The Playground

Netherlands ?

activity ?

Quote from Seatrout

Netherlands ?

activity ?

Soon noman's land...

Quote from Wyttenbach

Soon noman's land...

was on live chat when things got odd,,

no point in repeating the chat, you never know who is talking but it was a bit concerning.

live chat area

Quote from JedRothwell

If people lost their jobs, surely they would tell the mass media! Why would they honor this sworn secret if they were no longer employed by the CDC, or no longer allowed to practice medicine? They would be strongly motivated to blow the whistle and reveal to the world what happened.

The whole notion that millions of professionals worldwide are engaged in a gigantic conspiracy, and that not a single one of them has betrayed the conspiracy, or accidentally admitted it, or boasted while drunk perhaps -- is ridiculous. Step back and think about it for a moment and you will see it is utterly crazy.

(As it happens, there have been no firings at the CDC. I know people who work there, and I would have heard if there was a purge. The people who screwed up the tests in 2020 are still there. Those problems were revealed to the public in excruciating detail. Such problems and mistakes are never covered up for long in a government research institute. There are too many reasons for people to reveal them, as there would be if there was even one tiny reason to think the mRNA vaccines have caused serious problems or fatalities.)

Every doctor in every hospital on earth knows that the vast majority of seriously ill COVID patients are not vaccinated. They all say that vaccinations reduce fatalities about 100 times. They urge people to get vaccinated. Last year my doctor was spending 30 minutes a day pleading with people to get vaccinated. He was mad as hell about having to do this. But you are saying that's not what is happening. You are saying that millions of doctors are taking part in a gigantic conspiracy and lying to everyone -- my doctor is lying to me, and all the others to their patients, to the press, to reporters . . . Why would doctors do that? Who, or what organization, could compel them? They are not docile people. They are not helpless, or used to following arbitrary orders. There is not enough money in the world to buy them all off, and make them betray their professional obligations in such a serious manner, they would lose their licenses if this were revealed.

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Jed. You're perhaps the only reasonable person on this site these days. I fear you're fighting a losing battle.

Re conspiracy theorists vs the rest:

Any medical establishment can get politicised, and all public official medical information will be partly political. Why? Because public health is a political matter, balancing individual and common goods.

The benefits of free access to raw information, in this context, is arguable. If all documents used for deliberation are open it greatly inhibits what can be discussed, partly because sound bites get repeated and amplified in a way that distorts meaning. God help us if scientists have to become politicians in what they say and write.

I have no idea whether CDC is (too) political. It is an easy accusation to make of any public health body where what they say influences behaviour and they know that. It also can happen easily.

As far as information goes: the relevant information exists internationally and can be published in many different places. No-one prevents genuine research that is well written (which means not claiming things for which you have no support, and referencing all the relevant background, not just little bits that support your thesis) from being published. Some countries have a more robust attitude towards publishing raw data than others, so the idea there could be an international conspiracy to hide the truth in significant ways is just batty. You can't control scientists worldwide - even in a few specific cases pressure from institutions might matter - and scientists cover all shades of opinion.

As others have said, a lot of this thread now seems to be unreasonable. If you start by assuming there is a systematic international conspiracy to suppress vital information (which is just not possible) you can end up with whatever weird unbalanced views you like.

Most of the chatter here is based on such a view.

It is a pity, because challenging established views is important, and established views are sometimes wrong. Luckily, there are many real scientists who challenge views, and talk about things, without the conspiratorial bias that you see in posts here. The real ones are honest about uncertainties, and say when something is possible but very low probability without implying that it should affect all of our decisions.

On the internet those real individual graduated statements just don't get traction - they are not as interesting to most as exaggerated alarmist views - and not suitable as public health messages which need to be simple and punchy minimising uncertainty.

Here is something for those who believe that Ivermectin research is being suppressed.

Twitter Suppresses Published Results of a Peer Reviewed Study | NextBigFuture.com

Quote from ZenoOfElea

Here is something for those who believe that Ivermectin research is being suppressed.

AS we now know the nice side of the US Oligarchs ass (Biden) did finance the Twitter censorship.

We also know that India did kick out all these asses and finally did dispense 100'000'000 doses of Ivermectin++. The success is overwhelming. Shortest Omicron wave. Least infections from Omicron. Everything is double blind verified by the "blindly USA following" state Kerala.

Only idiots die from CoV-19 or from a CoV-19 fake vaccine or let themselves treat in mafia hospital.

Learn to treat yourself!

