Some chemical justification for HydroxyCQ plus Zithromax (azithromycin)..
Mar24 chemrxiv..
Azithromycin appears to directly stop the virus spike binding to the ACE2 receptor on lung tissue
HydroxyCQ indirectly stops the spike binding.
from
https://www.linkedin.com/in/samarth-sandeep-81a02487
https://github.com/IffTech/Hyd…uineAzithromycinPaperData
https://chemrxiv.org/articles/…n_-_ACE2_Complex/12015792
"Binding sites on the SARS-COV-2 Envelope (E) Protein identified by Polar+, a quantum mechanical optimization tool built by Iff Technologies
Discussion.
Based on the binding results provided above, hydroxychloroquine by itself appears to be ineffective
in directly inhibiting the SARS-CoV-2 spike-ACE2 interaction.
Instead, it seems to serve to increase the acidity of the ACE2 system in the interaction between the ACE2
and SARS-CoV-2 spike that could in many cases result in the degradation of the spike, and
potentially the discontinuation of the virus’ ability to spread further.
On the other hand, azithromycin provides high binding affinity when adjusted for energetics and
has a much better ability at directly targeting the binding interaction point between the
SARS-CoV-2 spike and ACE2.
Much of this has to do with azithromycin’s nearly symmetric design:
this allows the small molecule to effectively handle binding with ligands between both
the spike and the ACE2,
Big Pharma would charge mega dollars for this free IP.