How many negative studies are there? How many patients were enrolled in both?
I can't judge. I would have to look at the 253 studies and see if they have merit, and I am not qualified. There is a great deal of junk science in this world, so it is plausible these are all wrong.
We have been through this before. Look back and you will find that you backed off when presented with those 253 HCQ studies. It was only a short time ago.