The Playground

  • Antiviral Nephrotoxic?


    Acute Renal Failure due to Molnupiravire

    Acute Renal Failure due to Molnupiravire
    Molnipiravir is a promising RNA-Dependent RNA-Polymerase enzyme inhibitor that has started to be used in the treatment of SARS-COV-2. I present the first case…
    www.researchsquare.com


    Abstract

    Molnipiravir is a promising RNA-Dependent RNA-Polymerase enzyme inhibitor that has started to be used in the treatment of SARS-COV-2. I present the first case who was infected with the Omicron variant and developed acute renal failure due to the use of molnipiravir.67 Year-old male patient with the diagnosis of hypertension and chronic obstructive pulmonary disease developed severe nausea, vomiting and diarrhea with the use of drugs. In the patient's examinations, severe deterioration in kidney functions occurred. The patient who developed acute tubular necrosis was taken to hemodialysis twice. IV hydration and supportive treatments were started. In the follow-up, clinical and renal functions improved. In patients over 65 years of age and with comorbidities, the adverse effects of molnipiravir should be considered and followed closely.

  • Moving the question ..

    with the back side of the earth area "zone of pressure and the x flares in the front-ect what is the force on the back side of the planet? if not a lot of gasses escaped, turn into ice and collect for mass and fall back down or get pulled back to the sun..

    what gas do you think can do that? or am I just way off...

  • Clinical Study Suggests SaNOtize Nitric Oxide Nasal Spray Is Effective at Preventing COVID-19 after High-Risk Exposure

    https://www.businesswire.com/news/home/20220511005194/en/Clinical-Study-Suggests-SaNOtize-Nitric-Oxide-Nasal-Spray-Is-Effective-at-Preventing-COVID-19-after-High-Risk-Exposure


    The study was carried out during an emergency effort by the University to contain an Omicron outbreak in February, 2022. Medical personnel, students, and professors (1,039 individuals, aged 18-60) were quarantined in dormitories after possible COVID-19 exposure. Individuals were included in the current analysis if they had confirmed high-risk exposure to a COVID-19 infected roommate (defined as being within one to two meters of the infected individual for at least five minutes without a mask). NONS was offered to staff and students who reported exposure.


    After exclusion for being low-risk or testing positive via antigen test kit (ATK) within 24 hours, 625 student participants were included in the analysis. Of these, 203 participants used NONS at least four times per day and 422 volunteers did not use NONS. All volunteers were tested via ATK on the fifth, seventh, and tenth day of quarantine, and positive tests were confirmed by PCR.


    Among the 203 participants who used NONS, 13 tested positive (6.4% infection rate). Of the 422 in the control group, 108 participants tested positive (25.6% infection rate), a statistically significant difference from the treatment group (P<0.0001). Participants in the NONS group reported only a mild side effect of nasal irritation (8 of the 203, or 3.9%).

  • Virus that has killed scores of birds turns up in first wild mammal in Minnesota


    Virus that has killed scores of birds turns up in first wild mammal in Minnesota
    Fox kit in Anoka County tested positive for bird flu, according to the Department of Natural Resources.
    www.startribune.com



    A fox kit from Anoka County has tested positive for a deadly, highly contagious bird flu that has killed countless wild birds this spring to the concern of wildlife specialists.


    The positive case is the first confirmed of highly pathogenic avian influenza, or HPAI, in a wild mammal in Minnesota, according to the Department of Natural Resources.


    It's not unprecedented — two red fox kits in Ontario tested positive last week for the flu strain, the DNR said in a news release Wednesday. They were the first reported cases in mammals in North America

  • Western propaganda machine is showing cracks, it can no longer hide the truth!


    Breakthrough deaths comprise increasing proportion of those who died from COVID-19


    Breakthrough deaths comprise increasing proportion of those who died from COVID-19
    Experts said the increase in breakthrough deaths is to be expected with more Americans reaching full vaccination status.
    abcnews.go.com


    A growing proportion of COVID-19 deaths are occurring among the vaccinated, a new ABC News analysis of federal data shows.


    In August of 2021, about 18.9% of COVID-19 deaths occurred among the vaccinated. Six months later, in February 2022, that proportional percent of deaths had increased to more than 40%.

  • gas do you think can do that?

    Ions of water vapor caught in the Van Allan Belt? Just a guess...


    On another note. Balls of fire... Tied up light in a torus knot. Sort of like ball lighting or EVO. Ha ya got to love the thinking, musing, poetry and witty meanderings of James Clerk Maxwell. The creation of every knot in the Encyclopedia of Knots and Fancy Ropework described mathematically, oh my. Now as Knots of Light!


