Display MoreHere's another suggestion for prophylaxis, from a well-informed source.
1. Zinc plus ionophores can block replication of corona viruses (at least in vitro)
te Velthuis AJW, van den Worm SHE, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture. Plos Pathogens 2010; https://doi.org/10.1371/journa…1371/journal.ppat.1001176
2. Chloroquine is a ionophore, so its positive effects might in really be attributed to the weaponisation of zinc present in the patients, in this case administering zinc supplements could increase its effectiveness (and lack thereof might instead explain when it does not work)
Xue J, Moyer A, Peng B, Wu J, Hannafon BN, Ding WQ. Chloroquine Is a Zinc Ionophore. PLoS One. 2014; 9(10): e109180. doi: https://www.ncbi.nlm.nih.gov/p…1371/journal.pone.0109180
3. The effect of chloroquine reported by Prof. Raoult and other is consistent with the effects of zinc, i.e. a shorter infection period, even though there is no mention of zinc in his papers (I already sent a similar message to Prof Raoult): “A rapid fall of nasopharyngeal viral load tested by qPCR was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% patients at Day5. This allowed patients to rapidly de discharge from highly contagious wards with a mean length of stay of five days.”
https://www.mediterranee-infec…2020/03/COVID-IHU-2-1.pdf
4. chloroquine has side effects, while other ionophores like quercetin and epigallocatechin-gallate don’t
Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O'Sullivan CK, Fernández-Larrea JB. Zinc ionophore activity of quercetin Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem. 2014;62(32):8085-93. doi: 10.1021/jf5014633. https://www.ncbi.nlm.nih.gov/pubmed/25050823
5. Therefore this suggests a preventive treatment of 500mg quercetine and 25mg zinc (and more, up to 400mg, in case of infection) to the general population might reduce the symptoms and duration, thus flattening the curve, while having a low cost and no known side effects
Interestingly enough, the membrane protein ACE2, known as the main entry point of SARS-COV-2, is a Zn metalloprotein that acts as a ionophore of Zn itself, with quercetin and luteolin shown to bind to the exact same location on ACE2 as the spike protein of SARS-COV-2, with a better binding affinity than e.g. chloroquine. These flavonoids have also a much better safety profile than chloroquine, with a potentially harmful dose as much as 3-4 orders of magnitude higher than the assumed effective dose. I personally take a supplement of quercetin and luteolin since the beginning of February.