Oral administration of S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and accelerates recovery from clinical aspects of COVID-19

Oral administration of S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and accelerates recovery from clinical aspects of COVID-19

In parallel with vaccination, oral antiviral agents are highly anticipated to act as countermeasures for the treatment of the coronavirus disease 2019…

www.biorxiv.org

Abstract

In parallel with vaccination, oral antiviral agents are highly anticipated to act as countermeasures for the treatment of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Oral antiviral medication demands not only high antiviral activity but also target specificity, favorable oral bioavailability, and high metabolic stability. Although a large number of compounds have been identified as potential inhibitors of SARS-CoV-2 infection in vitro, few have proven to be effective in vivo. Here, we show that oral administration of S-217622, a novel inhibitor of SARS-CoV-2 main protease (Mpro, also known as 3C-like protease), decreases viral load and ameliorates the disease severity in SARS-CoV-2-infected hamsters. S-217622 inhibited viral proliferation at low nanomolar to sub-micromolar concentrations in cells. Oral administration of S-217622 demonstrated eminent pharmacokinetic properties and accelerated recovery from acute SARS-CoV-2 infection in hamster recipients. Moreover, S-217622 exerted antiviral activity against SARS-CoV-2 variants of concern (VOCs), including the highly pathogenic Delta variant and the recently emerged Omicron variant. Overall, our study provides evidence that S-217622, an antiviral agent that is under evaluation in a phase II/III clinical trial, possesses remarkable antiviral potency and efficacy against SARS-CoV-2 and is a prospective oral therapeutic option for COVID-19.

Discussion

In this study, we characterized the antiviral activity of S-217622, a newly identified SARS-CoV-2 Mpro inhibitor. Our in vitro experiments revealed that S-217622 exhibits remarkable antiviral potency against all VOCs. Current vaccines and monoclonal antibody medications target the viral spike protein, which accumulates amino acid variations among SARS-CoV-2 variants16, 17. In contrast, viral Mpro is less divergent, leading to the comparable susceptibility of VOCs to S-217622. Although host factors involved in virus proliferation could be targets for antivirals, viral proteins are specific and favorable targets for antiviral development23. Overall, SARS-CoV-2 Mpro is a prospective target and the inhibitor S-217622 is a broadly reactive antiviral against SARS-CoV-2 variants.

Prophylactic administration of S-217622 prominently decreased viral load in both nasal turbinates and lung tissues. Hamsters receiving high doses of S-217622 developed no detectable neutralizing antibodies at 18 days after inoculation. This result indicates that administration of S-217622 confers sterile protection against SARS-CoV-2 in the recipient animal and suggests the potential of S-217622 as a preventive medication for high-risk individuals who have close contact with patients with COVID-19, and potential treatment of those with active disease. In animal experiments, prophylactic administration at pre-infection or infection stages is a highly sensitive experimental method to detect the efficacy of antivirals24, 25. Our experiments showed that S-217622 has an anti-SARS-CoV-2 effect and facilitates recovery from the acute infection stage even in a post-exposure treatment environment, highlighting the high antiviral activity and the therapeutic potential of S-217622.

MPV and nirmatrelvir have been approved as oral antiviral medications for clinical use; however, concerns remain regarding the efficacy and potential risks. The results of a recent clinical trial showed that MPV treatment decreased the risk of hospitalization for COVID-19 by 30%26, 27. Our experiments also showed that therapeutic treatment with MPV had a limited effect on viral load and body weight decrease in hamsters. It also has been reported that MPV has mutagenesis for not only viral RNA but also host DNA in cell-based assays28. Nirmatrelvir is another Mpr° inhibitor and is reported to have an excellent in vivo efficacy, with an 88% reduction in the risk of hospitalization or death29. A previous study, along with our data, shows that nirmatrelvir is highly sensitive to the multidrug transporter, P-gp, and requires a P-gp inhibitor to exhibit activity in Vero cells12. For clinical use, nirmatrelvir requires co-administration with a CYP3A4 inhibitor (ritonavir) as a pharmacokinetic booster to slow the metabolism of nirmatrelvir. Because the ritonavir booster also affects the metabolism of other medications, clinicians need to consider the potential other drug-drug interactions during treatments30. In contrast, S-217622 showed expected bioavailability and concentration without any pharmacokinetic booster for humans in a phase I trial10. Consequently, S-217622 has different biological properties from the preceding medications and is expected to be an alternative candidate for COVID-19 therapy.

We note some limitations of our study. First, therapeutic treatment with S-217622 was insufficient to control pneumonia in SARS-CoV-2-infected hamsters, although they regained lost body weight earlier compared to vehicle controls. We assume that the initial virus proliferation stimulated host immunity and subsequent inflammation31, 32, and combination with antiviral and anti-inflammatory medication may lead to better results and outcomes33. Second, this study was conducted using hamsters as a COVID-19 model and the efficacy in human patients cannot be inferred. However, S-217622 is currently under evaluation in a phase II/III clinical trial. Third, the development of a resistant viral clone against S-217622 and its virological properties will need to be investigated in future studies.

In summary, our study has demonstrated the remarkable antiviral activity of S-217622 through in vitro and in vivo experiments. This scientific evidence will be invaluable when considering the application of S-217622 as a medication for COVID-19.

Est. Cost- $500-$700 per pill!

How well do vaccine protect from hospitalization?

Swiss real data!

Switzerland has >2/3 Moderna as the "prime vaccine" So we here see only about 1:1 rate relation between unvaxx vax going to hospital.

