS,MERS, etc) have achieved and learnt, not HIV which is a different type of virus.
and also knowledge of the present efficacy of MERS SARS vaccines..
AFAIK there are none in the field.
THH might take some time to actually read the paper..before commenting on it..
and discover why the endocytosis mechanism is worthy inter alia of
the paper being accepted by Cambridge,org..
The SARS-CoV-2 spike is significantly different from any other SARS that we have studied (Lu et al, 2020)
. The additional charge it carries (SARS-CoV-2 S1, isoelectric point (pI) pI=8.24 versus human SARS-CoV S1, pI= 5.67)
will strongly improve the interactions with the receptor C-type lectin tail on CLEC4M/DC-SIGNR, which may, by itself,
mediate the endocytosis of pathogens by acting as an attachment receptor, as happens for a number of other highly
pathogenic viruses such as Ebolavirus, Marburg, HIV-1, Hepatitis C, Measles, human CytoMegalo Virus, Influenza
and others (Marzi et al., 2004; Uniprot – Q9N2X3; Uniprot – Q2NNX6).