    "Light Knots: Physicists use Maxwell's Equations to Describe Field Lines that Encode Torus Knots and Links" by Bob Yirka , Phys.org

    Light knots: Physicists use Maxwell's equations to describe field lines that encode torus knots and links
    (Phys.org) —A team of physicists, two from the U.S., and one each from Poland and Spain has used Maxwell's equations to describe field lines that encode all…
    phys.org

    A team of physicists, two from the U.S., and one each from Poland and Spain has used Maxwell's equations to describe field lines that encode all torus knots and links. As they describe in their paper published in the journal Physical Review Letters, the result of using the equations could lead to a method of creating light in the real world that can be tied into knots.


    To Hermann Stoffkraft, Ph.D.

    A Paradoxical Ode

    After Shelley


    (James Clerk Maxwell's Last Poem)

    "My Soul’s an Amphicheiral Knot"


    My soul’s an amphicheiral knot

    Upon a liquid vortex wrought

    By Intellect in the Unseen residing,

    While thou dost like a convict sit

    With marlinspike untwisting it

    Only to find my knottiness abiding;

    Since all the tools for my untying

    In four-dimensioned space are lying,

    Where playful fancy intersperses

    Whole avenues of universes;

    Where Klein and Clifford fill the void

    With one unbounded, finite homaloid,

    Whereby the Infinite is hopelessly destroyed.

    II

    But when thy Science lifts her pinions

    In Speculation’s wild dominions,

    I treasure every dictum thou emittest;

    While down the stream of Evolution

    We drift, and look for no solution

    But that of the survival of the fittest.

    Till in that twilight of the gods

    When earth and sun are frozen clods,

    When, all its energy degraded,

    Matter in æther shall have faded,

    We, that is, all the work we’ve done,

    As waves in æther, shall for ever run

    In swift-expanding spheres, through heavens beyond the sun.

    III

    Great Principle of all we see,

    Thou endless Continuity!

    By thee are all our angles gently rounded;

    Our misfits are by thee adjusted,

    And as I still in thee have trusted,

    So let my methods never be confounded!

    O never may direct Creation

    Break in upon my contemplation,

    Still may the causal chain, ascending,

    Appear unbroken and unending,

    And, where that chain is lost to sight

    Let viewless fancies guide my darkling flight

    Through Æon-haunted worlds, in order infinite.


    Taped to the bottom of the page of Tait’s scrap-book is an addendum, sent by Maxwell some time afterwards:


    Last three lines of Ode to Stoffkraft should be as follows.


    While Residents in the Unseen— Æons or Emanations—intervene,

    And from my shrinking soul the Unconditioned screen.


    Was Maxwell teasing Tait by pointing out an unfortunate consequence of his philosophy—that the Principle of Continuity should prevent us from ever encountering the Unconditioned, even after death?Maxwell’s thoughts about dying remain hidden from us. Whatever they were, they must have been certain and comforting to him. According to an at-tending physician, “No man ever met death more consciously or more calmly.”


    Reference

    "The Last Poem of James Clerk

    Maxwell" by Daniel S. Silver

    Pg. 1266, Notices of the AMS

    Volume 55, Number 10

  • In August of 2021, about 18.9% of COVID-19 deaths occurred among the vaccinated. Six months later, in February 2022, that proportional percent of deaths had increased to more than 40%.

    Looks like the US counting method is sponsored by big pharma. In all other places on the planet 2x,3x,4x vaxx deaths by far outnumber unvaxx deaths also by rate now! Most vaxx die silently of other causes than CoV-19 at rates up to 3x than unvaxx....

  • Putative Role of Vitamin D for COVID-19 Vaccination

    Putative Role of Vitamin D for COVID-19 Vaccination - PubMed
    Severe acute respiratory syndrome coronavirus 2 is a new, highly pathogenic virus that has recently elicited a global pandemic called the 2019 coronavirus…
    pubmed.ncbi.nlm.nih.gov


    Putative Role of Vitamin D for COVID-19 Vaccination - PubMed
    Severe acute respiratory syndrome coronavirus 2 is a new, highly pathogenic virus that has recently elicited a global pandemic called the 2019 coronavirus…
    pubmed.ncbi.nlm.nih.gov


    Abstract

    Severe acute respiratory syndrome coronavirus 2 is a new, highly pathogenic virus that has recently elicited a global pandemic called the 2019 coronavirus disease (COVID-19). COVID-19 is characterized by significant immune dysfunction, which is caused by strong but unregulated innate immunity with depressed adaptive immunity. Reduced and delayed responses to interferons (IFN-I/IFN-III) can increase the synthesis of proinflammatory cytokines and extensive immune cell infiltration into the airways, leading to pulmonary disease. The development of effective treatments for severe COVID-19 patients relies on our knowledge of the pathophysiological components of this imbalanced innate immune response. Strategies to address innate response factors will be essential. Significant efforts are currently underway to develop vaccines against SARS-CoV-2. COVID-19 vaccines, such as inactivated DNA, mRNA, and protein subunit vaccines, have already been applied in clinical use. Various vaccines display different levels of effectiveness, and it is important to continue to optimize and update their composition in order to increase their effectiveness. However, due to the continuous emergence of variant viruses, improving the immunity of the general public may also increase the effectiveness of the vaccines. Many observational studies have demonstrated that serum levels of vitamin D are inversely correlated with the incidence or severity of COVID-19. Extensive evidence has shown that vitamin D supplementation could be vital in mitigating the progression of COVID-19 to reduce its severity. Vitamin D defends against SARS-CoV-2 through a complex mechanism through interactions between the modulation of innate and adaptive immune reactions, ACE2 expression, and inhibition of the renin-angiotensin system (RAS). However, it remains unclear whether Vit-D also plays an important role in the effectiveness of different COVID-19 vaccines. Based on analysis of the molecular mechanism involved, we speculated that vit-D, via various immune signaling pathways, plays a complementary role in the development of vaccine efficacy.