These figures clearly show that boosters of course give no protection. Just as a reminder. First row 3x/4x vaxx, second row: unvaxx third row 2x,3x vaxx. 4th row vaccine type unknown thus number (2,3,4x) of vaxx unkown. Total ratio 76 vaxx : 33 unvaxx. Vaxx Switzerland total 70%.

So here the high damage the Pfizer crap gene therapy causes is just compensated by the small benefit Moderna still gives with Omicron.

What did our chief Parrot say about fake "vaccine" protection? Brain damage fallacy...

Quote from ZenoOfElea

Here is something for those who believe that Ivermectin research is being suppressed.

Twitter Suppresses Published Results of a Peer Reviewed Study | NextBigFuture.com

University of Minnesota ivermectin trial nearing completion

University of Minnesota ivermectin trial nearing completion

Proof of effectiveness would give doctors outpatient COVID-19 therapies amid limited antiviral and antibody supplies.

www.startribune.com

University of Minnesota has wrapped up it's ivermectin trial and results are expected to be released in April.

Earthquake: Japan hit by shock cutting power to millions

The quake rattles Tokyo and triggers a tsunami advisory for parts of the north-east coast.

www.bbc.co.uk

A powerful earthquake has hit north-east Japan, cutting power to two million homes and prompting a tsunami advisory for parts of the coast.

The magnitude 7.3 tremor struck the same region where a major quake triggered the Fukushima nuclear disaster, 11 years ago.

In some areas it was too forceful for people to stand, and buildings rattled in the capital Tokyo, AFP reports.

Aftershocks are possible in Fukushima, Miyagi and Yamagata prefectures.

The quake took place at 23:36 (14:36 GMT), Japanese authorities said.

Quote from Alan Smith

In some areas it was too forceful for people to stand, and buildings rattled in the capital Tokyo, AFP reports.

In central Tokyo it was just magnitude 4. Nothing special, in the suburbs it was 5. Fukushima was 6.

2 million without power :: https://mainichi.jp/english/ar…20317/p2g/00m/0na/005000c

Seems like its still moving

Quote from ZenoOfElea

Here is something for those who believe that Ivermectin research is being suppressed.

Twitter Suppresses Published Results of a Peer Reviewed Study | NextBigFuture.com

Just to make sure the sane side of this argument is represented - though I doubt amny here will like it.

Twitter is a social media platform. It is actually a private company - and sets its own policies about what is allowed. Of course it responds to public pressure.

If you are a pressure group advocating something you may feel that lack of access to twitter is a big deal. I don't however know of any scientists who would care much, and twitter is not the main way new scientific information is distributed.

No-one is censoring high quality peer-reviewed studies, even on twitter.

Preprints, and low quality (= self-published in journals that will publish anything) studies are rather different.

So: twitter censors harmful propaganda - yes. It is not the government, social media don't exercise censorship that well, they are blamed both for censoring too much and not enough.

No-one to my knowledge is censoring scientific information: it would in any case be impossible to do this given the 100s of 1000s of scientific journals with varying editorial policies in different countries.

THH

On the topic of "social media platforms cannot be relied on as gatekeepers, and censorship on them does not help"

people have complex reasons for sharing misinformation, and we won’t change this by giving them more facts

Nowhere truer than on this thread.

Royal Society cautions against online censorship of scientific misinformation | University of Oxford

www.ox.ac.uk

Professor Gina Neff, another working group member and Professor of Technology & Society at the Oxford Internet Institute, adds, ‘Scientific misinformation doesn’t just affect individuals, it can harm society and even future generations if allowed to spread unchecked.

‘Our polling showed people have complex reasons for sharing misinformation, and we won’t change this by giving them more facts.’

Meanwhile, Professor Michael Bronstein, Oxford Deep Mind professor of artificial intelligence and working group member, points out,

Quote

Members of the public often lack the tools to tell authoritative sources from fictitious ones...consequently fall victim both to honest mistakes and misreading of scientific results as well as intentional manipulation
Professor Michael Bronstein,

Professor Rasmus Kleis Nielsen, of Oxford University’s Reuters Institute for the study of journalism, concludes, ‘a lot of citizens [would have] their worst suspicions confirmed’ if access to information were limited – even if it is misinformation.

Yup, THH its set up so not to know what or who to believe.

old as war itself.

Quote from Wyttenbach

In central Tokyo it was just magnitude 4.

From my son in Shibuya, central Tokyo.

" Everybody is fine - bit of a wobble here and a few things fell off shelves and a few drawers came open.

Power stayed on all night."

IMO good interview with Prof. Dr. Martin HADITSCH. Dated Jan. 22

Currently in AT compulsory vaxx. has been already suspended and it will completely fall apart, if his predictions come true.

I really feel sorry for those (young) people, who have been persuated and pushed to take the vaccine just to be able to take part at social live. More and more questions arise, since new studies and obvious facts surface. There is a (health) price to pay and it will be high for especially younger people.

BTW we have the 3rd secretary of health within two years. It's a hot chair!