Building small reactors have pros and cons. If it is too small you can load only small amount of fuel. If fuel does not perform well you will be unable to measure it.
In other words smaller reactors require much more precise measurement and better knowledge of what is happening.
Reactor body must be designed accordingly to fuel amount. If there is too much fuel in small space you will see very big pressure changes. But pressure has direct impact on the operation. Big deflections are bad in Mizuno style reactor. If reactor is too big you need again more sensitive instruments.
In my opinion Rossi is clever and lucky man. From very cheap instruments he was able to find what is important. The most intriguing thing to me is how it was possible he found important principle of operation. Because he was really not scientist nor had a proper tools to do the research. I think the most important difference is that he was using bigger amount of Nickel where you can easily see if it works or not. I started in the very similar way without knowing anything about transition metals.
Because we have access to nearly anything it was very easy to start without any limitation. I think the biggest enemy in the LENR research is nothing else than YOU as scientist. And on the other hand big scientists can't really hold a proper tools and work manually. They are trying to do simple things in super expensive way which ruins their budget for another experiments. Or they even can't start.
For example thing that you can learn. Instead of very expensive vacuum pumps you can use cheap Lithium.