  • North Korea just announced it's first Covid cases. It will be very interesting to see what omicrom does to an unvaccinated nation.

    I guess they are low on V-D3 but not obese. So they will do still better than all vaxx countries.

    As said: With omicron we now have 80% of all hospital cases among vaxx with a vaxx ratio of only 70%...


    Also all idiot countries with mask prevent/delay soft infections and artificially prolongate the "pandemic". Look at Switzerland, Denmark/Sweden,Norway where cases and deaths are very low.

  • Still thinking if the gasses created and shed from earths moving throughout space we should see the trail back through time. Seems I'm over thinking things again...

  • Umm....


    Its like groundhog day.


    In fact the subtitle in the paper says it too...


    https://www.sciencedirect.com/science/article/abs/pii/0001691880900463#:~:text=The%20base%2Drate%20fallacy%20is,%2C%20and%20social%2Dpsychological%20settings.


    There is also another effect: most of the unvaccinated now have already caught COVID, so are second time rounders. Most of the ones who were going to die will have done it first time!

  • Breakthrough deaths comprise increasing proportion of those who died from COVID-19 Experts said the increase in breakthrough deaths is to be expected with more Americans reaching full vaccination status. abcnews.go.com

    In other words, more messaging to get boosted, double boosted, etc.

    The hospitalized lady on the exam table seems to be in bad enough condition that she didn't take her left shoe off.

  • "My Soul’s an Amphicheiral Knot"

    Wikipedia


    An amphicheiral knot is one which has an orientation-reversing self-homeomorphism of the 3-sphere, α, fixing the knot set-wise. All amphicheiral alternating knots have even crossing number. The first amphicheiral knot with odd crossing number is a 15-crossing knot discovered by Hoste et al.


    Fully amphicheiral


    If a knot is isotopic to both its reverse and its mirror image, it is fully amphicheiral. The simplest knot with this property is the figure-eight knot.


    In knot theory, a figure-eight knot (also called Listing's knot is the unique knot with a crossing number of four. This makes it the knot with the third-smallest possible crossing number, after the unknot and the trefoil knot. The figure-eight knot is a prime knot. wiki - link

    Figure 8 knot https://en.m.wikipedia.org/wik…e-eight_knot_(mathematics)


    Positive amphicheiral


    If the self-homeomorphism, α, preserves the orientation of the knot, it is said to be positive amphicheiral. This is equivalent to the knot being isotopic to its mirror. No knots with crossing number smaller than twelve are positive amphicheiral and noninvertible


    Negative amphicheiral


    If the self-homeomorphism, α, reverses the orientation of the knot, it is said to be negative amphicheiral. This is equivalent to the knot being isotopic to the reverse of its mirror image. The noninvertible knot with this property that has the fewest crossings is the knot 8.17 wiki - Link

    Knot 8 17 https://en.m.wikipedia.org/wiki/File:8_17_Knot.svg

  • Mark U meets so many people dying from vaccines... when no-one else does.

    Well, dying is a bit strong. Injured in one way or another. If I recall rightly Bob shared an account of a few of his acquaintances getting injured.

    Let me see. My uncle got shingles within a week of his second shot, and was hospitalized with pulmonary edema about three days after his third shot. (His brother, my father in law, passed away three days after his fourth dose.) But! I'm happy to report that my uncle is fine after his fourth shot two weeks ago. My hardy wife was totally incapacitated for over a day after her second dose. One of my kids had large lumps under his right armpit for 2 months after his second dose. A few months ago I bumped into a 65ish year old slim fit guy I hadn't seen in years. He shared the crazy news of how he had a heart attack in the last year, and his wife a stroke. (She is now in a care home because of it.) I asked him if they had been vaccinated, then I asked him if his heart attack and her stroke had occurred soon after vaccination. It hadn't even occurred to him, and he was a bit rattled to compute they had both occurred within a few weeks after their vaccinations. Then there was my neighbour's friend who lost vision in one eye after vaccination, and another friend of the same neighbour who lost his hearing in one ear after vaccination.

    This is off the top of my head. But my current social circle is pretty small, so no doubt I'm missing out on a lot of stuff.